Myl9

Summary

Gene Symbol: Myl9
Description: myosin, light polypeptide 9, regulatory
Alias: AI327049, MLC20, Mylc2c, RLC-C, myosin light chain, regulatory C, myosin regulatory light chain 2, smooth muscle isoform, myosin regulatory light chain 9, myosin regulatory light polypeptide 9
Species: mouse

Top Publications

  1. ncbi Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis
    S W Kubalak
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093
    J Biol Chem 269:16961-70. 1994
  2. ncbi Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
  3. ncbi Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
    Eloi Montanez
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 28:3132-44. 2009
  4. ncbi Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    Aram F Hezel
    MGH Cancer Center, Simches Research Building, CPZN 4216, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 28:2414-25. 2008
  5. ncbi Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Mol Biol Cell 18:2305-12. 2007
  6. ncbi ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
    Yoshihiko Shimizu
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 168:941-53. 2005
  7. ncbi Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel
    B Vannier
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:2060-4. 1999
  8. ncbi Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND
    D Srivastava
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Nat Genet 16:154-60. 1997
  9. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
  10. ncbi GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
    C T Kuo
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Genes Dev 11:1048-60. 1997

Scientific Experts

  • D Srivastava
  • Xuefei Ma
  • Inju Park
  • Xiao Sheng Jiang
  • Eloi Montanez
  • Aram F Hezel
  • Yoshihiko Shimizu
  • Do Han Kim
  • Chunghee Cho
  • Dongwook Kim
  • Zee Yong Park
  • Jihye Kim
  • Boyeon Lee
  • Ekaterina Lifirsu
  • Woo Jin Park
  • Jun Tae Kwon
  • Heejin Choi
  • Sora Jin
  • Cecil Han
  • Zheng Li
  • Alfred L Yergey
  • Lynne A Holtzclaw
  • Peter S Backlund
  • Forbes D Porter
  • Christopher A Wassif
  • Li Song
  • Johannes Altstätter
  • Sara A Wickström
  • Haiyan Chu
  • Reinhard Fassler
  • Nabeel Bardeesy
  • Avital Swisa
  • Zvi Granot
  • Yuval Dor
  • Sushma Gurumurthy
  • Ronald A Depinho
  • B Vannier
  • Gerry C Chu
  • Gerald Bailey
  • Yoichi Noda
  • Makoto M Taketo
  • Dean Thumkeo
  • Jeongsin Keel
  • Shuh Narumiya
  • Toshimasa Ishizaki
  • Fumio Matsumura
  • Hiroko Oshima
  • Masanobu Oshima
  • C T Kuo
  • J D Molkentin
  • G Boulay
  • L Birnbaumer
  • M Jiang
  • N Qin
  • X Zhu
  • M Peyton
  • D Brown
  • S W Kubalak
  • R Anandappa
  • Q Lin
  • E E Morrisey
  • S A Duncan
  • M M Lu
  • J M Leiden
  • K Sigrist
  • E N Olson
  • C Soudais
  • M S Parmacek
  • T X O'Brien
  • K R Chien
  • W C Miller-Hance
  • E Dyson

Detail Information

Publications11

  1. ncbi Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis
    S W Kubalak
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093
    J Biol Chem 269:16961-70. 1994
    ..The region-specific expression of the MLC-2a and MLC-2v genes in their respective chambers during early cardiogenesis provides genetic markers for chamber specification (atrial and ventricular) in both the in vitro and in vivo context...
  2. ncbi Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
    ..Developmental abnormalities of neuronal process formation may contribute to the neurocognitive deficits found in SLOS and may represent a potential target for therapeutic intervention...
  3. ncbi Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
    Eloi Montanez
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 28:3132-44. 2009
    ..Our findings show that alpha-pv represents an essential adhesion checkpoint that controls RhoA/ROCK-mediated contractility in vSMCs...
  4. ncbi Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    Aram F Hezel
    MGH Cancer Center, Simches Research Building, CPZN 4216, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 28:2414-25. 2008
    ..These genetic studies provide in vivo evidence of a key role for LKB1 in the establishment of epithelial cell polarity that is vital for pancreatic acinar cell function and viability and for the suppression of neoplasia...
  5. ncbi Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice
    Xuefei Ma
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1762, USA
    Mol Biol Cell 18:2305-12. 2007
    ..These studies show that the scaffolding properties of NM II-B play an important role in cell adhesion, thereby preventing hydrocephalus during mouse brain development...
  6. ncbi ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
    Yoshihiko Shimizu
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 168:941-53. 2005
    ..These results suggest that ROCK-I regulates closure of the eyelids and ventral body wall through organization of actomyosin bundles...
  7. ncbi Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel
    B Vannier
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:2060-4. 1999
    ..e., classical CCE. The findings support the general hypothesis that Trp proteins are subunits of store- and receptor-operated Ca2+ channels...
  8. ncbi Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND
    D Srivastava
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Nat Genet 16:154-60. 1997
    ....
  9. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    ..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
  10. ncbi GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
    C T Kuo
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Genes Dev 11:1048-60. 1997
    ..However, they define a critical role for GATA4 in regulating the rostral-to-caudal and lateral-to-ventral folding of the embryo that is needed for normal cardiac morphogenesis...
  11. ncbi Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity
    Inju Park
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    Biochem J 434:171-80. 2011
    ..highly conserved non-muscle RLCs of the mouse: MYL (myosin light chain) 12A (referred to as MYL12A), MYL12B and MYL9 (MYL12A/12B/9)...