Myc

Summary

Gene Symbol: Myc
Description: myelocytomatosis oncogene
Alias: AU016757, Myc2, Niard, Nird, bHLHe39, c-myc proto-oncogene, myc proto-oncogene protein, transcription factor p64
Species: mouse

Top Publications

  1. doi Modelling Myc inhibition as a cancer therapy
    Laura Soucek
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143 0875, USA
    Nature 455:679-83. 2008
  2. ncbi c-Myc regulates mammalian body size by controlling cell number but not cell size
    A Trumpp
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 414:768-73. 2001
  3. pmc c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
    Troy A Baudino
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 16:2530-43. 2002
  4. ncbi Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization
    Mark A Gregory
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:51606-12. 2003
  5. doi GSK-3 is a master regulator of neural progenitor homeostasis
    Woo Yang Kim
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 12:1390-7. 2009
  6. pmc Widespread microRNA repression by Myc contributes to tumorigenesis
    Tsung Cheng Chang
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 40:43-50. 2008
  7. pmc Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
    C M Eischen
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 13:2658-69. 1999
  8. pmc Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia
    Letetia Jones
    Helen Diller Family Comprehensive Cancer Center and Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:2581-94. 2010
  9. doi c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice
    H Momota
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 27:4392-401. 2008
  10. pmc Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation
    Jonas A Nilsson
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 24:1560-9. 2004

Detail Information

Publications171 found, 100 shown here

  1. doi Modelling Myc inhibition as a cancer therapy
    Laura Soucek
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143 0875, USA
    Nature 455:679-83. 2008
    b>Myc is a pleiotropic basic helix-loop-helix leucine zipper transcription factor that coordinates expression of the diverse intracellular and extracellular programs that together are necessary for growth and expansion of somatic cells...
  2. ncbi c-Myc regulates mammalian body size by controlling cell number but not cell size
    A Trumpp
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 414:768-73. 2001
    Overexpression of the proto-oncogene c-myc has been implicated in the genesis of diverse human tumours. c-Myc seems to regulate diverse biological processes, but its role in tumorigenesis and normal physiology remains enigmatic...
  3. pmc c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
    Troy A Baudino
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 16:2530-43. 2002
    c-Myc promotes cell growth and transformation by ill-defined mechanisms. c-myc(-/-) mice die by embryonic day 10.5 (E10.5) with defects in growth and in cardiac and neural development...
  4. ncbi Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization
    Mark A Gregory
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:51606-12. 2003
    The c-Myc protein is a transcription factor that is a central regulator of cell growth and proliferation...
  5. doi GSK-3 is a master regulator of neural progenitor homeostasis
    Woo Yang Kim
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 12:1390-7. 2009
    ..Our results indicate that GSK-3 signaling is an essential mediator of homeostatic controls that regulate neural progenitors during mammalian brain development...
  6. pmc Widespread microRNA repression by Myc contributes to tumorigenesis
    Tsung Cheng Chang
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 40:43-50. 2008
    The c-Myc oncogenic transcription factor (Myc) is pathologically activated in many human malignancies. Myc is known to directly upregulate a pro-tumorigenic group of microRNAs (miRNAs) known as the miR-17-92 cluster...
  7. pmc Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
    C M Eischen
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 13:2658-69. 1999
    Transgenic mice expressing the c-Myc oncogene driven by the immunoglobulin heavy chain enhancer (Emu) develop B-cell lymphoma and exhibit a mean survival time of approximately 6 months...
  8. pmc Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia
    Letetia Jones
    Helen Diller Family Comprehensive Cancer Center and Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:2581-94. 2010
    ..It has been hypothesized that gain of the MYC protooncogene is of central importance in trisomy 8, but the experimental data to support this are limited and ..
  9. doi c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice
    H Momota
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 27:4392-401. 2008
    ..As elevated c-Myc expression, activation of Wnt/beta-catenin signaling and dysfunction of p53 are seen in human PNETs, we ..
  10. pmc Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation
    Jonas A Nilsson
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 24:1560-9. 2004
    b>Myc oncoproteins are overexpressed in most cancers and are sufficient to accelerate cell proliferation and provoke transformation. However, in normal cells Myc also triggers apoptosis...
  11. ncbi The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    J M Adams
    Nature 318:533-8. 1985
    Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth...
  12. ncbi Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
    M V Barone
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 378:509-12. 1995
    ..Both AP1 and Myc are activated in fibroblasts in response to growth factor stimulation, and various experiments suggest their ..
  13. pmc Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells
    Benjamin L Kidder
    EMD Serono Research Institute, Inc, Rockland, Massachusetts, United States of America
    PLoS ONE 3:e3932. 2008
    ..Stat3 and c-Myc TFs are essential for maintaining mouse ES cell self-renewal...
  14. ncbi Reversible tumorigenesis by MYC in hematopoietic lineages
    D W Felsher
    Department of Medicine, G W Hooper Foundation, San Francisco, California, USA
    Mol Cell 4:199-207. 1999
    ..we have used the tetracycline regulatory system to generate transgenic mice that conditionally express the MYC protooncogene in hematopoietic cells...
  15. ncbi Beta-catenin is essential for pancreatic acinar but not islet development
    L Charles Murtaugh
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 132:4663-74. 2005
    ..Thus, our data are consistent with a crucial role for canonical Wnt signals in acinar lineage specification and differentiation...
  16. ncbi Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    Stella Pelengaris
    Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Cell 109:321-34. 2002
    To explore the role of c-Myc in carcinogenesis, we have developed a reversible transgenic model of pancreatic beta cell oncogenesis using a switchable form of the c-Myc protein...
  17. pmc Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene
    Cheryl M Koh
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Am J Pathol 178:1824-34. 2011
    ..We verify that activation of the MYC oncogene, which is overexpressed in most human PIN and prostatic adenocarcinomas, leads to formation of enlarged ..
  18. pmc AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
    Davide F Robbiani
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Cell 135:1028-38. 2008
    ..One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy-chain locus (IgH) and is found in Burkitt's lymphomas in humans and plasmacytomas in ..
  19. pmc Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix
    Chi Zhang
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:6936-41. 2008
    ..5 Osx-null embryos, expression of the Wnt antagonist Dkk1 was abolished, and that of Wnt target genes c-Myc and cyclin D1 was increased. Moreover, our studies demonstrated that Osx bound to and activated the Dkk1 promoter...
  20. ncbi Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas
    S Crews
    Science 218:1319-21. 1982
    Hybridization studies with viral oncogene probes indicate that c-myc, the cellular gene homologous to the transforming gene of avian myelocytomatosis virus, resides on mouse chromosome 15 and in many plasmacytomas is translocated to the ..
  21. doi Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology
    Oscar M Pello
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Milan, Italy
    Blood 119:411-21. 2012
    ..In the present study, we report that alternative polarization of macrophages requires the transcription factor c-MYC. In macrophages, IL-4 and different stimuli sustaining M2-like polarization induce c-MYC expression and its ..
  22. pmc Bim is a suppressor of Myc-induced mouse B cell leukemia
    Alexander Egle
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:6164-9. 2004
    ..Bim protein levels were elevated in the apoptosis-prone B lymphoid cells of Emicro-Myc-transgenic mice, and Bim-mutant Emicro-Myc mice had increased numbers of IgM-bearing B cells...
  23. pmc Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors
    Andreas Lorenz
    Center for Neuropathology, Ludwig Maximilians University, 81377 Munich, Germany
    Mol Cell Biol 31:3326-38. 2011
    ..In summary, we conclude that cerebellar granule neurons essentially require appropriate levels of Wnt signaling to balance their proliferation and differentiation...
  24. ncbi A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas
    S R Hann
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 52:185-95. 1988
    The c-myc gene comprises three exons with a single large AUG-initiated open reading frame extending from exon 2 through exon 3. Exon 1 lacks any AUG codons...
  25. doi Pim kinase-dependent inhibition of c-Myc degradation
    Y Zhang
    School of Molecular Biosciences, Washington State University, Pullman, WA 99163, USA
    Oncogene 27:4809-19. 2008
    ..Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed...
  26. pmc Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC
    Rahul Nahar
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA
    Blood 118:4174-8. 2011
    ..Inducible activation of BCL6 downstream of the pre-B cell receptor results in transcriptional repression of MYC and CCND2...
  27. pmc Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear
    Benjamin Kopecky
    Department of Biology, University of Iowa, Iowa City, Iowa, USA
    Dev Dyn 240:1373-90. 2011
    ..The proto-oncogene N-Myc is a member of the Myc family that regulates proliferation...
  28. pmc c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo
    Chen He
    Pacific Vascular Research Laboratory, Division of Vascular Surgery, Departments of Surgery and Anatomy, University of California, San Francisco, CA 94143, USA
    Development 135:2467-77. 2008
    The c-myc proto-oncogene, which is crucial for the progression of many human cancers, has been implicated in key cellular processes in diverse cell types, including endothelial cells that line the blood vessels and are critical for ..
  29. ncbi Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation
    S R Hann
    Department of Cell Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 2175
    Genes Dev 6:1229-40. 1992
    c-myc belongs to a small, yet growing, group of eukaryotic mRNAs that initiate translation inefficiently from a non-AUG codon upstream from a more efficient AUG codon...
  30. pmc Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
    Apostolos Klinakis
    Department of Genetics and Development, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:9262-7. 2006
    ..Up-regulation of Myc in these tumors prompted a genetic investigation of a potential Notch1/Myc functional relationship in breast ..
  31. pmc Burkitt lymphoma in the mouse
    A L Kovalchuk
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:1183-90. 2000
    Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences of immunoglobulin (Ig) H chain or kappa (Ig kappa) or lambda (Ig lambda) L chain genes and effecting deregulated expression of MYC are the hallmarks ..
  32. pmc Angiopoietins 3 and 4: diverging gene counterparts in mice and humans
    D M Valenzuela
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 96:1904-9. 1999
    ..Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist...
  33. doi Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse
    Ching Yu Huang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 38:342-9. 2008
    c-Myc induces widely varying cellular effects, including cell proliferation and cell death...
  34. ncbi Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, La Jolla 92093 0627, USA
    Hum Mol Genet 13:1057-67. 2004
    ..Mnt can inhibit Myc-dependent cell transformation and is hypothesized to counterbalance the effects of c-Myc on growth and ..
  35. pmc Myc represses transcription through recruitment of DNA methyltransferase corepressor
    Carmen Brenner
    Free University of Brussels, Faculty of Medicine, Laboratory of Molecular Virology, Brussels, Belgium
    EMBO J 24:336-46. 2005
    The Myc transcription factor is an essential mediator of cell growth and proliferation through its ability to both positively and negatively regulate transcription...
  36. pmc Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice
    Wan Cheung Cheung
    Cell Signaling Technology Inc, Beverly, Massachusetts, USA
    J Clin Invest 113:1763-73. 2004
    Deregulated expression of both Myc and Bcl-X(L) are consistent features of human plasma cell neoplasms (PCNs)...
  37. pmc Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism
    Efren Riu
    Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, and Center of Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Biochem J 368:931-7. 2002
    Overexpression of the c-Myc transcription factor in liver induces glucose uptake and utilization...
  38. doi N-myc controls proliferation, morphogenesis, and patterning of the inner ear
    Elena Dominguez-Frutos
    Institute of Biology and Molecular Genetics, University of Valladolid and Spanish National Research Council, E 47003 Valladolid, Spain
    J Neurosci 31:7178-89. 2011
    b>Myc family members play crucial roles in regulating cell proliferation, size, and differentiation during organogenesis. Both N-myc and c-myc are expressed throughout inner ear development...
  39. pmc Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas
    Rajeev M Nepal
    Department of Immunology, University of Toronto, Medical Sciences Building, Toronto, Canada
    Proc Natl Acad Sci U S A 106:18698-703. 2009
    C-Myc is one of the most common targets of genetic alterations in human cancers. Although overexpression of c-Myc in the B cell compartment predisposes to lymphomas, secondary mutations are required for disease manifestation...
  40. pmc Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    Valerie Horsley
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 126:597-609. 2006
    ..Blimp1 appears to govern cellular input into the gland since its loss leads to elevated c-myc expression, augmented cell proliferation, and SG hyperplasia...
  41. pmc Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
    J J Jacobs
    Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Genes Dev 13:2678-90. 1999
    The bmi-1 and myc oncogenes collaborate strongly in murine lymphomagenesis, but the basis for this collaboration was not understood...
  42. ncbi c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis
    Teresa Bianchi
    Ludwig Institute for Cancer Research LICR, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Blood 107:3992-9. 2006
    ..Surprisingly, we show here that haploinsufficiency of the protooncogene c-myc leads to a highly selective decrease in CD44(high) CD8 T cells in mice...
  43. doi A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene
    Remi Fiancette
    Faculte de Medecine, Unité Mixte de Recherche 6101, Centre National de la Recherche Scientifique, 87025 Limoges, France
    J Immunol 187:5772-82. 2011
    Although c-myc is classically described as the driving oncogene in Burkitt's lymphoma (BL), deregulation and mutations of c-myc have been reported in multiple solid tumors and in other mature B cell malignancies such as mantle cell ..
  44. ncbi Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice
    K Blyth
    Molecular Oncology Laboratory, University of Glasgow Veterinary School, Bearsden
    Oncogene 19:773-82. 2000
    To study the effects of the Myc oncoprotein in a regulatable in vivo system, we generated lines of transgenic mice in which a tamoxifen inducible Myc fusion protein (c-mycER) is expressed under the control of the CD2 locus control region...
  45. ncbi Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
    B R Stanton
    Molecular Embryology Section, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genes Dev 6:2235-47. 1992
    b>myc genes are thought to function in the processes of cellular proliferation and differentiation...
  46. ncbi Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas
    L W Stanton
    Nature 303:401-6. 1983
    Comparative nucleotide sequence analysis of a rearranged c-myc gene in a murine plasmacytoma and c-myc cDNA from normal spleen reveals that chromosomal translocation in the plasmacytoma breaks the c-myc gene within the first exon or ..
  47. ncbi A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice
    A C Davis
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Genes Dev 7:671-82. 1993
    To directly assess c-myc function in cellular proliferation, differentiation, and embryogenesis, we have used homologous recombination in embryonic stem cells to generate both heterozygous and homozygous c-myc mutant ES cell lines...
  48. ncbi Evidence from transgenic mice that myc regulates hepatic glycolysis
    A Valera
    Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Spain
    FASEB J 9:1067-78. 1995
    The product of the c-myc proto-oncogene (c-Myc) is involved in the control of cell proliferation, differentiation, and apoptosis. It acts as a transcription factor that recognizes the CACGTG motif...
  49. ncbi c-Myc and apoptosis
    G Packham
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biochim Biophys Acta 1242:11-28. 1995
  50. pmc MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells
    Tsuyoshi Iwata
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9427. 2010
    Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate...
  51. ncbi The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX
    J Yuan
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Oncogene 17:1109-18. 1998
    The genes of the myc/max/mad family play an important role in controlling cell proliferation and differentiation. We have identified the first homologues of the mad and max genes in the nematode C...
  52. ncbi Down-regulation of c-myc and bcl-2 gene expression in PU.1-induced apoptosis in murine erythroleukemia cells
    F Kihara-Negishi
    Department of Cell Genetics, Sasaki Institute, Tokyo, Japan
    Int J Cancer 76:523-30. 1998
    ..Semi-quantitative RT-PCR revealed that expression of c-myc and bcl-2 genes was reduced during the apoptotic process, while expression of bax and bcl-X(L) genes was not ..
  53. ncbi Sequential expression of the MAD family of transcriptional repressors during differentiation and development
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncogene 16:967-77. 1998
    Members of the Myc proto-oncogene family encode transcription factors that function in multiple aspects of cell behavior, including proliferation, differentiation, transformation and apoptosis...
  54. ncbi Negative regulation of c-Myc transcription by pancreas duodenum homeobox-1
    Lei Chen
    International Co operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, 200438 Shanghai, People s Republic of China
    Endocrinology 148:2168-80. 2007
    ..duodenal homeobox factor-1 (Pdx1) is essential for pancreatic development and insulin gene transcription, whereas c-Myc has a deleterious effect on islet function. However, the relationship between c-Myc and Pdx1 is poorly concerned...
  55. ncbi Molecular cloning of mouse collectin liver 1
    Takao Kawai
    Division of Food Microbiology, Osaka Prefectural Institute of Public Health, 1 3 69 Nakamichi, Higashinari ku, Osaka 537 0025, Japan
    Biosci Biotechnol Biochem 66:2134-45. 2002
    ..The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish...
  56. ncbi Myc and Max associate in vivo
    E M Blackwood
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 6:71-80. 1992
    Max is a helix-loop-helix zipper protein that associates in vitro with Myc family proteins to form a sequence-specific DNA-binding complex...
  57. pmc TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas
    Ryan M Young
    Department of Dermatology, Charles C Gates Regenerative Medicine and Stem Cell Program, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA
    Blood 114:5016-23. 2009
    ..We hypothesized that TC-PTP may be a tumor-promoting gene that is regulated by MYC overexpression in B cells...
  58. pmc Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss
    Alicia M Cole
    Beatson Institute of Cancer Research, Glasgow, United Kingdom School of Biosciences, Cardiff, United Kingdom
    Cancer Res 70:8149-58. 2010
    ..activation of β-catenin/T-cell factor 4 signaling and hence transcription of Wnt target genes such as c-Myc. Our and other previous studies have shown that although cyclin D1 is required for adenoma formation, it is not ..
  59. ncbi Non-transcriptional control of DNA replication by c-Myc
    David Dominguez-Sola
    Institute for Cancer Genetics, Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    Nature 448:445-51. 2007
    The c-Myc proto-oncogene encodes a transcription factor that is essential for cell growth and proliferation and is broadly implicated in tumorigenesis...
  60. ncbi Pim family kinases enhance tumor growth of prostate cancer cells
    Wei Wei Chen
    Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Cancer Res 3:443-51. 2005
    ..We have found that the cellular levels of c-Myc were elevated in the Pim-1 and Pim-2 transfectants under these conditions...
  61. pmc Miz1 is required for early embryonic development during gastrulation
    Sovana Adhikary
    Institute for Molecular Biology and Tumor Research Institute for Cytobiology and Cytopathology, University of Marburg, 35033 Marburg, Germany
    Mol Cell Biol 23:7648-57. 2003
    Miz1 is a member of the POZ domain/zinc finger transcription factor family. In vivo, Miz1 forms a complex with the Myc oncoprotein and recruits Myc to core promoter elements. Myc represses transcription through Miz1 binding sites...
  62. pmc MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
    Fiona M Watt
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nat Rev Cancer 8:234-42. 2008
    b>MYC in human epidermal stem cells can stimulate differentiation rather than uncontrolled proliferation. This discovery was, understandably, greeted with scepticism by researchers...
  63. pmc The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells
    A W Harris
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    J Exp Med 167:353-71. 1988
    Mice transgenic for a c-myc gene driven by the IgH enhancer (E mu-myc) were shown to almost invariably develop lymphomas, 90% succumbing in the first 5 mo of life...
  64. pmc Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal
    Matthew Bechard
    Paul D Coverdell Center for Biomedical and Health Sciences, Athens, Georgia 30602, USA
    Mol Cell Biol 29:2092-104. 2009
    Phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT1), and c-myc have well-established roles in promoting the maintenance of murine embryonic stem cells (mESCs)...
  65. doi C-myc as a modulator of renal stem/progenitor cell population
    Martin Couillard
    Institut de Recherches Cliniques de Montreal, Molecular Genetics and Development, Faculte de Medecine de l Universite de Montreal, Montreal, Quebec, Canada
    Dev Dyn 238:405-14. 2009
    The role of c-myc has been well-studied in gene regulation and oncogenesis but remains elusive in murine development from midgestation...
  66. ncbi Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis
    H Murakami
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892
    Cancer Res 53:1719-23. 1993
    Double transgenic mice bearing fusion genes consisting of mouse albumin enhancer/promoter-mouse c-myc complementary DNA and mouse metallothionein 1 promoter-human transforming growth factor alpha complementary DNA were generated to ..
  67. pmc Distinct thresholds govern Myc's biological output in vivo
    Daniel J Murphy
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 14:447-57. 2008
    Deregulated Myc triggers a variety of intrinsic tumor suppressor programs that serve to restrain Myc's oncogenic potential...
  68. doi Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration
    Xiuping Yu
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Prostate 69:249-62. 2009
    ..Although stabilizing mutations in APC and beta-Catenin are rare in primary prostate tumors, recent studies suggest that cytoplasmic/nuclear beta-Catenin is associated with advanced, metastatic, hormone-refractory prostate carcinoma...
  69. pmc Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression
    Shibin Ma
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
    Mol Cell Biol 30:4149-58. 2010
    ..driven by signals from the interleukin-7 receptor and the pre-B-cell receptor and is dependent on cyclin D3 and c-Myc. We have shown previously that interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to ..
  70. pmc The MYC protein activates transcription of the alpha-prothymosin gene
    M Eilers
    Department of Microbiology and Immunology, University of California San Francisco 94143 0552
    EMBO J 10:133-41. 1991
    The proto-oncogene MYC encodes a nuclear protein whose biochemical and physiological functions remain uncertain. We used an estrogen-regulated version of the MYC protein to explore these functions...
  71. ncbi Analysis of C-MYC function in normal cells via conditional gene-targeted mutation
    I M de Alboran
    Howard Hughes Medical Institute and Children s, Hospital, Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Immunity 14:45-55. 2001
    Germline inactivation of c-myc in mice causes embryonic lethality. Therefore, we developed a LoxP/Cre-based conditional mutation approach to test the role of c-myc in mouse embryonic fibroblasts (MEFs) and mature B lymphocytes...
  72. pmc Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1
    Anneli Gebhardt
    Institute for Cell Biology, University of Marburg, 35033 Marburg, Germany
    J Cell Biol 172:139-49. 2006
    b>Myc plays a key role in homeostasis of the skin. We show that Miz1, which mediates Myc repression of gene expression, is expressed in the epidermal basal layer...
  73. ncbi Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
    Almudena R Ramiro
    Laboratory of Molecular Immunology, The Rockefeller University, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Nature 440:105-9. 2006
    ..Here we find that translocations between c-myc and the IgH locus (Igh) are induced in primary B cells within hours of expression of the catalytically active form ..
  74. pmc Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer
    Jongchan Kim
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    PLoS Genet 5:e1000542. 2009
    ..Here we have modeled sporadic oncogene activation using a transgenic mouse in which c-MYC is focally activated in prostate luminal epithelial cells...
  75. pmc Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation
    Marianna Shafarenko
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 N Broad St, Philadelphia, PA 19140, USA
    Blood 106:871-8. 2005
    ..In addition, we have shown that deregulated expression of the proto-oncogene c-myc blocks the myeloid terminal differentiation program...
  76. ncbi The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice
    A Elson
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Oncogene 11:181-90. 1995
    A number of properties of the cancer-related genes c-myc and p53 suggest that they might collaborate to induce tumorigenesis...
  77. pmc c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
    Esther Baena
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 102:7286-91. 2005
    The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis...
  78. doi C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia
    William E Blanco-Bose
    Genetics and Stem Cell Laboratory, Ecole Polytechnique Federale de Lausanne EPFL, ISREC Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland
    Hepatology 48:1302-11. 2008
    ..In this study, we identify c-Myc as a gene induced by CAR and demonstrate that TCPOBOP-induced proliferation of hepatocytes depends on c-Myc ..
  79. ncbi Multiple mechanisms of tumorigenesis in E mu-myc transgenic mice
    C L Sidman
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267
    Cancer Res 53:1665-9. 1993
    Transgenic mice bearing a c-myc oncogene under control of the immunoglobulin heavy chain enhancer (E mu-myc mice) reproducibly develop and die from tumors of the B lymphocyte lineage (J.M. Adams, A.W. Harris, C.A. Pinkert, L.M...
  80. doi Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function
    Nicole C Dubois
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, School of Life Science, 1066 Epalinges, Switzerland
    Development 135:2455-65. 2008
    The c-Myc protein has been implicated in playing a pivotal role in regulating the expression of a large number of genes involved in many aspects of cellular function...
  81. pmc Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
    Maria Barna
    Department of Biochemistry and Biophysics, University of California San Francisco, Rock Hall Room 384C, 1550 Fourth Street, San Francisco, California 94158 2517, USA
    Nature 456:971-5. 2008
    The Myc oncogene regulates the expression of several components of the protein synthetic machinery, including ribosomal proteins, initiation factors of translation, RNA polymerase III and ribosomal DNA...
  82. pmc Myc stimulates B lymphocyte differentiation and amplifies calcium signaling
    Tania Habib
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    J Cell Biol 179:717-31. 2007
    Deregulated expression of the Myc family of transcription factors (c-, N-, and L-myc) contributes to the development of many cancers by a mechanism believed to involve the stimulation of cell proliferation and inhibition of ..
  83. pmc AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
    Alexander L Kovalchuk
    Laboratory of Cancer Biology and Genetics, Cancer Genomics Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:2989-3001. 2007
    ..and somatic hypermutation, and has also been implicated in translocations between Ig switch regions and c-Myc in plasma cell tumors in mice...
  84. ncbi Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes
    T A Stewart
    Cell 38:627-37. 1984
    We have produced 13 strains of transgenic mice that carry an otherwise normal mouse myc gene in which increasingly larger portions of the myc promoter region have been replaced by a hormonally inducible mouse mammary tumor virus promoter...
  85. pmc Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma
    Priscilla N Kelly
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Melbourne, Australia
    Blood 109:4907-13. 2007
    Although myc and bcl-2 synergize in tumor development, particularly lymphomagenesis, it is not known whether endogenous bcl-2 is required for myc-induced tumorigenesis...
  86. ncbi N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Cancer Res 66:8655-61. 2006
    We examined the genetic requirements for the Myc family of oncogenes in normal Sonic hedgehog (Shh)-mediated cerebellar granule neuronal precursor (GNP) expansion and in Shh pathway-induced medulloblastoma formation...
  87. pmc Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway
    Weiguang Zhong
    The Cardiovascular Research Laboratories, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    EMBO J 25:3869-79. 2006
    c-Myc (Myc) is highly expressed in developing embryos where it regulates body size by controlling proliferation but not cell size...
  88. ncbi Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
    K Kelly
    Cell 35:603-10. 1983
    We show that c-myc is an inducible gene that is regulated by specific growth signals in a cell-cycle-dependent manner...
  89. ncbi Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling
    Vesna Todorovic
    Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA
    Development 134:3723-32. 2007
    ..This phenotype reveals a crucial role for Ltbp1L and matrix as extracellular regulators of Tgf-beta activity in heart organogenesis...
  90. pmc Acceleration of c-myc-induced hepatocarcinogenesis by Co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption
    E Santoni-Rugiu
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Am J Pathol 154:1693-700. 1999
    We have previously shown in transgenic mice that transforming growth factor (TGF)-alpha dramatically enhances c-myc-induced hepatocarcinogenesis by promoting proliferation and survival of hepatocellular carcinoma (HCC) cells...
  91. pmc N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
    Paul S Knoepfler
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 16:2699-712. 2002
    To address the role of N-myc in neurogenesis and in nervous system tumors, it was conditionally disrupted in neuronal progenitor cells (NPCs) with a nestin-Cre transgene...
  92. ncbi c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death
    I Moreno de Alborán
    Department of Immunology and Oncology DIO Pharmacia CSIC, Centro Nacional de Biotecnologia CNB CSIC, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Cell Death Differ 11:61-8. 2004
    C-myc gene is a member of the myc family of proto-oncogenes involved in proliferation, differentiation, and apoptosis...
  93. pmc Scaffold attachment regions stimulate HSP70.1 expression in mouse preimplantation embryos but not in differentiated tissues
    E M Thompson
    Unite de Biologie du Developpement, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Mol Cell Biol 14:4694-703. 1994
    ..These results suggest a limited capacity of SARs to act as insulating elements but are consistent with a proposed model of SAR-mediated chromatin opening and closing...
  94. ncbi Prostatic neoplasia in transgenic mice with prostate-directed overexpression of the c-myc oncoprotein
    X Zhang
    Department of Urology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Prostate 43:278-85. 2000
    ..In order to test the in vivo effects of chronic overexpression of the mouse c-myc protooncogene on the prostate glands of transgenic mice, we created several lines of C(3)1-c-myc transgenic mice ..
  95. ncbi Regionally restricted expression of the transcription factor c-myc intron 1 binding protein during brain development
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Comp Neurol 467:581-92. 2003
    ..In a screen of developing cerebral cortex, we identified the transcription factor c-myc intron 1 binding protein (mibp1) due to its abundant expression...
  96. pmc Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice
    B Scheijen
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    J Virol 71:9-16. 1997
    Insertional mutagenesis with Moloney murine leukemia virus (MoMLV) in c-myc and Pim-1 transgenic mice permits the identification of oncogenes that collaborate with the transgenes in lymphomagenesis...
  97. ncbi Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation
    Shu Chun Teng
    Institute of Biochemistry, National Yang Ming University, Taipei 112, Taiwan
    J Biol Chem 279:14649-55. 2004
    The c-myc proto-oncogene encodes a ubiquitous transcription factor involved in the control of cell growth and differentiation and implicated in inducing tumorigenesis...
  98. pmc The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
    S B McMahon
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Mol Cell Biol 20:556-62. 2000
    The c-Myc protein functions as a transcription factor to facilitate oncogenic transformation; however, the biochemical and genetic pathways leading to transformation remain undefined...
  99. ncbi The alternatively initiated c-Myc proteins differentially regulate transcription through a noncanonical DNA-binding site
    S R Hann
    Department of Cell Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 2175
    Genes Dev 8:2441-52. 1994
    The myc proto-oncogene family has been implicated in multiple cellular processes, including proliferation, differentiation, and apoptosis...
  100. ncbi Sustained loss of a neoplastic phenotype by brief inactivation of MYC
    Meenakshi Jain
    Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA 94305 5151, USA
    Science 297:102-4. 2002
    ..We used a conditional transgenic mouse model for MYC-induced tumorigenesis to demonstrate that brief inactivation of MYC results in the sustained regression of tumors ..
  101. pmc Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors
    Sefat E Khuda
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 181:7537-49. 2008
    Deregulation of the c-Myc oncogene is tightly associated with human and murine plasma cell (PC) neoplasms...

Research Grants35

  1. The role of PTEN phosphorylation remodeling in hematopoietic stem cell regulation
    Jiwang Zhang; Fiscal Year: 2011
    ..The predicted outcome will greatly help our ability to expand hematopoietic stem cells in vitro and hence improve the outcome of clinical stem cell transplantation. ..
  2. The role of PTEN phosphorylation remodeling in hematopoietic stem cell regulation
    Jiwang Zhang; Fiscal Year: 2010
    ..The predicted outcome will greatly help our ability to expand hematopoietic stem cells in vitro and hence improve the outcome of clinical stem cell transplantation. ..
  3. Multiple mutations in tumor maintenance
    Katrina Podsypanina; Fiscal Year: 2007
    ..Research will focus on Myc and Ras pathway oncogenes in tumor progression and maintenance, initially by using a mouse mammary tumor model ..
  4. Myc Antagonism and Tumor Suppression by Mnt
    Peter Hurlin; Fiscal Year: 2007
    The Myc family of transcripton factors play a fundamental role in regulating cell proliferation and can promote tumorigenesis when deregulated and/or overexpressed...
  5. Mechanisms of endoderm specification along the A-P axis
    James Wells; Fiscal Year: 2009
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..
  6. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2010
    ..Completion of our proposal will enable us to determine if thiazole antibiotics are suitable for further clinical development. ..
  7. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..
  8. Colon Cell Differentiation: NAB and MUC2 Gene Expression
    Anna Velcich; Fiscal Year: 2009
    ..5. Finally, we will extend our use of microarray technology to determine how NaB perturbs profiles of gene expression that define lineage specific differentiation (Velcich et al., submitted). ..
  9. FUNCTION OF A DUAL SPECIFICITY TRANSCRIPTION FACTOR
    Peter Hurlin; Fiscal Year: 2003
    DESCRIPTION (adapted from the applicant's desciption): The Myc family proteins play fundamental roles in controlling cell proliferation, and frequently contribute to oncogenesis...
  10. P21 transcriptional inhibitors as proapoptotic compounds
    Andrei Gartel; Fiscal Year: 2003
    ..This study may improve treatment of cancer by leading to the identification of new compounds that will increase the efficiency of cell death promoting anticancer drugs for cancer treatment. ..
  11. Inactivation of the Muc2 gene and colorectal cancer
    Anna Velcich; Fiscal Year: 2005
    ....