Gene Symbol: Myom2
Description: myomesin 2
Alias: AW146149, myomesin-2, skeletal muscle 165kD protein, skeletal muscle 165kDa protein
Schoenauer R, Lange S, Hirschy A, Ehler E, Perriard J, Agarkova I. Myomesin 3, a novel structural component of the M-band in striated muscle. J Mol Biol. 2008;376:338-51 pubmed publisher
..We propose that each member of the myomesin family is a component of one of the distinct ultrastructures, the M-lines, which modulate the mechanical properties of the M-bands in different muscle types. ..
Hirschy A, Schatzmann F, Ehler E, Perriard J. Establishment of cardiac cytoarchitecture in the developing mouse heart. Dev Biol. 2006;289:430-41 pubmed
..These observations help to understand the mechanisms that lead to the formation of a functional heart during development at a cellular level. ..
Potthoff M, Arnold M, McAnally J, Richardson J, Bassel Duby R, Olson E. Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol. 2007;27:8143-51 pubmed
..These results reveal a key role for Mef2c in maintenance of sarcomere integrity and postnatal maturation of skeletal muscle. ..
Beqqali A, Monshouwer Kloots J, Monteiro R, Welling M, Bakkers J, Ehler E, et al
. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci. 2010;123:1141-50 pubmed publisher
..These findings suggest that CHAP is a critical component of the sarcomere with an important role in muscle development. ..
Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996;76:371-423 pubmed
..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
Steiner F, Weber K, Fürst D. Structure and expression of the gene encoding murine M-protein, a sarcomere-specific member of the immunoglobulin superfamily. Genomics. 1998;49:83-95 pubmed
..These results provide the first complete characterization of a gene for a member of the intracellular branch of the immunoglobulin superfamily. ..
Carlsson L, Li Z, Paulin D, Thornell L. Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice. Exp Cell Res. 1999;251:213-23 pubmed
..The presence of nestin at neuromuscular and myotendinous junctions might provide enough strength for preservation and organization of the junctional areas, although desmin is lacking. ..
Gokhin D, Lewis R, McKeown C, Nowak R, Kim N, Littlefield R, et al
. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J Cell Biol. 2010;189:95-109 pubmed publisher
..Thus, Tmod3 and -4 compensate for the absence of Tmod1 structurally but not functionally. We conclude that Tmod1 is a novel regulator of skeletal muscle physiology. ..
Hayashi S, Manabe I, Suzuki Y, Relaix F, Oishi Y. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. elife. 2016;5: pubmed publisher
..These results indicate that Klf5 is an essential regulator of skeletal muscle differentiation, acting in concert with myogenic transcription factors such as MyoD and Mef2. ..