Gene Symbol: Myrf
Description: myelin regulatory factor
Alias: 6030439E18, Gm1804, Gm98, Mrf, myelin regulatory factor, myelin gene regulatory factor
Species: mouse
Products:     Myrf

Top Publications

  1. Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, et al. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013;152:248-61 pubmed publisher
  2. Hornig J, Fröb F, Vogl M, Hermans Borgmeyer I, Tamm E, Wegner M. The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genet. 2013;9:e1003907 pubmed publisher
    ..Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved ..
  3. Emery B, Agalliu D, Cahoy J, Watkins T, Dugas J, Mulinyawe S, et al. Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell. 2009;138:172-85 pubmed publisher
    ..Here we identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination...
  4. Weng Q, Chen Y, Wang H, Xu X, Yang B, He Q, et al. Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system. Neuron. 2012;73:713-28 pubmed publisher
    ..Thus, our findings reveal that Sip1-mediated antagonism of inhibitory signaling is critical for promoting CNS myelination and point to new mediators for myelin repair...
  5. Koenning M, Jackson S, Hay C, Faux C, Kilpatrick T, Willingham M, et al. Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. J Neurosci. 2012;32:12528-42 pubmed publisher
    ..whether continued oligodendrocyte expression of the recently identified transcription factor myelin gene regulatory factor (MRF) is required to maintain the integrity of myelin in the adult CNS...
  6. Vogl M, Reiprich S, Küspert M, Kosian T, Schrewe H, Nave K, et al. Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci. 2013;33:6679-90 pubmed publisher
    ..We conclude that Sox10 functions during terminal differentiation of myelinating glia, at least in part by Med12-dependent recruitment of the Mediator complex. ..
  7. Bujalka H, Koenning M, Jackson S, Perreau V, Pope B, Hay C, et al. MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol. 2013;11:e1001625 pubmed publisher
    ..We previously identified a putative transcription factor, Myelin Regulatory Factor (Myrf), as being vital for CNS myelination...
  8. Hoffmann S, Hos D, Küspert M, Lang R, Lovell Badge R, Wegner M, et al. Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development. 2014;141:39-50 pubmed publisher
    ..This study presents one of the few cases in which SoxB1 proteins, including the stem cell factor Sox2, are associated with differentiation rather than precursor functions. ..
  9. Wu W, Zhen X, Shi N. DNA-binding domain of myelin-gene regulatory factor: purification, crystallization and X-ray analysis. Acta Crystallogr F Struct Biol Commun. 2017;73:393-397 pubmed publisher
    ..Myelin-gene regulatory factor (MRF) is a recently identified transcription factor that is required for myelin-sheath formation...

More Information


  1. Bischof M, Weider M, Küspert M, Nave K, Wegner M. Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation. J Neurosci. 2015;35:21-35 pubmed publisher
  2. Kim D, Choi J, Fan C, Shearer R, Sharif M, Busch P, et al. Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation. Nucleic Acids Res. 2017;45:5112-5125 pubmed publisher
    b>Myrf is a key transcription factor for oligodendrocyte differentiation and central nervous system myelination...
  3. Baroti T, Schillinger A, Wegner M, Stolt C. Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. J Neurochem. 2016;136:316-28 pubmed publisher
    ..By itself, it has little impact on oligodendrocyte development but supports Sox5 and Sox6 during the process as a functionally redundant transcription factor. ..
  4. Parada C, Han D, Grimaldi A, Sarrión P, Park S, Pelikan R, et al. Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015;142:3734-45 pubmed publisher
    ..Because the ERK pathway serves as a crucial point of convergence for multiple signaling pathways, our study will facilitate a better understanding of the molecular regulatory mechanisms of craniofacial development. ..
  5. Weider M, Wegener A, Schmitt C, Küspert M, Hillgärtner S, Bösl M, et al. Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells. PLoS Genet. 2015;11:e1005008 pubmed publisher
    ..2 and Myrf. An upstream enhancer mediated the direct induction of the Olig2 gene...
  6. McKenzie I, Ohayon D, Li H, de Faria J, Emery B, Tohyama K, et al. Motor skill learning requires active central myelination. Science. 2014;346:318-22 pubmed publisher
    ..By genetically manipulating the transcription factor myelin regulatory factor in OL precursors, we blocked production of new OLs during adulthood without affecting preexisting OLs or ..
  7. Yan X, Lukas J, Witt M, Wree A, Hübner R, Frech M, et al. Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse. Metab Brain Dis. 2011;26:299-306 pubmed publisher
    ..factors of oligodendrocytes, such as SRY-related HMG-box 10 (Sox10), Yin Yang 1 factor (YY1) and myelin gene regulatory factor (MRF), in different parts of the brain and spinal cord was performed in NPC1-mutant mice...
  8. Huang B, Wei W, Wang G, Gaertig M, Feng Y, Wang W, et al. Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron. 2015;85:1212-26 pubmed publisher well as age-dependent demyelination and reduced expression of myelin genes that are downstream of myelin regulatory factor (MYRF or MRF), a transcriptional regulator that specifically activates and maintains the expression of ..
  9. Moyon S, Huynh J, Dutta D, Zhang F, Ma D, Yoo S, et al. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Rep. 2016;15:748-760 pubmed publisher
    ..Therefore, loss of Dnmt1 in OPCs is not sufficient to induce a lineage switch but acts as an important determinant of the coordination between RNA splicing and protein synthesis necessary for myelin formation. ..
  10. Xiao L, Ohayon D, McKenzie I, Sinclair Wilson A, Wright J, Fudge A, et al. Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning. Nat Neurosci. 2016;19:1210-1217 pubmed publisher
    ..Conditional deletion of myelin regulatory factor (Myrf) in oligodendrocyte precursors blocked formation of new Enpp6(+) oligodendrocytes and impaired ..
  11. Muth K, Piefke S, Weider M, Sock E, Hermans Borgmeyer I, Wegner M, et al. The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes. Glia. 2016;64:2120-2132 pubmed publisher
    ..The transcription factors Sox10 and Myrf are both central to this process and jointly regulate expression of myelin genes...