Gene Symbol: Mtf2
Description: metal response element binding transcription factor 2
Alias: 9230112N11Rik, AA537621, C76717, M96, Pcl2, metal-response element-binding transcription factor 2, mPCl2, metal regulatory transcription factor 2, metal response element DNA-binding protein M96, polycomb-like protein 2, ziRF1, zinc-regulated factor 1
Species: mouse
Products:     Mtf2

Top Publications

  1. Shen X, Kim W, Fujiwara Y, Simon M, Liu Y, Mysliwiec M, et al. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 2009;139:1303-14 pubmed publisher
    ..Our results demonstrate that dynamic regulation of Polycomb complex activity orchestrated by JMJ balances self-renewal and differentiation, highlighting the involvement of chromatin dynamics in cell-fate transitions. ..
  2. Li G, Margueron R, Ku M, Chambon P, Bernstein B, Reinberg D. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 2010;24:368-80 pubmed publisher
    ..Jarid2 colocalizes with Ezh2 and MTF2, a homolog of Drosophila Pcl, at endogenous genes in embryonic stem (ES) cells...
  3. Walker E, Chang W, Hunkapiller J, Cagney G, Garcha K, Torchia J, et al. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010;6:153-66 pubmed publisher
    ..We identified the PcG protein PCL2 (polycomb-like 2) in a genome-wide screen for regulators of self-renewal and pluripotency and predicted that it ..
  4. Li X, Isono K, Yamada D, Endo T, Endoh M, Shinga J, et al. Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol. 2011;31:351-64 pubmed publisher
    ..Mammalian Polycomb-like gene Pcl2/Mtf2 is expressed as four different isoforms, and the longest one contains a Tudor domain and two plant homeodomain ..
  5. Zhang Z, Jones A, Sun C, Li C, Chang C, Joo H, et al. PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells. 2011;29:229-40 pubmed publisher
    ..Here, we report that PRC2 in mouse ES cells contains at least three additional subunits: JARID2, MTF2, and a novel protein denoted esPRC2p48...
  6. Casanova M, Preissner T, Cerase A, Poot R, Yamada D, Li X, et al. Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells. Development. 2011;138:1471-82 pubmed publisher
    ..In this study we have analysed the function of the mouse PcG protein polycomblike 2 (Pcl2), one of three homologues of the Drosophila Polycomblike (Pcl) protein...
  7. Inouye C, Remondelli P, Karin M, Elledge S. Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. DNA Cell Biol. 1994;13:731-42 pubmed
    ..The protein encoded by this cDNA, M96, shows similarity to the trithorax proteins. Expression of a functional DNA-binding form of M96 requires Zn2+ ions...
  8. Remondelli P, Leone A. Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter. Biochem J. 1997;323 ( Pt 1):79-85 pubmed
    ..Zn2+ ions modulate the MRE-binding activity, suggesting that the M96-encoded protein is a Zn2+-regulated factor (ZiRF1)...
  9. Kitaguchi T, Nakata K, Nagai T, Aruga J, Mikoshiba K. Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior patterning of the neural tissue. Dev Genes Evol. 2001;211:309-14 pubmed
    ..XPcl2 shows greater amino acid sequence homology to human and mouse M96 (hPcl2, mPcl2) than Xenopus Pcl1 (XPcl1), mouse Tctex3 (mPcl1) and human PHF1 (hPcl1), indicating that at least two types of ..

More Information


  1. Wang S, He F, Xiong W, Gu S, Liu H, Zhang T, et al. Polycomblike-2-deficient mice exhibit normal left-right asymmetry. Dev Dyn. 2007;236:853-61 pubmed
    ..Our previous studies demonstrate that the chick Pcl2 is essential for the left-right asymmetry by silencing Shh expression in the right side of the node (Wang et al...
  2. Attia M, Forster A, Rachez C, Freemont P, Avner P, Rogner U. Interaction between nucleosome assembly protein 1-like family members. J Mol Biol. 2011;407:647-60 pubmed publisher
  3. Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho Santos M, et al. Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet. 2012;8:e1002576 pubmed publisher
    ..We also show that Pcl3 and its paralog, Pcl2, exist in different PRC2 complexes but bind many of the same PRC2 targets, particularly CpG islands regulated by ..
  4. Ballaré C, Lange M, Lapinaite A, Martin G, Morey L, Pascual G, et al. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012;19:1257-65 pubmed publisher
    ..These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells. ..