Munc13 3

Summary

Gene Symbol: Munc13 3
Description: unc-13 homolog C (C. elegans)
Alias: 1500037O19Rik, AU019458, D9Ertd414e, Munc13-3, Unc13h3, protein unc-13 homolog C, unc13 homolog 3
Species: mouse
Products:     Munc13 3

Top Publications

  1. Caqueret A, Boucher F, Michaud J. Laminar organization of the early developing anterior hypothalamus. Dev Biol. 2006;298:95-106 pubmed
    ..In addition, our analysis suggests that Sim1 function is required for the production or the survival of postmitotic neurons as well as for correct positioning of AH neurons...
  2. Lipstein N, Schaks S, Dimova K, Kalkhof S, Ihling C, Kölbel K, et al. Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity. Mol Cell Biol. 2012;32:4628-41 pubmed publisher
  3. Vogl C, Cooper B, Neef J, Wojcik S, Reim K, Reisinger E, et al. Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. J Cell Sci. 2015;128:638-44 pubmed publisher
    ..We conclude that IHCs use an unconventional priming machinery that involves otoferlin. ..
  4. Yang C, Kiser P, Zheng Y, Varoqueaux F, Mower G. Bidirectional regulation of Munc13-3 protein expression by age and dark rearing during the critical period in mouse visual cortex. Neuroscience. 2007;150:603-8 pubmed
    ..Munc13 proteins serve a central priming function in synaptic vesicle exocytosis at glutamatergic and GABAergic synapses and this work contributes to the growing evidence indicating a role of Munc13 genes in synaptic plasticity. ..
  5. Bao J, Reim K, Sakaba T. Target-dependent feedforward inhibition mediated by short-term synaptic plasticity in the cerebellum. J Neurosci. 2010;30:8171-9 pubmed publisher
  6. Man K, Imig C, Walter A, Pinheiro P, Stevens D, Rettig J, et al. Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. elife. 2015;4: pubmed publisher
    ..Our data demonstrate that the molecular steps of SV and LDCV priming are very similar while SV and LDCV docking mechanisms are distinct. ..
  7. Augustin I, Korte S, Rickmann M, Kretzschmar H, Sudhof T, Herms J, et al. The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. J Neurosci. 2001;21:10-7 pubmed
    ..This, in turn, would lead to increases in paired-pulse facilitation and could contribute to the observed deficit in motor learning. ..
  8. Varoqueaux F, Sons M, Plomp J, Brose N. Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse. Mol Cell Biol. 2005;25:5973-84 pubmed
    ..Thus, non-Munc13 priming proteins exist at this synapse or vesicle priming occurs in part spontaneously: i.e., without dedicated priming proteins in the release machinery. ..
  9. Beierlein M, Fioravante D, Regehr W. Differential expression of posttetanic potentiation and retrograde signaling mediate target-dependent short-term synaptic plasticity. Neuron. 2007;54:949-59 pubmed
    ..Moreover, PTP was reduced at the PF-->GC synapse compared to the PF-->PC synapse. Thus, the target-dependence of PF synapses arises from the differential expression of both retrograde signaling and PTP. ..

More Information

Publications14

  1. Chen Z, Cooper B, Kalla S, Varoqueaux F, Young S. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci. 2013;33:8336-51 pubmed publisher
    ..Based on these data, we conclude that Munc13-2 and Munc13-3 isoforms limit the ability of Munc13-1 to regulate calcium-dependent replenishment of readily releasable pool and slow pool to fast pool conversion in central synapses. ..
  2. Ishiyama S, Schmidt H, Cooper B, Brose N, Eilers J. Munc13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum. J Neurosci. 2014;34:14687-96 pubmed publisher
    ..We conclude that Munc13-3 is responsible for an additional step of molecular and/or positional "superpriming" that substantially increases the efficacy of Ca(2+)-triggered release. ..
  3. Nicod J, Davies R, Cai N, Hassett C, Goodstadt L, Cosgrove C, et al. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nat Genet. 2016;48:912-8 pubmed publisher
    ..These findings have implications for diverse areas of mammalian biology and demonstrate how genome-wide association studies can be extended via low-coverage sequencing to species with highly recombinant outbred populations. ..
  4. Lalonde R, Strazielle C. Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry. Brain Res. 2007;1140:51-74 pubmed
    ..We describe neurochemical characteristics of these mutants with respect to regional brain metabolism as well as amino acid and biogenic amine concentrations, uptake sites, and receptors. ..
  5. Cooper B, Hemmerlein M, Ammermüller J, Imig C, Reim K, Lipstein N, et al. Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses. J Neurosci. 2012;32:8040-52 pubmed publisher
    ..Their function is only moderately affected by Munc13 loss, which leads to slight perturbations of signal integration in the retina. ..