Mxd1

Summary

Gene Symbol: Mxd1
Description: MAX dimerization protein 1
Alias: AW122478, Mad, Mad1, max dimerization protein 1, max dimerizer 1
Species: mouse

Top Publications

  1. ncbi Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6
    R Parker
    Garvan Institute of Medical Research, Neurobiology Program, St Vincent s Hospital, Darlinghurst, Sydney, NSW, Australia
    Biochim Biophys Acta 1491:369-75. 2000
  2. pmc Vitamin D receptor as a master regulator of the c-MYC/MXD1 network
    Reyhaneh Salehi-Tabar
    Department of Medicine, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 109:18827-32. 2012
  3. pmc IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
    Pascal Descargues
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 105:2487-92. 2008
  4. ncbi Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc
    K Gupta
    Section of Hematology Oncology, Childrens Hospital of Pittsburgh, Pennsylvania 15213, USA
    Oncogene 16:1149-59. 1998
  5. ncbi Mad1 is a transcriptional repressor of Bcl-6
    Sang C Lee
    Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Immunol 43:1965-71. 2006
  6. ncbi The telomere repeat binding protein Trf1 interacts with the spindle checkpoint protein Mad1 and Nek2 mitotic kinase
    Graham Prime
    Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Cell Cycle 4:121-4. 2005
  7. pmc MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation
    Gretchen Poortinga
    Division of Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia
    EMBO J 23:3325-35. 2004
  8. ncbi Molecular determinants of the interaction of Mad with the PAH2 domain of mSin3
    Xavier Le Guezennec
    Department of Molecular Biology, Centre for Molecular and Biomolecular Informatics, University of Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 279:25823-9. 2004
  9. ncbi Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)
    E Nili
    Pediatric Hemato Oncology Department, Division of Hematology, Chaim Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine, Tel Aviv University, Israel
    J Cell Sci 114:3297-307. 2001
  10. ncbi Dwarfism and dysregulated proliferation in mice overexpressing the MYC antagonist MAD1
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cell Growth Differ 10:785-96. 1999

Scientific Experts

  • C Queva
  • K P Foley
  • Reyhaneh Salehi-Tabar
  • N A Jenkins
  • N G Copeland
  • Pascal Descargues
  • Sang C Lee
  • D E Ayer
  • Graham Prime
  • Xavier Le Guezennec
  • Gretchen Poortinga
  • D J Gilbert
  • R N Eisenman
  • Vassil Dimitrov
  • David Goltzman
  • Loan Nguyen-Yamamoto
  • P J Hurlin
  • Leon Glass
  • E Nili
  • John H White
  • Thomas Quail
  • Beum Soo An
  • Luz E Tavera-Mendoza
  • R Parker
  • L Chin
  • Gangwen Han
  • Xiao Jing Wang
  • Michael Karin
  • M J FitzGerald
  • Philip Owens
  • Olexandr Korchynskyi
  • Yuji Sano
  • Alok K Sil
  • Andrea Bottaro
  • Richard A Insel
  • Luojing Chen
  • K Gupta
  • E Steingrimsson
  • David Markie
  • Katherine M Hannan
  • R A DePinho
  • Anna Jenkins
  • Kerith Sharkey
  • Carl R Walkley
  • A D Domashenko
  • C M Cultraro
  • Grant A McArthur
  • Yves Brandenburger
  • Hendrik G Stunnenberg
  • Ross D Hannan
  • Richard B Pearson
  • Meaghan Wall
  • Hayley Snelling
  • Manuela Palatsides
  • Gert Vriend
  • G S Cojocaru
  • G Rechavi
  • A J Simon
  • F Brok-Simoni
  • D Ginsberg
  • Y Kalma
  • R Berger
  • P J Koskinen
  • S Shaklai
  • N Amariglio
  • H Herzog
  • J Crawford
  • H J Eyre
  • M Liu
  • I Vastrik
  • G R Sutherland
  • R E Bellas
  • K K Mann
  • G E Sonenshein
  • M Arsura
  • W Yang
  • M Wu
  • E V Prochownik
  • L Grove
  • N Uchida
  • X Yin
  • S Edelhoff
  • G Anand
  • K E Latham
  • K S Hatton
  • S Segal
  • T Bino
  • H W Lee
  • C Cordon-Cardo
  • A Lymboussakis

Detail Information

Publications24

  1. ncbi Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6
    R Parker
    Garvan Institute of Medical Research, Neurobiology Program, St Vincent s Hospital, Darlinghurst, Sydney, NSW, Australia
    Biochim Biophys Acta 1491:369-75. 2000
    ..However, although successful cell surface expression in a heterologous expression system can be achieved no specific binding to this ligand family can be detected, indicating that perhaps additional factors are required for binding...
  2. pmc Vitamin D receptor as a master regulator of the c-MYC/MXD1 network
    Reyhaneh Salehi-Tabar
    Department of Medicine, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 109:18827-32. 2012
    ..through multiple mechanisms, the balance in function of c-MYC and its antagonist the transcriptional repressor MAD1/MXD1. 1,25D inhibited transcription of c-MYC-regulated genes in vitro, and topical 1,25D suppressed expression of c-MYC ..
  3. pmc IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
    Pascal Descargues
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 105:2487-92. 2008
    ..IKKalpha was found to control several Myc antagonists, including Mad1, Mad2, and Ovol1, through the association with TGFbeta-regulated Smad2/3 transcription factors and is required for ..
  4. ncbi Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc
    K Gupta
    Section of Hematology Oncology, Childrens Hospital of Pittsburgh, Pennsylvania 15213, USA
    Oncogene 16:1149-59. 1998
    ..Four additional bHLH-ZIP proteins, Mad1, Mxi1, Mad3 and Mad4, heterodimerize with Max and also repress transcription of c-myc-responsive genes...
  5. ncbi Mad1 is a transcriptional repressor of Bcl-6
    Sang C Lee
    Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Immunol 43:1965-71. 2006
    ..down-regulation of Bcl-6, activation of Blimp-1, modulation of Myc, and specifically with the up-regulation of the Mad1 and Mad4 transcription factors, which play a critical role in cell differentiation and cell cycle regulation...
  6. ncbi The telomere repeat binding protein Trf1 interacts with the spindle checkpoint protein Mad1 and Nek2 mitotic kinase
    Graham Prime
    Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Cell Cycle 4:121-4. 2005
    ..Telomeric Repeat Binding Factor 1 (Trf1) as a protein that interacts directly with the spindle checkpoint protein Mad1 and the mitotic kinase Nek2...
  7. pmc MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation
    Gretchen Poortinga
    Division of Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia
    EMBO J 23:3325-35. 2004
    ..Here we show that granulocytic cells deficient in the c-MYC antagonist MAD1 display increased cell volume, rDNA transcription and protein synthesis...
  8. ncbi Molecular determinants of the interaction of Mad with the PAH2 domain of mSin3
    Xavier Le Guezennec
    Department of Molecular Biology, Centre for Molecular and Biomolecular Informatics, University of Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 279:25823-9. 2004
    ..PAH2 has been shown to interact strongly with the Sin3 interacting domain (SID) of the tumor suppressor Mad. This PAH2/Mad complex has been studied extensively by NMR, but the molecular determinants that dictate the ..
  9. ncbi Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)
    E Nili
    Pediatric Hemato Oncology Department, Division of Hematology, Chaim Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine, Tel Aviv University, Israel
    J Cell Sci 114:3297-307. 2001
    ..Co-expression of both LAP2beta and mGCL with the E2F-DP complex resulted in a reduced transcriptional activity equal to that exerted by the pRb protein...
  10. ncbi Dwarfism and dysregulated proliferation in mice overexpressing the MYC antagonist MAD1
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cell Growth Differ 10:785-96. 1999
    ..The ectopic expression of Mad1 in transgenic mice led to early postnatal lethality and dwarfism and had a profound inhibitory effect on the ..
  11. ncbi Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network
    K P Foley
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Biochim Biophys Acta 1423:M37-47. 1999
    ..Recently, targeted gene deletions of two members of this gene family, Mad1 and Mxi1, have been carried out in mice...
  12. ncbi Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc
    M J FitzGerald
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Oncogene 18:2489-98. 1999
    ..In in vitro protein:protein association assays, dMax interacted with c-Myc, N-Myc, L-Myc, Mad1, Mxi1, Mad3 and Mad4, but not with itself or wild-type Max. These interactions required an intact leucine zipper...
  13. pmc Contrasting roles for Myc and Mad proteins in cellular growth and differentiation
    L Chin
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 92:8488-92. 1995
    ..Myc on cellular growth and gene expression are antagonized by activities of another member of the Myc superfamily, Mad. Characterization of the mouse homolog of human mad on the structural level revealed that domains shown previously ..
  14. ncbi Sequential expression of the MAD family of transcriptional repressors during differentiation and development
    C Queva
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncogene 16:967-77. 1998
    ..protein is at the center of this network in that it associates with MYC as well as with the family of MAD proteins: MAD1, MXI1, MAD3 and MAD4...
  15. pmc Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation
    K P Foley
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North Mailstop A2 025, P O Box 19024, Seattle, WA 98109 1024, USA
    EMBO J 17:774-85. 1998
    The switch from transcriptionally activating MYC-MAX to transcriptionally repressing MAD1-MAX protein heterodimers has been correlated with the initiation of terminal differentiation in many cell types...
  16. pmc Function of the c-Myc antagonist Mad1 during a molecular switch from proliferation to differentiation
    C M Cultraro
    NCI Navy Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889 5105, USA
    Mol Cell Biol 17:2353-9. 1997
    ..Cotransfection of a constitutive c-myc with a zinc-inducible mad1 results in clones expressing both genes, whereby a switch from proliferation to differentiation can be modulated...
  17. ncbi Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development
    A D Domashenko
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Mol Reprod Dev 47:57-65. 1997
    ..The mxi mRNA was not detectable and the mad mRNA was detectable only as a maternal transcript...
  18. pmc Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    EMBO J 15:2030. 1996
  19. pmc Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
    P J Hurlin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    EMBO J 14:5646-59. 1995
    ..zipper (bHLHZip) protein Max associates with members of the Myc family, as well as with the related proteins Mad (Mad1) and Mxi1...
  20. ncbi Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity
    D E Ayer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 72:211-22. 1993
    ..One cDNA identified encodes a new member of the bHLH-Zip protein family, Mad. Human Mad protein homodimerizes poorly but binds Max in vitro, forming a sequence-specific DNA binding complex ..
  21. ncbi Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19
    S Edelhoff
    Department of Pathology, University of Washington, Seattle 98195
    Oncogene 9:665-8. 1994
    Both the MAD and the MXI1 genes encode basic-helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors which bind Max in vitro, forming a sequence-specific DNA-binding complex similar to the Myc-Max heterodimer...
  22. ncbi Mouse alpha N-catenin: two isoforms, specific expression in the nervous system, and chromosomal localization of the gene
    N Uchida
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 163:75-85. 1994
    ..These results suggest that alpha N-catenin plays specific roles in neural cell-cell interactions. We also localized the mouse alpha N-catenin gene to chromosome 6...
  23. pmc Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro
    I Vastrik
    Molecular Cancer Biology Laboratory, Haartman Institute, University of Helsinki, Finland
    J Cell Biol 128:1197-208. 1995
    b>Mad is a basic region helix-loop-helix leucine zipper transcription factor which can dimerize with the Max protein and antagonize transcriptional activation by the Myc-Max transcription factor heterodimer...
  24. ncbi Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
    D E Ayer
    Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 80:767-76. 1995
    The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor...