Mxd4

Summary

Gene Symbol: Mxd4
Description: Max dimerization protein 4
Alias: 2810410A03Rik, Mad4, bHLHc12, max dimerization protein 4, max dimerizer 4, max-associated protein 4, max-interacting transcriptional repressor MAD4
Species: mouse

Top Publications

  1. ncbi Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc
    Louise Kime
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem J 370:291-8. 2003
  2. ncbi Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    EMBO J 14:5646-59. 1995
  3. ncbi Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    EMBO J 15:2030. 1996
  4. ncbi Sequential expression of the MAD family of transcriptional repressors during differentiation and development
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncogene 16:967-77. 1998
  5. ncbi Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc
    K Gupta
    Section of Hematology Oncology, Childrens Hospital of Pittsburgh, Pennsylvania 15213, USA
    Oncogene 16:1149-59. 1998
  6. ncbi Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc
    M J FitzGerald
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Oncogene 18:2489-98. 1999
  7. ncbi OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival
    Nicole A Vasilevsky
    Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213 2933, USA
    Eur J Immunol 41:1024-34. 2011
  8. ncbi A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
    M A Farmer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 98:13820-5. 2001

Detail Information

Publications8

  1. ncbi Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc
    Louise Kime
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem J 370:291-8. 2003
    ..b>Mad4 RNA is highly induced and persists in terminally differentiated cells, in agreement with observations in other ..
  2. ncbi Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    EMBO J 14:5646-59. 1995
    ..Here we report the identification and characterization of two novel Mad1- and Mxi1-related proteins, Mad3 and Mad4. Mad3 and Mad4 interact with both Max and mSin3 and repress transcription from a promoter containing CACGTG binding ..
  3. ncbi Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    EMBO J 15:2030. 1996
  4. ncbi Sequential expression of the MAD family of transcriptional repressors during differentiation and development
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncogene 16:967-77. 1998
    ..of this network in that it associates with MYC as well as with the family of MAD proteins: MAD1, MXI1, MAD3 and MAD4. Whereas MYC-MAX complexes activate transcription, MAD-MAX complexes repress transcription through identical E-box ..
  5. ncbi Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc
    K Gupta
    Section of Hematology Oncology, Childrens Hospital of Pittsburgh, Pennsylvania 15213, USA
    Oncogene 16:1149-59. 1998
    ..Four additional bHLH-ZIP proteins, Mad1, Mxi1, Mad3 and Mad4, heterodimerize with Max and also repress transcription of c-myc-responsive genes...
  6. ncbi Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc
    M J FitzGerald
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Oncogene 18:2489-98. 1999
    ..In in vitro protein:protein association assays, dMax interacted with c-Myc, N-Myc, L-Myc, Mad1, Mxi1, Mad3 and Mad4, but not with itself or wild-type Max. These interactions required an intact leucine zipper...
  7. ncbi OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival
    Nicole A Vasilevsky
    Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213 2933, USA
    Eur J Immunol 41:1024-34. 2011
    ..Direct ex vivo examination of Ag-stimulated murine T cells show that the Myc antagonists, Mxd4 and Mnt, are transiently upregulated and translocated to the nucleus following OX40 engagement and may be involved ..
  8. ncbi A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
    M A Farmer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 98:13820-5. 2001
    ..A human ortholog of the Chr. 3 QTL, if one exists, would map to Chr. 4q or 1p...