Muc5ac

Summary

Gene Symbol: Muc5ac
Description: mucin 5, subtypes A and C, tracheobronchial/gastric
Alias: 2210005L13Rik, MGM, mucin-5AC, gastric mucin
Species: mouse
Products:     Muc5ac

Top Publications

  1. Escande F, Porchet N, Bernigaud A, Petitprez D, Aubert J, Buisine M. The mouse secreted gel-forming mucin gene cluster. Biochim Biophys Acta. 2004;1676:240-50 pubmed
    ..in GenBank, we determined the complete gene structure of the four mouse secreted gel-forming mucin genes Muc2, Muc5ac, Muc5b and Muc6 and the organization of the genomic locus harboring these genes...
  2. Cressman V, Hicks E, Funkhouser W, Backlund D, Koller B. The relationship of chronic mucin secretion to airway disease in normal and CFTR-deficient mice. Am J Respir Cell Mol Biol. 1998;19:853-66 pubmed
    ..aureus and P. aeruginosa. Therefore, factors in addition to the absence of high levels of mucus secretion protect the mouse from the airway disease seen in human CF patients. ..
  3. Wang I, Yu C, Hu F. Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice. Mol Vis. 2009;15:108-19 pubmed
    ..and the expression of mucins was evaluated through the toxicity of diphtheria toxin A driven by a human mucin, MUC5AC, promoter...
  4. Shekels L, Lyftogt C, Kieliszewski M, Filie J, Kozak C, Ho S. Mouse gastric mucin: cloning and chromosomal localization. Biochem J. 1995;311 ( Pt 3):775-85 pubmed
    ..The purpose of this study was to clone a mouse gastric mucin which would provide a foundation for analysis of mucin gene regulation...
  5. Hasnain S, Evans C, Roy M, Gallagher A, Kindrachuk K, Barron L, et al. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011;208:893-900 pubmed publisher
    De novo expression of Muc5ac, a mucin not normally expressed in the intestinal tract, is induced in the cecum of mice resistant to Trichuris muris infection...
  6. Ha U, Lim J, Kim H, Wu W, Jin S, Xu H, et al. MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 2008;283:30624-31 pubmed publisher
    ..that the PAK4-JNK signaling pathway acted as a negative regulator for Streptococcus pneumoniae pneumolysin-induced MUC5AC mucin transcription...
  7. Young H, Williams O, Chandra D, Bellinghausen L, Pérez G, Suárez A, et al. Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Am J Respir Cell Mol Biol. 2007;37:273-90 pubmed
    ..Five orthologous genes (MUC2, MUC5AC, MUC5B, MUC6, and MUC19) encode the mammalian gel-forming mucin family, and several have been implicated in asthma,..
  8. Lakshmanan I, Rachagani S, Hauke R, Krishn S, Paknikar S, Seshacharyulu P, et al. MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling. Oncogene. 2016;35:4112-21 pubmed publisher
    b>MUC5AC is a secretory mucin aberrantly expressed in various cancers. In lung cancer, MUC5AC is overexpressed in both primary and metastatic lesions; however, its functional role is not well understood...
  9. Rodríguez Piñeiro A, Bergström J, Ermund A, Gustafsson J, Schütte A, Johansson M, et al. Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins. Am J Physiol Gastrointest Liver Physiol. 2013;305:G348-56 pubmed publisher
    ..g., Clca1, Zg16, Klk1). This study provides a deeper knowledge of the gastrointestinal mucus proteome that will be important in further understanding this poorly studied mucosal protection system. ..

More Information

Publications74

  1. Ge L, Liu Y, Lin X, Shen H, Jia Y, Dong X, et al. Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway. Int Immunopharmacol. 2016;33:90-8 pubmed publisher
    ..The effect of ambroxol on the expression of mucoprotein 5 AC (MUC5AC) and proinflammatory cytokines in NCI-H292 cells stimulated with cigarette smoke extract (CSE)...
  2. Snitow M, Li S, Morley M, Rathi K, Lu M, Kadzik R, et al. Ezh2 represses the basal cell lineage during lung endoderm development. Development. 2015;142:108-17 pubmed publisher
    ..Together, these findings show that Ezh2 restricts the basal cell lineage during normal lung endoderm development to allow the proper patterning of epithelial lineages during lung formation. ..
  3. Kono Y, Nishiuma T, Okada T, Kobayashi K, Funada Y, Kotani Y, et al. Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. Pulm Pharmacol Ther. 2010;23:36-42 pubmed publisher
    ..the role of SphK in airway mucin production, we utilized the mouse asthmatic model and found that both SphK and MUC5AC expression were increased and co-localized in airway epithelium...
  4. Das B, Cash M, Hand A, Shivazad A, Culp D. Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells. J Histochem Cytochem. 2009;57:383-96 pubmed publisher
    ..These changes in Muc19/Smgc gene expression delineate multiple stages of salivary mucous cell cytodifferentiation and subsequent maturation during embryonic gland development through the first 4 weeks of postnatal life...
  5. Zhou M, Chen H, Cheng S, Mei L, Zhang H, Xie M, et al. Effect of dexamethasone on expression of AGR2 protein in asthmatic mice. J Huazhong Univ Sci Technolog Med Sci. 2013;33:33-36 pubmed publisher
    This study examined the expression of the anterior gradient-2 (AGR2) protein and Muc5ac protein in the lung tissues of asthmatic mice and the effect of dexamethasone, with an attempt to explore the role of AGR2 in the over-secretion of ..
  6. Guha A, Vasconcelos M, Cai Y, Yoneda M, Hinds A, Qian J, et al. Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A. 2012;109:12592-7 pubmed publisher
  7. Floyd A, Zhou X, Evans C, Rompala O, Zhu L, Wang M, et al. Mucin deficiency causes functional and structural changes of the ocular surface. PLoS ONE. 2012;7:e50704 pubmed publisher
    b>MUC5AC is the most abundant gel-forming mucin in the ocular system. However, the specific function is unknown...
  8. Tan Y, Zhang W, Yang L, Jiang S. The effect of formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice. Eur Rev Med Pharmacol Sci. 2011;15:743-50 pubmed
    ..the effect of long-acting beta2-adrenoceptor agonist formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice. Forty female BABL/c mice were randomly divided into four groups with 10 mice in each...
  9. Mao J, Kim B, Rajurkar M, Shivdasani R, McMahon A. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010;137:1721-9 pubmed publisher
    ..Together, these studies provide new insights into tissue interactions underlying mammalian gastrointestinal organogenesis and disease. ..
  10. Tukler Henriksson J, Coursey T, Corry D, de Paiva C, Pflugfelder S. IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2015;56:4186-97 pubmed publisher
    ..The cultured conjunctival epithelium expressed goblet cell associated keratin 7 and mucins MUC5AC and MUC2 and when stimulated with IL-13 showed increased proliferation at D3 and D7 (P < 0...
  11. Kim B, Woo J, Kanellopoulou C, Shivdasani R. Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development. 2011;138:1081-6 pubmed publisher
    ..These results indicate that miRNAs are required for proper digestive tract organogenesis and that miR-7a and miR-203 control expression of the stomach homeotic regulator Barx1. ..
  12. Reynolds S, Zemke A, Giangreco A, Brockway B, Teisanu R, Drake J, et al. Conditional stabilization of beta-catenin expands the pool of lung stem cells. Stem Cells. 2008;26:1337-46 pubmed publisher
    ..Our data demonstrate that the differentiation-modulating activities of stabilized beta-catenin account for expansion of tissue stem cells. ..
  13. Holmén Larsson J, Thomsson K, Rodríguez Piñeiro A, Karlsson H, Hansson G. Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution. Am J Physiol Gastrointest Liver Physiol. 2013;305:G357-63 pubmed publisher
    The mouse intestinal mucus is mainly made up by the gel-forming Muc2 mucin and the stomach surface mucus Muc5ac, both extensively O-glycosylated...
  14. Deshmukh H, Shaver C, Case L, Dietsch M, Wesselkamper S, Hardie W, et al. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008;38:446-54 pubmed
    ..of cigarette smoke and an endogenous mediator of oxidative stress, increases airway mucin 5, subtypes A and C (MUC5AC) production; however, the mechanism remains unclear...
  15. Almolki A, Guenegou A, Golda S, Boyer L, Benallaoua M, Amara N, et al. Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans. Am J Pathol. 2008;173:981-92 pubmed publisher
    ..In both rats and mice, 5-day CS exposure increased HO-1 expression and activity, mucus secretion, MUCIN 5AC (MUC5AC) gene and protein expression, and local inflammation, along with up-regulation of dual oxidase 1 gene ..
  16. Jang M, Kim S, Lee K, Kim T, Moon K, Park C, et al. The tyrosine phosphatase, SHP-1, is involved in bronchial mucin production during oxidative stress. Biochem Biophys Res Commun. 2010;393:137-43 pubmed publisher
    ..Cultured cells were treated with hydrogen peroxide (H(2)O(2)), and Mucin 5AC(MUC5AC) gene expression and mucin production were determined...
  17. Buchweitz J, Harkema J, Kaminski N. Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice. Toxicol Pathol. 2007;35:424-35 pubmed
    ..IL-13 levels were unaffected by PR8 treatment. Concurrent with inflammation, MUC5AC gene expression was markedly increased by PR8 treatment at 7 dpi...
  18. Desseyn J, Laine A. Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse. Genomics. 2003;81:433-6 pubmed
    ..This gene is clustered with the three secreted large gel-forming mucins Muc2, Muc5ac, and Muc5b in a region that exhibits synteny with human chromosome 11p15...
  19. Boase N, Rychkov G, Townley S, Dinudom A, Candi E, Voss A, et al. Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun. 2011;2:287 pubmed publisher
    ..Thus, we provide critical in vivo evidence that Nedd4-2 is essential for correct regulation of ENaC expression, fetal and postnatal lung function and animal survival. ..
  20. Hashimoto S, Chen H, Que J, Brockway B, Drake J, Snyder J, et al. ?-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. J Cell Sci. 2012;125:932-42 pubmed publisher
    ..Our data suggest that Wnt negatively regulates a SOX2-dependent signaling program required for developmental progression of the bronchiolar lineage. ..
  21. Li W, Yan F, Zhou H, Lin X, Wu Y, Chen C, et al. P. aeruginosa lipopolysaccharide-induced MUC5AC and CLCA3 expression is partly through Duox1 in vitro and in vivo. PLoS ONE. 2013;8:e63945 pubmed publisher
    ..that reactive oxygen species (ROS) are involved in Pseudomonas aeruginosa lipopolysaccharide (PA-LPS) induced MUC5AC in airway epithelial cells...
  22. Kim B, Miletich I, Mao J, McMahon A, Sharpe P, Shivdasani R. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007;134:3603-13 pubmed
    ..These observations place Barx1 proximally within a Wt1 pathway of spleen development and reveal how a homeotic regulator employs different molecular mechanisms to mold neighboring organs. ..
  23. Danielian P, Bender Kim C, Caron A, Vasile E, Bronson R, Lees J. E2f4 is required for normal development of the airway epithelium. Dev Biol. 2007;305:564-76 pubmed
    ..Importantly, the combination of no ciliated cells and excess mucous cells can account for the chronic rhinitis and increased susceptibility to opportunistic infections that causes the postnatal lethality of E2f4 mutant mice. ..
  24. Song K, Kim H, Kim K, Lee J, Yoon J. Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway. Am J Respir Cell Mol Biol. 2009;41:40-9 pubmed publisher
    ..The mechanism by which LPS induces MUC5AC overexpression, however, has not been fully explored...
  25. Tomasetto C, Masson R, Linares J, Wendling C, Lefebvre O, Chenard M, et al. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterology. 2000;118:70-80 pubmed
  26. Koeppen M, McNamee E, Brodsky K, Aherne C, Faigle M, Downey G, et al. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2013;6:762-75 pubmed publisher
    ..Initial transcriptional profiling of airway mucins revealed a selective and robust induction of MUC5AC upon cyclic mechanical stretch exposure of pulmonary epithelia (Calu-3)...
  27. Xuan S, Sussel L. GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling. Development. 2016;143:780-6 pubmed publisher
    ..These studies establish the importance of GATA4/6-mediated inhibition of hedgehog signaling as a major mechanism regulating pancreatic endoderm specification during patterning of the gut tube. ..
  28. Grisanti L, Revenkova E, Gordon R, Iomini C. Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway. Development. 2016;143:2160-71 pubmed publisher
    ..Thus, we have uncovered a function of the primary cilium in maintaining homeostasis of the CE by balancing proliferation and vertical migration of basal CECs through modulation of Notch signaling. ..
  29. Contreras Ruiz L, Zorzi G, Hileeto D, Lopez Garcia A, Calonge M, Seijo B, et al. A nanomedicine to treat ocular surface inflammation: performance on an experimental dry eye murine model. Gene Ther. 2013;20:467-77 pubmed publisher
    b>MUC5AC is a glycoprotein with gel-forming properties, whose altered expression has been implicated in the pathogenesis of dry eye disease...
  30. Dillard P, Wetsel R, Drouin S. Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses. Am J Respir Crit Care Med. 2007;175:1250-8 pubmed
    ..examined in a model of allergic airway disease for the presence of goblet cells and the gel-forming secreted mucin Muc5ac. Lungs from antigen-challenged C3a receptor-deficient mice revealed a dramatic decrease in goblet cells and Muc5ac ..
  31. Sanders P, Koval O, Jaffer O, Prasad A, Businga T, Scott J, et al. CaMKII is essential for the proasthmatic effects of oxidation. Sci Transl Med. 2013;5:195ra97 pubmed publisher
    ..bronchial epithelial ox-CaMKII was required to increase a ROS- and picrotoxin-sensitive Cl(-) current (ICl) and MUC5AC expression, upstream events in asthma progression...
  32. PEREZ VILAR J, Randell S, Boucher R. C-Mannosylation of MUC5AC and MUC5B Cys subdomains. Glycobiology. 2004;14:325-37 pubmed
    ..The entire Cys1 and Cys5 and Cys1 and Cys3 subdomains in MUC5AC and MUC5B, respectively, each with six carboxyl terminal histidine residues, were pulse-labeled with [(35)S]..
  33. Roy M, Livraghi Butrico A, Fletcher A, McElwee M, Evans S, Boerner R, et al. Muc5b is required for airway defence. Nature. 2014;505:412-6 pubmed publisher
    ..b>MUC5AC and MUC5B are evolutionarily conserved genes that encode structurally related mucin glycoproteins, the principal ..
  34. Mahoney J, Mori M, Szymaniak A, Varelas X, Cardoso W. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 2014;30:137-50 pubmed publisher
    ..Our data reveal a role for the Hippo-Yap pathway in integrating growth-factor-induced cues in the developing and adult lung potentially key for homeostasis and regeneration repair. ..
  35. Ou Yang H, Wu C, Qu S, Li Z. Notch signaling downregulates MUC5AC expression in airway epithelial cells through Hes1-dependent mechanisms. Respiration. 2013;86:341-6 pubmed publisher
    Mucus overproduction is one of the major pathological features of asthma, and MUC5AC is the major mucin component of airway mucus...
  36. Arnold K, Sarkar A, Yram M, Polo J, Bronson R, Sengupta S, et al. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011;9:317-29 pubmed publisher
    ..Thus, our results identify Sox2 expression in numerous adult endodermal and ectodermal stem cell compartments, which are critical for normal tissue regeneration and survival. ..
  37. Szymaniak A, Mahoney J, Cardoso W, Varelas X. Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015;34:283-96 pubmed publisher
    ..Our findings demonstrate that polarity-dependent cues control airway cell differentiation, offering important molecular insights into organ patterning. ..
  38. Jonckheere N, Van Der Sluis M, Velghe A, Buisine M, Sutmuller M, Ducourouble M, et al. Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1. Biochem J. 2004;377:797-808 pubmed
    ..In our laboratory we have shown previously that MUC5AC is aberrantly expressed in rectosigmoid villous adenomas...
  39. Shahzeidi S, Aujla P, Nickola T, Chen Y, Alimam M, Rose M. Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma. Exp Lung Res. 2003;29:549-65 pubmed
    ..Increased Muc5ac and Muc2 mRNA expression occurred following ovalbumin or IL13, but not saline, exposure...
  40. Jono H, Lim J, Xu H, Li J. PKC? synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1. PLoS ONE. 2012;7:e31049 pubmed publisher
    ..Here we show that CARMA1 acts as a key signaling mediator for synergistic upregulation of MUC5AC mucin by bacterium nontypeable Haemophilus influenzae (NTHi) and phorbol ester PMA in respiratory epithelial cells...
  41. Roy M, Rahmani M, Hernandez J, Alexander S, Ehre C, Ho S, et al. Mucin production during prenatal and postnatal murine lung development. Am J Respir Cell Mol Biol. 2011;44:755-60 pubmed publisher
    ..Muc5b transcripts were abundant at all time points from E14.5 to PN28. By contrast, transcript levels of Muc5ac and Muc2 were approximately 300 and 85,000 times lower, respectively...
  42. Chen Y, Zhao Y, Wu R. In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model. Am J Respir Crit Care Med. 2001;164:1059-66 pubmed
    ..overlapping genomic clones (AC020817 and AC020794) that contained the sequence of both 3pmmuc5b-1 and the mouse Muc5ac gene. Like their human homologs, the genomic order of the mouse Muc genes is 5'-Muc5ac-Muc5b-3'...
  43. Marko C, Tisdale A, Spurr Michaud S, Evans C, Gipson I. The ocular surface phenotype of Muc5ac and Muc5b null mice. Invest Ophthalmol Vis Sci. 2014;55:291-300 pubmed publisher
    Recent development of mice null for either Muc5ac or Muc5b mucin allows study of their specific roles at the mouse ocular surface...
  44. Nollet S, Forgue Lafitte M, Kirkham P, Bara J. Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors. Int J Cancer. 2002;99:336-43 pubmed
    ..We have mapped 2 new gastric mucin epitopes and the M1-f epitope previously characterized by the 19/21M1 MAbs on MUC5AC-encoded apomucin...
  45. Verzi M, Khan A, Ito S, Shivdasani R. Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 2008;135:591-600 pubmed publisher
    ..Foxq1 coding mutations show virtual absence of mRNA and protein for the backbone of the major stomach mucin MUC5AC. These observations correspond to a paucity of foveolar cell secretory vesicles and notable loss of stomach but ..
  46. Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, et al. IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models. Allergy. 2017;72:1043-1053 pubmed publisher
    ..The induction of Muc5ac, a representative mucin in asthmatic airways, was reduced in Nfkbid-/- mTEC, whereas the induction of ..
  47. Evans C, Raclawska D, Ttofali F, Liptzin D, Fletcher A, Harper D, et al. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun. 2015;6:6281 pubmed publisher
    ..Overproduction of the mucin MUC5AC is an additional disease feature that, while strongly associated pathologically, is poorly understood functionally...
  48. Cheng Z, Dai L, Wang X, Jia L, Jing X, Li P, et al. MicroRNA-145 down-regulates mucin 5AC to alleviate airway remodeling and targets EGFR to inhibit cytokine expression. Oncotarget. 2017;8:46312-46325 pubmed publisher
    ..airway remodeling and cytokine expression by targeting epidermal growth factor receptor (EGFR) to regulate mucin 5AC (MUC5AC)...
  49. Arbi M, Pefani D, Kyrousi C, Lalioti M, Kalogeropoulou A, Papanastasiou A, et al. GemC1 controls multiciliogenesis in the airway epithelium. EMBO Rep. 2016;17:400-13 pubmed publisher
    ..GemC1-knockout mice are born with airway epithelia devoid of multiciliated cells. Our results identify GemC1 as an essential regulator of ciliogenesis in the airway epithelium and a candidate gene for mucociliary disorders. ..
  50. Magalhães A, Rossez Y, Robbe Masselot C, Maes E, Gomes J, Shevtsova A, et al. Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding. Sci Rep. 2016;6:25575 pubmed publisher
    ..The secreted MUC5AC mucin is the main component of the gastric mucus layer, and BabA-mediated binding of H...
  51. Dif F, Wu Y, Burgel P, Ollero M, Leduc D, Aarbiou J, et al. Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice. Eur Respir J. 2010;36:1120-30 pubmed publisher
    ..Mucus production was assessed using histological analyses, immuno-histochemistry and MUC5AC ELISA...
  52. Guseh J, Bores S, Stanger B, Zhou Q, Anderson W, Melton D, et al. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development. 2009;136:1751-9 pubmed publisher
    ..Occasional distal cystic cells appeared to differentiate into normal proximal airway cells, suggesting that ectopic Notch signaling arrests the normal differentiation of distal lung progenitors before they initiate an alveolar program. ..
  53. Ehre C, Worthington E, Liesman R, Grubb B, Barbier D, O Neal W, et al. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs. Proc Natl Acad Sci U S A. 2012;109:16528-33 pubmed publisher
    b>MUC5AC, a major gel-forming mucin expressed in the lungs, is secreted at increased rates in response to infectious agents, implying that mucins exert a protective role against inhaled pathogens...
  54. Chand H, Woldegiorgis Z, Schwalm K, McDonald J, Tesfaigzi Y. Acute inflammation induces insulin-like growth factor-1 to mediate Bcl-2 and Muc5ac expression in airway epithelial cells. Am J Respir Cell Mol Biol. 2012;47:784-91 pubmed publisher
    ..and, similar to previous studies, increased expression of the prosurvival protein Bcl-2 and induced expression of Muc5ac. Suppression of IGF-1 expression using retroviral shRNA blocked Bcl-2 expression in human and murine airway ..
  55. Vock C, Yildirim A, Wagner C, Schlick S, Lunding L, Lee C, et al. Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signalling components. Clin Exp Allergy. 2015;45:1447-58 pubmed publisher
    ..This might represent a protective strategy to prevent mucus plugging of distal airways and thus impaired ventilation of attached alveoli. ..
  56. Jin N, Cho S, Raso M, Wistuba I, Smith Y, Yang Y, et al. Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009;136:3347-56 pubmed publisher
    ..These results demonstrate that Mig-6 is required for prenatal and perinatal lung development, in part through the regulation of EGF signaling, as well as for maintaining proper pulmonary vascularization. ..
  57. Zhu Y, Ehre C, Abdullah L, Sheehan J, Roy M, Evans C, et al. Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways. J Physiol. 2008;586:1977-92 pubmed publisher
    ..airways was not caused by an inflammatory, metaplastic-like response: bronchial-alveolar lavage leucocyte numbers, Muc5ac and Muc5b mRNA levels, and Clara cell ultrastructure (except for increased secretory granule numbers) were all ..
  58. Que J, Okubo T, Goldenring J, Nam K, Kurotani R, Morrisey E, et al. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007;134:2521-31 pubmed
    ..These findings suggest that Sox2 plays a second role in establishing the boundary between the keratinized, squamous esophagus/forestomach and glandular hindstomach. ..
  59. Lukacs N, Moore M, Rudd B, Berlin A, Collins R, Olson S, et al. Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus. Am J Pathol. 2006;169:977-86 pubmed
    ..cell hyper/metaplasia, whereas the Line 19 induced goblet cell expansion and significant increases in gob5 and MUC5AC mRNA and protein levels in vivo...
  60. Yan F, Li W, Zhou H, Wu Y, Ying S, Chen Z, et al. Interleukin-13-induced MUC5AC expression is regulated by a PI3K-NFAT3 pathway in mouse tracheal epithelial cells. Biochem Biophys Res Commun. 2014;446:49-53 pubmed publisher
    ..is involved in the pathogenesis of asthma, but whether it can directly regulate IL-13-induced mucus (particularly MUC5AC) production is still not clear...
  61. Jonckheere N, Vincent A, Franquet Ansart H, Witte Bouma J, Korteland Van Male A, Leteurtre E, et al. GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells. Biochim Biophys Acta. 2012;1819:869-76 pubmed publisher
    During human embryonic and fetal development of the gastrointestinal tract, the gene encoding the MUC5AC mucin has a spatio-temporal pattern of expression restricted to the stomach...
  62. Matsumoto S, Konishi H, Maeda R, Kiryu Seo S, Kiyama H. Expression analysis of the regenerating gene (Reg) family members Reg-III? and Reg-III? in the mouse during development. J Comp Neurol. 2012;520:479-94 pubmed publisher
    ..g., microbes) in the outer world, whereas the transient expression of Reg-III? in the nervous system may be associated with the development of the peripheral nervous system including such processes as myelination. ..
  63. Nakagawa S, Naganuma T, Shioi G, Hirose T. Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol. 2011;193:31-9 pubmed publisher
    ..We propose that paraspeckles are nonessential, subpopulation-specific nuclear bodies formed secondary to particular environmental triggers. ..
  64. Song K, Choi Y, Kim J, Lee H, Lee T, Yoon J. Suppression of prostaglandin E2-induced MUC5AC overproduction by RGS4 in the airway. Am J Physiol Lung Cell Mol Physiol. 2009;296:L684-92 pubmed publisher
    The mechanism by which E-prostanoid (EP) receptor is critically involved in PGE(2)-induced mucin 5AC (MUC5AC) gene expression in the airway has been unclear...
  65. Inatomi T, Tisdale A, Zhan Q, Spurr Michaud S, Gipson I. Cloning of rat Muc5AC mucin gene: comparison of its structure and tissue distribution to that of human and mouse homologues. Biochem Biophys Res Commun. 1997;236:789-97 pubmed
    The human mucin gene MUC5AC codes for a large mucin which has tandem repeat units and cysteine rich regions characteristic of several members of this class of glycoproteins...