Mxd4

Summary

Gene Symbol: Mxd4
Description: Max dimerization protein 4
Alias: 2810410A03Rik, Mad4, bHLHc12, max dimerization protein 4, max dimerizer 4, max-associated protein 4, max-interacting transcriptional repressor MAD4
Species: mouse

Top Publications

  1. pmc Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc
    Louise Kime
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem J 370:291-8. 2003
  2. doi The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro
    Katalin Boros
    Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, UK
    Exp Hematol 39:1090-100. 2011
  3. pmc Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    EMBO J 14:5646-59. 1995
  4. pmc Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    EMBO J 15:2030. 1996
  5. ncbi Sequential expression of the MAD family of transcriptional repressors during differentiation and development
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncogene 16:967-77. 1998
  6. ncbi Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc
    K Gupta
    Section of Hematology Oncology, Childrens Hospital of Pittsburgh, Pennsylvania 15213, USA
    Oncogene 16:1149-59. 1998
  7. ncbi Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc
    M J FitzGerald
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Oncogene 18:2489-98. 1999
  8. pmc OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival
    Nicole A Vasilevsky
    Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213 2933, USA
    Eur J Immunol 41:1024-34. 2011
  9. pmc A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
    M A Farmer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 98:13820-5. 2001

Detail Information

Publications9

  1. pmc Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc
    Louise Kime
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem J 370:291-8. 2003
    ..b>Mad4 RNA is highly induced and persists in terminally differentiated cells, in agreement with observations in other ..
  2. doi The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro
    Katalin Boros
    Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, UK
    Exp Hematol 39:1090-100. 2011
    ..The transcription factor Mxd4, a member of the Myc-Max-Mad network, was identified in a global gene expression profiling screen as being tightly ..
  3. pmc Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    EMBO J 14:5646-59. 1995
    ..Here we report the identification and characterization of two novel Mad1- and Mxi1-related proteins, Mad3 and Mad4. Mad3 and Mad4 interact with both Max and mSin3 and repress transcription from a promoter containing CACGTG binding ..
  4. pmc Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    EMBO J 15:2030. 1996
  5. ncbi Sequential expression of the MAD family of transcriptional repressors during differentiation and development
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncogene 16:967-77. 1998
    ..of this network in that it associates with MYC as well as with the family of MAD proteins: MAD1, MXI1, MAD3 and MAD4. Whereas MYC-MAX complexes activate transcription, MAD-MAX complexes repress transcription through identical E-box ..
  6. ncbi Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc
    K Gupta
    Section of Hematology Oncology, Childrens Hospital of Pittsburgh, Pennsylvania 15213, USA
    Oncogene 16:1149-59. 1998
    ..Four additional bHLH-ZIP proteins, Mad1, Mxi1, Mad3 and Mad4, heterodimerize with Max and also repress transcription of c-myc-responsive genes...
  7. ncbi Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc
    M J FitzGerald
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Oncogene 18:2489-98. 1999
    ..In in vitro protein:protein association assays, dMax interacted with c-Myc, N-Myc, L-Myc, Mad1, Mxi1, Mad3 and Mad4, but not with itself or wild-type Max. These interactions required an intact leucine zipper...
  8. pmc OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival
    Nicole A Vasilevsky
    Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213 2933, USA
    Eur J Immunol 41:1024-34. 2011
    ..Direct ex vivo examination of Ag-stimulated murine T cells show that the Myc antagonists, Mxd4 and Mnt, are transiently upregulated and translocated to the nucleus following OX40 engagement and may be involved ..
  9. pmc A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
    M A Farmer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 98:13820-5. 2001
    ..A human ortholog of the Chr. 3 QTL, if one exists, would map to Chr. 4q or 1p...