Gene Symbol: Ncan
Description: neurocan
Alias: C230035B04, Cspg3, Cspg3-rs, Tgfbit, neurocan core protein, TGFbeta-induced transcript, brain, chondroitin sulfate proteoglycan 3, related sequence
Species: mouse
Products:     Ncan

Top Publications

  1. Rauch U, Grimpe B, Kulbe G, Arnold Ammer I, Beier D, Fassler R. Structure and chromosomal localization of the mouse neurocan gene. Genomics. 1995;28:405-10 pubmed
    ..The multidomain structure and the preferential expression of neurocan in the brain suggest a potential involvement in these diseases. ..
  2. Hevner R, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, et al. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001;29:353-66 pubmed
    ..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development. ..
  3. Geissler M, Gottschling C, Aguado A, Rauch U, Wetzel C, Hatt H, et al. Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation. J Neurosci. 2013;33:7742-55 pubmed publisher
    ..Remarkably, the knock-out neuron phenotypes could not be rescued by wild-type astrocytes. We conclude that the elimination of four ECM genes compromises neuronal function. ..
  4. Yi J, Katagiri Y, Susarla B, Figge D, Symes A, Geller H. Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice. J Comp Neurol. 2012;520:3295-313 pubmed publisher
    ..In summary, we describe a dual response in CSPGs whereby they may be actively involved in complex repair processes following TBI. ..
  5. Bekku Y, Oohashi T. Neurocan contributes to the molecular heterogeneity of the perinodal ECM. Arch Histol Cytol. 2010;73:95-102 pubmed
    ..Taken together, these findings indicate that neurocan contributes to the molecular heterogeneity of the perinodal matrix, and its nodal expression is dependent on Bral1. ..
  6. Cichon S, Mühleisen T, Degenhardt F, Mattheisen M, Miro X, Strohmaier J, et al. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. Am J Hum Genet. 2011;88:372-81 pubmed publisher
    ..Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with BD in 2411 patients and 3613 controls (rs1064395, p = 3...
  7. Mozhui K, Hamre K, Holmes A, Lu L, Williams R. Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Behav Genet. 2007;37:223-43 pubmed
    ..Other candidates include Large, and Thra. Responses to drugs of abuse and locomotor activity were the most notable behavioral correlates of the BLAc traits. ..
  8. Yan H, Zhu X, Xie J, Zhao Y, Liu X. ?-amyloid increases neurocan expression through regulating Sox9 in astrocytes: A potential relationship between Sox9 and chondroitin sulfate proteoglycans in Alzheimer's disease. Brain Res. 2016;1646:377-383 pubmed publisher
    ..05). Our study shows the viability and proliferation of astrocytes are significantly increased by A? in a dose dependent manner. Moreover, A? may effectively up-regulate the neurocan expression via regulating Sox9. ..
  9. Akita K, Toda M, Hosoki Y, Inoue M, Fushiki S, Oohira A, et al. Heparan sulphate proteoglycans interact with neurocan and promote neurite outgrowth from cerebellar granule cells. Biochem J. 2004;383:129-38 pubmed

More Information


  1. Hirakawa S, Oohashi T, Su W, Yoshioka H, Murakami T, Arata J, et al. The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Biochem Biophys Res Commun. 2000;276:982-9 pubmed
    ..These results suggest that brain link protein-1 may have distinct function from cartilage link protein-1 and play specific roles, especially in the adult brain. ..
  2. Meyer C, Zizioli D, Lausmann S, Eskelinen E, Hamann J, Saftig P, et al. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J. 2000;19:2193-203 pubmed
    ..MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor. ..
  3. Perlick H, Medghalchi S, Spencer F, Kendzior R, Dietz H. Mammalian orthologues of a yeast regulator of nonsense transcript stability. Proc Natl Acad Sci U S A. 1996;93:10928-32 pubmed
    ..Thus, despite apparent differences between yeast and mammalian nonsense-mediated RNA decay, these data suggest that the two pathways use functionally related machinery...
  4. Whitmer J, Koslovsky J, Bahler M, Mercer J. Chromosomal location of three unconventional myosin heavy chain genes in the mouse. Genomics. 1996;38:235-7 pubmed
    ..The mouse loci have been named Myo1e, Myo1c, and Myo9b; they map to chromosomes 9 (MGD position 41), 11 (MGD position 46), and 8 (MGD position 31.5), respectively. ..
  5. Blackshear P, Silver J, Nairn A, Sulik K, Squier M, Stumpo D, et al. Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice. Exp Neurol. 1997;145:46-61 pubmed
  6. Lutz C, Frankel W, Richards J, Thompson D. Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8. Genomics. 1997;41:498-500 pubmed
  7. Li H, Leung T, Hoffman S, Balsamo J, Lilien J. Coordinate regulation of cadherin and integrin function by the chondroitin sulfate proteoglycan neurocan. J Cell Biol. 2000;149:1275-88 pubmed
    ..These data suggest that the coordinate inhibition of cadherin and integrin function on interaction of neurocan with its receptor may prevent cell and neurite migration across boundaries. ..
  8. Miro X, Meier S, Dreisow M, Frank J, Strohmaier J, Breuer R, et al. Studies in humans and mice implicate neurocan in the etiology of mania. Am J Psychiatry. 2012;169:982-90 pubmed publisher
    Genome-wide association has been reported between the NCAN gene and bipolar disorder...
  9. Beccari T, Appolloni M, Stirling J, Orlacchio A. Assignment of lysosomal alpha-D-mannosidase to mouse chromosome 8. Mamm Genome. 1996;7:707-8 pubmed
  10. Coram R, Stillwagon S, Guggilam A, Jenkins M, Swanson M, Ladd A. Muscleblind-like 1 is required for normal heart valve development in vivo. BMC Dev Biol. 2015;15:36 pubmed publisher
    ..Together, these data indicate that MBNL1 plays a conserved role in negatively regulating TGFβ signaling, and is required for normal valve morphogenesis and homeostasis in vivo. ..
  11. Araya R, Kudo M, Kawano M, Ishii K, Hashikawa T, Iwasato T, et al. BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci. 2008;38:417-30 pubmed publisher
    ..These results suggest that BMPRIA signaling in astrocytes regulates the expression of VEGF for proper cerebrovascular angiogenesis and has a role on in the formation of the blood-brain-barrier. ..
  12. Harigaya T, Ogawa H, Tsunoda S, Nagasawa H. The mRNA expression of neurocan, a brain-specific chondroitin sulfate proteoglycan, in neoplastic mammary glands in mice. Zoolog Sci. 1996;13:665-8 pubmed
    ..The 5'-nucleotide sequence of sequential 246bp in the amplified cDNA of 527bp was completely identical to a middle part of mouse neurocan cDNA sequence, one of the chondroitin-sulfate proteoglycan expressed in the nervous tissue. ..
  13. Rauch U, Zhou X, Roos G. Extracellular matrix alterations in brains lacking four of its components. Biochem Biophys Res Commun. 2005;328:608-17 pubmed
    ..Further, an almost quadruple knockout like extracellular environment was noticed in the brains of triple knockout mice lacking both tenascins and brevican, since these brains had strongly reduced levels of neurocan. ..
  14. Leung K, Margolis R, Chan S. Expression of phosphacan and neurocan during early development of mouse retinofugal pathway. Brain Res Dev Brain Res. 2004;152:1-10 pubmed
  15. Lutz C, Richards J, Scott K, Sinha S, Yang Feng T, Frankel W, et al. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. Genomics. 1997;46:287-90 pubmed
    ..The physical association of these receptor genes correlates with ligand-binding properties, rather than sequence identity, and suggests a complex evolutionary relationship. ..
  16. Zhou X, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, et al. Neurocan is dispensable for brain development. Mol Cell Biol. 2001;21:5970-8 pubmed
    ..These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain. ..
  17. Rice D, Sheldon M, D ARCANGELO G, Nakajima K, Goldowitz D, Curran T. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 1998;125:3719-29 pubmed
    ..This suggests that Dab1 accumulates in the absence of a Reln-evoked signal. Taken together, these results indicate that Dab1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain. ..
  18. Jansen S, Gottschling C, Faissner A, Manahan Vaughan D. Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules. Hippocampus. 2017;27:920-933 pubmed publisher
    ..Homer 1a and of the P/Q-type calcium channel, Cav 1.2 were unchanged in KO mice. Taken together, findings suggest that in mice that lack multiple ECM proteins, synaptic plasticity is intact, but is fundamentally different. ..
  19. Yamaguchi Y. Lecticans: organizers of the brain extracellular matrix. Cell Mol Life Sci. 2000;57:276-89 pubmed
    ..We propose that the hyaluronan-lectican-tenascin-R complex constitutes the core assembly of the adult brain extracellular matrix, which is found mainly in pericellular spaces of neurons as 'perineuronal nets'. ..
  20. Ohyama K, Ikeda E, Kawamura K, Maeda N, Noda M. Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex. Brain Res Dev Brain Res. 2004;148:121-7 pubmed
    ..These results indicate that PTPzeta is a useful marker for early-generated neocortical neurons in mice: Cajal-Retzius neurons as well as the subplate neurons. ..
  21. Quattromani M, Hakon J, Rauch U, Bauer A, Wieloch T. Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components. Neurobiol Dis. 2018;112:91-105 pubmed publisher
    ..We conclude that Q4 mice represent a valuable model to study how the elimination of ECM genes compromises neuronal function and plasticity mechanisms after stroke. ..
  22. Shen Y, Tenney A, Busch S, Horn K, Cuascut F, Liu K, et al. PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science. 2009;326:592-6 pubmed publisher
    ..These results indicate that PTPsigma can act as a receptor for CSPGs and may provide new therapeutic approaches to neural regeneration. ..
  23. Li H, Oohira A, Ogawa M, Kawamura K, Kawano H. Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice. Eur J Neurosci. 2005;22:2689-96 pubmed
    ..Fukuda et al. (1997) Journal of Comparative Neurology, 382, 141-152]. ..
  24. Clarris H, Rauch U, Key B. Dynamic spatiotemporal expression patterns of neurocan and phosphacan indicate diverse roles in the developing and adult mouse olfactory system. J Comp Neurol. 2000;423:99-111 pubmed
  25. Weisz P, Solem M, Barnes D. Expression of a TGF beta regulated, brain-specific mRNA in serum-free mouse embryo (SFME) cells. Neurosci Lett. 1993;154:153-6 pubmed
    ..This mRNA was detected only in RNA preparations from brain among a number of tissues examined, and may provide an additional marker of TGF beta-regulated differentiation in these cells. ..