Msi1

Summary

Gene Symbol: Msi1
Description: musashi RNA-binding protein 1
Alias: Msi1h, Musahi1, m-Msi-1, RNA-binding protein Musashi homolog 1, Musashi homolog 1(Drosophila), musashi-1
Species: mouse
Products:     Msi1

Top Publications

  1. Sakakibara S, Imai T, Hamaguchi K, Okabe M, Aruga J, Nakajima K, et al. Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell. Dev Biol. 1996;176:230-42 pubmed
  2. Nishimura S, Wakabayashi N, Toyoda K, Kashima K, Mitsufuji S. Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium. Dig Dis Sci. 2003;48:1523-9 pubmed
    ..This is the first report outlining expression of Musashi-1 in human colon crypt cells. ..
  3. Murata J, Murayama A, Horii A, Doi K, Harada T, Okano H, et al. Expression of Musashi1, a neural RNA-binding protein, in the cochlea of young adult mice. Neurosci Lett. 2004;354:201-4 pubmed
    Musashi1 (Msi1) is an RNA-binding protein expressed in neural stem/progenitor cells, astroglial progenitor cells and astrocytes in the vertebrate central nervous system...
  4. Raji B, Dansault A, Leemput J, de la Houssaye G, Vieira V, Kobetz A, et al. The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye. Mol Vis. 2007;13:1412-27 pubmed
    Musashi-1 (Msi1) is an RNA-binding protein produced in various types of stem cells including neural stem/progenitor cells and astroglial progenitor cells in the vertebrate central nervous system...
  5. Sakakibara S, Okano H. Expression of neural RNA-binding proteins in the postnatal CNS: implications of their roles in neuronal and glial cell development. J Neurosci. 1997;17:8300-12 pubmed
    ..These observations imply that these two RNA-binding proteins may be involved in the development of neurons and glia by regulating gene expression at the post-transcriptional level. ..
  6. Takahashi T, Suzuki H, Imai T, Shibata S, Tabuchi Y, Tsuchimoto K, et al. Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa. PLoS ONE. 2013;8:e53540 pubmed publisher
    Upregulation of the RNA-binding protein Musashi-1 (Msi1) has been shown to occur in rat gastric corpus mucosa after ethanol-induced mucosal injury. However, there is no direct evidence linking Msi1 with gastric regeneration...
  7. Wang X, Yin Y, Yuan H, Sakamaki T, Okano H, Glazer R. Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways. Mol Cell Biol. 2008;28:3589-99 pubmed publisher
    The RNA-binding protein Musashi1 (Msi1) is a positive regulator of Notch-mediated transcription in Drosophila melanogaster and neural progenitor cells and has been identified as a putative human breast stem cell marker...
  8. Muto J, Imai T, Ogawa D, Nishimoto Y, Okada Y, Mabuchi Y, et al. RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways. PLoS ONE. 2012;7:e33431 pubmed publisher
    Musashi1 (MSI1) is an RNA-binding protein that plays critical roles in nervous-system development and stem-cell self-renewal. Here, we examined its role in the progression of glioma...
  9. Ohyama T, Nagata T, Tsuda K, Kobayashi N, Imai T, Okano H, et al. Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions. Nucleic Acids Res. 2012;40:3218-31 pubmed publisher
    Mammalian Musashi1 (Msi1) is an RNA-binding protein that regulates the translation of target mRNAs, and participates in the maintenance of cell 'stemness' and tumorigenesis...

More Information

Publications72

  1. Kawase S, Imai T, Miyauchi Hara C, Yaguchi K, Nishimoto Y, Fukami S, et al. Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells. Mol Brain. 2011;4:14 pubmed publisher
    ..The Musashi1 (Msi1) protein, which belongs to an evolutionarily conserved family of RNA-binding proteins, is a marker for neural stem/..
  2. Kawahara H, Okada Y, Imai T, Iwanami A, Mischel P, Okano H. Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation. J Biol Chem. 2011;286:16121-30 pubmed publisher
    Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural stem/progenitor cells (NS/PCs) as well as in other tissue stem cells...
  3. Kawahara H, Imai T, Imataka H, Tsujimoto M, Matsumoto K, Okano H. Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J Cell Biol. 2008;181:639-53 pubmed publisher
    Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural stem cells...
  4. Sureban S, May R, George R, Dieckgraefe B, McLeod H, Ramalingam S, et al. Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo. Gastroenterology. 2008;134:1448-58 pubmed publisher
    ..Our results show the involvement of Msi-1 in cancer cell proliferation, inhibition of apoptosis, and mitotic catastrophe, suggesting an important potential mechanism for its role in tumorigenesis. ..
  5. Sugiyama Nakagiri Y, Akiyama M, Shibata S, Okano H, Shimizu H. Expression of RNA-binding protein Musashi in hair follicle development and hair cycle progression. Am J Pathol. 2006;168:80-92 pubmed
    ..These observations suggest that Musashi functions not only in the asymmetric division of early progenitor cells but also in the differentiation of IRS cells during HF development and hair cycle progression. ..
  6. Potten C, Booth C, Tudor G, Booth D, Brady G, Hurley P, et al. Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation. 2003;71:28-41 pubmed
    ..These observations suggest that Musashi-1 is a marker of stem and early lineage progenitor cells in murine intestinal tissue. ..
  7. Nagata T, Kanno R, Kurihara Y, Uesugi S, Imai T, Sakakibara S, et al. Structure, backbone dynamics and interactions with RNA of the C-terminal RNA-binding domain of a mouse neural RNA-binding protein, Musashi1. J Mol Biol. 1999;287:315-30 pubmed
  8. Sakakibara S, Nakamura Y, Satoh H, Okano H. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. J Neurosci. 2001;21:8091-107 pubmed
    Musashi1 (Msi1) is a mammalian neural RNA-binding protein highly enriched in neural precursor cells that are capable of generating both neurons and glia during embryonic and postnatal CNS development...
  9. Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, et al. Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron. 2010;67:407-21 pubmed publisher
    ..which plays crucial roles in axonal midline crossing, is regulated by a neural RNA-binding protein Musashi1 (Msi1)...
  10. Horisawa K, Imai T, Okano H, Yanagawa H. 3'-Untranslated region of doublecortin mRNA is a binding target of the Musashi1 RNA-binding protein. FEBS Lett. 2009;583:2429-34 pubmed publisher
    Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural stem cells, and is considered to be a stemness factor. A known function of Msi1 is translational repression of specifically bound mRNAs...
  11. Kayahara T, Sawada M, Takaishi S, Fukui H, Seno H, Fukuzawa H, et al. Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS Lett. 2003;535:131-5 pubmed
    ..These findings suggest that not only the cells just above Paneth cells but also the crypt base columnar cells between the Paneth cells have stem cell characteristics. ..
  12. Sakakibara S, Nakamura Y, Yoshida T, Shibata S, Koike M, Takano H, et al. RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci U S A. 2002;99:15194-9 pubmed
    ..In mammals, two members of this family, Musashi1 (Msi1) and Musashi2 (Msi2), are strongly coexpressed in neural precursor cells, including CNS stem cells...
  13. Miyanoiri Y, Kobayashi H, Imai T, Watanabe M, Nagata T, Uesugi S, et al. Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and back. J Biol Chem. 2003;278:41309-15 pubmed
    ..The biological role of RBD2 with lower affinity is also discussed. ..
  14. Siddall N, McLaughlin E, Marriner N, Hime G. The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity. Proc Natl Acad Sci U S A. 2006;103:8402-7 pubmed
    ..We describe the complementary expression patterns of the murine Msi paralogues Msi1 and Msi2 during spermatogenesis, which support the idea of distinct, evolutionarily conserved roles of Msi.
  15. Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, et al. The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol Cell Biol. 2001;21:3888-900 pubmed
    Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural progenitor cells, including neural stem cells...
  16. Lan S, Yu T, Xia Z, Yuan Y, Shi L, Lin Y, et al. Musashi 1-positive cells derived from mouse embryonic stem cells can differentiate into neural and intestinal epithelial-like cells in vivo. Cell Biol Int. 2010;34:1171-80 pubmed publisher
    Msi1 (Musashi 1) is regarded as a marker for neural and intestinal epithelial stem cells...
  17. Oki K, Kaneko N, Kanki H, Imai T, Suzuki N, Sawamoto K, et al. Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia. Neurosci Res. 2010;66:390-5 pubmed publisher
    ..the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-binding protein and another marker of neural stem/progenitor cells...
  18. Murphy D, Cieply B, Carstens R, Ramamurthy V, Stoilov P. The Musashi 1 Controls the Splicing of Photoreceptor-Specific Exons in the Vertebrate Retina. PLoS Genet. 2016;12:e1006256 pubmed publisher
    ..lack prototypical neuronal splicing factors and their splicing profile is driven to a significant degree by the Musashi 1 (MSI1) protein...
  19. Ratti A, Fallini C, Cova L, Fantozzi R, Calzarossa C, Zennaro E, et al. A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA. J Cell Sci. 2006;119:1442-52 pubmed
    ..Since the gene encoding Musashi-1 (Msi1) contains a conserved ARE in its 3' untranslated region, we focused on the possibility of a mechanistic ..
  20. Yu T, Chen Q, Gong Y, Xia Z, Royal C, Huang K. Higher expression patterns of the intestinal stem cell markers Musashi-1 and hairy and enhancer of split 1 and their correspondence with proliferation patterns in the mouse jejunum. Med Sci Monit. 2010;16:BR68-74 pubmed
    ..In this study the expression patterns of the small intestinal stem cell (SISC) markers Musashi-1 (Msi1) and hairy and enhancer of split 1 (Hes1) were identified and the relationship between their expression and ..
  21. Ose T, Kadowaki Y, Fukuhara H, Kazumori H, Ishihara S, Udagawa J, et al. Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine. Oncogene. 2007;26:349-59 pubmed
    ..Reg I was considered to be a regulator of cell growth that is required to generate and maintain the villous structure of the small intestine. ..
  22. Lim S, Kaldis P. Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells. Stem Cells. 2012;30:1509-20 pubmed publisher
    ..Our data thus demonstrate the induction of neurogenic divisions in the absence of critical mediators of G1/S transition-Cdk2 and Cdk4, and highlight their evolutionary importance in the determination of cortical thickness. ..
  23. Sakaguchi H, Yaoi T, Suzuki T, Okano H, Hisa Y, Fushiki S. Spatiotemporal patterns of Musashi1 expression during inner ear development. Neuroreport. 2004;15:997-1001 pubmed
    ..To investigate the involvement of Msi1 in the inner ear development, we studied the expression of Msi1 in mouse inner ears with RT-PCR and ..
  24. Nakamura Y, Sakakibara S, Miyata T, Ogawa M, Shimazaki T, Weiss S, et al. The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells. J Neurosci. 2000;20:283-93 pubmed
  25. Fox R, Lytle N, Jaquish D, Park F, Ito T, Bajaj J, et al. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016;534:407-411 pubmed publisher
    ..This population could be effectively targeted by deletion of either Msi1 or Msi2, which led to a striking defect in the progression of pancreatic intraepithelial neoplasia to ..
  26. Martínez C, Cornejo V, Lois P, Ellis T, Solis N, Wainwright B, et al. Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source. PLoS ONE. 2013;8:e65818 pubmed publisher
    ..We conclude that endogenous Shh signaling is a critical mechanism regulating the proliferation of stem cell lineages in the embryonic dorsal tissue. ..
  27. MacNicol M, Cragle C, Arumugam K, Fosso B, Pesole G, MacNicol A. Functional Integration of mRNA Translational Control Programs. Biomolecules. 2015;5:1580-99 pubmed publisher
    ..Continued study of regulated ribonucleoprotein complex dynamics promises valuable new insights into mRNA translational control and may suggest novel therapeutic strategies for the treatment of disease. ..
  28. Ying Y, Li L, Cao W, Yan D, Zeng Q, Kong X, et al. The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion. FEBS Lett. 2012;586:3674-80 pubmed publisher
    ..Additionally, syntabulin was preferentially phosphorylated by the Epac2 agonist 8-pCPT-2'-O-Me-cAMP, suggesting that syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion. ..
  29. Sutherland J, Sobinoff A, Fraser B, Redgrove K, Davidson T, Siddall N, et al. RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus. FASEB J. 2015;29:2759-68 pubmed publisher
    ..We focus in depth on the role and function of the vertebrate Musashi ortholog Musashi-1 (MSI1)...
  30. ErLin S, WenJie W, LiNing W, BingXin L, MingDe L, Yan S, et al. Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress. Mol Biol Cell. 2015;26:1947-56 pubmed publisher
    ..We also note a role for Msi-1 in regulating Sertoli cell fate following heat-induced injury, likely through the induction of stress granule formation and subsequent activation of p-ERK1/2 signaling. ..
  31. Jadhav S, Ajay A, Trivedi P, Seematti J, Pellegrini K, Craciun F, et al. RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA. J Biol Chem. 2016;291:14085-94 pubmed publisher
    ..Here, we report a novel mechanism in kidney fibrosis involving a RBP, Musashi homologue 1 (Msi1), which is expressed in tubular epithelial cells...
  32. Iwaoka R, Nagata T, Tsuda K, Imai T, Okano H, Kobayashi N, et al. Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA. Molecules. 2017;22: pubmed publisher
    Musashi-1 (Msi1) controls the maintenance of stem cells and tumorigenesis through binding to its target mRNAs and subsequent translational regulation...
  33. Dobson N, Zhou Y, Flint N, Armstrong R. Musashi1 RNA-binding protein regulates oligodendrocyte lineage cell differentiation and survival. Glia. 2008;56:318-30 pubmed
    Expression of Musashi1 (Msi1), an evolutionarily conserved RNA-binding protein, in neural stem cells of the subventricular zone in the postnatal and adult CNS indicates a potential role in the generation of oligodendrocytes...
  34. Takahashi M, Kojima M, Nakajima K, Suzuki Migishima R, Takeuchi T. Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain. Dev Biol. 2007;303:549-60 pubmed
    ..in the repression of cardiac myocyte proliferation, we found many ectopic clusters expressing both cyclin D1 and Musashi 1 in the MZ of mutant embryos...
  35. Backman M, Machon O, Van Den Bout C, Krauss S. Targeted disruption of mouse Dach1 results in postnatal lethality. Dev Dyn. 2003;226:139-44 pubmed
    ..Neural stem cells derived from mutant and wild-type newborn brains display similar growth kinetics when cultivated in vitro. ..
  36. Petersen P, Zou K, Krauss S, Zhong W. Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat Neurosci. 2004;7:803-11 pubmed
  37. Katz Y, Li F, Lambert N, Sokol E, Tam W, Cheng A, et al. Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state. elife. 2014;3:e03915 pubmed publisher
    ..Knockdown of Msis in epithelial cancer cells promoted loss of epithelial identity. Our results show that mammalian Msi proteins contribute to an epithelial gene expression program in neural and mammary cell types. ..
  38. Elkouris M, Balaskas N, Poulou M, Politis P, Panayiotou E, Malas S, et al. Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis. Stem Cells. 2011;29:89-98 pubmed publisher
    ..Thus, our results demonstrate that Sox1 regulates the size of the cortical NP pool via suppression of Prox1-mediated neurogenic cell divisions. ..
  39. Hisaoka T, Morikawa Y, Komori T, Sugiyama T, Kitamura T, Senba E. Characterization of TROY-expressing cells in the developing and postnatal CNS: the possible role in neuronal and glial cell development. Eur J Neurosci. 2006;23:3149-60 pubmed
    ..These findings suggest that the signaling from TROY regulates neuronal differentiation at least in part. ..
  40. Takeda H, Koso H, Tessarollo L, Copeland N, Jenkins N. Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells. Genesis. 2013;51:128-34 pubmed publisher
    The RNA-binding protein Musashi1 (Msi1) is one of two mammalian homologues of Drosophila Musashi, which is required for the asymmetric cell division of sensory organ precursor cells...
  41. Akamatsu W, Fujihara H, Mitsuhashi T, Yano M, Shibata S, Hayakawa Y, et al. The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc Natl Acad Sci U S A. 2005;102:4625-30 pubmed
    ..Taken together, the results suggest that HuD is required at multiple points during neuronal development, including negative regulation of proliferative activity and neuronal cell-fate acquisition of neural stem/progenitor cells. ..
  42. Koso H, Tsuhako A, Lai C, Baba Y, Otsu M, Ueno K, et al. Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina. Glia. 2016;64:2005-24 pubmed publisher
    ..Taken together, our data indicate that Sall1 regulates microglial morphology during development. GLIA 2016;64:2005-2024. ..
  43. Wang S, Li N, Yousefi M, Nakauka Ddamba A, Li F, Parada K, et al. Transformation of the intestinal epithelium by the MSI2 RNA-binding protein. Nat Commun. 2015;6:6517 pubmed publisher
    ..Taken together, our findings identify MSI2 as a central component in an unappreciated oncogenic pathway promoting intestinal transformation. ..
  44. Sutherland J, Sobinoff A, Gunter K, Fraser B, Pye V, Bernstein I, et al. Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis. Biomolecules. 2015;5:1228-44 pubmed publisher
    ..In this study we determined the expression of mammalian Musashi proteins MSI1 and MSI2 during mouse folliculogenesis, and through the use of a MSI2-specific knockout mouse model we identified ..
  45. Yousefi M, Li N, Nakauka Ddamba A, Wang S, Davidow K, Schoenberger J, et al. Msi RNA-binding proteins control reserve intestinal stem cell quiescence. J Cell Biol. 2016;215:401-413 pubmed
    ..These findings delineate a molecular mechanism governing reserve ISC quiescence and demonstrate a necessity for the activity of this rare stem cell population in intestinal regeneration. ..
  46. Nikpour P, Baygi M, Steinhoff C, Hader C, Luca A, Mowla S, et al. The RNA binding protein Musashi1 regulates apoptosis, gene expression and stress granule formation in urothelial carcinoma cells. J Cell Mol Med. 2011;15:1210-24 pubmed publisher
    The RNA-binding protein Musashi1 (MSI1) is a marker of progenitor cells in the nervous system functioning as a translational repressor...
  47. Nahas G, Murthy R, Patel S, Ganta T, Greco S, Rameshwar P. The RNA-binding protein Musashi 1 stabilizes the oncotachykinin 1 mRNA in breast cancer cells to promote cell growth. FASEB J. 2016;30:149-59 pubmed publisher
    ..Western blot analysis and RNA supershift identified Musashi 1 (Msi1) as the binding protein...
  48. Rutledge C, Lau H, Mangan H, Hardy L, Sunnotel O, Guo F, et al. Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements. PLoS ONE. 2014;9:e88385 pubmed publisher
    ..Furthermore we show by RNA immunoprecipitation that Musashi1 (MSI1) binds to the MBE and that this element is required for polyadenylation in oocytes...
  49. Nickerson P, Myers T, Clarke D, Chow R. Changes in Musashi-1 subcellular localization correlate with cell cycle exit during postnatal retinal development. Exp Eye Res. 2011;92:344-52 pubmed publisher
    ..These data provide evidence that nuclear, and cytoplasmic sequestering of Musashi-1 in retinal cells is context-specific, and may contribute to downstream functioning of Musashi-1. ..
  50. Hoeck J, Jandke A, Blake S, Nye E, Spencer Dene B, Brandner S, et al. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci. 2010;13:1365-72 pubmed publisher
    ..Thus Fbw7 controls neurogenesis by antagonizing Notch and c-Jun N-terminal kinase (JNK)/c-Jun signaling. ..
  51. Morgan S, Yasin S, Uwanogho D, Jeffries A, Price J. Positional specification in a neural stem cell line involves modulation of Musashi1 expression. Stem Cells Dev. 2010;19:579-92 pubmed publisher
    ..We postulate that it is the ability of MHP36 cells to adopt either cortical or striatal positional specification that is key to their functional efficacy in a number of models of neurological disease. ..
  52. Susaki K, Kaneko J, Yamano Y, Nakamura K, Inami W, Yoshikawa T, et al. Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors. Exp Eye Res. 2009;88:347-55 pubmed publisher
    Musashi-1 (Msi1), an RNA-binding protein (RBP), has been postulated to play important roles in the maintenance of the stem-cell state, differentiation, and tumorigenesis...
  53. Matsumoto S, Banine F, Struve J, Xing R, Adams C, Liu Y, et al. Brg1 is required for murine neural stem cell maintenance and gliogenesis. Dev Biol. 2006;289:372-83 pubmed
  54. Kawase S, Kuwako K, Imai T, Renault Mihara F, Yaguchi K, Itohara S, et al. Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells. Stem Cells Dev. 2014;23:2250-61 pubmed publisher
    ..The RNA-binding protein Musashi1 (Msi1), which is often employed as a marker for NS/PCs, regulates Notch signaling to maintain NS/PCs in undifferentiated ..
  55. Clingman C, Deveau L, Hay S, Genga R, Shandilya S, Massi F, et al. Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite. elife. 2014;3: pubmed publisher
    ..In this study, we show that RNA-binding by the stem cell translation regulator Musashi-1 (MSI1) is allosterically inhibited by 18-22 carbon ?-9 monounsaturated fatty acids...
  56. Cragle C, MacNicol A. Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2. J Biol Chem. 2014;289:14239-51 pubmed publisher
    ..Finally, we report a similar co-association also occurs between murine Musashi and GLD2 orthologs, suggesting that coupling of Musashi to the polyadenylation apparatus is a conserved mechanism to promote target mRNA translation. ..
  57. O Valle F, Peregrina M, Crespo Lora V, Galindo Moreno P, Roman M, Padial Molina M, et al. Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis. Biomed Res Int. 2015;2015:681456 pubmed publisher
    ..Adult stem cell marker Musashi-1 (Msi1) plays an important role in regulating the maintenance and differentiation of stem/precursor cells...
  58. Gresset A, Coulpier F, Gerschenfeld G, Jourdon A, Matesic G, Richard L, et al. Boundary Caps Give Rise to Neurogenic Stem Cells and Terminal Glia in the Skin. Stem Cell Reports. 2015;5:278-90 pubmed publisher
    ..It provides genetic tools to study and manipulate this population of high interest for medical applications. ..
  59. Cambuli F, Correa B, Rezza A, Burns S, Qiao M, Uren P, et al. A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness. Stem Cells. 2015;33:3621-34 pubmed publisher
    ..Compared with wild type litters, v-Msi1 mice exhibited increased intestinal crypt size accompanied by enhanced proliferation...
  60. Asai R, Okano H, Yasugi S. Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse. Dev Growth Differ. 2005;47:501-10 pubmed
    ..Based on our observations of the expression patterns of Msi-1 and c-hairy-1 in the adult small intestine, we speculate that Msi-1 is also a stem cell marker of the chicken small intestinal epithelium...
  61. Yamamoto S, Yoshino I, Shimazaki T, Murohashi M, Hevner R, Lax I, et al. Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells. Proc Natl Acad Sci U S A. 2005;102:15983-8 pubmed
    ..However, mutant NSPCs were able to self-renew, demonstrating that Shp2-binding sites on FRS2alpha play an important role in NSPC proliferation but are dispensable for NSPC self-renewing capacity after FGF2 stimulation. ..
  62. Andrieu D, Watrin F, Niinobe M, Yoshikawa K, Muscatelli F, Fernandez P. Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression. Gene Expr Patterns. 2003;3:761-5 pubmed
    ..Furthermore, they are also consistent with the putative role of Necdin in signaling events promoted by p75NTR during mouse nervous system development. ..
  63. Odle A, Benes H, Melgar Castillo A, Akhter N, Syed M, Haney A, et al. Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression. Endocrinology. 2018;159:883-894 pubmed publisher
    ..determined that these Gnrhr mRNA MBE were active: (1) RNA electrophoretic mobility shift assay analyses showed that MSI1 specifically bound Gnrhr mRNA 3'-UTR; (2) RNA immunoprecipitation of pituitary fractions with MSI1 antibody pulled ..