myelin associated oligodendrocytic basic protein


Gene Symbol: myelin associated oligodendrocytic basic protein
Description: myelin-associated oligodendrocytic basic protein
Alias: AI835053, AI839848, MOBP155, MOBP170, MOBP69, MOBP73, MOBP81, R74645, myelin-associated oligodendrocyte basic protein
Species: mouse

Top Publications

  1. Montague P, Dickinson P, McCallion A, Stewart G, Savioz A, Davies R, et al. Developmental expression of the murine Mobp gene. J Neurosci Res. 1997;49:133-43 pubmed
    ..of 3' untranslated region (UTR), is homologous to 3' UTR sequences found in the rat Mobp splice variants rOP1, Mobp81-A and Mobp-99. The mmsv-2 sequence, encoding 81 amino acids, closely resembles the rat Mobp81-A splice variant...
  2. Montague P, Kirkham D, McCallion A, Davies R, Kennedy P, Klugmann M, et al. Reduced levels of a specific myelin-associated oligodendrocytic basic protein isoform in shiverer myelin. Dev Neurosci. 1999;21:36-42 pubmed
    ..Our data suggest that incorporation of this MOBP isoform into shiverer myelin may be influenced by the presence of MBP or be a consequence of a disrupted MDL...
  3. McCallion A, Stewart G, Montague P, Griffiths I, Davies R. Splicing pattern, transcript start distribution, and DNA sequence of the mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein. Mol Cell Neurosci. 1999;13:229-36 pubmed
    ..This study provides the platform for a more detailed analysis of the function of the Mobp gene product and subsequent evaluation of its possible involvement in known neuropathies. ..
  4. Yool D, Montague P, McLaughlin M, McCulloch M, Edgar J, Nave K, et al. Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia. 2002;39:256-67 pubmed
    ..Although MOBP is not essential for myelination, it appears that its absence is not simply compensated for by increased expression of the "classic" myelin basic protein (MBP). ..
  5. Kagami Y, Furuichi T. Investigation of differentially expressed genes during the development of mouse cerebellum. Brain Res Gene Expr Patterns. 2001;1:39-59 pubmed
  6. Holz A, Schaeren Wiemers N, Schaefer C, Pott U, Colello R, Schwab M. Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein. J Neurosci. 1996;16:467-77 pubmed
    ..One isoform, designated MOBP81, was shown to be expressed abundantly during development...
  7. McCallion A, Guenet J, Montague P, Griffiths I, Savioz A, Davies R. The mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein maps to distal chromosome 9. Mamm Genome. 1996;7:847-9 pubmed
  8. Holz A, Frank M, Copeland N, Gilbert D, Jenkins N, Schwab M. Chromosomal localization of the myelin-associated oligodendrocytic basic protein and expression in the genetically linked neurological mouse mutants ducky and tippy. J Neurochem. 1997;69:1801-9 pubmed
    ..Our results suggest that alterations in the Mobp gene are not the cause for the severe neurological phenotypes of ducky and tippy mice. ..
  9. Montague P, Barrie J, Thomson C, Kirkham D, McCallion A, Davies R, et al. Cytoskeletal and nuclear localization of myelin oligodendrocytic basic protein isoforms. Eur J Neurosci. 1998;10:1321-8 pubmed
    ..Here we report on the subcellular distribution of two of these polypeptides termed MOBP81 and MOBP170 in transiently transfected Cos7 cells using an antibody raised against a region common to all isoforms of MOBP...

More Information


  1. Yamamoto Y, Yoshikawa H, Nagano S, Kondoh G, Sadahiro S, Gotow T, et al. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin. Eur J Neurosci. 1999;11:847-55 pubmed
    ..These results suggest that MOBP is essential for normal arrangement of the radial component. ..
  2. Sadahiro S, Yoshikawa H, Yagi N, Yamamoto Y, Yanagihara T, Kimura M, et al. Morphometric analysis of the myelin-associated oligodendrocytic basic protein-deficient mouse reveals a possible role for myelin-associated oligodendrocytic basic protein in regulating axonal diameter. Neuroscience. 2000;98:361-7 pubmed
    ..Taken together, myelin-associated oligodendrocytic basic protein seemed to play a role in controlling axonal diameter and in keeping axons round. ..
  3. Montague P, McCallion A, Barrie J, Edgar J, McLaughlin M, Davies R, et al. Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia. 2005;50:80-5 pubmed
    ..that extends in frame into Mobp exon 4 yielding a predicted MOBP isoform comprising 155 amino acids, designated MOBP155. This newly characterized isoform possessing a novel N-terminus shares a common C-terminus with MOBP170...
  4. Weng J, Symons M, Singh S. Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice. Alcohol Clin Exp Res. 2009;33:1409-16 pubmed publisher
    ..The nature of this association remains to be established and may reflect a direct effect of these genes or an indirect effect caused by linked genes on mouse chromosome 9. ..
  5. Dillman A, Hauser D, Gibbs J, Nalls M, McCoy M, Rudenko I, et al. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013;16:499-506 pubmed publisher
    ..We provide this data set and analysis as a resource for understanding gene expression in the embryonic and adult cerebral cortex. ..
  6. Mardaryev A, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, et al. Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016;212:77-89 pubmed publisher
  7. Schäfer I, Müller C, Luhmann H, White R. MOBP levels are regulated by Fyn kinase and affect the morphological differentiation of oligodendrocytes. J Cell Sci. 2016;129:930-42 pubmed publisher
    ..Here, we show, by several approaches in cultured primary oligodendrocytes, that MOBP synthesis is stimulated by Fyn activity. Moreover, we reveal a new function for MOBP in oligodendroglial morphological differentiation. ..