N acetylgalactosamine 4 sulfate 6 O sulfotransferase


Gene Symbol: N acetylgalactosamine 4 sulfate 6 O sulfotransferase
Description: carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
Alias: 4631426J05Rik, BRAG, GalNAc4S-6ST, GalNAcS-6ST, MAd5, mKIAA0598, carbohydrate sulfotransferase 15, B-cell RAG-associated gene protein, GalNAc 4-sulfate 6-O-sulfotransferase, N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
Species: mouse

Top Publications

  1. Salgueiro A, Filipe M, Belo J. N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase expression during early mouse embryonic development. Int J Dev Biol. 2006;50:705-8 pubmed
    ..These results open the possibility of a role for GalNAc4S-6ST during early mouse development. ..
  2. Ohtake Niimi S, Kondo S, Ito T, Kakehi S, Ohta T, Habuchi H, et al. Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast . J Biol Chem. 2010;285:20793-805 pubmed publisher
    ..These observations suggest that CS containing GalNAc(4,6-SO(4)) residues in BMMCs may contribute to retain the active proteases in the granules of BMMCs but not for the maturation of BMMCs into connective tissue-type mast cells. ..
  3. Somma G, Alger H, McGuire R, Kretlow J, Ruiz F, Yatsenko S, et al. Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. J Assoc Res Otolaryngol. 2012;13:335-49 pubmed publisher
    ..We propose that genes critical for inner ear patterning and differentiation are lost at the head bobber locus and are candidate genes for human deafness and vestibular disorders. ..
  4. Duelli A, Rönnberg E, Waern I, Ringvall M, Kolset S, Pejler G. Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases. J Immunol. 2009;183:7073-83 pubmed publisher
    ..Taken together, these data show that MC maturation is associated with the expression of a distinct signature of genes involved in SG proteoglycan synthesis, and that MC activation modulates their expression. ..
  5. Brown J, Xia J, Zhuang B, Cho K, Rogers C, Gama C, et al. A sulfated carbohydrate epitope inhibits axon regeneration after injury. Proc Natl Acad Sci U S A. 2012;109:4768-73 pubmed publisher
    ..These results demonstrate that a specific sugar epitope within chondroitin sulfate polysaccharides can direct important physiological processes and provide new therapeutic strategies to regenerate axons after CNS injury. ..
  6. Buniello A, Hardisty Hughes R, Pass J, Bober E, Smith R, Steel K. Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS ONE. 2013;8:e56274 pubmed publisher
    ..Therefore, we propose that headbobber is a useful model to gain insight into the mechanisms underlying deafness in human 10qter deletion syndrome. ..
  7. Suzuki K, Arumugam S, Yokoyama J, Kawauchi Y, Honda Y, Sato H, et al. Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis. PLoS ONE. 2016;11:e0158967 pubmed publisher
    ..b>Carbohydrate sulfotransferase 15 (CHST15), which catalyzes sulfation of chondroitin sulfate to produce rare E-disaccharide units, is a ..
  8. Verkoczy L, Marsden P, Berinstein N. hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1). Eur J Immunol. 1998;28:2839-53 pubmed
  9. Akita K, von Holst A, Furukawa Y, Mikami T, Sugahara K, Faissner A. Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance. Stem Cells. 2008;26:798-809 pubmed
    ..The synergistic activities of C/D-STs might allow for the adaptive modification of CS/DS proteoglycans with diversely sulfated CS/DS chains in the extracellular microenvironment that surrounds neural stem cells. ..

More Information


  1. Ohtake S, Kondo S, Morisaki T, Matsumura K, Kimata K, Habuchi O. Expression of sulfotransferases involved in the biosynthesis of chondroitin sulfate E in the bone marrow derived mast cells. Biochim Biophys Acta. 2008;1780:687-95 pubmed publisher
  2. Ishii M, Maeda N. Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex. J Biol Chem. 2008;283:32610-20 pubmed publisher
    ..These results revealed that specific oversulfated structures in CS chains play critical roles in the migration of neuronal precursors during cortical development. ..
  3. Gonçalves L, Filipe M, Marques S, Salgueiro A, Becker J, Belo J. Identification and functional analysis of novel genes expressed in the Anterior Visceral Endoderm. Int J Dev Biol. 2011;55:281-95 pubmed publisher
    ..Taken together, these data point to the importance of reporting novel genes present in the AVE. ..
  4. Mizumoto S, Watanabe M, Yamada S, Sugahara K. Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis. Biomed Res Int. 2013;2013:656319 pubmed publisher
  5. Paul A, Crow M, Raudales R, He M, Gillis J, Huang Z. Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 2017;171:522-539.e20 pubmed publisher
    ..This molecular genetic framework of neuronal identity integrates cell phenotypes along multiple axes and provides a foundation for discovering and classifying neuron types. ..