Gene Symbol: Myod1
Description: myogenic differentiation 1
Alias: AI503393, MYF3, MyoD, Myod-1, bHLHc1, myoblast determination protein 1
Species: mouse
Products:     Myod1

Top Publications

  1. Relaix F, Rocancourt D, Mansouri A, Buckingham M. A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature. 2005;435:948-53 pubmed
  2. Shih H, Gross M, Kioussi C. Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch. Proc Natl Acad Sci U S A. 2007;104:5907-12 pubmed
    ..5. The diminutive first branchial arch of mutants could not be explained by loss of mesoderm alone, suggesting that Pitx2 contributes to the earliest specification of jaw itself. ..
  3. Gensch N, Borchardt T, Schneider A, Riethmacher D, Braun T. Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development. 2008;135:1597-604 pubmed publisher
    The development of myogenic cells is mainly determined by expression of two myogenic factors, Myf5 and Myod1 (MyoD), which genetically compensate for each other during embryogenesis...
  4. L honoré A, Lamb N, Vandromme M, Turowski P, Carnac G, Fernandez A. MyoD distal regulatory region contains an SRF binding CArG element required for MyoD expression in skeletal myoblasts and during muscle regeneration. Mol Biol Cell. 2003;14:2151-62 pubmed
    We show here that the distal regulatory region (DRR) of the mouse and human MyoD gene contains a conserved SRF binding CArG-like element...
  5. Sabourin L, Rudnicki M. The molecular regulation of myogenesis. Clin Genet. 2000;57:16-25 pubmed
    ..years, several studies have unraveled important mechanisms by which the four myogenic regulatory factors (MRFs: MyoD, Myf-5, myogenin, and MRF4) control the specification and the differentiation of the muscle lineage...
  6. Arnold H, Braun T. Genetics of muscle determination and development. Curr Top Dev Biol. 2000;48:129-64 pubmed
    ..Finally, we present recent evidence on genes that play a role in regeneration of muscle in adult organisms. ..
  7. Kruger M, Mennerich D, Fees S, Schafer R, Mundlos S, Braun T. Sonic hedgehog is a survival factor for hypaxial muscles during mouse development. Development. 2001;128:743-52 pubmed
    ..Our data suggest that Shh acts similarly in both somitic compartments as a survival and proliferation factor and not as a primary inducer of myogenesis. ..
  8. Lagha M, Sato T, Regnault B, Cumano A, Zuniga A, Licht J, et al. Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo. BMC Genomics. 2010;11:696 pubmed publisher
    ..In the progenitor cell population, Pax7 and also Hdac5 which is a potential repressor of Foxc2, are subject to positive control by Pax3. ..
  9. Rosenberg M, Georges S, Asawachaicharn A, Analau E, Tapscott S. MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 2006;175:77-85 pubmed
    ..The MyoD transcription factor directly activates the expression of a large number of skeletal muscle genes, but also ..

More Information


  1. Borycki A, Li J, Jin F, Emerson C, Epstein J. Pax3 functions in cell survival and in pax7 regulation. Development. 1999;126:1665-74 pubmed defects; furthermore, Pax3 is essential for the proper activation of the myogenic determination factor gene, MyoD, during early muscle development and PAX3 chromosomal translocations result in muscle tumors, providing evidence ..
  2. Figliola R, Maione R. MyoD induces the expression of p57Kip2 in cells lacking p21Cip1/Waf1: overlapping and distinct functions of the two cdk inhibitors. J Cell Physiol. 2004;200:468-75 pubmed
    The myogenic factor MyoD induces the expression of the cdk inhibitor p21 to promote cell cycle withdrawal in differentiating myoblasts...
  3. Cornelison D, Olwin B, Rudnicki M, Wold B. MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficient. Dev Biol. 2000;224:122-37 pubmed
    b>MyoD-deficient mice are without obvious deleterious muscle phenotype during embryogenesis and fetal development, and adults in the laboratory have grossly normal skeletal muscle and life span...
  4. Vaccarello G, Figliola R, Cramerotti S, Novelli F, Maione R. p57Kip2 is induced by MyoD through a p73-dependent pathway. J Mol Biol. 2006;356:578-88 pubmed
    ..We have previously shown that p57 is a target of the myogenic factor MyoD in cells lacking p21...
  5. Gruenbaum Cohen Y, Harel I, Umansky K, Tzahor E, Snapper S, Shilo B, et al. The actin regulator N-WASp is required for muscle-cell fusion in mice. Proc Natl Acad Sci U S A. 2012;109:11211-6 pubmed publisher
    ..WASp-family elements appear therefore to act as universal mediators of the myogenic cell-cell fusion mechanism underlying formation of functional muscle fibers, in both vertebrate and invertebrate species. ..
  6. Vasyutina E, Lenhard D, Wende H, Erdmann B, Epstein J, Birchmeier C. RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc Natl Acad Sci U S A. 2007;104:4443-8 pubmed
    ..In addition, satellite cells are not formed late in fetal development in conditional RBP-J mutant mice. We conclude that RBP-J is required in the developing muscle to set aside proliferating progenitors and satellite cells...
  7. Tintignac L, Sirri V, Leibovitch M, Lecluse Y, Castedo M, Metivier D, et al. Mutant MyoD lacking Cdc2 phosphorylation sites delays M-phase entry. Mol Cell Biol. 2004;24:1809-21 pubmed
    The transcription factors MyoD and Myf-5 control myoblast identity and differentiation. MyoD and Myf-5 manifest opposite cell cycle-specific expression patterns...
  8. Hirai H, Verma M, Watanabe S, Tastad C, Asakura Y, Asakura A. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol. 2010;191:347-65 pubmed publisher
    ..b>MyoD is a myogenic transcription factor that plays essential roles in muscle differentiation...
  9. Lagha M, Kormish J, Rocancourt D, Manceau M, Epstein J, Zaret K, et al. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev. 2008;22:1828-37 pubmed publisher
    ..These results provide new insight into the Pax-initiated regulatory network that modulates stem cell maintenance versus tissue differentiation. ..
  10. Gayraud Morel B, Chretien F, Flamant P, Gomès D, Zammit P, Tajbakhsh S. A role for the myogenic determination gene Myf5 in adult regenerative myogenesis. Dev Biol. 2007;312:13-28 pubmed
    The myogenic determination genes Myf5, Myod and Mrf4 direct skeletal muscle cell fate prenatally...
  11. Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, et al. Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell. 2009;17:892-9 pubmed publisher
    ..This provides insight into how cell fate choices are orchestrated by these lineage genes in the dermomyotome. ..
  12. Sabourin L, Girgis Gabardo A, Seale P, Asakura A, Rudnicki M. Reduced differentiation potential of primary MyoD-/- myogenic cells derived from adult skeletal muscle. J Cell Biol. 1999;144:631-43 pubmed
    To gain insight into the regeneration deficit of MyoD-/- muscle, we investigated the growth and differentiation of cultured MyoD-/- myogenic cells...
  13. Tallquist M, Weismann K, Hellstrom M, Soriano P. Early myotome specification regulates PDGFA expression and axial skeleton development. Development. 2000;127:5059-70 pubmed
    ..PDGFA expression in the myotome was fully restored in embryos in which MyoD has been introduced at the Myf5 locus but to a lesser extent in similar myogenin knock-in embryos...
  14. Liu R, Birke O, Morse A, Peacock L, Mikulec K, Little D, et al. Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskelet Disord. 2011;12:288 pubmed publisher
    ..We hypothesized that myogenic cells of the MyoD-lineage are able to contribute to bone repair...
  15. Wyzykowski J, Winata T, Mitin N, Taparowsky E, Konieczny S. Identification of novel MyoD gene targets in proliferating myogenic stem cells. Mol Cell Biol. 2002;22:6199-208 pubmed
    ..control point for skeletal myogenesis revolves around the muscle basic helix-loop-helix gene family that includes MyoD, Myf-5, myogenin, and MRF4...
  16. Vasyutina E, Stebler J, Brand Saberi B, Schulz S, Raz E, Birchmeier C. CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005;19:2187-98 pubmed
    ..Our analysis reveals a role of SDF1/CXCR4 signaling in the development of migrating muscle progenitors and shows that a threshold number of progenitor cells is required to generate muscle of appropriate size. ..
  17. Hu P, Geles K, Paik J, Depinho R, Tjian R. Codependent activators direct myoblast-specific MyoD transcription. Dev Cell. 2008;15:534-46 pubmed publisher
    ..Here, we identify MyoD, a key regulator of myogenesis, as a direct target of FoxO3 and Pax3/7 in myoblasts...
  18. Harfe B, McManus M, Mansfield J, Hornstein E, Tabin C. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005;102:10898-903 pubmed
    ..Thus, Dicer is required for the formation of normal mouse limbs. Strikingly, however, we did not detect defects in basic patterning or in tissue-specific differentiation of Dicer-deficient limb buds. ..
  19. Rinon A, Lazar S, Marshall H, Büchmann Møller S, Neufeld A, Elhanany Tamir H, et al. Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis. Development. 2007;134:3065-75 pubmed
    ..We suggest that CNC cells control craniofacial development by regulating positional interactions with mesoderm-derived muscle progenitors that together shape the cranial musculoskeletal architecture in vertebrate embryos. ..
  20. Prunotto C, Crepaldi T, Forni P, Ieraci A, Kelly R, Tajbakhsh S, et al. Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles. Dev Dyn. 2004;231:582-91 pubmed
    ..Surprisingly, however, X-gal staining showed that, in this mutant, hyoid arch-derived facial muscles were either reduced or absent, thus revealing that Met also contributes to the development of muscles in the head...
  21. Gianakopoulos P, Mehta V, Voronova A, Cao Y, Yao Z, Coutu J, et al. MyoD directly up-regulates premyogenic mesoderm factors during induction of skeletal myogenesis in stem cells. J Biol Chem. 2011;286:2517-25 pubmed publisher
    ..Furthermore, MyoD required cellular aggregation to induce myogenesis in P19 embryonal carcinoma stem cells...
  22. Haase G, Dessaud E, Garces A, de Bovis B, Birling M, Filippi P, et al. GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Neuron. 2002;35:893-905 pubmed
    ..Thus, GDNF acts as a peripheral signal to induce PEA3 expression in specific motor neuron pools thereby regulating both cell body position and muscle innervation. ..
  23. Chen J, Love C, Goldhamer D. Two upstream enhancers collaborate to regulate the spatial patterning and timing of MyoD transcription during mouse development. Dev Dyn. 2001;221:274-88 pubmed
    b>MyoD is a member of the basic-helix-loop-helix (bHLH) transcription factor family, which regulates muscle determination and differentiation in vertebrates...
  24. Beylkin D, Allen D, Leinwand L. MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes. Dev Biol. 2006;294:541-53 pubmed
    ..that work in conjunction to activate transcription, but only the embryonic MyHC E-boxes bind a complex containing MyoD. In addition, our results reveal activation by calcineurin that is transduced only partially by its conventional ..
  25. Sun L, Trausch Azar J, Ciechanover A, Schwartz A. Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation. J Biol Chem. 2005;280:26448-56 pubmed
    ..b>MyoD, a key muscle regulatory factor, and its negative regulator Id1 have both been shown to be degraded by the ..
  26. Starkey J, Yamamoto M, Yamamoto S, Goldhamer D. Skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt nonmyogenic fates. J Histochem Cytochem. 2011;59:33-46 pubmed publisher
    ..The authors investigated satellite cell developmental potential in single fiber and clonal cultures derived from MyoD(iCre/+);R26R(EYFP/+) muscle, in which essentially all satellite cells are permanently labeled...
  27. Parker M, Perry R, Fauteux M, Berkes C, Rudnicki M. MyoD synergizes with the E-protein HEB beta to induce myogenic differentiation. Mol Cell Biol. 2006;26:5771-83 pubmed
    The MyoD family of basic helix-loop-helix transcription factors function as heterodimers with members of the E-protein family to induce myogenic gene activation...
  28. Cao Y, Yao Z, Sarkar D, Lawrence M, Sanchez G, Parker M, et al. Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming. Dev Cell. 2010;18:662-74 pubmed publisher
    Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal muscle gene expression, predicting that MyoD binds directly to many genes expressed during differentiation...
  29. Chargé S, Brack A, Bayol S, Hughes S. MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element. BMC Dev Biol. 2008;8:5 pubmed publisher
    b>MyoD is a transcription factor implicated in the regulation of adult muscle gene expression...
  30. Micheli L, Leonardi L, Conti F, Buanne P, Canu N, Caruso M, et al. PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. Mol Cell Biol. 2005;25:2242-59 pubmed
    ..1 [IFRD1], Tis7), which we have previously shown to be required for myoblast differentiation, is both induced by MyoD and potentiates the transcriptional activity of MyoD, thus revealing a positive regulatory loop between these ..
  31. Zhang X, Patel S, McCarthy J, Rabchevsky A, Goldhamer D, Esser K. A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle. Nucleic Acids Res. 2012;40:3419-30 pubmed publisher
    The myogenic differentiation 1 (MyoD) gene is a master regulator of myogenesis...
  32. Mal A, Sturniolo M, Schiltz R, Ghosh M, Harter M. A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. EMBO J. 2001;20:1739-53 pubmed
    The molecular mechanism(s) that are responsible for suppressing MyoD's transcriptional activities in undifferentiated skeletal muscle cells have not yet been determined...
  33. Kim C, Neiswender H, Baik E, Xiong W, Mei L. Beta-catenin interacts with MyoD and regulates its transcription activity. Mol Cell Biol. 2008;28:2941-51 pubmed publisher
    ..We showed that beta-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E ..
  34. Hu J, McGlinn E, Harfe B, Kardon G, Tabin C. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev. 2012;26:2088-102 pubmed publisher
    ..We identify neuroepithelial cell transforming gene 1 (Net1) as a downstream target and effector of Shh signaling in that context. ..
  35. Grifone R, Jarry T, Dandonneau M, Grenier J, Duprez D, Kelly R. Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos. Dev Dyn. 2008;237:3071-8 pubmed publisher
    ..The critical requirement for Tbx1 during muscle development is thus in the robust onset of myogenic specification in pharyngeal mesoderm. ..
  36. L honoré A, Ouimette J, Lavertu Jolin M, Drouin J. Pitx2 defines alternate pathways acting through MyoD during limb and somitic myogenesis. Development. 2010;137:3847-56 pubmed publisher
    The MyoD gene is part of the core regulatory network that governs skeletal myogenesis and acts as an essential determinant of the myogenic cell fate...
  37. Fulco M, Schiltz R, Iezzi S, King M, Zhao P, Kashiwaya Y, et al. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell. 2003;12:51-62 pubmed
    ..Sir2 forms a complex with the acetyltransferase PCAF and MyoD and, when overexpressed, retards muscle differentiation...
  38. Laclef C, Hamard G, Demignon J, Souil E, Houbron C, Maire P. Altered myogenesis in Six1-deficient mice. Development. 2003;130:2239-52 pubmed
    ..5, by a severe reduction and disorganisation of primary myofibers in most body muscles. While Myf5, MyoD and myogenin are correctly expressed in the somitic compartment in early Six1(-/-) embryos, by E11...
  39. Chen J, Ramachandran R, Goldhamer D. Essential and redundant functions of the MyoD distal regulatory region revealed by targeted mutagenesis. Dev Biol. 2002;245:213-23 pubmed
    Transgenic analyses have defined two MyoD enhancers in mammals, the core enhancer and distal regulatory region (DRR); these enhancers exhibit complementary activities and together are sufficient to recapitulate MyoD expression in ..
  40. Al Madhoun A, Mehta V, Li G, Figeys D, Wiper Bergeron N, Skerjanc I. Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 2011;30:2477-89 pubmed publisher
    ..MEF2 factors establish skeletal muscle commitment by amplifying and synergizing with MyoD. While phosphorylation is known to regulate MEF2 function, lineage-specific regulation is unknown...
  41. Schuster Gossler K, Cordes R, Gossler A. Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A. 2007;104:537-42 pubmed
  42. Spiller M, Kambadur R, Jeanplong F, Thomas M, Martyn J, Bass J, et al. The myostatin gene is a downstream target gene of basic helix-loop-helix transcription factor MyoD. Mol Cell Biol. 2002;22:7066-82 pubmed
    ..We also demonstrate by band shift and chromatin immunoprecipitation assay that the E6 E-box motif binds to MyoD in vitro and in vivo...
  43. L honoré A, Rana V, Arsic N, Franckhauser C, Lamb N, Fernandez A. Identification of a new hybrid serum response factor and myocyte enhancer factor 2-binding element in MyoD enhancer required for MyoD expression during myogenesis. Mol Biol Cell. 2007;18:1992-2001 pubmed
    b>MyoD is a critical myogenic factor induced rapidly upon activation of quiescent satellite cells, and required for their differentiation during muscle regeneration...
  44. Schmidt K, Glaser G, Wernig A, Wegner M, Rosorius O. Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis. J Biol Chem. 2003;278:29769-75 pubmed
    ..Concomitantly, expression of MyoD and myogenin decreased and basal as well as MyoD-induced activities of the myogenin promoter were strongly reduced ..
  45. Di Carlo A, De Mori R, Martelli F, Pompilio G, Capogrossi M, Germani A. Hypoxia inhibits myogenic differentiation through accelerated MyoD degradation. J Biol Chem. 2004;279:16332-8 pubmed
    ..We showed that hypoxia reversibly inhibited MyoD, Myf5, and myogenin expression...
  46. Blais A, Tsikitis M, Acosta Alvear D, Sharan R, Kluger Y, Dynlacht B. An initial blueprint for myogenic differentiation. Genes Dev. 2005;19:553-69 pubmed
    ..We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)--MyoD and myogenin--and Myocyte Enhancer Factor 2 (MEF2)...
  47. Dogra C, Changotra H, Mohan S, Kumar A. Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein. J Biol Chem. 2006;281:10327-36 pubmed
    ..TWEAK inhibited the expression of myogenic regulatory factors MyoD and myogenin and also induced the degradation of MyoD protein...
  48. Arnold J, Werling U, Braunstein E, Liao J, Nowotschin S, Edelmann W, et al. Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development. 2006;133:977-87 pubmed
    ..These results show that Tbx1 in the PE is required for the patterning and development of the pharyngeal apparatus, thereby disrupting the formation of its derivative structures. ..
  49. Dong F, Sun X, Liu W, Ai D, Klysik E, Lu M, et al. Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development. 2006;133:4891-9 pubmed
    ..Conditional inactivation in mice and manipulation of Pitx2 expression in chick mandible cultures revealed an autonomous function in expansion and survival of branchial arch mesoderm. ..
  50. Borycki A, Brunk B, Tajbakhsh S, Buckingham M, Chiang C, Emerson C. Sonic hedgehog controls epaxial muscle determination through Myf5 activation. Development. 1999;126:4053-63 pubmed
    ..myogenesis in the mouse embryo, we have analyzed the expression of the myogenic determination genes, Myf5 and MyoD, and other regulatory genes in somites of Shh null embryos and in explants of presomitic mesoderm from wild-type ..
  51. Kassar Duchossoy L, Gayraud Morel B, Gomès D, Rocancourt D, Buckingham M, Shinin V, et al. Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice. Nature. 2004;431:466-71 pubmed
    ..Two determination factors of the basic helix-loop-helix myogenic regulatory factor (MRF) family, Myf5 and Myod, are thought to direct this transition because double-mutant mice totally lack skeletal muscle fibres and myoblasts...
  52. Kablar B, Tajbakhsh S, Rudnicki M. Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent. Development. 2000;127:1627-39 pubmed
    ..To investigate smooth-to-skeletal esophageal muscle transition, we analyzed Myf5nlacZ knock-in mice, MyoD-lacZ and myogenin-lacZ transgenic embryos with a panel of the antibodies reactive with myogenic regulatory factors (..
  53. Chen J, Goldhamer D. The core enhancer is essential for proper timing of MyoD activation in limb buds and branchial arches. Dev Biol. 2004;265:502-12 pubmed
    Transgenic analyses have defined two transcriptional enhancers that regulate MyoD expression in mammals, the core enhancer and distal regulatory region; these enhancers exhibit complementary activities and together are sufficient to ..
  54. Cao Y, Kumar R, Penn B, Berkes C, Kooperberg C, Boyer L, et al. Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters. EMBO J. 2006;25:502-11 pubmed
    ..of genome-wide and promoter-specific DNA binding and expression analyses to assess the functional roles of Myod and Myog in regulating the program of skeletal muscle gene expression...
  55. Berkes C, Bergstrom D, Penn B, Seaver K, Knoepfler P, Tapscott S. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol Cell. 2004;14:465-77 pubmed
    Skeletal muscle differentiation is initiated by the transcription factor MyoD, which binds directly to the regulatory regions of genes expressed during skeletal muscle differentiation and initiates chromatin remodeling at specific ..
  56. Yamamoto M, Shook N, Kanisicak O, Yamamoto S, Wosczyna M, Camp J, et al. A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis. Genesis. 2009;47:107-14 pubmed publisher
    ..Finally, by the simultaneous use of both Cre and FLP deleters, R26(NZG) allows lineage relationships to be interrogated with greater refinement than is possible with single recombinase reporter systems. ..
  57. Stuelsatz P, Keire P, Almuly R, Yablonka Reuveni Z. A contemporary atlas of the mouse diaphragm: myogenicity, vascularity, and the Pax3 connection. J Histochem Cytochem. 2012;60:638-57 pubmed publisher
    ..The novel information in this "contemporary atlas" can be further explored in the context of diaphragm pathology and genetic disorders. ..
  58. Anderson C, Williams V, Moyon B, Daubas P, Tajbakhsh S, Buckingham M, et al. Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity. Genes Dev. 2012;26:2103-17 pubmed publisher
    ..Thus, Shh production in the limb ZPA is essential for the spatiotemporal control of myogenesis and coordinates muscle and skeletal development by acting directly to regulate the formation of specific ventral muscles. ..
  59. Kablar B, Krastel K, Ying C, Tapscott S, Goldhamer D, Rudnicki M. Myogenic determination occurs independently in somites and limb buds. Dev Biol. 1999;206:219-31 pubmed
    Gene targeting has indicated that the bHLH transcription factors Myf-5 and MyoD are required for myogenic determination because skeletal myoblasts and myofibers are entirely ablated in mouse embryos lacking both Myf-5 and MyoD...
  60. White J, Scaffidi A, Davies M, McGeachie J, Rudnicki M, Grounds M. Myotube formation is delayed but not prevented in MyoD-deficient skeletal muscle: studies in regenerating whole muscle grafts of adult mice. J Histochem Cytochem. 2000;48:1531-44 pubmed
    We compared the time course of myogenic events in vivo in regenerating whole muscle grafts in MyoD(-/-) and control BALB/c adult mice using immunohistochemistry and electron microscopy...
  61. Kardon G, Harfe B, Tabin C. A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning. Dev Cell. 2003;5:937-44 pubmed
    ..We propose that Tcf4-expressing cells establish a prepattern in the limb mesoderm that determines the sites of myogenic differentiation and thus establishes the basic pattern of limb muscles. ..
  62. Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller M, et al. Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005;132:2235-49 pubmed
    ..the myotome, absence of Six1 and Six4 impairs the expression of the myogenic regulatory factors myogenin and Myod1, and Mrf4 expression becomes undetectable...
  63. L honoré A, Coulon V, Marcil A, Lebel M, Lafrance Vanasse J, Gage P, et al. Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development. Dev Biol. 2007;307:421-33 pubmed
    ..These experiments suggest that Pitx genes are important for myogenesis and that Pitx2 and Pitx3 may have partly redundant roles. ..
  64. Kassar Duchossoy L, Giacone E, Gayraud Morel B, Jory A, Gomès D, Tajbakhsh S. Pax3/Pax7 mark a novel population of primitive myogenic cells during development. Genes Dev. 2005;19:1426-31 pubmed
    ..These findings identify critical cell populations during lineage restriction, and provide a framework for defining myogenic cell states for therapeutic studies. ..
  65. Roth J, Shikama N, Henzen C, Desbaillets I, Lutz W, Marino S, et al. Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 2003;22:5186-96 pubmed
    ..Similarly, ES cells homozygous for a p300 AT or a p300 null mutation fail to activate Myf5 and MyoD transcription efficiently, while Pax3, acting genetically upstream of these MRFs, is expressed...
  66. McDermott A, Gustafsson M, Elsam T, Hui C, Emerson C, Borycki A. Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development. 2005;132:345-57 pubmed
    ..Together, our data demonstrate both positive and negative regulatory functions for Gli2 and Gli3 in the control of Myf5 activation in the epaxial muscle progenitor cells and in dorsoventral and mediolateral patterning of the somite. ..
  67. Bajard L, Relaix F, Lagha M, Rocancourt D, Daubas P, Buckingham M. A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb. Genes Dev. 2006;20:2450-64 pubmed
    ..Mutation of the Pax3 site abolishes all expression controlled by the 145-bp sequence in transgenic mouse embryos. We conclude that Pax3 directly regulates Myf5 in the hypaxial somite and its derivatives. ..
  68. Vinagre T, Moncaut N, Carapuco M, Novoa A, Bom J, Mallo M. Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains. Dev Cell. 2010;18:655-61 pubmed publisher
    ..Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation. ..
  69. Asakura A, Hirai H, Kablar B, Morita S, Ishibashi J, Piras B, et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle. Proc Natl Acad Sci U S A. 2007;104:16552-7 pubmed
    b>MyoD is a myogenic master transcription factor that plays an essential role in muscle satellite cell (muscle stem cell) differentiation...
  70. Watanabe S, Hirai H, Asakura Y, Tastad C, Verma M, Keller C, et al. MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells. Stem Cells. 2011;29:505-16 pubmed publisher
    ..Continuous expression of the MyoD gene, a master transcription factor for skeletal muscle specification, inhibited this reprogramming process in ..
  71. Relaix F, Rocancourt D, Mansouri A, Buckingham M. Divergent functions of murine Pax3 and Pax7 in limb muscle development. Genes Dev. 2004;18:1088-105 pubmed
  72. Mokalled M, Johnson A, Creemers E, Olson E. MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration. Genes Dev. 2012;26:190-202 pubmed publisher
    ..These abnormalities mimic those associated with genetic deletion of MyoD, a master regulator of myogenesis, which is down-regulated in the absence of MASTR and MRTF-A...
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    ..Together, these studies demonstrate that limb embryonic and fetal myogenic cells develop from distinct, but related progenitors and have different cell-autonomous requirements for beta-catenin. ..
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    ..Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis. ..
  75. Yablonka Reuveni Z, Rudnicki M, Rivera A, Primig M, Anderson J, Natanson P. The transition from proliferation to differentiation is delayed in satellite cells from mice lacking MyoD. Dev Biol. 1999;210:440-55 pubmed
    Satellite cells from adult rat muscle coexpress proliferating cell nuclear antigen and MyoD upon entry into the cell cycle, suggesting that MyoD plays a role during the recruitment of satellite cells...
  76. Harford T, Shaltouki A, Weyman C. Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis. 2010;15:71-82 pubmed publisher
    We have previously reported that the level of MyoD expression correlates with the level of apoptosis that occurs in a subpopulation of skeletal myoblasts induced to differentiate by serum withdrawal...
  77. Brent A, Schweitzer R, Tabin C. A somitic compartment of tendon progenitors. Cell. 2003;113:235-48 pubmed
    ..The tendon primordia thus form in a location abutting the two tissues that the mature tendons must ultimately connect. Tendon progenitor formation may reveal a general mechanism for the specification of other somitic subcompartments. ..
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    ..Here we show, with immunohistochemistry, Western blotting, and electron microscopy that MyoD, a member of the MRF family, also plays a role in fetal synapse formation. In the diaphragm of 14...
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    ..Exacerbated loss of fibre nuclei per unit length during ageing of myoD-null mice provides the first experimental support for the hypothesis that a satellite cell defect causes inadequate ..
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    ..As in the body, Myod acts epistatically to the initiating cascades in the head...
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    ..The myogenic basic helix-loop-helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over the program of ..