Gene Symbol: Ms4a4b
Description: membrane-spanning 4-domains, subfamily A, member 4B
Alias: AI463180, Chandra, Ly116, membrane-spanning 4-domains, subfamily A, member 4B, lymphocyte antigen 116
Venkataraman C, Schaefer G, Schindler U. Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes. J Immunol. 2000;165:632-6 pubmed
..In this study, we have identified a novel four-transmembrane domain protein, Chandra, that is differentially expressed in Th1 cells...
Liang Y, Tedder T. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72:119-27 pubmed
..1 along with CD20, FcepsilonRIbeta, and HTm4. Thus, like CD20 and FcepsilonRIbeta, the other MS4A family members are likely to be components of oligomeric cell surface complexes that serve diverse signal transduction functions. ..
Liang Y, Buckley T, Tu L, Langdon S, Tedder T. Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics. 2001;53:357-68 pubmed
..Like CD20 and FcepsilonRIbeta, the 10 other human MS4A family members are likely to be components of oligomeric cell surface complexes involved in signal transduction in diverse cell lineages. ..
Howie D, Nolan K, Daley S, Butterfield E, Adams E, Garcia Rueda H, et al
. MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation. J Immunol. 2009;183:4197-204 pubmed publisher
..Naive T cells transduced with MS4A4B become able to respond to lower levels of Ag...
Xu H, Williams M, Spain L. Patterns of expression, membrane localization, and effects of ectopic expression suggest a function for MS4a4B, a CD20 homolog in Th1 T cells. Blood. 2006;107:2400-8 pubmed
..One family member, Chandra/MS4a4B, was reported to be expressed in T helper 1 (Th1) T cells but not Th2 T cells...
Xiao Y, Peperzak V, Keller A, Borst J. CD27 instructs CD4+ T cells to provide help for the memory CD8+ T cell response after protein immunization. J Immunol. 2008;181:1071-82 pubmed
..CD27 induced a Th1-diagnostic gene expression profile in CD4(+) T cells, which included the membrane molecule MS4A4B. Accordingly, CD27 increased the frequency of IFN-gamma- and IL-2-producing CD4(+) T cells...
Xu H, Yan Y, Williams M, Carey G, Yang J, Li H, et al
. MS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle. PLoS ONE. 2010;5:e13780 pubmed publisher
b>MS4a4B, a CD20 homologue in T cells, is a novel member of the MS4A gene family in mice...
Yan Y, Zhang G, Williams M, Carey G, Li H, Yang J, et al
. TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation. Mol Immunol. 2012;52:71-8 pubmed publisher
b>MS4a4B is a novel member of the membrane-spanning 4-domain family, subfamily A (MS4A) specifically expressed in mouse T cells...
Yan Y, Li Z, Zhang G, Williams M, Carey G, Zhang J, et al
. Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis. Apoptosis. 2013;18:1106-19 pubmed publisher
..In previous studies, we have investigated the function of MS4a4B, a novel CD20 homologue, in T cell proliferation...