Gene Symbol: Msn
Description: moesin
Alias: C78546, moesin, membrane-organizing extension spike protein
Species: mouse
Products:     Msn

Top Publications

  1. Sato N, Funayama N, Nagafuchi A, Yonemura S, Tsukita S. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J Cell Sci. 1992;103 ( Pt 1):131-43 pubmed
    ..Sequence analysis has demonstrated that this protein is a mouse homologue of human moesin (98.3% identity) and that it shares 71.7% and 80.1% identity with ezrin and radixin, respectively...
  2. Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, et al. Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction. J Biol Chem. 2010;285:4060-73 pubmed publisher
    ..activation of transforming growth factor-beta (TGF-beta) signaling in a manner dependent on hyaluronan-CD44-moesin interaction...
  3. Okayama T, Kikuchi S, Ochiai T, Ikoma H, Kubota T, Ichikawa D, et al. Attenuated response to liver injury in moesin-deficient mice: impaired stellate cell migration and decreased fibrosis. Biochim Biophys Acta. 2008;1782:542-8 pubmed publisher
    ..Cell migration requires an intact actin cytoskeleton that is linked to the plasma membrane by ezrin-radixin-moesin (ERM) proteins. We have previously found that the linker protein in HSCs is exclusively moesin...
  4. Hirata T, Nomachi A, Tohya K, Miyasaka M, Tsukita S, Watanabe T, et al. Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis. Int Immunol. 2012;24:705-17 pubmed publisher
    b>Moesin is a member of the ezrin-radixin-moesin (ERM) family of cytoskeletal proteins. These proteins organize membrane domains by interacting with plasma membrane proteins and the actin cytoskeleton...
  5. Oshiro N, Fukata Y, Kaibuchi K. Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures. J Biol Chem. 1998;273:34663-6 pubmed
    Rho-associated kinase (Rho-kinase), which is activated by the small GTPase Rho, phosphorylates moesin at Thr558 in vitro...
  6. Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol. 1998;140:885-95 pubmed
    CD44 has been identified as a membrane-binding partner for ezrin/radixin/moesin (ERM) proteins, plasma membrane/actin filament cross-linkers...
  7. Doi Y, Itoh M, Yonemura S, Ishihara S, Takano H, Noda T, et al. Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout. J Biol Chem. 1999;274:2315-21 pubmed
    Ezrin/radixin/moesin (ERM) proteins are general cross-linkers between the plasma membrane and actin filaments. Because their expression is regulated in a tissue-specific manner, each ERM protein has been proposed to have unique functions...
  8. Belkina N, Liu Y, Hao J, Karasuyama H, Shaw S. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc Natl Acad Sci U S A. 2009;106:4707-12 pubmed publisher
    ERM (ezrin-radixin-moesin) proteins mediate linkage of actin cytoskeleton to plasma membrane in many cells...
  9. Allenspach E, Cullinan P, Tong J, Tang Q, Tesciuba A, Cannon J, et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity. 2001;15:739-50 pubmed
    ..These results indicate that ERM proteins organize a complex distal to the T cell/APC interaction site and provide evidence that full T cell activation may involve removal of inhibitory proteins from the immunological synapse. ..

More Information


  1. Schierwagen R, Maybüchen L, Hittatiya K, Klein S, Uschner F, Braga T, et al. Statins improve NASH via inhibition of RhoA and Ras. Am J Physiol Gastrointest Liver Physiol. 2016;311:G724-G733 pubmed publisher
    ..Inhibition of RAC1 (by NSC) showed no significant effect at all. Inhibition of RhoA and Ras downstream signaling by statins is responsible for the beneficial hepatic effects in NASH. ..
  2. Wilgenbus K, Hsieh C, Lankes W, Milatovich A, Francke U, Furthmayr H. Structure and localization on the X chromosome of the gene coding for the human filopodial protein moesin (MSN). Genomics. 1994;19:326-33 pubmed
    b>Moesin is a member of a recently discovered family of closely related proteins that includes ezrin, radixin, and merlin...
  3. Moon Y, Kim J, Choi S, Kim K, Kim H, Sun W. Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex. Neuroreport. 2011;22:304-8 pubmed publisher
    ..In this study, we observed that the phosphorylation and expressions of ezrin-radixin-moesin (ERM) proteins, which are linkers for cell surface with actin cytoskeleton, are induced in the activated microglia/..
  4. Wang L, Li Q, Du J, Chen B, Li Q, Huang X, et al. Advanced glycation end products induce moesin phosphorylation in murine retinal endothelium. Acta Diabetol. 2012;49:47-55 pubmed publisher
    ..This study was to investigate the role of moesin and its underlying signal transduction in retinal vascular hyper-permeability induced by AGE-modified mouse serum ..
  5. Tarchini B, Jolicoeur C, Cayouette M. A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells. Dev Cell. 2013;27:88-102 pubmed publisher
    ..G?i is additionally required for lateral orientation of cochlear hair cells, providing a possible mechanism to couple the emergence of asymmetric stereocilia bundles with planar cell polarity. ..
  6. Sayyed S, Jouret F, Vermeersch M, Pérez Morga D, Schurmans S. The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins. Kidney Int. 2017;92:125-139 pubmed publisher
    ..substrate and decreased PtdIns4P product when SHIP2 was inactivated, associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP...
  7. Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y. Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin. J Biol Chem. 2012;287:39041-9 pubmed publisher
    ..the activation of TLCN-dependent intracellular signaling cascade including the phosphorylation of ezrin/radixin/moesin actin-binding proteins and recruitment of F-actin and phosphatidylinositol 4,5-bisphosphate for morphological ..
  8. Pines M, Levi O, Genin O, Lavy A, Angelini C, Allamand V, et al. Elevated Expression of Moesin in Muscular Dystrophies. Am J Pathol. 2017;187:654-664 pubmed publisher
    Fibrosis is the main complication of muscular dystrophies. We identified moesin, a member of the ezrin-radixin-moesin family, in dystrophic muscles of mice representing Duchenne and congenital muscular dystrophies (DMD and CMD, ..
  9. Matsumoto H, Daikoku T, Wang H, Sato E, Dey S. Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation. Biol Reprod. 2004;70:729-36 pubmed
    ..examined the possibility for a potential cross talk between the blastocyst and uterus involving the ezrin/radixin/moesin (ERM) proteins and ERM-associated cytoskeletal cross-linker proteins CD43, CD44, ICAM-1, and ICAM-2...
  10. Fazioli F, Wong W, Ullrich S, Sakaguchi K, Appella E, Di Fiore P. The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation. Oncogene. 1993;8:1335-45 pubmed
    ..1 family of proteins and highly related to ezrin and moesin. We demonstrated that, despite a high degree of relatedness, these three proteins exhibit a distinct receptor-..
  11. Haynes J, Srivastava J, Madson N, Wittmann T, Barber D. Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol Biol Cell. 2011;22:4750-64 pubmed publisher
    ..We show that efficient actin filament remodeling during EMT depends on increased expression of the ezrin/radixin/moesin (ERM) protein moesin...
  12. Itoh K, Sakakibara M, Yamasaki S, Takeuchi A, Arase H, Miyazaki M, et al. Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J Immunol. 2002;168:541-4 pubmed
    ..which connects the membrane raft and cytoskeleton by binding to both Cbp through its PDZ domain and ezrin-radixin-moesin through the C terminus...
  13. Miyawaki A, Mitsuhara Y, Orimoto A, Nakayasu Y, Tsunoda S, Obana M, et al. Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. Am J Physiol Heart Circ Physiol. 2016;311:H476-86 pubmed publisher
    ..were preferentially increased in cardiomyocytes at EAM3w, compared with preimmunized (EAM0w) hearts, and that moesin was the most remarkably upregulated among them...
  14. Liu X, Yang T, Suzuki K, Tsukita S, Ishii M, Zhou S, et al. Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient. J Exp Med. 2015;212:267-80 pubmed publisher
    ..Here we report that in resting neutrophils, the ERM (ezrin, radixin, and moesin) protein moesin in its active form (phosphorylated and membrane bound) prevented cell polarization by inhibiting ..
  15. Bogatcheva N, Zemskova M, Gorshkov B, Kim K, Daglis G, Poirier C, et al. Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability. Am J Respir Cell Mol Biol. 2011;45:1185-94 pubmed publisher
    ..The known PKC substrates ezrin, radixin, and moesin (ERM) were recently implicated in the regulation of endothelial permeability...
  16. Wei Z, Li Y, Ye F, Zhang M. Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin. J Biol Chem. 2015;290:11384-92 pubmed publisher
    ..role of Crb in cell polarity is governed by its conserved, 37-residue cytoplasmic tail (Crb-CT) via binding to moesin and protein associated with Lin7-1 (PALS1)...
  17. Pan Y, Tseng W, Chang P, Chen H. Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts. J Cell Sci. 2013;126:5670-80 pubmed publisher
    ..b>Moesin, a member of the ERM (ezrin, radixin and moesin) protein family, was identified as a substrate of JNK...
  18. Nomachi A, Yoshinaga M, Liu J, Kanchanawong P, Tohyama K, Thumkeo D, et al. Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE. 2013;8:e82590 pubmed publisher
    ..that agonist-induced S1PR1 internalization in T cells occurs via clathrin-mediated endocytosis and is regulated by moesin, an ezrin-radixin-moesin (ERM) family member...
  19. Kobori T, Fujiwara S, Miyagi K, Harada S, Nakamoto K, Nakagawa T, et al. Involvement of moesin in the development of morphine analgesic tolerance through P-glycoprotein at the blood-brain barrier. Drug Metab Pharmacokinet. 2014;29:482-9 pubmed publisher
    ..Ezrin/radixin/moesin (ERM) are scaffold proteins that are known to regulate the plasma membrane localization of some drug transporters ..
  20. Guo X, Wang L, Chen B, Li Q, Wang J, Zhao M, et al. ERM protein moesin is phosphorylated by advanced glycation end products and modulates endothelial permeability. Am J Physiol Heart Circ Physiol. 2009;297:H238-46 pubmed publisher
    ..This study directly evaluated the involvement of moesin phosphorylation in AGE-induced alterations and the effects of the RhoA and p38 MAPK pathways on this process...
  21. Larson S, Lee H, Hung P, Matthews L, Robinson D, Evans J. Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and Ezrin-Radixin-Moesin (ERM) proteins. Mol Biol Cell. 2010;21:3182-92 pubmed publisher
    ..We further demonstrate that actin, myosin-II, and the ERM (Ezrin/Radixin/Moesin) family of proteins are enriched in complementary cortical domains and mediate cellular mechanics in mammalian ..
  22. Lu X, Beck G, Gilbert L, Camalier C, Bateman N, Hood B, et al. Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor ? action in osteoblast differentiation. J Bone Miner Res. 2011;26:209-19 pubmed publisher
    ..Activation of Prx1 by TNF may contribute to reduced bone formation in inflammatory arthritis, menopause, and aging. ..
  23. Strilic B, Kucera T, Eglinger J, Hughes M, McNagny K, Tsukita S, et al. The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell. 2009;17:505-15 pubmed publisher
    ..We show that ECs adhere to each other, and that CD34-sialomucins, Moesin, F-actin, and non-muscle Myosin II localize at the endothelial cell-cell contact to define the luminal cell ..
  24. Matsumoto M, Hirata T. Moesin regulates neutrophil rolling velocity in vivo. Cell Immunol. 2016;304-305:59-62 pubmed publisher here that in TNF-?-treated cremaster muscle venules, slow leukocyte rolling was impaired in mice deficient in moesin, a member of the ezrin-radixin-moesin (ERM) family...
  25. Hashimoto S, Amaya F, Matsuyama H, Ueno H, Kikuchi S, Tanaka M, et al. Dysregulation of lung injury and repair in moesin-deficient mice treated with intratracheal bleomycin. Am J Physiol Lung Cell Mol Physiol. 2008;295:L566-74 pubmed publisher
    b>Moesin belongs to the ezrin/radixin/moesin (ERM) protein family and participates in cellular functions, such as morphogenesis and motility, by cross-linking between the actin cytoskeleton and plasma membranes...
  26. Pearson H, Perez Mancera P, Dow L, Ryan A, Tennstedt P, Bogani D, et al. SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011;121:4257-67 pubmed publisher
    ..These data suggest that the polarity network could provide a new avenue for therapeutic intervention. ..
  27. Nodari A, Previtali S, Dati G, Occhi S, Court F, Colombelli C, et al. Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008;28:6714-9 pubmed publisher
    ..These data indicate that, similar to its role in skin, alpha6beta4 integrin confers stability to myelin in peripheral nerves. ..
  28. Gómez C, Descoteaux A. Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages. Biochem Biophys Res Commun. 2018;495:1964-1971 pubmed publisher
    ..Through proteomics, we identified moesin and the non-muscle myosin-IIA as proteins interacting with SHP-1 during phagocytosis...
  29. Rao P, Ho T, Skiba N, Maddala R. Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins. Biochem Biophys Res Commun. 2008;368:508-14 pubmed publisher
    ..Importantly, ezrin, radixin, and moesin (ERM), heat-shock cognate protein 70, and beta/gamma-crystallins were identified as major cytoskeletal-associated ..
  30. Staser K, Shew M, Michels E, Mwanthi M, Yang F, Clapp D, et al. A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. Exp Hematol. 2013;41:56-66.e2 pubmed publisher
    ..PP2A then dephosphorylates threonine 567 of Ezrin/Radixin/Moesin (ERM) molecules that have been shown to couple F-actin to the plasma membrane in other cell systems...
  31. Lee Y, Choi I, Sheen Y, Park S, Kwon H. Moesin is a biomarker for the assessment of genotoxic carcinogens in mouse lymphoma. Mol Cells. 2012;33:203-10 pubmed publisher
    ..increase or decrease in intensity compared to control cells on a 2-D gel, we focused on the candidate biomarker moesin. Western analysis using monoclonal rabbit anti-moesin confirmed the identity of the protein and its increased ..
  32. Liang H, McKinnon R, Nebert D. Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice. Biochem Pharmacol. 1997;54:1127-31 pubmed
    ..These data indicate that the complete absence of the microsomal CYP1A2 enzyme has no measurable effect on hepatic expression of the Cyp1a1, gene, the only other known member of the mammalian CYP1A cytochrome P450 subfamily. ..
  33. Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed publisher
    b>Moesin is a member of the ezrin-radixin-moesin (ERM) family of proteins that are important for organizing membrane domains and receptor signaling and regulating the migration of effector T cells...
  34. Jaleel M, Nichols R, Deak M, Campbell D, Gillardon F, Knebel A, et al. LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem J. 2007;405:307-17 pubmed
    ..This led to the discovery that moesin, a protein which anchors the actin cytoskeleton to the plasma membrane, is efficiently phosphorylated by LRRK2, at ..
  35. Zhu H, Yeo S, Ng J, Htoon H, Beuerman R. Moesin as a key cytoskeleton regulator in corneal fibrosis. Ocul Surf. 2013;11:119-32 pubmed publisher
    ..b>Moesin siRNA was delivered into the corneal stroma by iontophoresis in vivo...
  36. Lee J, Silva Gagliardi N, Tepass U, McGlade C, Anderson K. The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Development. 2007;134:2007-16 pubmed
    ..We propose that mouse Lulu (Epb4.1l5) helps anchor the actin-myosin contractile machinery to the membrane to allow the dynamic rearrangements of epithelia that mediate embryonic morphogenesis. ..
  37. Nüesch J, Bär S, Lachmann S, Rommelaere J. Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading. J Virol. 2009;83:5854-63 pubmed publisher
    ..We show that proteins of the ezrin-radixin-moesin (ERM) family are essential for virus propagation and spreading through their functions as adaptors for PKCeta...
  38. Ramkumar N, Omelchenko T, Silva Gagliardi N, McGlade C, Wijnholds J, Anderson K. Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol. 2016;18:1281-1291 pubmed publisher
  39. Lee W, Kwon O, Han M, Lee Y, Kim S, Kim K, et al. Role of moesin in HMGB1-stimulated severe inflammatory responses. Thromb Haemost. 2015;114:350-63 pubmed publisher
    ..b>Moesin is a cytoskeletal protein involved in cytoskeletal changes and paracellular gap formation...
  40. Furthmayr H, Lankes W, Amieva M. Moesin, a new cytoskeletal protein and constituent of filopodia: its role in cellular functions. Kidney Int. 1992;41:665-70 pubmed
  41. Darmellah A, Rayah A, Auger R, Cuif M, Prigent M, Arpin M, et al. Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein. J Biol Chem. 2012;287:34583-95 pubmed publisher
    ..Here, we demonstrate that the activation of ezrin, radixin, and moesin (ERM) proteins is required for the P2X7R-dependent proteolytic processing of APP leading to sAPP? release...
  42. Garcia G, Sadighi Akha A, Miller R. Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells. J Immunol. 2007;179:6403-9 pubmed
    Cytoskeletal proteins of the ezrin-radixin-moesin (ERM) family contribute to T cell activation in response to Ag, and also to T cell polarization in response to connective tissue matrix proteins and chemokine gradients...
  43. Rasmussen M, Alexander R, Darborg B, Møbjerg N, Hoffmann E, Kapus A, et al. Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications. Am J Physiol Cell Physiol. 2008;294:C197-212 pubmed
    ..Here we investigated the possible roles of ezrin/radixin/moesin (ERM) proteins in these events...
  44. Krawetz R, Mackenzie M, Sun Q, Walton P, Kelly G. Galpha13 activation rescues moesin-depletion induced apoptosis in F9 teratocarcinoma cells. Exp Cell Res. 2006;312:3224-40 pubmed
    ..ERM (ezrin-radixin-moesin) proteins, known to link F-actin to transmembrane receptors, are also redistributed during differentiation...
  45. Huang T, You Y, Spoor M, Richer E, Kudva V, Paige R, et al. Foxj1 is required for apical localization of ezrin in airway epithelial cells. J Cell Sci. 2003;116:4935-45 pubmed
    ..ERM (ezrin, radixin, moesin) family members link polarized proteins with cytoskeletal actin...
  46. Lamb R, Roy C, Diefenbach T, Vinters H, Johnson M, Jay D, et al. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol. 2000;2:281-7 pubmed
    ..Here we show that hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins...
  47. Sperka T, Geissler K, Merkel U, Scholl I, Rubio I, Herrlich P, et al. Activation of Ras requires the ERM-dependent link of actin to the plasma membrane. PLoS ONE. 2011;6:e27511 pubmed publisher
    ..demonstrate that the activation of Ras requires, in addition, the essential participation of ezrin, radixin and/or moesin (ERM), a family of actin-binding proteins, and of actin...
  48. Cunningham K, Uchida Y, O Donnell E, Claudio E, Li W, Soneji K, et al. Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. Hum Mol Genet. 2011;20:3198-206 pubmed publisher
    ..These mice represent the first CCM2 animal model for CCM and should provide the means to elucidate disease mechanisms and evaluate therapeutic strategies for human CCM. ..
  49. Cannon J, Mody P, Blaine K, Chen E, Nelson A, Sayles L, et al. CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol Biol Cell. 2011;22:954-63 pubmed publisher
    ..uropod and the distal pole complex (DPC) opposite the immunological synapse via association with the ezrin-radixin-moesin (ERM) family of actin regulatory proteins...
  50. Wakayama T, Nakata H, Kurobo M, Sai Y, Iseki S. Expression, localization, and binding activity of the ezrin/radixin/moesin proteins in the mouse testis. J Histochem Cytochem. 2009;57:351-62 pubmed publisher
    The ezrin, radixin, and moesin (ERM) proteins represent a family of adaptor proteins linking transmembrane proteins to the cytoskeleton...
  51. Satooka H, Nagakubo D, Sato T, Hirata T. The ERM Protein Moesin Regulates CD8+ Regulatory T Cell Homeostasis and Self-Tolerance. J Immunol. 2017;199:3418-3426 pubmed publisher
    The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins that link membrane proteins with actin filaments in the cell cortex and regulate many cellular processes, including cell shape determination, membrane ..