Mybpc2

Summary

Gene Symbol: Mybpc2
Description: myosin binding protein C, fast-type
Alias: myosin-binding protein C, fast-type, C-protein, skeletal muscle fast isoform, fast MyBP-C, fast-type C-protein
Species: mouse
Products:     Mybpc2

Top Publications

  1. Cohen S, Brault J, Gygi S, Glass D, Valenzuela D, Gartner C, et al. During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 2009;185:1083-95 pubmed publisher
    ..Because these proteins stabilize the thick filament, their selective ubiquitylation may facilitate thick filament disassembly. However, the thin filament components decreased by a mechanism not requiring MuRF1...
  2. Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996;76:371-423 pubmed
    ..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
  3. Duriez P, Shah G. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem Cell Biol. 1997;75:337-49 pubmed
    ..The putative biological functions for early cleavage of PARP in apoptosis are also discussed. ..
  4. Kurasawa M, Sato N, Matsuda A, Koshida S, Totsuka T, Obinata T. Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles. Muscle Nerve. 1999;22:196-207 pubmed
    ..We also suggest that the expression of S isoform may be stimulated in degenerating human dystrophic muscles. ..
  5. Gautel M, F├╝rst D, Cocco A, Schiaffino S. Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle. Circ Res. 1998;82:124-9 pubmed
    ..This suggests that transcomplementation of MyBP-C isoforms is possible in skeletal but not cardiac muscle. ..