Mtch2

Summary

Gene Symbol: Mtch2
Description: mitochondrial carrier 2
Alias: 2310034D24Rik, 4930539J07Rik, HSPC032, mitochondrial carrier homolog 2
Species: mouse
Products:     Mtch2

Top Publications

  1. Eswarappa S, Potdar A, Koch W, Fan Y, Vasu K, Lindner D, et al. Programmed translational readthrough generates antiangiogenic VEGF-Ax. Cell. 2014;157:1605-18 pubmed publisher
    ..Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets...
  2. Zaltsman Y, Shachnai L, Yivgi Ohana N, Schwarz M, Maryanovich M, Houtkooper R, et al. MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol. 2010;12:553-562 pubmed publisher
    ..Here we show that MTCH2/MIMP (mitochondrial carrier homologue 2/Met-induced mitochondrial protein), a novel truncated BID (tBID)-..
  3. Bar Lev Y, Moshitch Moshkovitz S, Tsarfaty G, Kaufman D, Horev J, Resau J, et al. Mimp/Mtch2, an Obesity Susceptibility Gene, Induces Alteration of Fatty Acid Metabolism in Transgenic Mice. PLoS ONE. 2016;11:e0157850 pubmed publisher
    ..Mimp/Mtch2 is a mitochondrial carrier protein homologue, which localizes to the mitochondria and induces mitochondrial ..
  4. Rottiers V, Francisco A, Platov M, Zaltsman Y, Ruggiero A, Lee S, et al. MTCH2 is a conserved regulator of lipid homeostasis. Obesity (Silver Spring). 2017;25:616-625 pubmed publisher
    ..The functional role of mitochondrial carrier homolog 2 (MTCH2), a human obesity-associated gene, in lipid homeostasis was investigated in Caenorhabditis ..
  5. Ruivenkamp C, van Wezel T, Zanon C, Stassen A, Vlcek C, Csik├│s T, et al. Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nat Genet. 2002;31:295-300 pubmed
    ..Our data suggest that PTPRJ is relevant to the development of several different human cancers. ..
  6. Shamas Din A, Bindner S, Zhu W, Zaltsman Y, Campbell C, Gross A, et al. tBid undergoes multiple conformational changes at the membrane required for Bax activation. J Biol Chem. 2013;288:22111-27 pubmed publisher
    ..Using automated high-throughput image analysis in cells, we show that down-regulation of Mtch2 causes a significant delay between tBid and Bax relocalization in cells...
  7. Maryanovich M, Zaltsman Y, Ruggiero A, Goldman A, Shachnai L, Zaidman S, et al. An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nat Commun. 2015;6:7901 pubmed publisher
    ..Here we show that loss of mitochondrial carrier homologue 2 (MTCH2) increases mitochondrial OXPHOS, triggering HSC and progenitor entry into cycle...
  8. Buzaglo Azriel L, Kuperman Y, Tsoory M, Zaltsman Y, Shachnai L, Zaidman S, et al. Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity. Cell Rep. 2016;14:1602-1610 pubmed publisher
    b>Mitochondrial carrier homolog 2 (MTCH2) is a repressor of mitochondrial oxidative phosphorylation (OXPHOS), and its locus is associated with increased BMI in humans...