Gene Symbol: Myom1
Description: myomesin 1
Alias: D430047A17Rik, myomesin-1, myomesin family member 1, skelemin
Species: mouse
Products:     Myom1

Top Publications

  1. du Puy L, Beqqali A, van Tol H, Monshouwer Kloots J, Passier R, Haagsman H, et al. Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments. Int J Dev Biol. 2012;56:301-9 pubmed publisher
    ..RNA interference mediated knock-down of SARCOSIN in the C2C12 myoblast cell line appeared to be stimulatory in the early phase of differentiation, but inhibitory at a later phase of differentiation. ..
  2. Potthoff M, Arnold M, McAnally J, Richardson J, Bassel Duby R, Olson E. Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol. 2007;27:8143-51 pubmed
    ..These results reveal a key role for Mef2c in maintenance of sarcomere integrity and postnatal maturation of skeletal muscle. ..
  3. Price M, Gomer R. Skelemin, a cytoskeletal M-disc periphery protein, contains motifs of adhesion/recognition and intermediate filament proteins. J Biol Chem. 1993;268:21800-10 pubmed
    In striated muscle, myofibrils are anchored to an interconnecting cytoskeleton of desmin intermediate filaments. Skelemin (195 kDa) may be a link between myofibrils and the intermediate filament cytoskeleton...
  4. Tyser R, Miranda A, Chen C, Davidson S, Srinivas S, Riley P. Calcium handling precedes cardiac differentiation to initiate the first heartbeat. elife. 2016;5: pubmed publisher
    ..NCX1 blockade impacted on CaMKII signalling to down-regulate cardiac gene expression, leading to impaired differentiation and failed crescent maturation. ..
  5. Beqqali A, Monshouwer Kloots J, Monteiro R, Welling M, Bakkers J, Ehler E, et al. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci. 2010;123:1141-50 pubmed publisher
    ..These findings suggest that CHAP is a critical component of the sarcomere with an important role in muscle development. ..
  6. Krishnan J, Ahuja P, Bodenmann S, Knapik D, Perriard E, Krek W, et al. Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function. Circ Res. 2008;103:1139-46 pubmed publisher
  7. Reddy K, Fox J, Price M, Kulkarni S, Gupta S, Das B, et al. Nuclear localization of Myomesin-1: possible functions. J Muscle Res Cell Motil. 2008;29:1-8 pubmed publisher
    Myomesin-I (also known as Skelemin) is a approximately 185 kDa protein, which is highly expressed in striated muscle. It contains the prototypic class-I (type-III fibronectin) and class-II (C2-immunoglobulin) motifs...
  8. Gokhin D, Lewis R, McKeown C, Nowak R, Kim N, Littlefield R, et al. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J Cell Biol. 2010;189:95-109 pubmed publisher
    ..Thus, Tmod3 and -4 compensate for the absence of Tmod1 structurally but not functionally. We conclude that Tmod1 is a novel regulator of skeletal muscle physiology. ..
  9. Schoenauer R, Lange S, Hirschy A, Ehler E, Perriard J, Agarkova I. Myomesin 3, a novel structural component of the M-band in striated muscle. J Mol Biol. 2008;376:338-51 pubmed publisher
    ..We propose that each member of the myomesin family is a component of one of the distinct ultrastructures, the M-lines, which modulate the mechanical properties of the M-bands in different muscle types. ..

More Information


  1. Agarkova I, Auerbach D, Ehler E, Perriard J. A novel marker for vertebrate embryonic heart, the EH-myomesin isoform. J Biol Chem. 2000;275:10256-64 pubmed
    ..It represents the major myomesin isoform at early embryonic stages of heart but is rapidly down-regulated around birth. Thus, the strict developmental regulation of the EH-myomesin makes it an ideally suited marker for embryonic heart. ..
  2. Carlsson L, Li Z, Paulin D, Thornell L. Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice. Exp Cell Res. 1999;251:213-23 pubmed
    ..The presence of nestin at neuromuscular and myotendinous junctions might provide enough strength for preservation and organization of the junctional areas, although desmin is lacking. ..
  3. Zhang B, Xiao W, Qiu H, Zhang F, Moniz H, Jaworski A, et al. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 2014;124:209-21 pubmed publisher
    ..Thus, our results demonstrate that loss of NDST1 causes defective diaphragm vascular development and CDH and that heparan sulfate facilitates angiogenic SLIT3-ROBO4 signaling during vascular development. ..
  4. Weinert S, Bergmann N, Luo X, Erdmann B, Gotthardt M. M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006;173:559-70 pubmed
  5. Wooldridge A, Fortner C, Lontay B, Akimoto T, Neppl R, Facemire C, et al. Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem. 2008;283:11850-9 pubmed publisher
    ..Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity. ..
  6. Cohen S, Brault J, Gygi S, Glass D, Valenzuela D, Gartner C, et al. During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 2009;185:1083-95 pubmed publisher
    ..Because these proteins stabilize the thick filament, their selective ubiquitylation may facilitate thick filament disassembly. However, the thin filament components decreased by a mechanism not requiring MuRF1...
  7. Otten J, van der Ven P, Vakeel P, Eulitz S, Kirfel G, Brandau O, et al. Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs. Cardiovasc Res. 2010;85:739-50 pubmed publisher
    ..Furthermore, it indicates that XinC may be involved in the development of human cardiac hypertrophy. ..
  8. Steiner F, Weber K, Fürst D. M band proteins myomesin and skelemin are encoded by the same gene: analysis of its organization and expression. Genomics. 1999;56:78-89 pubmed
    ..splicing of a single exon gives rise to two polypeptides, described in the literature as myomesin and skelemin, respectively. A single transcriptional start point was detected in both skeletal and cardiac muscle...
  9. Gorbatyuk V, Nguyen K, Podolnikova N, Deshmukh L, Lin X, Ugarova T, et al. Skelemin association with αIIbβ3 integrin: a structural model. Biochemistry. 2014;53:6766-75 pubmed publisher
    ..Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin αIIbβ3...
  10. Hirschy A, Schatzmann F, Ehler E, Perriard J. Establishment of cardiac cytoarchitecture in the developing mouse heart. Dev Biol. 2006;289:430-41 pubmed
    ..These observations help to understand the mechanisms that lead to the formation of a functional heart during development at a cellular level. ..
  11. Podolnikova N, O Toole T, Haas T, Lam S, Fox J, Ugarova T. Adhesion-induced unclasping of cytoplasmic tails of integrin alpha(IIb)beta3. Biochemistry. 2009;48:617-29 pubmed publisher
    ..Using the integrin-binding skelemin fragment as a marker of exposure of residues involved in the clasp between alpha(IIb) and beta(3) cytoplasmic ..
  12. Reddy K, Gascard P, Price M, Negrescu E, Fox J. Identification of an interaction between the m-band protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1- and beta3-integrins in non-muscle cells. J Biol Chem. 1998;273:35039-47 pubmed
    ..This sequence was 100% identical to a sequence in skelemin, a protein identified previously in skeletal muscle...
  13. McKeown C, Nowak R, Gokhin D, Fowler V. Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo. Dev Dyn. 2014;243:800-17 pubmed publisher
    ..Our data also identify a novel ?TM1/Tmod1-based pathway stabilizing F-actin at cell-cell junctions, which may be required for maintenance of cell shapes during embryonic cardiac morphogenesis. ..
  14. Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996;76:371-423 pubmed
    ..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
  15. Braun A, Bordoy R, Stanchi F, Moser M, Kostka G G, Ehler E, et al. PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res. 2003;284:239-50 pubmed
    ..Finally, we demonstrate that PINCH2 localizes to focal adhesions in NIH 3T3 cells and to Z-disks in primary rat cardiomyocytes. ..