Gene Symbol: Ncaph2
Description: non-SMC condensin II complex, subunit H2
Alias: condensin-2 complex subunit H2, kleisin beta
Gosling K, Makaroff L, Theodoratos A, Kim Y, Whittle B, Rui L, et al
. A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development. Proc Natl Acad Sci U S A. 2007;104:12445-50 pubmed
..A missense mutation in an unusual alternatively spliced first exon of the kleisin beta gene, a member of the condensin II complex, was shown to be responsible and act in a T cell-autonomous manner...
Rawlings J, Gatzka M, Thomas P, Ihle J. Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence. EMBO J. 2011;30:263-76 pubmed publisher
..This mechanism ensures that cytokine driven proliferation can only occur in the context of TCR stimulation. ..
Lee J, Ogushi S, Saitou M, Hirano T. Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Mol Biol Cell. 2011;22:3465-77 pubmed publisher
Theodoratos A, Wilson L, Gosling K, Fahrer A. Splice variants of the condensin II gene Ncaph2 include alternative reading frame translations of exon 1. FEBS J. 2012;279:1422-32 pubmed publisher
..Here, we investigated the transcription and translation of the mouse Ncaph2 gene, which encodes a subunit of condensin II...
Houlard M, Godwin J, Metson J, Lee J, Hirano T, Nasmyth K. Condensin confers the longitudinal rigidity of chromosomes. Nat Cell Biol. 2015;17:771-81 pubmed publisher
..Pre-assembled meiotic bivalents unravel when condensin is inactivated by TEV cleavage, proving that it actually holds chromatin fibres together. ..
Nishide K, Hirano T. Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet. 2014;10:e1004847 pubmed publisher
..Our results demonstrate that condensins I and II have overlapping and non-overlapping functions in NSCs, and also provide evolutionary insight into intricate balancing acts of the two condensin complexes. ..
Gosling K, Goodnow C, Verma N, Fahrer A. Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse. Immunology. 2008;125:208-17 pubmed publisher
..mouse strain has a defect in T-cell development caused by a mutation in the ubiquitous kleisin-beta (also known as Ncaph2). Kleisin-beta is a subunit of the condensin II complex involved in chromosome condensation during mitosis...
Martin C, Murray J, Carroll P, Leitch A, Mackenzie K, Halachev M, et al
. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Genes Dev. 2016;30:2158-2172 pubmed
..In addition, hypomorphic Ncaph2 mice have significantly reduced brain size, with frequent anaphase chromatin bridge formation observed in apical ..
Woodward J, Taylor G, Soares D, Boyle S, Sie D, Read D, et al
. Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Genes Dev. 2016;30:2173-2186 pubmed
..Together, our data challenge the view that mitotic chromosome formation is an invariant process during development and provide evidence that defective mitotic chromosome structure can promote tumorigenesis. ..