Muc1

Summary

Gene Symbol: Muc1
Description: mucin 1, transmembrane
Alias: CD227, EMA, Muc-1, mucin-1, episialin
Species: mouse
Products:     Muc1

Top Publications

  1. Cano D, Murcia N, Pazour G, Hebrok M. Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development. 2004;131:3457-67 pubmed
    ..Thus, polaris and primary cilia function are required for the maturation and maintenance of proper tissue organization in the pancreas. ..
  2. Al Masri A, Gendler S. Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis. Oncogene. 2005;24:5799-808 pubmed
    b>MUC1 is an integral membrane mucin glycoprotein that is normally expressed on the apical surface of most simple, secretory epithelia and hematopoietic cells...
  3. McAuley J, Linden S, Png C, King R, Pennington H, Gendler S, et al. MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest. 2007;117:2313-24 pubmed
    ..A rapid progressive increase in gastrointestinal expression of mucin 1 (Muc1) cell surface mucin followed infection of mice with the bacterial pathogen Campylobacter jejuni...
  4. Spicer A, Duhig T, Chilton B, Gendler S. Analysis of mammalian MUC1 genes reveals potential functionally important domains. Mamm Genome. 1995;6:885-8 pubmed
  5. Schroeder J, Adriance M, Thompson M, Camenisch T, Gendler S. MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion. Oncogene. 2003;22:1324-32 pubmed
    b>MUC1 is aberrantly expressed in greater than 90% of all breast carcinomas, yet its function as a tumor antigen is not fully understood...
  6. Pierreux C, Poll A, Kemp C, Clotman F, Maestro M, Cordi S, et al. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology. 2006;130:532-41 pubmed
    ..HNF-6 controls a network of genes involved in cilium formation and in hereditary polycystic diseases. Finally, HNF-6 deficiency represents a genetically defined model of pancreatic cystic disease. ..
  7. Schroeder J, Thompson M, Gardner M, Gendler S. Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem. 2001;276:13057-64 pubmed
    b>MUC1 is a large (>400 kDa), heavily glycosylated transmembrane protein that is aberrantly expressed on greater than 90% of human breast carcinomas and subsequent metastases...
  8. Lynn F, Smith S, Wilson M, Yang K, Nekrep N, German M. Sox9 coordinates a transcriptional network in pancreatic progenitor cells. Proc Natl Acad Sci U S A. 2007;104:10500-5 pubmed
    ..These studies indicate that Sox9 plays a dual role in pancreatic progenitor cells: both maintaining a stable transcriptional network and supporting the programs by which these cells differentiate into distinct lineages. ..
  9. Spicer A, Rowse G, Lidner T, Gendler S. Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem. 1995;270:30093-101 pubmed
    ..This suggests that Muc-1 plays an important role in the progression of mammary carcinoma. ..

More Information

Publications93

  1. McGuckin M, Every A, Skene C, Linden S, Chionh Y, Swierczak A, et al. Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology. 2007;133:1210-8 pubmed
    The MUC1 mucin is expressed on the cell surface of epithelial cells lining the gastric mucosa...
  2. Besmer D, Curry J, Roy L, Tinder T, Sahraei M, Schettini J, et al. Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis. Cancer Res. 2011;71:4432-42 pubmed publisher
    b>MUC1 is overexpressed and aberrantly glycosylated in more than 60% of pancreatic ductal adenocarcinomas. The functional role of MUC1 in pancreatic cancer has yet to be fully elucidated due to a dearth of appropriate models...
  3. Poh T, Bradley J, Mukherjee P, Gendler S. Lack of Muc1-regulated beta-catenin stability results in aberrant expansion of CD11b+Gr1+ myeloid-derived suppressor cells from the bone marrow. Cancer Res. 2009;69:3554-62 pubmed publisher
    ..We discovered that bone marrow (BM) progenitor cells from the Muc1 knockout (KO) mice differentiated into CD11b(+)Gr1(+) MDSCs in vitro under granulocyte macrophage colony-..
  4. Umehara T, Kato K, Park Y, Lillehoj E, Kawauchi H, Kim K. Prevention of lung injury by Muc1 mucin in a mouse model of repetitive Pseudomonas aeruginosa infection. Inflamm Res. 2012;61:1013-20 pubmed publisher
    ..Pa) infection results in lung inflammation and injury and, if so, whether these responses are affected by Muc1 mucin...
  5. Parry G, Li J, Stubbs J, Bissell M, Schmidhauser C, Spicer A, et al. Studies of Muc-1 mucin expression and polarity in the mouse mammary gland demonstrate developmental regulation of Muc-1 glycosylation and establish the hormonal basis for mRNA expression. J Cell Sci. 1992;101 ( Pt 1):191-9 pubmed
    ..We conclude that the expression of Muc-1 is regulated at several different levels and by a number of different factors. We speculate that this may reflect different functional roles for Muc-1 at different stages of mammary development. ..
  6. Kato K, Lillehoj E, Park Y, Umehara T, Hoffman N, Madesh M, et al. Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88. J Immunol. 2012;188:2014-22 pubmed publisher
    b>MUC1 is a membrane-tethered mucin glycoprotein expressed on the apical surface of mucosal epithelial cells. Previous in vivo and in vitro studies established that MUC1 counterregulates airway inflammation by suppressing TLR signaling...
  7. Lynn F, Sanchez L, Gomis R, German M, Gasa R. Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network. PLoS ONE. 2008;3:e2430 pubmed publisher
  8. Perez S, Cano D, Dao Pick T, Rougier J, Werb Z, Hebrok M. Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes. 2005;54:694-701 pubmed
    ..However, islet formation is unaffected in transgenic mice with modified tissue inhibitor of metalloproteinase-1 (TIMP1) levels, suggesting that MMP activity may contribute little to islet morphogenesis in vivo. ..
  9. Ng G, Sutton P. The MUC1 mucin specifically inhibits activation of the NLRP3 inflammasome. Genes Immun. 2016;17:203-6 pubmed publisher
    b>MUC1 is a cell membrane-associated mucin, expressed ubiquitously on the mucosal epithelia as well as by immune cells, that limits the inflammatory response to multiple pathogens...
  10. Al Bataineh M, Kinlough C, Poland P, Pastor Soler N, Sutton T, Mang H, et al. Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2016;310:F569-79 pubmed publisher
    ..b>Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol 308: F1452-F1462, 2015)...
  11. Shalom Barak T, Nicholas J, Wang Y, Zhang X, Ong E, Young T, et al. Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts. Mol Cell Biol. 2004;24:10661-9 pubmed
    ..Here, we show that the mucin gene Muc1 is a PPARgamma target, whose expression is lost in PPARgamma null placentas...
  12. Gaudier E, Rival M, Buisine M, Robineau I, Hoebler C. Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon. Physiol Res. 2009;58:111-9 pubmed
    ..We demonstrated that butyrate stimulated the gene expression of both secreted (Muc2) and membrane-linked (Muc1, Muc3, Muc4) mucins. Butyrate especially induced a 6-fold increase in Muc2 gene expression in proximal colon...
  13. Sahraei M, Roy L, Curry J, Teresa T, Nath S, Besmer D, et al. MUC1 regulates PDGFA expression during pancreatic cancer progression. Oncogene. 2012;31:4935-45 pubmed publisher
    Pancreatic ductal adenocarcinoma (PDA) has one of the worst prognoses of all cancers. Mucin 1 (MUC1), a transmembrane mucin glycoprotein, is a key modulator of several signaling pathways that affect oncogenesis, motility and metastasis...
  14. Hendley A, Provost E, Bailey J, WANG Y, Cleveland M, Blake D, et al. p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015;399:41-53 pubmed publisher
    ..Taken together, our data demonstrate an essential role for p120 catenin in pancreas development. ..
  15. Choi S, Park Y, Koga T, Treloar A, Kim K. TNF-? is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol. 2011;44:255-60 pubmed publisher
    b>Muc1 is a heterodimeric mucin that is expressed on the apical surface of airway epithelial cells as well as hematopoietic cells...
  16. Li Y, Yi H, Yao Y, Liao X, Xie Y, Yang J, et al. The cytoplasmic domain of MUC1 induces hyperplasia in the mammary gland and correlates with nuclear accumulation of ?-catenin. PLoS ONE. 2011;6:e19102 pubmed publisher
    b>MUC1 is an oncoprotein that is overexpressed in up to 90% of breast carcinomas...
  17. Soares M, Mehta V, Finn O. Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection. J Immunol. 2001;166:6555-63 pubmed
    Low-frequency CTL and low-titer IgM responses against tumor-associated Ag MUC1 are present in cancer patients but do not prevent cancer growth...
  18. Koido S, Tanaka Y, Chen D, Kufe D, Gong J. The kinetics of in vivo priming of CD4 and CD8 T cells by dendritic/tumor fusion cells in MUC1-transgenic mice. J Immunol. 2002;168:2111-7 pubmed
    ..injection or the kinetics of CD4+ and CD8+ T cell activation. In the present study, fluorescence-labeled dendritic/MUC1-positive tumor fusion cells (FC/MUC1) were injected s.c. into MUC1-transgenic mice...
  19. Shiraga T, Smith D, Nuthall H, Hollingsworth M, Harris A. Identification of two novel elements involved in human MUCI gene expression in vivo. Mol Med. 2002;8:33-41 pubmed
    b>MUC1, a membrane-tethered glycoprotein that is expressed on a number of epithelial cell types in vivo, is over-expressed in adenocarcinomas and thought to play a significant role in tumour progression and metastasis...
  20. Phillipson M, Johansson M, Henriksnäs J, Petersson J, Gendler S, Sandler S, et al. The gastric mucus layers: constituents and regulation of accumulation. Am J Physiol Gastrointest Liver Physiol. 2008;295:G806-12 pubmed publisher
    ..Mucus thickness was measured in vivo with micropipettes in anesthetized mice [isoflurane; C57BL/6, Muc1-/-, inducible nitric oxide synthase (iNOS)-/-, and neuronal NOS (nNOS)-/-] and rats (inactin) after surgical ..
  21. Nishida A, Lau C, Zhang M, Andoh A, Shi H, Mizoguchi E, et al. The membrane-bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice. Gastroenterology. 2012;142:865-874.e2 pubmed publisher
    ..interleukin (IL)-17, along with IL-22, which stimulates colonic epithelial cells to produce a membrane-bound mucin, Muc1. Muc1 is a component of the colonic mucus, which functions as a lubricant and a physiologic barrier between luminal ..
  22. Hillman G, Reich L, Rothstein S, Abernathy L, Fountain M, Hankerd K, et al. Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen. J Immunother Cancer. 2017;5:4 pubmed publisher
    ..To investigate whether tumor irradiation augments the immune response to MUC1 tumor antigen, we have tested the efficacy of tumor irradiation combined with an MVA-MUC1-IL2 cancer vaccine (..
  23. Dharmaraj N, Gendler S, Carson D. Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model. Biol Reprod. 2009;81:1182-8 pubmed publisher
    ..b>MUC1, a transmembrane mucin expressed at the apical surface of uterine epithelia, acts as a barrier to microbial ..
  24. Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger B, et al. Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology. 2009;136:2325-33 pubmed publisher
    ..In the embryo, hepatoblasts differentiate to cholangiocytes, which give rise to the bile ducts. Here, we investigated duct development in mouse liver and characterized the role of the SRY-related HMG box transcription factor 9 (SOX9)...
  25. Hick A, van Eyll J, Cordi S, Forez C, Passante L, Kohara H, et al. Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1. BMC Dev Biol. 2009;9:66 pubmed publisher
    ..Our data also suggest that SDF-1 controls the branching morphogenesis of several exocrine tissues. ..
  26. Wang H, Afdhal N, Gendler S, Wang D. Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation. J Lipid Res. 2004;45:438-47 pubmed
    ..To study whether mucin gene 1 (Muc1) influences susceptibility to cholesterol cholelithiasis, we investigated male Muc1-deficient (Muc1(-/-)) and wild-..
  27. Mailleux A, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge J. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007;12:221-34 pubmed
    ..These data provide important mechanistic information on the processes involved in sculpting the mammary gland and demonstrate that BIM is a critical regulator of apoptosis in vivo. ..
  28. Braga V, Pemberton L, Duhig T, Gendler S. Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development. Development. 1992;115:427-37 pubmed
    ..However, it remains to be established using in vitro systems, whether the temporal and local expression of the Muc-1 gene coincident with the morphogenetic events described here is relevant for the process. ..
  29. Ng G, Menheniott T, Every A, Stent A, Judd L, Chionh Y, et al. The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome. Gut. 2016;65:1087-99 pubmed publisher
    The mucin MUC1, best known for providing an epithelial barrier, is an important protective host factor in both humans and mice during Helicobacter pylori pathogenesis...
  30. Zhang K, Wang J, Jiang H, Xu X, Wang S, Zhang C, et al. Tanshinone IIA inhibits lipopolysaccharide-induced MUC1 overexpression in alveolar epithelial cells. Am J Physiol Cell Physiol. 2014;306:C59-65 pubmed publisher
    ..b>Mucin 1 (Muc1) plays important anti-inflammatory roles in resolution of acute lung inflammation...
  31. Banerjee D, Fernandez H, Patil P, Premaratne P, Quiding Järbrink M, Lindén S. Epithelial MUC1 promotes cell migration, reduces apoptosis and affects levels of mucosal modulators during acetylsalicylic acid (aspirin)-induced gastropathy. Biochem J. 2015;465:423-31 pubmed publisher
    b>MUC1 is a transmembrane mucin highly expressed in the stomach. Although extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited...
  32. Kato K, Zemskova M, Hanss A, Kim M, Summer R, Kim K. Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis. Biochem Biophys Res Commun. 2017;493:1230-1235 pubmed publisher
    b>MUC1 (MUC in human and Muc in animals) is a membrane-tethered mucin expressed on the apical surface of lung epithelial cells...
  33. Shalom Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy J, Xu J, et al. Placental PPAR? regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012;372:143-55 pubmed publisher
    ..These findings offer insights not only into the placental functions of PPAR?, but also into unique, previously unsuspected biosynthetic functions of trophoblasts. ..
  34. Every A, Chionh Y, Skene C, McGuckin M, Sutton P. Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection. Helicobacter. 2008;13:489-93 pubmed publisher
    The mucin Muc1 is constitutively expressed by the gastric mucosa and is likely the first point of direct contact between the host stomach and the adherent pathogens...
  35. Magenheim J, Klein A, Stanger B, Ashery Padan R, Sosa Pineda B, Gu G, et al. Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol. 2011;359:26-36 pubmed publisher
    ..These results uncover a novel layer of regulation coordinating pancreas morphogenesis and endocrine/exocrine differentiation, and suggest ways to enhance the yield of beta cells from stem cells. ..
  36. Desai T, Brownfield D, Krasnow M. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014;507:190-4 pubmed publisher
    ..We propose that local signals regulate AT2 stem-cell activity: a signal transduced by EGFR-KRAS controls self-renewal and is hijacked during oncogenesis, whereas another signal controls reprogramming to AT1 fate. ..
  37. Menon B, Kaiser Marko C, Spurr Michaud S, Tisdale A, Gipson I. Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16. Mucosal Immunol. 2015;8:1000-8 pubmed publisher
    ..In this study, the hypothesis that the MAMs MUC1 and MUC16, expressed on the apical surface of the corneal epithelium, suppress Toll-like receptor (TLR)-mediated ..
  38. Kim Y, Gum J. Diversity of mucin genes, structure, function, and expression. Gastroenterology. 1995;109:999-1001 pubmed
  39. Marty Santos L, Cleaver O. Pdx1 regulates pancreas tubulogenesis and E-cadherin expression. Development. 2016;143:101-12 pubmed publisher
    ..These findings demonstrate a novel link between regulators of epithelial architecture, specification of pancreatic cell fate and organogenesis. ..
  40. Kim B, Woo J, Kanellopoulou C, Shivdasani R. Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development. 2011;138:1081-6 pubmed publisher
    ..These results indicate that miRNAs are required for proper digestive tract organogenesis and that miR-7a and miR-203 control expression of the stomach homeotic regulator Barx1. ..
  41. Williams M, Bauer S, Lu W, Guo J, Walter S, Bushnell T, et al. Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands. J Innate Immun. 2010;2:123-43 pubmed publisher
    ..b>Muc1 is the only cell surface mucin or MUC gene product that is expressed in DC...
  42. Li Y, Dinwiddie D, Harrod K, Jiang Y, Kim K. Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2010;298:L558-63 pubmed publisher
    b>MUC1 is a transmembrane glycoprotein expressed on the apical surface of airway epithelial cells and plays an anti-inflammatory role during airway bacterial infection...
  43. Bonal C, Thorel F, Ait Lounis A, Reith W, Trumpp A, Herrera P. Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology. 2009;136:309-319.e9 pubmed publisher
  44. Spicer A, Parry G, Patton S, Gendler S. Molecular cloning and analysis of the mouse homologue of the tumor-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism. J Biol Chem. 1991;266:15099-109 pubmed
    ..here the full-length cDNA sequence and genomic structure of the mouse homologue of the tumor-associated mucin, MUC1. This mucin (previously called polymorphic epithelial mucin) is present at the apical surface of most glandular ..
  45. Vos H, de Vries Y, Hilkens J. The mouse episialin (Muc1) gene and its promoter: rapid evolution of the repetitive domain in the protein. Biochem Biophys Res Commun. 1991;181:121-30 pubmed
    We have cloned the Muc1 gene of the mouse, encoding the murine equivalent of human episialin (also known as EMA or PEM), a mucin-like glycoprotein that is overexpressed in carcinoma cells...
  46. Sand F, Hörnblad A, Johansson J, Lorén C, Edsbagge J, Ståhlberg A, et al. Growth-limiting role of endothelial cells in endoderm development. Dev Biol. 2011;352:267-77 pubmed publisher
    ..Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs. ..
  47. Mukherjee P, Ginardi A, Madsen C, Sterner C, Adriance M, Tevethia M, et al. Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred. J Immunol. 2000;165:3451-60 pubmed
    ..In humans, 90% of pancreatic adenocarcinomas overexpress altered forms of a tumor-specific Ag, mucin 1 (MUC1; an epithelial mucin glycoprotein), which is a potential target for immunotherapy...
  48. Carrasco M, Delgado I, Soria B, Martin F, Rojas A. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012;122:3504-15 pubmed publisher
    ..Our results place GATA factors at the top of the transcriptional network hierarchy controlling pancreas organogenesis...
  49. Seymour P, Freude K, Tran M, Mayes E, Jensen J, Kist R, et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007;104:1865-70 pubmed
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies. ..
  50. Surveyor G, Gendler S, Pemberton L, Das S, Chakraborty I, Julian J, et al. Expression and steroid hormonal control of Muc-1 in the mouse uterus. Endocrinology. 1995;136:3639-47 pubmed
    ..Collectively, these data indicate that Muc-1 expression in mouse uterine epithelium is strongly influenced by ovarian steroids. It is suggested that the loss of Muc-1 contributes to generation of a receptive uterine state. ..
  51. Chaika N, Gebregiworgis T, Lewallen M, Purohit V, Radhakrishnan P, Liu X, et al. MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. Proc Natl Acad Sci U S A. 2012;109:13787-92 pubmed publisher
    ..Here, we demonstrate that MUC1, a large, type I transmembrane protein that is overexpressed in several carcinomas including pancreatic ..
  52. Magenheim J, Ilovich O, Lazarus A, Klochendler A, Ziv O, Werman R, et al. Blood vessels restrain pancreas branching, differentiation and growth. Development. 2011;138:4743-52 pubmed publisher
    ..The effects are seen both in vivo and ex vivo, indicating a perfusion-independent mechanism. Thus, the vasculature controls pancreas morphogenesis and growth by reducing branching and differentiation of primitive epithelial cells. ..
  53. Bondow B, Faber M, Wojta K, Walker E, Battle M. E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 2012;371:1-12 pubmed publisher
    ..In summary, our data demonstrate that E-cadherin is essential for intestinal epithelial morphogenesis and homeostasis during embryonic development. ..
  54. Comelli E, Simmering R, Faure M, Donnicola D, Mansourian R, Rochat F, et al. Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota. Genomics. 2008;91:70-7 pubmed
    ..These findings show that a well-established microbial community participates in the regulation of the gut mucus layer and that its composition and adequacy to the host are key factors in this process. ..
  55. Saeki N, Sakamoto H, Yoshida T. Mucin 1 gene (MUC1) and gastric-cancer susceptibility. Int J Mol Sci. 2014;15:7958-73 pubmed publisher
    ..GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein...
  56. Jayewickreme C, Shivdasani R. Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015;405:21-32 pubmed publisher
    ..The sum of evidence suggests that potent BARX1 functions in intestinal rotation and stomach myogenesis occur through this small group of intermediary transcription factors. ..
  57. Sugiura D, Aida S, Denda Nagai K, Takeda K, Kamata Sakurai M, Yagita H, et al. Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases. Cancer Sci. 2008;99:2477-84 pubmed publisher
    The effects of MUC1 DNA vaccination on the orthotopic growth and liver metastasis of colon carcinoma cells were investigated in mice...
  58. Kopinke D, Murtaugh L. Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol. 2010;10:38 pubmed publisher
    ..cells, comprising the exocrine pancreas, can be genetically marked by virtue of their expressing the mucin gene Muc1. Using these mice, we performed time-specific lineage tracing to determine if these cells undergo endocrine ..
  59. Budiu R, Diaconu I, Chrissluis R, Dricu A, Edwards R, Vlad A. A conditional mouse model for human MUC1-positive endometriosis shows the presence of anti-MUC1 antibodies and Foxp3+ regulatory T cells. Dis Model Mech. 2009;2:593-603 pubmed publisher
    ..We postulated that the mucin 1 (MUC1) glycoprotein, which is normally present on eutopic human endometrial glands and overexpressed in ..
  60. Wang S, Jensen J, Seymour P, Hsu W, Dor Y, Sander M, et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A. 2009;106:9715-20 pubmed publisher
    ..These findings demonstrate that Neurog3 is required not only for initiating endocrine cell differentiation, but also for promoting islet cell maturation and maintaining islet function. ..
  61. Van Klinken B, Dekker J, Buller H, Einerhand A. Mucin gene structure and expression: protection vs. adhesion. Am J Physiol. 1995;269:G613-27 pubmed
    ..However, when an opposing cell has specific receptors for mucins, adhesion can override the barrier function. Therefore, mucins may be powerful two-edged swords: they are both protective and adhesive...
  62. Sheng Y, Triyana S, Wang R, Das I, Gerloff K, Florin T, et al. MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunol. 2013;6:557-68 pubmed publisher
    The MUC1 cell-surface mucin is highly expressed on the gastric mucosal surface, while MUC13 is highly expressed on the intestinal mucosal surface. Polymorphisms in both MUC1 and MUC13 have been linked to inflammatory bowel diseases...
  63. Tanida S, Akita K, Ishida A, Mori Y, Toda M, Inoue M, et al. Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of ?-catenin and subsequent cell growth. J Biol Chem. 2013;288:31842-52 pubmed publisher
    Because MUC1 carries a variety of sialoglycans that are possibly recognized by the siglec family, we examined MUC1-binding siglecs and found that Siglec-9 prominently bound to MUC1...
  64. Wang P, Dharmaraj N, Brayman M, Carson D. Peroxisome proliferator-activated receptor gamma activation inhibits progesterone-stimulated human MUC1 expression. Mol Endocrinol. 2010;24:1368-79 pubmed publisher
    b>Mucin 1 (MUC1) is a type I transmembrane glycoprotein abundantly expressed on nearly all epithelial tissues and overexpressed by many cancer cells...
  65. Banerjee S, Mujumdar N, Dudeja V, Mackenzie T, Krosch T, Sangwan V, et al. MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization. PLoS ONE. 2012;7:e43020 pubmed publisher
    b>MUC1 is a type I transmembrane glycoprotein aberrantly overexpressed in various cancer cells including pancreatic cancer. The cytosolic end of MUC1 (MUC1-c) is extensively involved in a number of signaling pathways...
  66. Bechard M, Bankaitis E, Hipkens S, Ustione A, Piston D, Yang Y, et al. Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells. Genes Dev. 2016;30:1852-65 pubmed publisher
    ..We propose that Sox9(+) Neurog3(TA.LO) endocrine-biased progenitors feed production of Neurog3(HI) endocrine-committed cells during pancreas organogenesis. ..
  67. Zhang L, Ma T, Brozick J, Babalola K, Budiu R, Tseng G, et al. Effects of Kras activation and Pten deletion alone or in combination on MUC1 biology and epithelial-to-mesenchymal transition in ovarian cancer. Oncogene. 2016;35:5010-20 pubmed publisher
    Mucin1 (MUC1) is an epithelial glycoprotein overexpressed in ovarian cancer and actively involved in tumor cell migration and metastasis...
  68. Nair R, Kerätär J, Autio K, Masud A, Finnilä M, Autio Harmainen H, et al. Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Hum Mol Genet. 2017;26:2104-2117 pubmed publisher
    ..We conclude that disrupted mtFAS leads to deficiency in mitochondrial respiration, which lies at the root of the observed pantropic effects on embryonic and placental development in these mouse models. ..
  69. Verzi M, Khan A, Ito S, Shivdasani R. Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 2008;135:591-600 pubmed publisher
    ..This study is the first to implicate a transcription factor in terminal differentiation of foveolar cells and begins to define the requirements to assemble highly specialized organelles and cells in the gastric mucosa. ..
  70. Julian J, Dharmaraj N, Carson D. MUC1 is a substrate for gamma-secretase. J Cell Biochem. 2009;108:802-15 pubmed publisher
    Understanding the underlying mechanisms by which a normal cell avoids the oncogenic potential of MUC1 signaling requires further definition of the pathways by which the MUC1 cytoplasmic tail is processed in both normal and tumor-derived ..
  71. Petersson J, Schreiber O, Hansson G, Gendler S, Velcich A, Lundberg J, et al. Importance and regulation of the colonic mucus barrier in a mouse model of colitis. Am J Physiol Gastrointest Liver Physiol. 2011;300:G327-33 pubmed publisher
    ..The colon of anesthetized Muc2(-/-), Muc1(-/-), wild-type (wt), and germ-free mice was exteriorized, the mucosal surface was visualized, and mucus thickness ..
  72. Hahn K, Beres B, Rowton M, Skinner M, Chang Y, Rawls A, et al. A deficiency of lunatic fringe is associated with cystic dilation of the rete testis. Reproduction. 2009;137:79-93 pubmed publisher
    ..Further, the dye studies demonstrated that many lunatic fringe mutant males had partial blocks of the connection between the rete testis and the efferent ducts bilaterally. ..
  73. Ueno K, Koga T, Kato K, Golenbock D, Gendler S, Kai H, et al. MUC1 mucin is a negative regulator of toll-like receptor signaling. Am J Respir Cell Mol Biol. 2008;38:263-8 pubmed
    b>MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells...
  74. Horn S, Kobberup S, Jørgensen M, Kalisz M, Klein T, Kageyama R, et al. Mind bomb 1 is required for pancreatic ?-cell formation. Proc Natl Acad Sci U S A. 2012;109:7356-61 pubmed publisher
    ..Our results reveal iterative use of Notch in pancreatic development to ensure correct P-D patterning and adequate ?-cell formation. ..
  75. Inyawilert W, Fu T, Lin C, Tang P. Let-7-mediated suppression of mucin 1 expression in the mouse uterus during embryo implantation. J Reprod Dev. 2015;61:138-44 pubmed publisher
    b>Mucin 1 (Muc1) is an integral transmembrane mucin glycoprotein expressed on the apical surface of most epithelia...
  76. Malmberg E, Noaksson K, Phillipson M, Johansson M, Hinojosa Kurtzberg M, Holm L, et al. Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression. Am J Physiol Gastrointest Liver Physiol. 2006;291:G203-10 pubmed
    The mouse model (Cftr(tm1UNC)/Cftr(tm1UNC)) for cystic fibrosis (CF) shows mucus accumulation and increased Muc1 mucin mRNA levels due to altered splicing (Hinojosa-Kurtzberg AM, Johansson MEV, Madsen CS, Hansson GC, and Gendler SJ...
  77. Jiang H, Przybyszewski J, Mitra D, Becker C, Brehm Stecher B, Tentinger A, et al. Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-? in colon of dextran sodium sulfate-treated C57BL/6 mice. J Nutr. 2011;141:1239-46 pubmed publisher
    ..Whey protein significantly increased cecal LGG content compared with the other diets. In the casein diet groups, MUC1 and TFF-3 expression in colon was significantly induced by DSS independent of LGG...
  78. Pochampalli M, Bitler B, Schroeder J. Transforming growth factor alpha dependent cancer progression is modulated by Muc1. Cancer Res. 2007;67:6591-8 pubmed
    ..Previous studies in our laboratory showed that EGFR could also be affected by the glycoprotein MUC1, which inhibits ligand-stimulated degradation of EGFR in breast epithelial cell lines...
  79. Kardon R, Price R, Julian J, Lagow E, Tseng S, Gendler S, et al. Bacterial conjunctivitis in Muc1 null mice. Invest Ophthalmol Vis Sci. 1999;40:1328-35 pubmed
    In contrast to wild-type mice, genetically engineered Mucin1 (Muc1) null animals display a marked propensity for development of blepharitis and conjunctivitis...
  80. Georgia S, Kanji M, Bhushan A. DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013;27:372-7 pubmed publisher
    ..We show that DNMT1 is bound to the p53 regulatory region and that loss of Dnmt1 results in derepression of the p53 locus. Haploinsufficiency of p53 rescues progenitor cell survival and cellular makeup of the Dnmt1-deleted pancreas. ..
  81. Johansson J, Voss U, Kesavan G, Kostetskii I, Wierup N, Radice G, et al. N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis. 2010;48:374-81 pubmed publisher
    ..The number of insulin secretory granules is significantly reduced in N-cadherin-deficient beta-cells, and as a consequence insulin secretion is decreased. ..
  82. Tirodkar T, Budiu R, Elishaev E, Zhang L, Mony J, Brozick J, et al. MUC1 positive, Kras and Pten driven mouse gynecologic tumors replicate human tumors and vary in survival and nuclear grade based on anatomical location. PLoS ONE. 2014;9:e102409 pubmed publisher
    ..The triple transgenic mice, briefly called MUC1KrasPten, express human MUC1 antigen as self and carry a silent oncogenic KrasG12D and Pten deletion mutation...
  83. Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, et al. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017;114:4816-4821 pubmed publisher
    ..Besides uncovering a regulatory mechanism, this study could be clinically relevant to dysfunctional ERα-caused endometrial disorders in women. ..
  84. Tomioka Y, Morimatsu M, Nishijima K, Usui T, Yamamoto S, Suyama H, et al. A soluble form of Siglec-9 provides an antitumor benefit against mammary tumor cells expressing MUC1 in transgenic mice. Biochem Biophys Res Commun. 2014;450:532-7 pubmed publisher
    Tumor-associated MUC1 binds to Siglec-9, which is expected to mediate tumor cell growth and negative immunomodulation...