Gene Symbol: Ncf1
Description: neutrophil cytosolic factor 1
Alias: NCF-47K, NOXO2, Ncf-1, p47-phox, p47, p47phox, neutrophil cytosol factor 1, 47 kDa neutrophil oxidase factor, NADPH oxidase subunit (47 kD), NADPH oxidase subunit (47kDa), neutrophil NADPH oxidase factor 1
Species: mouse
Products:     Ncf1

Top Publications

  1. Li J, Fan L, Christie M, Shah A. Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4. Mol Cell Biol. 2005;25:2320-30 pubmed
    ..these pathways is unclear; however, a recent study suggested that TRAF4 could bind to the NADPH oxidase subunit p47phox. Here, we investigated the potential interaction between p47phox phosphorylation and TRAF4 binding and their ..
  2. Endres R, Luz A, Schulze H, Neubauer H, Fütterer A, Holland S, et al. Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity. 1997;7:419-32 pubmed
  3. Thomas M, Gavrila D, McCormick M, Miller F, Daugherty A, Cassis L, et al. Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Circulation. 2006;114:404-413 pubmed publisher
    ..We reported that O2- levels, NADPH oxidase activity, and expression of the p47phox subunit of NADPH oxidase are increased in human abdominal aortic aneurysms (AAAs)...
  4. Sareila O, Jaakkola N, Olofsson P, Kelkka T, Holmdahl R. Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation. J Leukoc Biol. 2013;93:427-35 pubmed publisher
    ..are expressed, but only one is expressed as a protein, although at lower levels than the WT NCF1 (also known as p47phox)...
  5. Purushothaman D, Sarin A. Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis. J Exp Med. 2009;206:1515-23 pubmed publisher
    ..Thus, the NADPH oxidase may regulate adaptive immunity in addition to its previously well-characterized role in the innate response. ..
  6. Segal B, Davidson B, Hutson A, Russo T, Holm B, Mullan B, et al. Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2007;292:L760-8 pubmed
    ..To evaluate the specific role of the phagocyte NADPH oxidase-derived ROIs in acid lung injury, the p47phox-/- knockout mouse model of chronic granulomatous disease was used...
  7. Rusyn I, Yamashina S, Segal B, Schoonhoven R, Holland S, Cattley R, et al. Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators. Cancer Res. 2000;60:4798-803 pubmed
    ..b>p47phox is a critical subunit of NADPH OX; therefore, p47phox knockout mice were used to specifically address the ..
  8. Mardiney M, Jackson S, Spratt S, Li F, Holland S, Malech H. Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease. Blood. 1997;89:2268-75 pubmed
    The p47phox-/- mouse exhibits a phenotype similar to that of human chronic granulomatous disease (CGD) and, thus, is an excellent model for the study of gene transfer technology...
  9. Tse H, Thayer T, Steele C, Cuda C, Morel L, Piganelli J, et al. NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity. J Immunol. 2010;185:5247-58 pubmed publisher
    ..These data validate the role of superoxide in shaping Th responses and as a signaling intermediate to modulate Th17 and Th1 T cell responses...

More Information


  1. Hultqvist M, Olofsson P, Holmberg J, Bäckström B, Tordsson J, Holmdahl R. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A. 2004;101:12646-51 pubmed
    The Ncf1 gene was recently identified as a strong regulator of severe arthritis in rat. This finding was surprising, because the disease-promoting allele mediated a lower level of reactive oxygen species in NADPH oxidase-expressing cells...
  2. D Angelo C, De Luca A, Zelante T, Bonifazi P, Moretti S, Giovannini G, et al. Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease. J Immunol. 2009;183:4609-18 pubmed publisher
    ..Thus, PTX3 could be therapeutically used for the exploitation of NADPH-independent mechanism(s) of antifungal immune protection with limited immunopathology in CGD. ..
  3. Jackson S, Devadas S, Kwon J, Pinto L, Williams M. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol. 2004;5:818-27 pubmed
    ..Thus, mature T cells express a phagocyte-type NADPH oxidase that regulates elements of TCR signaling. ..
  4. Gao X, Standiford T, Rahman A, Newstead M, Holland S, Dinauer M, et al. Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice. J Immunol. 2002;168:3974-82 pubmed
  5. Segal B, Ding L, Holland S. Phagocyte NADPH oxidase, but not inducible nitric oxide synthase, is essential for early control of Burkholderia cepacia and chromobacterium violaceum infection in mice. Infect Immun. 2003;71:205-10 pubmed
  6. Doerries C, Grote K, Hilfiker Kleiner D, Luchtefeld M, Schaefer A, Holland S, et al. Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction. Circ Res. 2007;100:894-903 pubmed
    ..The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI. ..
  7. Vendrov A, Hakim Z, Madamanchi N, Rojas M, Madamanchi C, Runge M. Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells. Arterioscler Thromb Vasc Biol. 2007;27:2714-21 pubmed
  8. Patel V, Wang Z, Fan D, Zhabyeyev P, Basu R, Das S, et al. Loss of p47phox subunit enhances susceptibility to biomechanical stress and heart failure because of dysregulation of cortactin and actin filaments. Circ Res. 2013;112:1542-56 pubmed publisher
  9. Yao H, Edirisinghe I, Yang S, Rajendrasozhan S, Kode A, Caito S, et al. Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. Am J Pathol. 2008;172:1222-37 pubmed publisher
    ..Thus, these data suggest that genetic ablation of components of NADPH oxidase enhances susceptibility to the proinflammatory effects of CS leading to airspace enlargement and alveolar damage. ..
  10. Narni Mancinelli E, Campisi L, Bassand D, Cazareth J, Gounon P, Glaichenhaus N, et al. Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes. J Exp Med. 2007;204:2075-87 pubmed
    ..In this context, CCL3-secreting memory CD8+ T cells are able to mediate "bystander" killing of an unrelated pathogen upon antigen-specific reactivation, a mechanism that may be important for the design of therapeutic vaccines. ..
  11. Teng L, Fan L, Meijles D, Li J. Divergent effects of p47(phox) phosphorylation at S303-4 or S379 on tumor necrosis factor-? signaling via TRAF4 and MAPK in endothelial cells. Arterioscler Thromb Vasc Biol. 2012;32:1488-96 pubmed publisher
    ..production, but is not involved in TNF? signaling through TNF receptor-associated factor 4 and ERK1/2. p47(phox) requires serine phosphorylation at distinct sites to support specific signaling events in response to TNF?. ..
  12. Romani L, Fallarino F, De Luca A, Montagnoli C, D Angelo C, Zelante T, et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature. 2008;451:211-5 pubmed publisher
    ..Yet, this condition can be reverted by reactivating the pathway downstream of the superoxide-dependent step. ..
  13. Segal B, Han W, Bushey J, Joo M, Bhatti Z, Feminella J, et al. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS ONE. 2010;5:e9631 pubmed publisher
    ..These studies support a model in which NADPH oxidase-dependent, redox-mediated signaling is critical for termination of lung inflammation and suggest new potential therapeutic targets for CGD. ..
  14. Vasilevsky S, Liu Q, Koontz S, Kastenmayer R, Shea K, Jackson S. Role of p47phox in antigen-presenting cell-mediated regulation of humoral immunity in mice. Am J Pathol. 2011;178:2774-82 pubmed publisher
    ..These findings demonstrate a novel benefit of NADPH oxidase 2 deficiency (ie, dependent inflammation in antigen-presenting cell-mediated humoral immunity) and that anti-Lm Ab can be protective in an immunodeficient CGD host. ..
  15. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, Dikalova A, et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest. 2000;106:867-72 pubmed
  16. Barry Lane P, Patterson C, van der Merwe M, Hu Z, Holland S, Yeh E, et al. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. J Clin Invest. 2001;108:1513-22 pubmed
    ..SMCs from wild-type, p47phox(-/-), and gp91phox(-/-) mice differed markedly with respect to growth factor responsiveness and ROS generation...
  17. Boyle K, Gyori D, Sindrilaru A, Scharffetter Kochanek K, Taylor P, Mócsai A, et al. Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol. 2011;186:2978-89 pubmed publisher
    ..These results start to define the signaling network controlling neutrophil ROS responses to A. fumigatus hyphae. ..
  18. Donaldson M, Antignani A, Milner J, Zhu N, Wood A, Cardwell Miller L, et al. p47phox-deficient immune microenvironment signals dysregulate naive T-cell apoptosis. Cell Death Differ. 2009;16:125-38 pubmed publisher
  19. Liu G, Fang F, Zhou J, Koulajian K, Yang S, Lam L, et al. Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse. Diabetologia. 2012;55:2522-32 pubmed publisher
    ..We examined the effect of deleting p47 (phox) (also known as Ncf1), the gene for the NADPH oxidase subunit, on diabetic nephropathy in the Akita mouse (Ins2 (WT/C96Y)) by studying ..
  20. Tkalcevic J, Novelli M, Phylactides M, Iredale J, Segal A, Roes J. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity. 2000;12:201-10 pubmed
    ..The data demonstrate a critical role of the nonoxidative effector mechanisms of neutrophils in host immunity and immunopathology and identify elastase and cathepsin G as effectors in the endotoxic shock cascade downstream of TNFalpha. ..
  21. Sadikot R, Zeng H, Yull F, Li B, Cheng D, Kernodle D, et al. p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. J Immunol. 2004;172:1801-8 pubmed
    ..These data indicate that the NADPH oxidase-dependent respiratory burst stimulated by Pseudomonas infection contributes to host defense by modulating redox-dependent signaling through the NF-kappaB pathway. ..
  22. Hagenow K, Gelderman K, Hultqvist M, Merky P, Bäcklund J, Frey O, et al. Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice. J Immunol. 2009;183:874-81 pubmed publisher
    ..Low levels of ROS production due to a polymorphism in the neutrophil cytosolic factor 1 (Ncf1) gene are associated with autoimmunity and arthritis severity in mouse models induced with adjuvant...
  23. Richter C, Juan M, Will J, Brandes R, Kalinke U, Akira S, et al. Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol. 2009;182:4183-91 pubmed publisher
    ..We investigated the regulatory function of Ncf1, an organizing protein of NADPH oxidase, in the signaling cascade of Toll-like receptors...
  24. van de Loo F, Bennink M, Arntz O, Smeets R, Lubberts E, Joosten L, et al. Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. Am J Pathol. 2003;163:1525-37 pubmed
    ..In contrast to wild-type mice, arthritis elicited in both p47phox(-/-) and gp91(-/-) mice showed more severe joint inflammation, which developed into a granulomatous synovitis...
  25. Liu Q, Yi L, Sadiq Ali S, Koontz S, Wood A, Zhu N, et al. PP2A-dependent control of transcriptionally active FOXO3a in CD8(+) central memory lymphocyte survival requires p47(phox). Cell Death Dis. 2012;3:e375 pubmed publisher
    ..Our findings indicate a critical role for p47(phox) in a dynamic interplay between PP2A and FOXO3a that regulates pro-apoptotic Bim transcription in CD8(+) memory lymphocytes during infection. ..
  26. Pizzolla A, Hultqvist M, Nilson B, Grimm M, Eneljung T, Jonsson I, et al. Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. J Immunol. 2012;188:5003-11 pubmed publisher
    ..Mice with a spontaneous mutation in Ncf1, which encodes the NCF1 (p47(phox)) subunit of NOX2, have defective phagocyte NOX2 activity...
  27. Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, et al. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension. 2002;40:511-5 pubmed
    ..These results suggest a pivotal role of the NAD(P)H oxidase and its subunit p47(phox) in the vascular oxidant stress and the blood pressure response to angiotensin II in vivo. ..
  28. Segal B, Kuhns D, Ding L, Gallin J, Holland S. Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. J Leukoc Biol. 2002;71:410-6 pubmed
    ..These data suggest that LTB(4) and C5a have separate but overlapping roles in thioglycollate-elicited peritonitis, and at least the leukotriene component is, in turn, regulated by reactive oxidants...
  29. Deffert C, Carnesecchi S, Yuan H, Rougemont A, Kelkka T, Holmdahl R, et al. Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells. J Pathol. 2012;228:341-50 pubmed publisher
    ..which requires NOX2 activity to limit inflammation, we investigated mice with a loss of function mutation in the Ncf1 gene coding for the p$47^{\rm{phox}}$ subunit of NOX2 and mice with transgenic rescue of Ncf1 under control of the ..
  30. Hsich E, Segal B, Pagano P, Rey F, Paigen B, Deleonardis J, et al. Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase. Circulation. 2000;101:1234-6 pubmed
    ..However, the absence of a functional oxidase does not significantly affect the progression of atherosclerosis in the standard mouse apoE -/- model, nor does it significantly influence basal blood pressure. ..
  31. Fan L, Teng L, Li J. Knockout of p47 phox uncovers a critical role of p40 phox in reactive oxygen species production in microvascular endothelial cells. Arterioscler Thromb Vasc Biol. 2009;29:1651-6 pubmed publisher
    ..Dephosphorylation of p40(phox) is a prerequisite for agonist-induced p47(phox) phosphorylation, and p40(phox) through its dynamic dephosphorylation and rephosphorylation is involved in the regulation of agonist-induced ROS production. ..
  32. Jendrysik M, Vasilevsky S, Yi L, Wood A, Zhu N, Zhao Y, et al. NADPH oxidase-2 derived ROS dictates murine DC cytokine-mediated cell fate decisions during CD4 T helper-cell commitment. PLoS ONE. 2011;6:e28198 pubmed publisher
  33. Efimova O, Szankasi P, Kelley T. Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells. PLoS ONE. 2011;6:e16013 pubmed publisher
    ..Tregs and Teffs were isolated from the spleens of wild type (WT) C57BL/6 mice or Ncf1(p47phox)-deficient C57BL/6 mice which lack NADPH oxidase function...
  34. Jackson S, Gallin J, Holland S. The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med. 1995;182:751-8 pubmed
    ..We have created a mouse model of CGD by targeted disruption of p47phox, one of the genes in which mutations cause human CGD...
  35. Huang C, Zhan L, Hannigan M, Ai Y, Leto T. P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+. J Leukoc Biol. 2000;67:210-5 pubmed
    ..Molecular analysis by reverse transcriptase-polymerase chain reaction identified three abnormal p47phox mRNA transcripts...
  36. Reeves E, Lu H, Jacobs H, Messina C, Bolsover S, Gabella G, et al. Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature. 2002;416:291-7 pubmed
    ..We show that it is the proteases, thus activated, that are primarily responsible for the destruction of the bacteria. ..
  37. Li J, Shah A. Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit. J Biol Chem. 2003;278:12094-100 pubmed
    ..These data indicate that angiotensin II-stimulated endothelial NADPH oxidase activity is regulated through serine phosphorylation of p47(phox) and its enhanced binding to p22(phox). ..
  38. Hultqvist M, Bäcklund J, Bauer K, Gelderman K, Holmdahl R. Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice. J Immunol. 2007;179:1431-7 pubmed
    ..Low levels of ROS production, due to a mutation in the Ncf1 gene coding for the Ncf1 (alias p47(phox)) subunit of the NADPH oxidase complex, was shown to be associated with ..
  39. Bignell E, Negrete Urtasun S, Calcagno A, Arst H, Rogers T, Haynes K. Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. Infect Immun. 2005;73:5204-7 pubmed
    ..This demonstrates that p47(phox)(-/-) murine immunity contributes significantly to A. nidulans lethality. These data have wider implications for microbial virulence studies with p47(phox)(-/-) mice. ..
  40. Li J, Wheatcroft S, Fan L, Kearney M, Shah A. Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation. Circulation. 2004;109:1307-13 pubmed
    ..The p47phox subunit plays an important role in Ang II-induced oxidase activation, but its role in basal oxidase activity and ..
  41. Lavigne M, Malech H, Holland S, Leto T. Genetic requirement of p47phox for superoxide production by murine microglia. FASEB J. 2001;15:285-7 pubmed
    ..Here, we provide genetic evidence that p47phox, an essential component of the phagocyte NADPH oxidase, is required for superoxide anion release from microglia...
  42. Hultqvist M, Holmdahl R. Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice. Cell Immunol. 2005;233:97-101 pubmed
    ..By using an alternative approach, i.e., linkage analysis using relevant animal models we succeeded in finding the Ncf1 gene residing in the Pia4 quantitative trait locus to be responsible for the severity of pristane induced arthritis ..
  43. Krieglstein C, Cerwinka W, Laroux F, Salter J, Russell J, Schuermann G, et al. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med. 2001;194:1207-18 pubmed
    ..Mice genetically deficient ((-/-)) in either iNOS or the p47phox subunit of NADPH oxidase, transgenic (Tg) mice that overexpress SOD, and their respective wild-type (WT) ..
  44. Chao W, Yen C, Hsieh C, Huang Y, Tseng Y, Nigrovic P, et al. Mycobacterial infection induces higher interleukin-1? and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase. PLoS ONE. 2017;12:e0189453 pubmed publisher
    ..Here, we used a NADPH oxidase 2 (NOX2)-deficient mice (Ncf1-/-) to investigate the role of leukocyte-produced reactive oxygen species (ROS) in mycobacterium-induced ..
  45. Wang Q, Zhang M, Ding Y, Wang Q, Zhang W, Song P, et al. Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo. Circ Res. 2014;114:480-92 pubmed publisher
    ..Kyn pathway activation accelerates apoptosis and dysfunction of the endothelium by upregulating NAD(P)H-derived superoxide. ..
  46. Khmaladze I, Saxena A, Nandakumar K, Holmdahl R. B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production. Eur J Immunol. 2015;45:2243-51 pubmed publisher
    ..ACB mice are protected from collagen-induced arthritis. Introducing a mutation in the Ncf1 gene, leading to ROS deficiency, breaks this strong arthritis resistance. Disease development in Ncf1-mutated B10Q...
  47. Zhang W, Wei H, Tien Y, Frei B. Genetic ablation of phagocytic NADPH oxidase in mice limits TNF?-induced inflammation in the lungs but not other tissues. Free Radic Biol Med. 2011;50:1517-25 pubmed publisher
  48. Xu X, Yavar Z, Verdin M, Ying Z, Mihai G, Kampfrath T, et al. Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. Arterioscler Thromb Vasc Biol. 2010;30:2518-27 pubmed publisher
    ..5). Early-life exposure to high levels of PM(2.5) is a risk factor for subsequent development of insulin resistance, adiposity, and inflammation. Reactive oxygen species generation by NADPH oxidase appears to mediate this risk. ..
  49. Owens A, Subramanian V, Moorleghen J, Guo Z, McNamara C, Cassis L, et al. Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3. Circ Res. 2010;106:611-9 pubmed publisher
    ..In conclusion, Ang II promotes both aortic medial hypertrophy and hyperplasia in a region-specific manner via an oxidant mechanism. The ascending aortic hyperplasia is dependent on Id3. ..
  50. Jun J, Savransky V, Nanayakkara A, Bevans S, Li J, Smith P, et al. Intermittent hypoxia has organ-specific effects on oxidative stress. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1274-81 pubmed publisher
    ..In p47(phox)-deficient mice, MDA levels were higher at baseline and, unexpectedly, decreased during IH. In conclusion, oxidative stress levels and pathways under IH conditions are organ and duration specific. ..
  51. Reinehr R, Becker S, Braun J, Eberle A, Grether Beck S, Haussinger D. Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis. J Biol Chem. 2006;281:23150-66 pubmed
    ..ROS formation involves a rapid ceramide- and protein kinase Czeta (PKCzeta)-dependent serine phosphorylation of p47phox and subsequent activation of NADPH oxidase isoforms...
  52. Vogel S, Orrington Myers J, Broman M, Malik A. De novo ICAM-1 synthesis in the mouse lung: model of assessment of protein expression in lungs. Am J Physiol Lung Cell Mol Physiol. 2006;291:L496-501 pubmed
    ..Moreover, the general method presented herein has potential value in assessing mechanisms of gene and protein expression in the isolated-perfused mouse lung model. ..
  53. Yoshioka H, Niizuma K, Katsu M, Okami N, Sakata H, Kim G, et al. NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia. J Cereb Blood Flow Metab. 2011;31:868-80 pubmed publisher
    ..These findings suggest that NOX has pivotal roles in MSN injury after tGCI and could be a therapeutic target for brain ischemia. ..
  54. Feng J, Damrauer S, Lee M, Sellke F, Ferran C, Abid M. Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol. 2010;30:1703-10 pubmed publisher
    ..Endothelium-dependent vascular endothelial growth factor regulation of coronary vascular tone may require NADPH oxidase-derived ROS to activate phosphatidylinositol 3-kinase-Akt-endothelial NO synthase axis. ..
  55. Hattori H, Subramanian K, Sakai J, Jia Y, Li Y, Porter T, et al. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010;107:3546-51 pubmed publisher
    ..Together, these results present a physiological role for reactive oxygen species in regulating neutrophil functions and shed light on the pathogenesis of CGD. ..
  56. Miriyala S, Gongora Nieto M, Mingone C, Smith D, Dikalov S, Harrison D, et al. Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation. 2006;113:2818-25 pubmed
    ..infusion failed to stimulate aortic NADPH oxidases, increase blood pressure, and impair vasodilation responses in p47phox-deficient mice...
  57. Siu K, Li Q, Zhang Y, Guo J, Youn J, Du J, et al. NOX isoforms in the development of abdominal aortic aneurysm. Redox Biol. 2017;11:118-125 pubmed publisher
    ..We generated double mutants of hph-1-NOX1, hph-1-NOX2, hph-1-p47phox, and hph-1-NOX4. After two weeks of Ang II infusion, the incidence rate of AAA substantially dropped from 76...
  58. Park M, Hennig B, Toborek M. Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae. J Cell Mol Med. 2012;16:362-75 pubmed publisher
  59. Yang Z, Sharma A, Marshall M, Kron I, Laubach V. NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury. Am J Respir Cell Mol Biol. 2009;40:375-81 pubmed publisher
    ..NADPH oxidase may represent a novel therapeutic target for the treatment of IR injury after lung transplantation. ..
  60. Rathore R, Zheng Y, Niu C, Liu Q, Korde A, Ho Y, et al. Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. Free Radic Biol Med. 2008;45:1223-31 pubmed publisher
  61. Allan E, Tailor P, Balce D, Pirzadeh P, McKenna N, Renaux B, et al. NADPH oxidase modifies patterns of MHC class II-restricted epitopic repertoires through redox control of antigen processing. J Immunol. 2014;192:4989-5001 pubmed publisher
  62. Abramov A, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen M. Expression and modulation of an NADPH oxidase in mammalian astrocytes. J Neurosci. 2005;25:9176-84 pubmed
    ..The astrocytic NADPH oxidase is likely to play important roles in CNS physiology and pathology. ..