Muc4

Summary

Gene Symbol: Muc4
Description: mucin 4
Alias: 4933405I11Rik, Asgp, mucin-4, ascites sialoglycoprotein, mucin 4, ASGP, pancreatic adenocarcinoma mucin, testis mucin
Species: mouse
Products:     Muc4

Top Publications

  1. Desseyn J, Clavereau I, Laine A. Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4. Eur J Biochem. 2002;269:3150-9 pubmed
    ..16, which is the orthologous region of human chromosome 3q29 encompassing the large membrane-anchored mucin MUC4. Contigs analysis of the Human Genome Project did not reveal any other mucin on chromosome 3q29 and, interestingly, ..
  2. Jonckheere N, Vincent A, Perrais M, Ducourouble M, Male A, Aubert J, et al. The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem. 2007;282:22638-50 pubmed
    The human gene MUC4 encodes a large transmembrane mucin that is developmentally regulated and expressed along the undifferentiated pseudostratified epithelium, as early as 6.5 weeks during fetal development...
  3. Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, et al. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. Biochim Biophys Acta. 2015;1853:2392-403 pubmed publisher
    ..Altogether, we have identified miR-29a and miR-330-5p as two new tumor suppressive miRNAs that inhibit the expression of MUC1 oncogenic mucin in pancreatic cancer cells. ..
  4. Wang X, Ouyang H, Yamamoto Y, Kumar P, Wei T, Dagher R, et al. Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell. 2011;145:1023-35 pubmed publisher
    ..Our findings suggest that certain precancerous lesions, such as Barrett's, initiate not from genetic alterations but from competitive interactions between cell lineages driven by opportunity...
  5. Das S, Rachagani S, Sheinin Y, Smith L, Gurumurthy C, Roy H, et al. Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer. Oncogene. 2016;35:2645-54 pubmed publisher
    b>MUC4, a large transmembrane mucin normally expressed in the small and large intestine, is differentially expressed during inflammatory and malignant conditions of the colon...
  6. Chapela P, Broaddus R, Hawkins S, Lessey B, Carson D. Cytokine stimulation of MUC4 expression in human female reproductive tissue carcinoma cell lines and endometrial cancer. J Cell Biochem. 2015;116:2649-57 pubmed publisher
    b>MUC4, a transmembrane glycoprotein, interferes with cell adhesion, and promotes EGFR signaling in cancer. Studies in rat models have demonstrated steroid hormonal regulation of endometrial MUC4 expression...
  7. Jonckheere N, Skrypek N, Merlin J, Dessein A, Dumont P, Leteurtre E, et al. The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. PLoS ONE. 2012;7:e32232 pubmed publisher
    The mucin MUC4 and its membrane partner the ErbB2 oncogenic receptor are potential interacting partners in human pancreatic tumour development. However, the way they function is still largely unknown...
  8. Vasseur R, Skrypek N, Duchêne B, Renaud F, Martínez Maqueda D, Vincent A, et al. The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways. Biochim Biophys Acta. 2015;1849:1375-84 pubmed publisher
    ..In pancreatic cancer, one of the most deadly cancers in occidental countries, MUC4 is neo-expressed in the preneoplastic stages and thereafter is involved in cancer cell properties leading to cancer ..
  9. Senapati S, Gnanapragassam V, Moniaux N, Momi N, Batra S. Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells. Oncogene. 2012;31:3346-56 pubmed publisher
    b>MUC4 is a large transmembrane type I glycoprotein that is overexpressed in pancreatic cancer (PC) and has been shown to be associated with its progression and metastasis...

More Information

Publications17

  1. Kaur S, Sharma N, Krishn S, Lakshmanan I, Rachagani S, Baine M, et al. MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-?B signaling in pancreatic cancer. Clin Cancer Res. 2014;20:688-700 pubmed publisher
    b>MUC4 shows aberrant expression in early pancreatic lesions and a high specificity for pancreatic cancer. It thus has a high potential to be a sensitive and specific biomarker...
  2. Bondow B, Faber M, Wojta K, Walker E, Battle M. E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 2012;371:1-12 pubmed publisher
    ..In summary, our data demonstrate that E-cadherin is essential for intestinal epithelial morphogenesis and homeostasis during embryonic development. ..
  3. Wang I, Yu C, Hu F. Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice. Mol Vis. 2009;15:108-19 pubmed
    ..However, the membranous mucin, MUC4, compensates the decrease of MUC5AC in terms of the results of immunohistochemical staining, in situ hybridization, ..
  4. Gaudier E, Rival M, Buisine M, Robineau I, Hoebler C. Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon. Physiol Res. 2009;58:111-9 pubmed
    ..demonstrated that butyrate stimulated the gene expression of both secreted (Muc2) and membrane-linked (Muc1, Muc3, Muc4) mucins. Butyrate especially induced a 6-fold increase in Muc2 gene expression in proximal colon...
  5. Comelli E, Simmering R, Faure M, Donnicola D, Mansourian R, Rochat F, et al. Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota. Genomics. 2008;91:70-7 pubmed
    ..These findings show that a well-established microbial community participates in the regulation of the gut mucus layer and that its composition and adequacy to the host are key factors in this process. ..
  6. Lee C, Homer R, Cohn L, Link H, Jung S, Craft J, et al. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem. 2002;277:35466-74 pubmed
    ..These responses are mediated by multiple mechanisms with mucus metaplasia being dependent on and the inflammation and fibrosis being independent of an IL-13/IL-4R(alpha)/STAT-6 activation pathway. ..
  7. Miyahara N, Shoda J, Kawamoto T, Ishida H, Ueda T, Akimoto Y, et al. Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications. Oncol Rep. 2014;32:1796-802 pubmed publisher
    ..The expression level of Muc4, a potential functional ligand for erbB2, and its interaction with erbB2 in the gallbladder of BK5...
  8. Zhang J, Perez A, Yasin M, Soto P, Rong M, Theodoropoulos G, et al. Presence of MUC4 in human milk and at the luminal surfaces of blood vessels. J Cell Physiol. 2005;204:166-77 pubmed
    MUC4 is a heterodimeric membrane mucin, composed of a mucin subunit ASGP-1 (MUC4alpha) and a transmembrane subunit ASGP-2 (MUC4beta), which has been implicated in the protection of epithelial cell surfaces...