Myb

Summary

Gene Symbol: Myb
Description: myeloblastosis oncogene
Alias: AI550390, M16449, c-myb, gag-myb protein, myb proto-oncogene protein, myeloblastosis proto-oncogene product, proto-oncogene c-Myb, transcriptional activator Myb, tumor-specific myb protein
Species: mouse

Top Publications

  1. ncbi MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    Changchun Xiao
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:146-59. 2007
  2. ncbi A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
    M L Mucenski
    Children s Hospital Research Foundation, Department of Pediatrics, Cincinnati, Ohio
    Cell 65:677-89. 1991
  3. ncbi Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
    R A Shivdasani
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 373:432-4. 1995
  4. pmc Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305 0074, Japan
    Genes Dev 18:816-29. 2004
  5. doi MYB is essential for mammary tumorigenesis
    Rebecca Yu Miao
    Peter MacCallum Cancer Centre and Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia
    Cancer Res 71:7029-37. 2011
  6. ncbi A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
    Lawryn H Kasper
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Nature 419:738-43. 2002
  7. ncbi Critical functions for c-Myb at three checkpoints during thymocyte development
    Timothy P Bender
    The Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Nat Immunol 5:721-9. 2004
  8. pmc c-Myb is essential for early T cell development
    R D Allen
    Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genes Dev 13:1073-8. 1999
  9. pmc Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation
    Yen K Lieu
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Proc Natl Acad Sci U S A 106:21689-94. 2009
  10. pmc Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice
    Maria Kauppi
    Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 112:3148-53. 2008

Research Grants

  1. c-myb in B Cell Development and Function
    TIMOTHY BENDER; Fiscal Year: 2009
  2. iCyt Reflection Cell Sorter
    TIMOTHY BENDER; Fiscal Year: 2007
  3. Conditional Mutagenesis to Study c-Mby Function
    TIMOTHY BENDER; Fiscal Year: 2007
  4. CONDITIONAL MUTAGENESIS TO STUDY C MYB FUNCTION
    TIMOTHY BENDER; Fiscal Year: 2005
  5. Conditional Mutagenesis to Study c-Myb Function
    Timothy P Bender; Fiscal Year: 2010

Scientific Experts

  • P Garcia
  • Eva Matalova
  • Yen K Lieu
  • Nina Perälä
  • Peter Papathanasiou
  • K R Johnson
  • S A Ness
  • Ramsay G Robert
  • Vilborg Matre
  • TIMOTHY BENDER
  • L Robb
  • N Takakura
  • P W Chiang
  • Douglas J Hilton
  • Jordane Malaterre
  • Robert G Ramsay
  • Warren S Alexander
  • Minetaro Ogawa
  • Hiroshi Sakamoto
  • Chie Kanei-Ishii
  • Lloyd Pereira
  • Dane Cheasley
  • Taishan Hu
  • Carolyn A de Graaf
  • Maria Kauppi
  • Teruaki Nomura
  • Donald Metcalf
  • Craig D Hyland
  • Jon Frampton
  • Guoyou Dai
  • Francesca Corradini
  • Marina R Carpinelli
  • Lucia Knopfova
  • Masayoshi Ishida
  • Shunsuke Ishii
  • Emi Ichikawa-Iwata
  • Rebecca Yu Miao
  • Idoia Gimferrer
  • Jun Tanikawa
  • Amie Simmons
  • Jose Alberola-Ila
  • Mansoor Husain
  • Thomas J Gonda
  • Benjamin T Kile
  • Karolina M Kolodziejska
  • Maria Rosa Lidonnici
  • You Chin Lin
  • Z Kopecki
  • Siying Peng
  • Tomomasa Yokomizo
  • Tracy A Willson
  • Diane Maurice
  • Changchun Xiao
  • Shin ichi Nishikawa
  • Bruno Calabretta
  • Tetsuhiro Fujimoto
  • Klaus Rajewsky
  • Jodi K Lutwyche
  • Adrienne A Hilton
  • Roberto N De Guzman
  • Jay L Hess
  • Nicos A Nicola
  • Juan Carabana
  • Kazuhiro Maki
  • Mark L Sandberg
  • Matthew D Thomas
  • Atul Kumar
  • E P Reddy
  • Zhe Xiong Jin
  • Jeffrey M Perkel
  • Lawryn H Kasper
  • Peter Zandstra
  • Steven Kattman
  • Zuzana Pernicová
  • Lucie Pekarčíková
  • Gordon Keller
  • Jan Smarda
  • Marketa Hermanova
  • Omar El-Mounayri
  • Karel Soucek
  • Michal Masarik
  • Petr Benes
  • Yvette Drabsch
  • Gabriela Hernandez-Hoyos
  • Ryan Stanley Cross
  • Chi Wang
  • Elizabeth Vincan
  • Sandra Carpinteri
  • Sally Lightowler
  • Robin L Anderson

Detail Information

Publications97

  1. ncbi MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    Changchun Xiao
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:146-59. 2007
    ..A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development...
  2. ncbi A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
    M L Mucenski
    Children s Hospital Research Foundation, Department of Pediatrics, Cincinnati, Ohio
    Cell 65:677-89. 1991
    The c-myb proto-oncogene encodes a sequence-specific DNA-binding protein. To better understand its normal biological function, we have altered the c-myb gene by homologous recombination in mouse embryonic stem cells...
  3. ncbi Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
    R A Shivdasani
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 373:432-4. 1995
    ..Profound reduction in myeloid cells cultured in vivo from tal-1 null yolk sacs suggests a broader defect manifest at the myelo-erythroid or multipotential progenitor cell level...
  4. pmc Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305 0074, Japan
    Genes Dev 18:816-29. 2004
    The c-myb proto-oncogene product (c-Myb) regulates both the proliferation and apoptosis of hematopoietic cells by inducing the transcription of a group of target genes...
  5. doi MYB is essential for mammary tumorigenesis
    Rebecca Yu Miao
    Peter MacCallum Cancer Centre and Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia
    Cancer Res 71:7029-37. 2011
    b>MYB oncogene upregulation is associated with estrogen receptor (ER)-positive breast cancer, but disease requirements for MYB function in vivo have not been explored...
  6. ncbi A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
    Lawryn H Kasper
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Nature 419:738-43. 2002
    ..point mutations in the KIX domain of p300 designed to disrupt the binding surface for the transcription factors c-Myb and CREB, multilineage defects occur in haematopoiesis, including anaemia, B-cell deficiency, thymic hypoplasia, ..
  7. ncbi Critical functions for c-Myb at three checkpoints during thymocyte development
    Timothy P Bender
    The Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Nat Immunol 5:721-9. 2004
    The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations...
  8. pmc c-Myb is essential for early T cell development
    R D Allen
    Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genes Dev 13:1073-8. 1999
    The c-Myb transcription factor is important for fetal hematopoiesis and has been proposed to mediate later stages of lymphocyte development...
  9. pmc Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation
    Yen K Lieu
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Proc Natl Acad Sci U S A 106:21689-94. 2009
    ..By using conditional knockout technology, we disrupted the c-myb proto-oncogene specifically in adult bone marrow (BM) to demonstrate that this transcription factor is a regulator ..
  10. pmc Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice
    Maria Kauppi
    Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 112:3148-53. 2008
    ..a tyrosine to asparagine substitution at amino acid 630 (Y630N), disrupts the interaction between p300 and c-Myb. Mpl(-/-) p300(Plt6/+) mice displayed elevated platelet counts relative to Mpl(-/-) p300(+/+) controls, whereas ..
  11. pmc Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis
    Maria Rosa Lidonnici
    Department of Cancer Biology, and Kimmel Cancer Center, Thomas Jefferson University Medical College, Philadelphia, PA 19107, USA
    Blood 111:4771-9. 2008
    The c-Myb gene encodes a transcription factor required for proliferation and survival of normal myeloid progenitors and leukemic blast cells...
  12. ncbi Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development
    Hiroshi Sakamoto
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Blood 108:896-903. 2006
    ..c-Myb is a transcription factor that is essential for the development of definitive hematopoiesis...
  13. ncbi Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation
    Chie Kanei-Ishii
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 279:44582-9. 2004
    Recently we have shown that the c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via the pathway involving TAK1 (transforming growth factor-beta-activated kinase), HIPK2 (homeodomain-interacting protein ..
  14. ncbi c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
    Mark L Sandberg
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Dev Cell 8:153-66. 2005
    ..a mouse line that harbors a point mutation in the transactivation (TA) domain of the transcription factor c-Myb (M303V), which reduces c-Myb-dependent TA by disrupting its interaction with the transcriptional coactivator p300...
  15. ncbi The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10
    B A Mock
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Genomics 37:24-8. 1996
    ..1; we have also mapped Blimp1 to mouse Chromosome 10 at 14 cM distal to the Myb locus and to a region homologous to the location of BLIMP1...
  16. ncbi c-Myb is critical for B cell development and maintenance of follicular B cells
    Matthew D Thomas
    Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, VA 22908, USA
    Immunity 23:275-86. 2005
    The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes...
  17. pmc hph-1: a mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis
    V C Bode
    Division of Biology, Kansas State University, Manhattan 66506
    Genetics 118:299-305. 1988
    ..The initial symptomatology of the mutant phenotype suggests this mutant may represent a useful animal model for the study of hyperphenylalaninemia in man...
  18. pmc c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis
    Lucia Knopfova
    Department of Experimental Biology, Faculty of Science, Masaryk University, and International Clinical Research Center, CBCE, St Anne s University Hospital, Brno, Czech Republic
    Mol Cancer 11:15. 2012
    The c-Myb transcription factor is essential for the maintenance of stem-progenitor cells in bone marrow, colon epithelia, and neurogenic niches. c-Myb malfunction contributes to several types of malignancies including breast cancer...
  19. pmc c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells
    Jay L Hess
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 108:297-304. 2006
    ..Arrays identified c-Myb and a c-Myb target (Gstm1) among the genes with the strongest response to Hoxa9/Meis1...
  20. ncbi Retroviral insertional mutagenesis in murine promonocytic leukemias: c-myb and Mml1
    L Wolff
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892 4255, USA
    Curr Top Microbiol Immunol 211:191-9. 1996
    Studies have focused on two genetic loci, c-myb and Mml1, whose activation by retroviral insertional mutagenesis contribute to promonocytic leukemia in our acute monocytic leukemia (AMoL) model...
  21. ncbi A dominant interfering Myb mutant causes apoptosis in T cells
    D Taylor
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Genes Dev 10:2732-44. 1996
    The c-Myb transcription factor is required for the production of most hemopoietic lineages, but information is sparse about its mode of action and the key genes it regulates...
  22. ncbi Myb binding sites within the N-ras promoter repress transcription
    B Ganter
    Department of Pathology, Stanford University, School of Medicine, California 94305 5324, USA
    Oncogene 15:193-202. 1997
    In vitro and in vivo methods were combined to determine the function of the three Myb binding sites (NrasI, NrasII and NrasIII) within the promoter region of the mouse N-ras gene...
  23. ncbi Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac
    M C Yoder
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 7:335-44. 1997
    ..Surprisingly, 37-fold more CD34+c-Kit+ cells reside in the day 9 yolk sac than in the P-Sp. In sum, definitive HSC are coexistent, but not equal in number, in the murine yolk sac and P-Sp prior to fetal liver colonization...
  24. ncbi Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2
    A Hogg
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Oncogene 15:2885-98. 1997
    ..protein consisting of the ligand-binding domain of the estrogen receptor and a carboxyl-terminally truncated c-Myb protein (ERMYB)...
  25. pmc Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
    Marina R Carpinelli
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia
    Proc Natl Acad Sci U S A 101:6553-8. 2004
    ..Here we show that mutations in the c-Myb gene cause a myeloproliferative syndrome and supraphysiological expansion of megakaryocyte and platelet production ..
  26. doi A recessive screen for genes regulating hematopoietic stem cells
    Peter Papathanasiou
    Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia
    Blood 116:5849-58. 2010
    ..We demonstrate rapid identification of a novel mutation in the c-Myb transcription factor that results in thrombocythemia and myelofibrosis as proof of principal of the utility of our ..
  27. ncbi Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells
    Zhe Xiong Jin
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Immunol 169:3783-92. 2002
    ..RAG-2 promoter activity in B cell lines, contained binding sites for lymphoid enhancer-binding factor-1 (LEF-1), c-Myb, and Pax-5. We showed that these three transcription factors bound the promoter region in vitro and in vivo...
  28. pmc The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage
    Taishan Hu
    Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Nat Immunol 11:435-41. 2010
    ..Here we show that the transcription factor c-Myb has a central role in priming DP thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, ..
  29. ncbi Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski
    Teruaki Nomura
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 279:16715-26. 2004
    The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes...
  30. doi c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development
    You Chin Lin
    Genomics Research Center, Academia Sinica Taipei, Taiwan
    Mol Biol Evol 25:2189-98. 2008
    Human c-Myb proto-oncogene is highly expressed in hematopoietic progenitors as well as leukemia and certain solid tumor. However, the regulatory mechanisms of its expression and biological functions remain largely unclear...
  31. ncbi c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells
    Siying Peng
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Eur J Immunol 37:2868-80. 2007
    ..Immunoprecipitation and Western blot analyses demonstrate that c-Maf-c-Myb complex formation is enhanced among T cells from c-Maf Tg mice compared to non-Tg littermates following TCR ..
  32. pmc c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3
    Diane Maurice
    Institute of Cancer Research, Cancer Research UK Centre for Cell and Molecular Biology, London, UK
    EMBO J 26:3629-40. 2007
    ..This process is controlled by signalling from the T-cell receptor (TCR). Here, we show that the c-Myb transcription factor is a critical downstream regulator of positive selection, promoting the development of helper ..
  33. pmc Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo
    Tomomasa Yokomizo
    Institute of Basic Medical Sciences and Center for TARA, University of Tsukuba, Tsukuba, Japan
    EMBO J 26:184-96. 2007
    ..These results provide evidence of the presence of GATA-1(+) hemangioblastic cells in the extra-embryonic region and also their functional contribution to hematopoiesis in the embryo...
  34. pmc Regulation of T cell receptor delta gene rearrangement by c-Myb
    C Hernandez-Munain
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 183:289-93. 1996
    ..Transcriptional activation by E delta is dependent on c-Myb. To determine whether c-Myb plays a role in the activation of TCR-delta gene rearrangement, we compared VDJ ..
  35. ncbi Scc-1, a novel colon cancer susceptibility gene in the mouse: linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
    C J Moen
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    Oncogene 7:563-6. 1992
    ..The mapping of the Scc-1 gene indicates that the RCS system can be used to map and study the presently unknown genes which control cancer development...
  36. ncbi The Myb and Ahi-1 genes are physically very closely linked on mouse chromosome 10
    X Jiang
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada
    Mamm Genome 5:142-8. 1994
    ..site on mouse Chromosome (Chr) 10 in 16% of Abelson pre-B-cell lymphomas and shown to be closely linked to the Myb protooncogene...
  37. pmc Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro
    T J Gonda
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 8:1777-83. 1989
    Murine retroviruses which encode c-myb proteins that have either complete or truncated carboxy (C) termini were used to infect haemopoietic cells from murine fetal liver...
  38. ncbi The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer
    Y H Hsiang
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 154:5195-204. 1995
    ..Here we have determined that Myb-related transcription factors bind to the gamma 3 site and appear to be critical for the full activity of the TCR-..
  39. ncbi AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene
    H Okada
    Department of Cell Biology, Cancer Institute, Tokyo, Japan
    Oncogene 17:2287-93. 1998
    ..In addition, transcripts for the Vav, flk-2/flt-3, M-CSF receptor, G-CSF receptor and c-Myb genes were not detected in certain tissues of the (-/-) embryos...
  40. ncbi Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb
    Juan Carabana
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:4144-52. 2005
    ..EMSAs reveal that upstream stimulatory factor 1, Runx1, c-Myb, lymphoid enhancer binding factor 1, NF1, and E47 all interact with this promoter in vitro...
  41. ncbi Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21
    S P Oh
    Department of Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 19:494-9. 1994
    ..3 by fluorescence in situ hybridization. In addition, using an interspecific backcross panel, we have shown that the murine Col18a1 locus is on chromosome 10, close to the loci for Col6a1 and Col6a2...
  42. ncbi Enhanced proliferative potential of hematopoietic cells expressing degradation-resistant c-Myb mutants
    Francesca Corradini
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:30254-62. 2005
    The c-myb gene encodes a transcription factor required for proliferation, differentiation, and survival of hematopoietic cells...
  43. ncbi Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus
    Y Sunada
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
    J Biol Chem 269:13729-32. 1994
    ....
  44. pmc Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line
    Y Weinstein
    Proc Natl Acad Sci U S A 83:5010-4. 1986
    Among a series of myeloid leukemia cell lines, one (NFS-60) was found to have a rearrangement of the c-myb locus...
  45. doi c-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation
    P Garcia
    Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    J Thromb Haemost 9:1572-81. 2011
    Transcription factors are essential for blood cell formation. Mice expressing low levels of c-Myb (c-Myb(low)) have an increased number of bone marrow megakaryocytes (MKs) and corresponding thrombocytosis...
  46. doi Myb controls intestinal stem cell genes and self-renewal
    Dane Cheasley
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Stem Cells 29:2042-50. 2011
    ..Here, we show that transcription factor Myb governs ISC gene expression, particularly Lgr5...
  47. doi Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells
    Masayoshi Ishida
    Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, Canada, M5G 1L7
    Circ Res 110:253-64. 2012
    c-myb null (knockout) embryonic stem cells (ESC) can differentiate into cardiomyocytes but not contractile smooth muscle cells (SMC) in embryoid bodies (EB).
  48. doi Myb and the regulation of stem cells in the intestine and brain: a tale of two niches
    Jordane Malaterre
    Cancer Cell Biology Program, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Adv Exp Med Biol 786:353-68. 2013
    ..From a perspective of understanding the function of the transcription factor Myb, we have explored the biology of stem cell niches in both these radically different tissues...
  49. pmc A restriction fragment length polymorphism at the murine c-myb locus
    B Mock
    Nucleic Acids Res 15:4700. 1987
  50. ncbi Collagen loss and impaired wound healing is associated with c-Myb deficiency
    Z Kopecki
    Child Health Research Institute, North Adelaide, South Australia and School of Pharmacy and Medical Sciences, University of South Australia, Australia
    J Pathol 211:351-61. 2007
    ..It is also an established target gene of the transcription factor, c-Myb. When c-myb-/- embryos were examined it was observed that their skin was markedly thinner than normal...
  51. ncbi Over-expression of c-Myb increases the frequency of hemogenic precursors in the endothelial cell population
    Guoyou Dai
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 11:859-70. 2006
    ..The c-myb proto-oncogene is essential for the development of definitive hematopoiesis and was reported to be activated in ..
  52. pmc Molecular mechanisms associated with the regulation of apoptosis by the two alternatively spliced products of c-Myb
    Atul Kumar
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 N Broad Street, Philadelphia, PA 19140, USA
    Mol Cell Biol 23:6631-45. 2003
    The c-myb proto-oncogene encodes two alternatively spliced mRNAs, which in turn code for proteins of 75 kDa and 89 kDa...
  53. ncbi Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription
    M A Collart
    J Immunol 139:949-55. 1987
    ..Taken together, these results suggest a possible role for the c-fos gene product, a nuclear protein, in the modulation of the functional activity of differentiated macrophages...
  54. ncbi Sequential expression of proto-oncogenes during a mouse erythroleukemia cell differentiation
    K Todokoro
    Biochem Biophys Res Commun 135:1112-8. 1986
    ..erythrocytes was accompanied by sequential transient expression of the proto-oncogenes in the order of c-fos, c-myb, c-myc and c-k-ras, during the first 48 hr of differentiation induction...
  55. doi c-Myb-dependent smooth muscle cell differentiation
    Karolina M Kolodziejska
    Heart and Stroke Richard Lewar Center of Excellence in Cardiovascular Research, Department of Medicine, University of Toronto, Canada
    Circ Res 102:554-61. 2008
    Both in vitro and in vivo studies have implicated the c-Myb transcription factor in vascular smooth muscle cell (SMC) proliferation and hematopoiesis...
  56. pmc Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene
    P W Sobieszczuk
    Ludwig Institute for Cancer Research, Melbourne Branch of Tumor Biology, Parkville, Victoria, Australia
    Nucleic Acids Res 17:9593-611. 1989
    To study the control mechanism(s) that govern the transcription of c-myb, genomic clones corresponding to the 5' region of the murine c-myb gene have been isolated and characterized structurally and functionally...
  57. ncbi DNA binding-independent transcriptional activation of the vascular endothelial growth factor gene (VEGF) by the Myb oncoprotein
    Jodi K Lutwyche
    Division of Human Immunology and Hanson Institute, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia
    Biochem Biophys Res Commun 344:1300-7. 2006
    b>Myb is a key transcription factor that can regulate proliferation, differentiation, and apoptosis, predominantly in the haemopoietic system...
  58. ncbi A molecular genetic linkage map of mouse chromosome 10, including the Myb, S100b, Pah, Sl, and Ifg genes
    A Shimizu
    Department of Biochemistry, Institute for Developmental Research, Aichi Prefecture Colony, Japan
    Biochem Genet 30:529-35. 1992
    ..endonuclease fragment length variations (RFLV) on mouse chromosome 10 were detected in four genes, namely, the Myb protooncogene (Myb) and the genes for S100 beta protein (S100b), phenylalanine hydroxylase (Pah), and interferon-..
  59. ncbi c-myb effects on kinetic events during MEL cell differentiation
    R Danish
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0668
    Oncogene 7:901-7. 1992
    ..DMSO)-induced differentiation of Friend mouse erythroleukemia (MEL) cells there is a biphasic fall in c-myb mRNA levels. We have previously shown that constitutive expression of c-myb blocks differentiation...
  60. pmc Regulation of GATA-3 expression during CD4 lineage differentiation
    Idoia Gimferrer
    Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 186:3892-8. 2011
    ..This upregulation requires the presence of the transcription factor c-Myb. Furthermore, we show that TH-POK can also upregulate GATA-3 in double-positive thymocytes, suggesting the ..
  61. pmc Regulation of hematopoietic stem cells by their mature progeny
    Carolyn A de Graaf
    Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 107:21689-94. 2010
    ..Here, we demonstrate that the megakaryocytosis and increased platelet mass in mice with mutations in the Myb or p300 genes causes reduced circulating TPO concentration and TPO starvation of the stem-cell compartment, which ..
  62. doi Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney
    Nina Perälä
    Institute of Biomedicine Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Finland
    Differentiation 81:81-91. 2011
    ....
  63. ncbi Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by Southern blot analysis of rat x mouse somatic cell hybrid clones
    M Yasue
    Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan
    Genomics 12:659-64. 1992
    ..ATP1A2, ATP1A3, B2M, GSTP, and SMST; 5 mouse genes, Ncam, Ngfg, Pim-1, Tcp-1, and Trp53; and 5 human genes, MBP, MYB, NEFM, SCN2A, and TCRGC1, 17 structural genes including 15 newly assigned genes and 11 related DNA fragments were ..
  64. ncbi Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10
    S S Apte
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, MA 02115
    Eur J Biochem 206:217-24. 1992
    ....
  65. pmc Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core
    K Ogata
    Graduate School of Integrated Science, Yokohama City University, Japan
    Proc Natl Acad Sci U S A 89:6428-32. 1992
    The DNA-binding domain of the c-myb protooncogene product consists of three imperfect tandem repeats of 51 or 52 amino acids, each of which contains three conserved tryptophans, spaced 18 or 19 amino acids apart...
  66. pmc Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis
    Paloma García
    College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK or
    EMBO J 28:1492-504. 2009
    ..Here, we show that mice expressing low levels of the transcription factor c-Myb, as the result of genetic knockdown, develop a transplantable myeloproliferative phenotype that closely resembles ..
  67. pmc Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia
    Douglas J Hilton
    Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 113:5599-604. 2009
    The transcription factor c-Myb and coregulator p300 have a key role in maintaining production of controlled numbers of megakaryocytes and platelets...
  68. ncbi Molecular genetic markers spanning mouse chromosome 10
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 8:519-24. 1990
    ..markers in this map, four of which had not previously been positioned, include genes involved in oncogenesis (Gli, Myb, Tra-1), proviral integration (Emv-25), and immune responses (Ifg, Ifgr, Pfp)...
  69. ncbi Structural basis for cooperative transcription factor binding to the CBP coactivator
    Roberto N De Guzman
    Department of Molecular Biology MB2, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 355:1005-13. 2006
    ..the solution structure of the ternary complex formed by cooperative binding of activation domains from the c-Myb and mixed lineage leukemia (MLL) transcription factors to the KIX domain...
  70. pmc Multiple c-myb transcript cap sites are variously utilized in cells of mouse haemopoietic origin
    R J Watson
    EMBO J 6:1643-51. 1987
    Mouse c-myb gene transcripts in various cells of haemopoietic origin were analysed using S1 nuclease and RNase mapping techniques and by Northern blotting. It was found that the prevalent 3...
  71. ncbi Lymphoid expression and regulation of A20, an inhibitor of programmed cell death
    M Tewari
    Graduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor 48109
    J Immunol 154:1699-706. 1995
    ..5 centimorgans proximal to the c-myb locus...
  72. ncbi CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb
    D S Krause
    Johns Hopkins Oncology Center and Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, USA
    Exp Hematol 26:1086-92. 1998
    ..In this study we explored a possible role for c-Myb in CD34 regulation during developmental hematopoiesis...
  73. ncbi Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3
    M Taketo
    Banyu Tsukuba Research Institute Merck, Tsukuba, Japan
    Genomics 19:585-8. 1994
    ..None of the three loci cosegregated with each other. Tbxa2r mapped to Chr 10, Ptgerep2 mapped to the distal end of Chr 3. Possible human loci for these receptors are predicted based on the homology between mouse and human chromosomes...
  74. ncbi Defective development of the embryonic liver in N-myc-deficient mice
    S Giroux
    Centre de recherche en cancérologie de l Université Laval, Quebec, Canada
    Dev Biol 195:16-28. 1998
    ....
  75. ncbi Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes
    J Santos
    Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
    Cytogenet Cell Genet 62:217-9. 1993
    DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
  76. ncbi Skn 2 is linked to Myb on chromosome 10 of the mouse
    D Rees
    Department of Microbiology, University of New Mexico, School of Medicine, Albuquerque 87131
    Immunogenetics 39:363-6. 1994
  77. pmc The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 137:685-701. 1997
    ..Together, these results reveal remarkable diversity in BL composition and complexity in BL development...
  78. ncbi Arrest of spermatogenesis and defective breast development in mice lacking A-myb
    A Toscani
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Nature 386:713-7. 1997
    The Myb gene family currently consists of three members, named A-, B- and c-myb. These genes encode nuclear proteins that bind DNA in a sequence-specific manner and function as regulators of transcription...
  79. ncbi Temporal patterns of A-myb and B-myb gene expression during testis development
    K E Latham
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Oncogene 13:1161-8. 1996
    We recently reported the cloning and sequencing of the mouse A-myb proto-oncogene cDNA and the abundant expression of this mRNA primarily in the testis of adult mice...
  80. ncbi Detection of proteins that bind to the leucine zipper motif of c-Myb
    D Favier
    Hanson Centre for Cancer Research, Adelaide, South Australia
    Oncogene 9:305-11. 1994
    The product of the c-myb proto-oncogene, c-Myb, binds DNA and can enhance transcription of genes bearing copies of the DNA sequence it recognises...
  81. ncbi Secondary structure of the DNA-binding domain of the c-Myb oncoprotein in solution. A multidimensional double and triple heteronuclear NMR study
    N Jamin
    DBCM, Service de Biochimie et Génétique Moléculaire, Gif sur Yvette, France
    Eur J Biochem 216:147-54. 1993
    The DNA-binding domain of the c-Myb oncoprotein contains two repeats, R2 and R3, both of which have been proposed to be related to the helix-turn-helix (HTH) motif...
  82. ncbi The myb gene family in cell growth, differentiation and apoptosis
    I H Oh
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Oncogene 18:3017-33. 1999
    The myb gene family consists of three members, named A, B and c-myb which encode nuclear proteins that function as transcriptional transactivators...
  83. ncbi Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper
    T Nomura
    Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    J Biol Chem 268:21914-23. 1993
    The trans-activating and transforming capacities of the c-myb proto-oncogene product (c-Myb) are negatively regulated through a leucine zipper structure in its negative regulatory domain...
  84. ncbi Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos
    Kazuhiro Maki
    Department of Hematology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu machi, Shimotsuga gun, Tochigi 321 0293, Japan
    Blood 106:2147-55. 2005
    ..Maintained expression of PU.1 gene and decreased expression of LMO2 and SCL genes may explain the aberrant hematopoiesis in AML1/EVI1/+ fetal liver...
  85. pmc Transcription regulation by murine B-myb is distinct from that by c-myb
    R J Watson
    Ludwig Institute for Cancer Research, St Mary s Hospital Medical School, London, UK
    Nucleic Acids Res 21:267-72. 1993
    The transcription regulatory properties of murine B-myb protein were compared to those of c-myb...
  86. ncbi Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas
    G L Shen-Ong
    Science 226:1077-80. 1984
    Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1...
  87. pmc Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes
    A Y Sakaguchi
    Proc Natl Acad Sci U S A 81:525-9. 1984
    Molecular probes for the oncogenes of Rous sarcoma virus (v-src), avian myeloblastosis virus (v-myb), Kirsten murine sarcoma virus (v-Ki-ras), and Harvey murine sarcoma virus (v-Ha-ras) were hybridized to the DNA from mouse-Chinese ..
  88. ncbi DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas
    J F Mushinski
    Science 220:795-8. 1983
    ..These tumors expressed abundant c-myb RNA of unusually large size and showed DNA rearrangements of the c-myb locus.
  89. pmc Activation of c-myb is an early bone-marrow event in a murine model for acute promonocytic leukemia
    K Nason-Burchenal
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:1619-23. 1993
    Insertional mutagenesis of c-myb by Moloney murine leukemia virus occurs in 100% of promonocytic leukemias (MMLS) induced by the virus...
  90. ncbi epicardin: A novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads
    L Robb
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Dev Dyn 213:105-13. 1998
    ....
  91. ncbi Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb
    K Ogata
    Graduate School of Integrated Science, Yokohama City University, Japan
    Nat Struct Biol 2:309-20. 1995
    The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif...
  92. pmc Murine myb protooncogene mRNA: cDNA sequence and evidence for 5' heterogeneity
    T P Bender
    Proc Natl Acad Sci U S A 83:3204-8. 1986
    ..clones from a murine pro-B cell library to generate a composite sequence that includes 3413 bases of the murine c-myb mRNA...
  93. ncbi Identification of a c-myb attenuator-binding factor
    Jeffrey M Perkel
    Abramson Family Cancer Research Institute, University of Pennsylvania, Room 456, BRB 11 111, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Leuk Res 26:179-90. 2002
    Expression of the c-myb proto-oncogene is developmentally regulated at the level of transcription elongation...
  94. ncbi Expression of B-Myb during mouse embryogenesis
    J Sitzmann
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    Oncogene 12:1889-94. 1996
    B-myb is a member of the myb family of nuclear sequence-specific DNA-binding proteins which has been highly conserved among vertebrates...
  95. ncbi A mouse linkage testing stock possessing multiple copies of the endogenous ecotropic murine leukemia virus genome
    B A Taylor
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:221-32. 1989
    ..Ways of further improving the MEV stock are discussed. The location of the Myb proto-oncogene is defined relative to Sl and one of the C58/J proviruses on chromosome 10.
  96. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
    ..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis...
  97. pmc Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: identification by a subtractive screen of novel uniparental fibroblast lines
    G Piras
    Cancer and Developmental Biology Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Mol Cell Biol 20:3308-15. 2000
    ..In addition, loss of expression of ZAC has been described for a number of breast and ovarian carcinomas, suggesting that ZAC is a potential tumor suppressor gene...

Research Grants14

  1. c-myb in B Cell Development and Function
    TIMOTHY BENDER; Fiscal Year: 2009
    It is clear that the c-myb protooncogene plays a crucial role during hematopoiesis...
  2. iCyt Reflection Cell Sorter
    TIMOTHY BENDER; Fiscal Year: 2007
    ....
  3. Conditional Mutagenesis to Study c-Mby Function
    TIMOTHY BENDER; Fiscal Year: 2007
    It is clear that the Myb protooncogene plays a crucial role during hematopoiesis...
  4. CONDITIONAL MUTAGENESIS TO STUDY C MYB FUNCTION
    TIMOTHY BENDER; Fiscal Year: 2005
    DESCRIPTION (Applicant's Abstract): It is clear that the c-myb protooncogene plays a crucial role during hematopoiesis...
  5. Conditional Mutagenesis to Study c-Myb Function
    Timothy P Bender; Fiscal Year: 2010
    It is clear that the Myb protooncogene plays a crucial role during hematopoiesis...