Mttp

Summary

Gene Symbol: Mttp
Description: microsomal triglyceride transfer protein
Alias: 1810043K16Rik, MTP, microsomal triglyceride transfer protein large subunit, microsomal triglyceride transfer protein B, microsomal triglyceride transfer protein, large subunit
Species: mouse
Products:     Mttp

Top Publications

  1. Mohler P, Zhu M, Blade A, Ham A, Shelness G, Swift L. Identification of a novel isoform of microsomal triglyceride transfer protein. J Biol Chem. 2007;282:26981-8 pubmed
    Microsomal triglyceride transfer protein (MTP) has been studied extensively, primarily because of its role in the assembly of very low density lipoproteins by the liver and chylomicrons by the intestine...
  2. Hussain M, Rava P, Pan X, Dai K, Dougan S, Iqbal J, et al. Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr Opin Lipidol. 2008;19:277-84 pubmed publisher
    ..More knowledge is required, however, regarding its regulation and its role in the biosynthesis of apoB-containing lipoproteins and CD1d. ..
  3. Feig J, PARATHATH S, Rong J, Mick S, Vengrenyuk Y, Grauer L, et al. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation. 2011;123:989-98 pubmed publisher
    ..After lipid lowering, favorable changes in plaque composition were independent of changes in size. In addition, plaque CD68(+) cells became less inflammatory, an effect enhanced by treatment with pioglitazone. ..
  4. Terasawa Y, Cases S, Wong J, Jamil H, Jothi S, Traber M, et al. Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res. 1999;40:1967-77 pubmed
    ..be essential for this function: embryos lacking apolipoprotein (apo) B or microsomal triglyceride transfer protein (MTP), both of which participate in the assembly of triglyceride-rich lipoproteins, are apparently defective in their ..
  5. Björkegren J, Hägg S, Talukdar H, Foroughi Asl H, Jain R, Cedergren C, et al. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet. 2014;10:e1004201 pubmed publisher
    ..In atherosclerotic aortic wall from Ldlr(-/-)Apob (100/100) Mttp (flox/flox)Mx1-Cre mice, atherosclerosis regressed after PCL regardless of lesion stage...
  6. Lieu H, Withycombe S, Walker Q, Rong J, Walzem R, Wong J, et al. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation. 2003;107:1315-21 pubmed
    ..We bred Ldlr-/-Apob100/100 mice that were homozygous for a conditional allele for Mttp (the gene for microsomal triglyceride transfer protein) and the inducible Mx1-Cre transgene...
  7. Nakamuta M, Chang B, Hoogeveen R, Li W, Chan L. Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression and chromosomal localization. Genomics. 1996;33:313-6 pubmed
    Microsomal triglyceride transfer protein (MTP) catalyzes the transfer of triglyceride, cholesteryl ester, and phospholipid between membranes. It is essential for the secretion of apolipoprotein B from the cell...
  8. Skogsberg J, Lundström J, Kovacs A, Nilsson R, Noori P, Maleki S, et al. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet. 2008;4:e1000036 pubmed publisher
    ..mice with human-like hypercholesterolemia and a genetic switch to lower plasma lipoproteins (Ldlr(-/-)Apo(100/100)Mttp(flox/flox) Mx1-Cre)...
  9. Parathath S, Grauer L, Huang L, Sanson M, Distel E, Goldberg I, et al. Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes. 2011;60:1759-69 pubmed publisher
    ..Diabetes hindered plaque regression in atherosclerotic mice (based on CD68+ plaque content) and favorable changes in plaque macrophage characteristics after the reduction of elevated plasma LDL. ..

More Information

Publications79

  1. Dougan S, Rava P, Hussain M, Blumberg R. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med. 2007;204:533-45 pubmed
    Microsomal triglyceride transfer protein (MTP), an endoplasmic reticulum lipid transfer protein critical for apolipoprotein B (apoB) secretion, regulates CD1d antigen presentation...
  2. Xie Y, Kennedy S, Sidhu R, Luo J, Ory D, Davidson N. Liver X receptor agonist modulation of cholesterol efflux in mice with intestine-specific deletion of microsomal triglyceride transfer protein. Arterioscler Thromb Vasc Biol. 2012;32:1624-31 pubmed publisher
    ..those conclusions in mice with intestine-specific deletion of the microsomal triglyceride transfer protein (MTTP-IKO), where chylomicron formation is eliminated...
  3. Dominguez J, Xie Y, Dunne W, Yoseph B, Burd E, Coopersmith C, et al. Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia. PLoS ONE. 2012;7:e49159 pubmed publisher
    ..of sepsis in mice with conditional, intestine-specific deletion of microsomal triglyceride transfer protein (Mttp-IKO), which exhibit a block in chylomicron assembly together with lipid malabsorption...
  4. Xie Y, Newberry E, Young S, Robine S, Hamilton R, Wong J, et al. Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. J Biol Chem. 2006;281:4075-86 pubmed
    Microsomal TG transfer protein (MTTP) is required for the assembly and secretion of TG (TG)-rich lipoproteins from both enterocytes and hepatocytes...
  5. Améen C, Edvardsson U, Ljungberg A, Asp L, Akerblad P, Tuneld A, et al. Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver. J Biol Chem. 2005;280:1224-9 pubmed
    Microsomal triglyceride transfer protein (MTP) is rate-limiting in the assembly and secretion of lipoproteins containing apolipoprotein (apo) B...
  6. Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, et al. CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med. 2004;10:535-9 pubmed
    ..Hepatocytes from animals in which Mttp (the gene encoding MTP) has been conditionally deleted, and IECs in which Mttp gene products have been silenced, ..
  7. Raabe M, Flynn L, Zlot C, Wong J, Veniant M, Hamilton R, et al. Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes. Proc Natl Acad Sci U S A. 1998;95:8686-91 pubmed
    ..We used gene targeting to knock out the mouse MTP gene (Mttp)...
  8. Bjorkegren J, Veniant M, Kim S, Withycombe S, Wood P, Hellerstein M, et al. Lipoprotein secretion and triglyceride stores in the heart. J Biol Chem. 2001;276:38511-7 pubmed
    ..Thus, heart lipoprotein secretion helps regulate cardiac triglyceride stores and may protect the heart from the detrimental effects of surplus lipids. ..
  9. Raabe M, Veniant M, Sullivan M, Zlot C, Bjorkegren J, Nielsen L, et al. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest. 1999;103:1287-98 pubmed
    ..To define MTP's role in hepatic lipoprotein assembly, we recently knocked out the mouse MTP gene (Mttp). Unfortunately, achieving our objective was thwarted by a lethal embryonic phenotype...
  10. Sparks J, Sparks C. Overindulgence and metabolic syndrome: is FoxO1 a missing link?. J Clin Invest. 2008;118:2012-5 pubmed publisher
    ..VLDL assembly in the liver is catalyzed by microsomal triglyceride transfer protein (MTP). In this issue of the JCI, Kamagate et al...
  11. Iqbal J, Rudel L, Hussain M. Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem. 2008;283:19967-80 pubmed publisher
    ..of apoB lipoproteins, the assembly of which is critically dependent on microsomal triglyceride transfer protein (MTP)...
  12. Skogsberg J, Dicker A, Ryden M, Aström G, Nilsson R, Bhuiyan H, et al. ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes. PLoS ONE. 2008;3:e3771 pubmed publisher
    ..Thus, apoB100-LDL is a novel signaling molecule from the liver to peripheral fat deposits that may be an important link between atherogenic dyslipidemias and facets of the metabolic syndrome. ..
  13. Liao W, Hui T, Young S, Davis R. Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER. J Lipid Res. 2003;44:978-85 pubmed
    Microsomal triglyceride transfer protein (MTP) is an intraluminal protein in the endoplasmic reticulum (ER) that is essential for the assembly of apolipoprotein B (apoB)-containing lipoproteins...
  14. Wang W, Vootukuri S, Meyer A, Ahamed J, Coller B. Association between shear stress and platelet-derived transforming growth factor-?1 release and activation in animal models of aortic valve stenosis. Arterioscler Thromb Vasc Biol. 2014;34:1924-32 pubmed publisher
    ..We studied hypercholesterolemic Ldlr(-/-)Apob(100/100)/Mttp(fl/fl)/Mx1Cre(+/+) (Reversa) mice that develop AS on Western diet and a surgical ascending aortic constriction ..
  15. Kulinski A, Rustaeus S, Vance J. Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J Biol Chem. 2002;277:31516-25 pubmed
    ..assembly of very low density lipoproteins in hepatocytes requires the microsomal triacylglycerol transfer protein (MTP)...
  16. Miller J, Chu Y, Castaneda L, Serrano K, Brooks R, Heistad D. Vascular function during prolonged progression and regression of atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2013;33:459-65 pubmed publisher
    ..Both of these changes can be prevented by normalizing blood lipids during moderately severe or advanced atherosclerosis. ..
  17. Contos J, Chun J. The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene. 2001;267:243-53 pubmed
    ..Our results indicate both overlapping as well as distinct functions of lp(A1), lp(A2), and lp(A3). ..
  18. Iqbal J, Parks J, Hussain M. Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice. J Biol Chem. 2013;288:30432-44 pubmed publisher
    ..Intestinal deletions of Mttp and Abca1 decreased plasma cholesterol concentrations by 45 and 24%, respectively, whereas their combined deletion ..
  19. Hooper A, Burnett J, Watts G. Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein. Circ Res. 2015;116:193-205 pubmed publisher
    The microsomal triglyceride transfer protein (MTP), the product of the MTTP gene, is essential for the assembly and secretion of apolipoprotein B-containing lipoproteins, but when defective causes abetalipoproteinemia...
  20. Stefano J, de Oliveira C, Correa Giannella M, de Lima V, de Sa S, de Oliveira E, et al. Nonalcoholic steatohepatitis (NASH) in ob/ob mice treated with yo jyo hen shi ko (YHK): effects on peroxisome proliferator-activated receptors (PPARs) and microsomal triglyceride transfer protein (MTP). Dig Dis Sci. 2007;52:3448-54 pubmed
    ..In this study, we examined the hepatic expression of PPAR-alpha and -gamma and MTP in ob/ob mice receiving or not receiving YHK...
  21. Pan X, Munshi M, Iqbal J, Queiroz J, Sirwi A, Shah S, et al. Circadian regulation of intestinal lipid absorption by apolipoprotein AIV involves forkhead transcription factors A2 and O1 and microsomal triglyceride transfer protein. J Biol Chem. 2013;288:20464-76 pubmed publisher
    We have shown previously that Clock, microsomal triglyceride transfer protein (MTP), and nocturnin are involved in the circadian regulation of intestinal lipid absorption...
  22. Shindo N, Fujisawa T, Sugimoto K, Nojima K, Oze Fukai A, Yoshikawa Y, et al. Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model. J Hepatol. 2010;52:903-12 pubmed publisher
    ..Using vector-mediated hepatic expression of microsomal triglyceride transfer protein (MTP), a key molecule for very low density lipoprotein (VLDL) assembly and export, its contribution to the hepatic ..
  23. Swift L, Kakkad B, Boone C, Jovanovska A, Jerome W, Mohler P, et al. Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolism. FEBS Lett. 2005;579:3183-9 pubmed
    Microsomal triglyceride transfer protein (MTP) is a carrier of triglyceride essential for the assembly of apolipoprotein (apo)B-containing lipoproteins by the liver and the small intestine...
  24. Xie Y, Matsumoto H, Nalbantoglu I, Kerr T, Luo J, Rubin D, et al. Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer. PLoS ONE. 2013;8:e67819 pubmed publisher
    ..secretion and fat malabsorption, following intestine-specific deletion of microsomal triglyceride transfer protein (Mttp-IKO)...
  25. Larsson S, Skogsberg J, Björkegren J. The low density lipoprotein receptor prevents secretion of dense apoB100-containing lipoproteins from the liver. J Biol Chem. 2004;279:831-6 pubmed
    ..investigate the role of MTP and the LDL receptor in VLDL assembly, we bred mice harboring "floxed" Mttp alleles (Mttpflox/flox) and a Cre transgene on a low-density lipoprotein receptor-deficient background to generate ..
  26. López Parra M, Titos E, Horrillo R, Ferre N, González Périz A, Martínez Clemente M, et al. Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice. J Lipid Res. 2008;49:2513-23 pubmed publisher
    ..Furthermore, 5-LO inhibition restored hepatic microsomal TG transfer protein (MTP) activity in parallel with a stimulation of hepatic VLDL-TG and apoB secretion in ob/ob mice...
  27. Shelton J, Lee M, Richardson J, Patel S. Microsomal triglyceride transfer protein expression during mouse development. J Lipid Res. 2000;41:532-7 pubmed
    ..B (apoB, the major structural protein of secreted lipoproteins) and microsomal triglyceride transfer protein (MTP) whose normal activity is required for the secretion of apoB-containing lipoproteins...
  28. Pan X, Hussain M. Diurnal regulation of microsomal triglyceride transfer protein and plasma lipid levels. J Biol Chem. 2007;282:24707-19 pubmed
    ..Moreover, intestinal microsomal triglyceride transfer protein (MTP) activity, protein, mRNA, and gene transcription showed diurnal variations and were high at 2400 h...
  29. Iqbal J, Li X, Chang B, Chan L, Schwartz G, Chua S, et al. An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption. J Lipid Res. 2010;51:1929-42 pubmed publisher
    ..in the liver and intestine with the help of an intracellular chaperone, microsomal triglyceride transfer protein (MTP)...
  30. Josekutty J, Iqbal J, Iwawaki T, Kohno K, Hussain M. Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1?/cJun to enhance plasma ALT/AST. J Biol Chem. 2013;288:14372-83 pubmed publisher
    Microsomal triglyceride transfer protein (MTP) is a target to reduce plasma lipids because of its indispensable role in triglyceride-rich lipoprotein biosynthesis...
  31. Bartels E, Nielsen J, Hellgren L, Ploug T, Nielsen L. Cardiac expression of microsomal triglyceride transfer protein is increased in obesity and serves to attenuate cardiac triglyceride accumulation. PLoS ONE. 2009;4:e5300 pubmed publisher
    ..Lipoprotein formation depends on expression of microsomal triglyceride transfer protein (MTP); the mouse expresses two isoforms of MTP, A and B...
  32. Babeu J, Darsigny M, Lussier C, Boudreau F. Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation. Am J Physiol Gastrointest Liver Physiol. 2009;297:G124-34 pubmed publisher
  33. Beccari T, Bibi L, Stinchi S, Stirling J, Orlacchio A. Mouse beta-mannosidase: cDNA cloning, expression, and chromosomal localization. Biosci Rep. 2001;21:315-23 pubmed
    ..The mouse beta-mannosidase gene (Bmn) was mapped to the distal end of Chromosome (Chr) 3, in a region that is homologous with a segment of human Chr 4 containing the orthologous human gene. ..
  34. Chang B, Liao W, Li L, Nakamuta M, Mack D, Chan L. Liver-specific inactivation of the abetalipoproteinemia gene completely abrogates very low density lipoprotein/low density lipoprotein production in a viable conditional knockout mouse. J Biol Chem. 1999;274:6051-5 pubmed
    Conventional knockout of the microsomal triglyceride transfer protein large subunit (lMTP) gene is embryonic lethal in the homozygous state in mice...
  35. Soh J, Iqbal J, Queiroz J, Fernandez Hernando C, Hussain M. MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat Med. 2013;19:892-900 pubmed publisher
    ..Overproduction of lipoproteins, a process that is dependent on microsomal triglyceride transfer protein (MTP), can contribute to hyperlipidemia...
  36. Yarkov S, Mokrov G, Gudasheva T, Yarkova M, Seredenin S. [PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN LIGANDS]. Eksp Klin Farmakol. 2016;79:7-11 pubmed
    ..of new original 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamide derivatives with mitochondrial translocator protein (MTP) 18 kDa has been studied by radioligand binding assay. Compounds GML-1 (Ki = 5.2 x 10?? M) and GML-3 (Ki = 5...
  37. Björkegren J, Beigneux A, Bergo M, Maher J, Young S. Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J Biol Chem. 2002;277:5476-83 pubmed
    Recently, we generated mice lacking microsomal triglyceride transfer protein (MTP) in the liver (Mttp(Delta/Delta)) and demonstrated that very low density lipoprotein secretion from hepatocytes was almost completely blocked...
  38. Rector R, Morris E, Ridenhour S, Meers G, Hsu F, Turk J, et al. Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect. Hepatology. 2013;57:2213-23 pubmed publisher
    ..Here we used a murine model heterozygous (HET) for a mitochondrial trifunctional protein (MTP) gene defect to determine if a primary defect in mitochondrial long-chain fatty acid oxidation disrupts hepatic ..
  39. Wang F, Zhang X, Wang J, Chen M, Fan N, Ma Q, et al. LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver. J Mol Endocrinol. 2014;52:133-43 pubmed publisher
    ..Among the genes related to the lipid metabolism, we found that the diurnal expression pattern of the Mttp gene, which plays an important role in the regulation of plasma lipid levels, was impaired in Lgr4(m/m) mice and ..
  40. Teupser D, Tan M, Persky A, Breslow J. Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice. Proc Natl Acad Sci U S A. 2006;103:123-8 pubmed
    ..Awareness of these complexities may have major consequences for the identification of atherosclerosis susceptibility genes by quantitative trait locus mapping. ..
  41. Minehira Castelli K, Leonard S, Walker Q, Traber M, Young S. Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues. J Lipid Res. 2006;47:1733-8 pubmed
    ..tissues, we examined alpha-tocopherol metabolism in mice that lack microsomal triglyceride transfer protein (Mttp) expression in the liver and therefore cannot secrete VLDL (Mttp(Delta/Delta) mice)...
  42. Miller J, Weiss R, Serrano K, Castaneda L, Brooks R, Zimmerman K, et al. Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease. Arterioscler Thromb Vasc Biol. 2010;30:2482-6 pubmed publisher
  43. Li Z, Ding T, Pan X, Li Y, Li R, Sanders P, et al. Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression. J Biol Chem. 2012;287:20122-31 pubmed publisher
    ..Furthermore, these mice had higher microsomal triglyceride transfer protein (MTP) mRNA and protein levels...
  44. Xie Y, Fung H, Newberry E, Kennedy S, Luo J, Crooke R, et al. Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice. J Lipid Res. 2014;55:540-8 pubmed publisher
    ..Other studies demonstrated that liver-specific deletion of microsomal triglyceride transfer protein (Mttp-LKO) reduced LD-induced gallstone formation by increasing biliary phospholipid secretion...
  45. Pereira I, Stefano J, Oliveira C. Microsomal triglyceride transfer protein and nonalcoholic fatty liver disease. Expert Rev Gastroenterol Hepatol. 2011;5:245-51 pubmed publisher
    ..Liver lipid secretion is mediated by apoB100 and microsomal triglyceride transfer protein (MTP)...
  46. Rakhshandehroo M, Gijzel S, Siersbæk R, Broekema M, de Haar C, Schipper H, et al. CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein. J Biol Chem. 2014;289:22128-39 pubmed publisher
  47. DeBosch B, Heitmeier M, Mayer A, Higgins C, Crowley J, Kraft T, et al. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9:ra21 pubmed publisher
    ..Our data indicated that trehalose triggers beneficial cellular autophagy by inhibiting glucose transport. ..
  48. Swift L, Love J, Harris C, CHANG B, Jerome W. Microsomal triglyceride transfer protein contributes to lipid droplet maturation in adipocytes. PLoS ONE. 2017;12:e0181046 pubmed publisher
    Previous studies in our laboratory have established the presence of MTP in both white and brown adipose tissue in mice as well as in 3T3-L1 cells...
  49. Kim D, Zhang T, Lee S, Calabuig Navarro V, Yamauchi J, Piccirillo A, et al. FoxO6 integrates insulin signaling with MTP for regulating VLDL production in the liver. Endocrinology. 2014;155:1255-67 pubmed publisher
    ..correlated with the ability of FoxO6 to stimulate hepatic production of microsomal triglyceride transfer protein (MTP), a molecular chaperone that catalyzes the rate-limiting step in VLDL-TG assembly and secretion...
  50. Van Dyck F, Braem C, Chen Z, Declercq J, Deckers R, Kim B, et al. Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007;6:406-13 pubmed
    ..PlagL2 thus regulates important aspects of dietary lipid absorption, and the PlagL2(-/-) animal model has implications for the amelioration of obesity and the metabolic syndrome. ..
  51. Leung G, Veniant M, Kim S, Zlot C, Raabe M, Bjorkegren J, et al. A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J Biol Chem. 2000;275:7515-20 pubmed
    Microsomal triglyceride transfer protein (MTP) transfers lipids to apolipoprotein B (apoB) within the endoplasmic reticulum, a process that involves direct interactions between apoB and the large subunit of MTP...
  52. Ring H, Vameghi Meyers V, Min H, Nikolic J, Black D, Francke U. The mouse Fubp gene maps near the distal end of chromosome 3. Genomics. 1999;56:357-8 pubmed
  53. Yamamoto S, Yamazaki T, Komazaki S, Yamashita T, Osaki M, Matsubayashi M, et al. Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Dev Biol. 2014;393:33-43 pubmed publisher
    ..Taken together, our findings suggested that calumin serves to maintain the yolk sac integrity through participation in the ERAD activity, contributing to embryonic development. ..
  54. Ramsey S, Vengrenyuk Y, Menon P, Podolsky I, Feig J, Aderem A, et al. Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet. 2014;10:e1004828 pubmed publisher
  55. Scerbo D, Son N, Sirwi A, Zeng L, Sas K, Cifarelli V, et al. Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids. J Lipid Res. 2017;58:1132-1142 pubmed publisher
    ..Our data demonstrate that fasting-induced triglyceride accumulation in the kidney correlates with the plasma concentrations of NEFAs, but is not due to uptake of lipoprotein lipids and does not involve the fatty acid transporter, CD36. ..
  56. Gao S, He L, Ding Y, Liu G. Mechanisms underlying different responses of plasma triglyceride to high-fat diets in hamsters and mice: roles of hepatic MTP and triglyceride secretion. Biochem Biophys Res Commun. 2010;398:619-26 pubmed publisher
    ..Here by comparing the responses to HFD in hamsters and mice, we found that hepatic TG secretion, MTP expression and plasma free fatty acid (FFA) level were increased in hamsters on HFD feeding but decreased in mice...
  57. Anwar K, Iqbal J, Hussain M. Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. J Lipid Res. 2007;48:2028-38 pubmed
    ..Enterocytes from Mttp-deficient mice also secreted less vitamin E with chylomicrons...
  58. Miller J, Weiss R, Serrano K, Brooks R, Berry C, Zimmerman K, et al. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation. 2009;119:2693-701 pubmed publisher
    ..reducing elevated plasma lipid levels with a "genetic switch" in Reversa mice (Ldlr-/-/Apob(100/100)/Mttp(fl/fl)/Mx1-Cre+/+) reduces oxidative stress, reduces pro-osteogenic signaling, and retards the progression of ..
  59. Knecht T, Glass C. The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis. Adv Genet. 1995;32:141-98 pubmed
  60. Chen Z, Newberry E, Norris J, Xie Y, Luo J, Kennedy S, et al. ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J Lipid Res. 2008;49:2013-22 pubmed publisher
    Microsomal triglyceride transfer protein (Mttp) is a key player in the assembly and secretion of hepatic very low density lipoproteins (VLDL)...
  61. Kamagate A, Qu S, Perdomo G, Su D, Kim D, Slusher S, et al. FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest. 2008;118:2347-64 pubmed publisher
    ..VLDL production is facilitated by microsomal triglyceride transfer protein (MTP) in a rate-limiting step that is regulated by insulin...
  62. Swift L, Jovanovska A, Kakkad B, Ong D. Microsomal triglyceride transfer protein expression in mouse intestine. Histochem Cell Biol. 2005;123:475-82 pubmed
    ..and biochemical approaches were utilized to compare the expression of microsomal triglyceride transfer protein (MTP) and cellular retinol binding protein II (CRBPII) with the expression of apolipoprotein (apo)B and apoA-I along the ..
  63. Khatun I, Zeissig S, Iqbal J, Wang M, Curiel D, Shelness G, et al. Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice. Hepatology. 2012;55:1356-68 pubmed publisher
    Microsomal triglyceride transfer protein (MTP), essential for apolipoprotein B (apoB) biosynthesis, evolved as a phospholipid transfer protein and acquired triglyceride transfer activity during a transition from invertebrates to ..
  64. Olszak T, Neves J, Dowds C, Baker K, Glickman J, Davidson N, et al. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature. 2014;509:497-502 pubmed publisher
    ..upon IEC-specific deletion of IL-10, CD1d, and its critical regulator microsomal triglyceride transfer protein (MTP), as well as deletion of HSP110 in the radioresistant compartment...
  65. Dai K, Khatun I, Hussain M. NR2F1 and IRE1beta suppress microsomal triglyceride transfer protein expression and lipoprotein assembly in undifferentiated intestinal epithelial cells. Arterioscler Thromb Vasc Biol. 2010;30:568-74 pubmed publisher
    ..studies showed that binding of the nuclear receptor family 2 group F member 1 (NR2F1) to the DR1 element in the MTTP promoter suppresses MTTP expression in undifferentiated cells...
  66. Qiu W, Federico L, Naples M, Avramoglu R, Meshkani R, Zhang J, et al. Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins. Hepatology. 2008;48:1799-809 pubmed publisher
    ..Here, we demonstrate that hepatic protein levels of apoB100 and microsomal triglyceride transfer protein (MTP) are significantly down-regulated (73% and 36%, respectively) in the liver of PTEN liver-specific knockout (KO) ..
  67. Xie Y, Luo J, Kennedy S, Davidson N. Conditional intestinal lipotoxicity in Apobec-1-/- Mttp-IKO mice: a survival advantage for mammalian intestinal apolipoprotein B mRNA editing. J Biol Chem. 2007;282:33043-51 pubmed
    ..requires the coordinated interactions of apolipoprotein B (apoB) and the microsomal triglyceride transfer protein (Mttp)...
  68. Costabile B, Kim Y, Iqbal J, Zuccaro M, Wassef L, Narayanasamy S, et al. ?-Apo-10'-carotenoids Modulate Placental Microsomal Triglyceride Transfer Protein Expression and Function to Optimize Transport of Intact ?-Carotene to the Embryo. J Biol Chem. 2016;291:18525-35 pubmed publisher
    ..This study demonstrates that ?-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of ?-carotene for proper embryogenesis. ..
  69. Sagiv Y, Bai L, Wei D, Agami R, Savage P, Teyton L, et al. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med. 2007;204:921-8 pubmed
    Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident lipid transfer protein involved in the biosynthesis and lipid loading of apolipoprotein B...
  70. Minehira K, Young S, Villanueva C, Yetukuri L, Oresic M, Hellerstein M, et al. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008;49:2038-44 pubmed publisher
    ..issues, we examined mice that cannot secrete VLDL [due to the absence of microsomal triglyceride transfer protein (Mttp) in the liver]...