Myb

Summary

Gene Symbol: Myb
Description: myeloblastosis oncogene
Alias: AI550390, M16449, c-myb, transcriptional activator Myb, gag-myb protein, myb proto-oncogene protein, myeloblastosis proto-oncogene product, proto-oncogene c-Myb, tumor-specific myb protein
Species: mouse
Products:     Myb

Top Publications

  1. Kanei Ishii C, Ninomiya Tsuji J, Tanikawa J, Nomura T, Ishitani T, Kishida S, et al. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004;18:816-29 pubmed
    The c-myb proto-oncogene product (c-Myb) regulates both the proliferation and apoptosis of hematopoietic cells by inducing the transcription of a group of target genes...
  2. Hu T, Simmons A, Yuan J, Bender T, Alberola Ila J. The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage. Nat Immunol. 2010;11:435-41 pubmed publisher
    ..Here we show that the transcription factor c-Myb has a central role in priming DP thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, ..
  3. Hilton D, Kile B, Alexander W. Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood. 2009;113:5599-604 pubmed publisher
    The transcription factor c-Myb and coregulator p300 have a key role in maintaining production of controlled numbers of megakaryocytes and platelets...
  4. Malaterre J, Carpinelli M, Ernst M, Alexander W, Cooke M, Sutton S, et al. c-Myb is required for progenitor cell homeostasis in colonic crypts. Proc Natl Acad Sci U S A. 2007;104:3829-34 pubmed
    ..The role of c-Myb in crypt homeostasis has not been elucidated...
  5. Hess J, Bittner C, Zeisig D, Bach C, Fuchs U, Borkhardt A, et al. c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Blood. 2006;108:297-304 pubmed
    ..Arrays identified c-Myb and a c-Myb target (Gstm1) among the genes with the strongest response to Hoxa9/Meis1...
  6. Toscani A, Mettus R, Coupland R, Simpkins H, Litvin J, Orth J, et al. Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature. 1997;386:713-7 pubmed
    The Myb gene family currently consists of three members, named A-, B- and c-myb. These genes encode nuclear proteins that bind DNA in a sequence-specific manner and function as regulators of transcription...
  7. Corradini F, Cesi V, Bartella V, Pani E, Bussolari R, Candini O, et al. Enhanced proliferative potential of hematopoietic cells expressing degradation-resistant c-Myb mutants. J Biol Chem. 2005;280:30254-62 pubmed
    The c-myb gene encodes a transcription factor required for proliferation, differentiation, and survival of hematopoietic cells...
  8. Yoder M, Hiatt K, Dutt P, Mukherjee P, Bodine D, Orlic D. Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity. 1997;7:335-44 pubmed
    ..Surprisingly, 37-fold more CD34+c-Kit+ cells reside in the day 9 yolk sac than in the P-Sp. In sum, definitive HSC are coexistent, but not equal in number, in the murine yolk sac and P-Sp prior to fetal liver colonization. ..
  9. Hogg A, Schirm S, Nakagoshi H, Bartley P, Ishii S, Bishop J, et al. Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2. Oncogene. 1997;15:2885-98 pubmed
    ..protein consisting of the ligand-binding domain of the estrogen receptor and a carboxyl-terminally truncated c-Myb protein (ERMYB)...
  10. Nomura T, Tanikawa J, Akimaru H, Kanei Ishii C, Ichikawa Iwata E, Khan M, et al. Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski. J Biol Chem. 2004;279:16715-26 pubmed
    The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes...

Detail Information

Publications62

  1. Kanei Ishii C, Ninomiya Tsuji J, Tanikawa J, Nomura T, Ishitani T, Kishida S, et al. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004;18:816-29 pubmed
    The c-myb proto-oncogene product (c-Myb) regulates both the proliferation and apoptosis of hematopoietic cells by inducing the transcription of a group of target genes...
  2. Hu T, Simmons A, Yuan J, Bender T, Alberola Ila J. The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage. Nat Immunol. 2010;11:435-41 pubmed publisher
    ..Here we show that the transcription factor c-Myb has a central role in priming DP thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, ..
  3. Hilton D, Kile B, Alexander W. Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood. 2009;113:5599-604 pubmed publisher
    The transcription factor c-Myb and coregulator p300 have a key role in maintaining production of controlled numbers of megakaryocytes and platelets...
  4. Malaterre J, Carpinelli M, Ernst M, Alexander W, Cooke M, Sutton S, et al. c-Myb is required for progenitor cell homeostasis in colonic crypts. Proc Natl Acad Sci U S A. 2007;104:3829-34 pubmed
    ..The role of c-Myb in crypt homeostasis has not been elucidated...
  5. Hess J, Bittner C, Zeisig D, Bach C, Fuchs U, Borkhardt A, et al. c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Blood. 2006;108:297-304 pubmed
    ..Arrays identified c-Myb and a c-Myb target (Gstm1) among the genes with the strongest response to Hoxa9/Meis1...
  6. Toscani A, Mettus R, Coupland R, Simpkins H, Litvin J, Orth J, et al. Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature. 1997;386:713-7 pubmed
    The Myb gene family currently consists of three members, named A-, B- and c-myb. These genes encode nuclear proteins that bind DNA in a sequence-specific manner and function as regulators of transcription...
  7. Corradini F, Cesi V, Bartella V, Pani E, Bussolari R, Candini O, et al. Enhanced proliferative potential of hematopoietic cells expressing degradation-resistant c-Myb mutants. J Biol Chem. 2005;280:30254-62 pubmed
    The c-myb gene encodes a transcription factor required for proliferation, differentiation, and survival of hematopoietic cells...
  8. Yoder M, Hiatt K, Dutt P, Mukherjee P, Bodine D, Orlic D. Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity. 1997;7:335-44 pubmed
    ..Surprisingly, 37-fold more CD34+c-Kit+ cells reside in the day 9 yolk sac than in the P-Sp. In sum, definitive HSC are coexistent, but not equal in number, in the murine yolk sac and P-Sp prior to fetal liver colonization. ..
  9. Hogg A, Schirm S, Nakagoshi H, Bartley P, Ishii S, Bishop J, et al. Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2. Oncogene. 1997;15:2885-98 pubmed
    ..protein consisting of the ligand-binding domain of the estrogen receptor and a carboxyl-terminally truncated c-Myb protein (ERMYB)...
  10. Nomura T, Tanikawa J, Akimaru H, Kanei Ishii C, Ichikawa Iwata E, Khan M, et al. Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski. J Biol Chem. 2004;279:16715-26 pubmed
    The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes...
  11. Mucenski M, McLain K, Kier A, Swerdlow S, Schreiner C, Miller T, et al. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell. 1991;65:677-89 pubmed
    The c-myb proto-oncogene encodes a sequence-specific DNA-binding protein. To better understand its normal biological function, we have altered the c-myb gene by homologous recombination in mouse embryonic stem cells...
  12. Lieu Y, Kumar A, Pajerowski A, Rogers T, Reddy E. Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci U S A. 2004;101:14853-8 pubmed
    Previous reports have suggested that the protooncogene c-myb participates in T cell development in the thymus and mature T cell proliferation. We have generated two T cell-specific c-myb knockout mouse models, myb/LckCre and myb/CD4Cre...
  13. Lang G, White J, Argent Katwala M, Allinson C, Weston K. Myb proteins regulate the expression of diverse target genes. Oncogene. 2005;24:1375-84 pubmed
    ..b>Myb family transcription factors play a central role in hematopoiesis...
  14. Morita Y, Kanei Ishii C, Nomura T, Ishii S. TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation. Mol Biol Cell. 2005;16:5433-44 pubmed
    ..The c-myb proto-oncogene product (c-Myb) regulates proliferation and differentiation of hematopoietic cells...
  15. Schulz C, Gomez Perdiguero E, Chorro L, Szabo Rogers H, Cagnard N, Kierdorf K, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012;336:86-90 pubmed publisher
    ..We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk ..
  16. Tober J, McGrath K, Palis J. Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb. Blood. 2008;111:2636-9 pubmed publisher
    ..c-myb-null mouse fetuses lack definitive erythrocytes but contain primitive erythroblasts and hepatic megakaryocytes...
  17. Papathanasiou P, Tunningley R, Pattabiraman D, Ye P, Gonda T, Whittle B, et al. A recessive screen for genes regulating hematopoietic stem cells. Blood. 2010;116:5849-58 pubmed publisher
    ..We demonstrate rapid identification of a novel mutation in the c-Myb transcription factor that results in thrombocythemia and myelofibrosis as proof of principal of the utility of our ..
  18. Zhao L, Glazov E, Pattabiraman D, Al Owaidi F, Zhang P, Brown M, et al. Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb. Nucleic Acids Res. 2011;39:4664-79 pubmed publisher
    To gain insight into the mechanisms by which the Myb transcription factor controls normal hematopoiesis and particularly, how it contributes to leukemogenesis, we mapped the genome-wide occupancy of Myb by chromatin immunoprecipitation ..
  19. Zhang J, Markus J, Bies J, Paul T, Wolff L. Three murine leukemia virus integration regions within 100 kilobases upstream of c-myb are proximal to the 5' regulatory region of the gene through DNA looping. J Virol. 2012;86:10524-32 pubmed publisher
    ..In murine leukemia virus-induced myeloid leukemia in mice, integrated proviruses have been found upstream of c-myb in three regions, named Mml1, Mml2, and Mml3 (25, 50, and 70 kb upstream, respectively)...
  20. Kasper L, Boussouar F, Ney P, Jackson C, Rehg J, van Deursen J, et al. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature. 2002;419:738-43 pubmed
    ..point mutations in the KIX domain of p300 designed to disrupt the binding surface for the transcription factors c-Myb and CREB, multilineage defects occur in haematopoiesis, including anaemia, B-cell deficiency, thymic hypoplasia, ..
  21. Miao R, Drabsch Y, Cross R, Cheasley D, Carpinteri S, Pereira L, et al. MYB is essential for mammary tumorigenesis. Cancer Res. 2011;71:7029-37 pubmed publisher
    b>MYB oncogene upregulation is associated with estrogen receptor (ER)-positive breast cancer, but disease requirements for MYB function in vivo have not been explored...
  22. Maurice D, Hooper J, Lang G, Weston K. c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J. 2007;26:3629-40 pubmed
    ..This process is controlled by signalling from the T-cell receptor (TCR). Here, we show that the c-Myb transcription factor is a critical downstream regulator of positive selection, promoting the development of helper ..
  23. Kopecki Z, Luchetti M, Adams D, Strudwick X, Mantamadiotis T, Stoppacciaro A, et al. Collagen loss and impaired wound healing is associated with c-Myb deficiency. J Pathol. 2007;211:351-61 pubmed
    ..It is also an established target gene of the transcription factor, c-Myb. When c-myb-/- embryos were examined it was observed that their skin was markedly thinner than normal...
  24. Sakamoto H, Dai G, Tsujino K, Hashimoto K, Huang X, Fujimoto T, et al. Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development. Blood. 2006;108:896-903 pubmed
    ..c-Myb is a transcription factor that is essential for the development of definitive hematopoiesis...
  25. Hernandez Munain C, Lauzurica P, Krangel M. Regulation of T cell receptor delta gene rearrangement by c-Myb. J Exp Med. 1996;183:289-93 pubmed
    ..Transcriptional activation by E delta is dependent on c-Myb. To determine whether c-Myb plays a role in the activation of TCR-delta gene rearrangement, we compared VDJ ..
  26. Sunada Y, Bernier S, Kozak C, Yamada Y, Campbell K. Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus. J Biol Chem. 1994;269:13729-32 pubmed
  27. Tanikawa J, Ichikawa Iwata E, Kanei Ishii C, Nakai A, Matsuzawa S, Reed J, et al. p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. J Biol Chem. 2000;275:15578-85 pubmed
    ..HSF3 is specifically activated in unstressed proliferating cells by direct binding to the c-myb proto-oncogene product (c-Myb), which plays an important role in cellular proliferation...
  28. Yuan J, Crittenden R, Bender T. c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL. J Immunol. 2010;184:2793-804 pubmed publisher
    ..However, the molecular mechanisms controlling DP thymocyte survival remain poorly understood. The Myb proto-oncogene encodes a transcription factor required during multiple stages of T cell development...
  29. Haas M, Siegert M, Schürmann A, Sodeik B, Wolfes H. c-Myb protein interacts with Rcd-1, a component of the CCR4 transcription mediator complex. Biochemistry. 2004;43:8152-9 pubmed
    ..Using the yeast two-hybrid assay, we have identified the murine Rcd-1 protein as a cofactor of the c-myb proto-oncogene product...
  30. Sumner R, Crawford A, Mucenski M, Frampton J. Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factor. Oncogene. 2000;19:3335-42 pubmed
    The c-Myb transcriptional regulator is crucial to the development and functioning of haemopoietic cells, so much so that mouse embryos homozygous for an inactivated c-myb allele die from anaemia at about day 15 of gestation...
  31. Carpinelli M, Hilton D, Metcalf D, Antonchuk J, Hyland C, Mifsud S, et al. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A. 2004;101:6553-8 pubmed
    ..Here we show that mutations in the c-Myb gene cause a myeloproliferative syndrome and supraphysiological expansion of megakaryocyte and platelet production ..
  32. Greig K, de Graaf C, Murphy J, Carpinelli M, Pang S, Frampton J, et al. Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood. 2010;115:2796-805 pubmed publisher
    c-Myb is a transcription factor with functions in many hematopoietic lineages...
  33. Allen R, Bender T, Siu G. c-Myb is essential for early T cell development. Genes Dev. 1999;13:1073-8 pubmed
    The c-Myb transcription factor is important for fetal hematopoiesis and has been proposed to mediate later stages of lymphocyte development...
  34. Pani E, Menigatti M, Schubert S, Hess D, Gerrits B, Klempnauer K, et al. Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity. Biochim Biophys Acta. 2008;1783:1121-8 pubmed publisher
    Activity and stability of the proto-oncogene c-Myb are regulated by post-translational modifications, though the molecular mechanisms underlying such control are only partially understood...
  35. Bender T, Kremer C, Kraus M, Buch T, Rajewsky K. Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol. 2004;5:721-9 pubmed
    The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations...
  36. Vegiopoulos A, García P, Emambokus N, Frampton J. Coordination of erythropoiesis by the transcription factor c-Myb. Blood. 2006;107:4703-10 pubmed
    The involvement of the transcription factor c-Myb in promoting the proliferation and inhibition of erythroid cell differentiation has been established in leukemia cell models...
  37. Cheasley D, Pereira L, Lightowler S, Vincan E, Malaterre J, Ramsay R. Myb controls intestinal stem cell genes and self-renewal. Stem Cells. 2011;29:2042-50 pubmed publisher
    ..Here, we show that transcription factor Myb governs ISC gene expression, particularly Lgr5...
  38. Malaterre J, Mantamadiotis T, Dworkin S, Lightowler S, Yang Q, Ransome M, et al. c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. Stem Cells. 2008;26:173-81 pubmed
    ..Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice...
  39. Hsiang Y, Goldman J, Raulet D. The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer. J Immunol. 1995;154:5195-204 pubmed
    ..Here we have determined that Myb-related transcription factors bind to the gamma 3 site and appear to be critical for the full activity of the TCR-..
  40. Wolff L, Koller R, Bies J, Nazarov V, Hoffman B, Amanullah A, et al. Retroviral insertional mutagenesis in murine promonocytic leukemias: c-myb and Mml1. Curr Top Microbiol Immunol. 1996;211:191-9 pubmed
    Studies have focused on two genetic loci, c-myb and Mml1, whose activation by retroviral insertional mutagenesis contribute to promonocytic leukemia in our acute monocytic leukemia (AMoL) model...
  41. Peng S, Lalani S, Leavenworth J, Ho I, Pauza M. c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells. Eur J Immunol. 2007;37:2868-80 pubmed
    ..Immunoprecipitation and Western blot analyses demonstrate that c-Maf-c-Myb complex formation is enhanced among T cells from c-Maf Tg mice compared to non-Tg littermates following TCR ..
  42. Miglarese M, Richardson A, Aziz N, Bender T. Differential regulation of c-Myb-induced transcription activation by a phosphorylation site in the negative regulatory domain. J Biol Chem. 1996;271:22697-705 pubmed
    The c-myb protooncogene encodes a highly conserved 75-89-kDa transcription factor that contains three functional domains, an amino-terminal DNA binding domain (DBD), a central acidic transactivation domain, and a carboxyl-terminal ..
  43. Taylor D, Badiani P, Weston K. A dominant interfering Myb mutant causes apoptosis in T cells. Genes Dev. 1996;10:2732-44 pubmed
    The c-Myb transcription factor is required for the production of most hemopoietic lineages, but information is sparse about its mode of action and the key genes it regulates...
  44. Ganter B, Lipsick J. Myb binding sites within the N-ras promoter repress transcription. Oncogene. 1997;15:193-202 pubmed
    In vitro and in vivo methods were combined to determine the function of the three Myb binding sites (NrasI, NrasII and NrasIII) within the promoter region of the mouse N-ras gene...
  45. Tahirov T, Sato K, Ichikawa Iwata E, Sasaki M, Inoue Bungo T, Shiina M, et al. Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. Cell. 2002;108:57-70 pubmed
    c-Myb, but not avian myeloblastosis virus (AMV) v-Myb, cooperates with C/EBP beta to regulate transcription of myeloid-specific genes...
  46. Emambokus N, Vegiopoulos A, Harman B, Jenkinson E, Anderson G, Frampton J. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J. 2003;22:4478-88 pubmed
    The c-Myb transcription factor is expressed in immature haemopoietic cells and at key stages during differentiation...
  47. Xiao C, Calado D, Galler G, Thai T, Patterson H, Wang J, et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007;131:146-59 pubmed
    ..A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development...
  48. Lidonnici M, Corradini F, Waldron T, Bender T, Calabretta B. Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis. Blood. 2008;111:4771-9 pubmed publisher
    The c-Myb gene encodes a transcription factor required for proliferation and survival of normal myeloid progenitors and leukemic blast cells...
  49. Lin Y, Kuo M, Yu J, Kuo H, Lin R, Lo W, et al. c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development. Mol Biol Evol. 2008;25:2189-98 pubmed publisher
    Human c-Myb proto-oncogene is highly expressed in hematopoietic progenitors as well as leukemia and certain solid tumor. However, the regulatory mechanisms of its expression and biological functions remain largely unclear...
  50. Kauppi M, Murphy J, de Graaf C, Hyland C, Greig K, Metcalf D, et al. Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood. 2008;112:3148-53 pubmed publisher
    ..a tyrosine to asparagine substitution at amino acid 630 (Y630N), disrupts the interaction between p300 and c-Myb. Mpl(-/-) p300(Plt6/+) mice displayed elevated platelet counts relative to Mpl(-/-) p300(+/+) controls, whereas ..
  51. Sandberg M, Sutton S, Pletcher M, Wiltshire T, Tarantino L, Hogenesch J, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153-66 pubmed
    ..a mouse line that harbors a point mutation in the transactivation (TA) domain of the transcription factor c-Myb (M303V), which reduces c-Myb-dependent TA by disrupting its interaction with the transcriptional coactivator p300...
  52. Lieu Y, Reddy E. Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation. Proc Natl Acad Sci U S A. 2009;106:21689-94 pubmed publisher
    ..By using conditional knockout technology, we disrupted the c-myb proto-oncogene specifically in adult bone marrow (BM) to demonstrate that this transcription factor is a regulator ..
  53. Oh I, Reddy E. The myb gene family in cell growth, differentiation and apoptosis. Oncogene. 1999;18:3017-33 pubmed
    The myb gene family consists of three members, named A, B and c-myb which encode nuclear proteins that function as transcriptional transactivators...
  54. Kanei Ishii C, Nomura T, Tanikawa J, Ichikawa Iwata E, Ishii S. Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. J Biol Chem. 2004;279:44582-9 pubmed
    Recently we have shown that the c-myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via the pathway involving TAK1 (transforming growth factor-beta-activated kinase), HIPK2 (homeodomain-interacting protein ..
  55. Zor T, De Guzman R, Dyson H, Wright P. Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb. J Mol Biol. 2004;337:521-34 pubmed
    The hematopoietic transcription factor c-Myb activates transcription of target genes through direct interactions with the KIX domain of the co-activator CBP...
  56. Gonda T, Buckmaster C, Ramsay R. Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro. EMBO J. 1989;8:1777-83 pubmed
    Murine retroviruses which encode c-myb proteins that have either complete or truncated carboxy (C) termini were used to infect haemopoietic cells from murine fetal liver...
  57. Thomas M, Kremer C, Ravichandran K, Rajewsky K, Bender T. c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity. 2005;23:275-86 pubmed
    The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes...
  58. Hooper J, Maurice D, Argent Katwala M, Weston K. Myb proteins regulate expression of histone variant H2A.Z during thymocyte development. Immunology. 2008;123:282-9 pubmed
    The c-myb gene encodes a transcription factor required for the normal development of T cells in the thymus, and for subsequent peripheral T-cell activation and survival...
  59. Kaspar P, Ilencikova K, Zikova M, Horvath O, Cermák V, Bartunek P, et al. c-Myb inhibits myoblast fusion. PLoS ONE. 2013;8:e76742 pubmed publisher
    ..We investigated whether c-Myb could play a role in satellite cell biology because our previous results using satellite cell-derived mouse ..
  60. Nakajima T, Kitagawa K, Ohhata T, Sakai S, Uchida C, Shibata K, et al. Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. J Biol Chem. 2015;290:10368-81 pubmed publisher
    ..Our results suggest that Fbw7 is a bona fide E3 ubiquitin ligase for GATA2 in vivo. ..
  61. Weinstein Y, Ihle J, Lavu S, Reddy E. Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line. Proc Natl Acad Sci U S A. 1986;83:5010-4 pubmed
    Among a series of myeloid leukemia cell lines, one (NFS-60) was found to have a rearrangement of the c-myb locus...
  62. Phelep A, Laouari D, Bharti K, Burtin M, Tammaccaro S, Garbay S, et al. MITF - A controls branching morphogenesis and nephron endowment. PLoS Genet. 2017;13:e1007093 pubmed publisher
    ..Collectively, these results uncover a novel transcriptional network that controls branching morphogenesis during kidney development and identifies one of the first modifier genes of nephron endowment. ..