Mpo

Summary

Gene Symbol: Mpo
Description: myeloperoxidase
Alias: mKIAA4033, myeloperoxidase
Species: mouse
Products:     Mpo

Top Publications

  1. Valenzuela D, Economides A, Rojas E, Lamb T, Nunez L, Jones P, et al. Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci. 1995;15:6077-84 pubmed
  2. Zhang R, Brennan M, Shen Z, MacPherson J, Schmitt D, Molenda C, et al. Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation. J Biol Chem. 2002;277:46116-22 pubmed
    ..b>Myeloperoxidase (MPO), a heme protein secreted by activated leukocytes, generates reactive intermediates that promote lipid ..
  3. van Leeuwen M, Gijbels M, Duijvestijn A, Smook M, van de Gaar M, Heeringa P, et al. Accumulation of myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR-/- mice. Arterioscler Thromb Vasc Biol. 2008;28:84-9 pubmed
    ..Immunofluorescence double staining with anti-myeloperoxidase and anti-Ly-6G antibodies demonstrated the presence of myeloperoxidase in atherosclerotic lesions and its ..
  4. Tidén A, Sjögren T, Svensson M, Bernlind A, Senthilmohan R, Auchère F, et al. 2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation. J Biol Chem. 2011;286:37578-89 pubmed publisher
    b>Myeloperoxidase (MPO) is a prime candidate for promoting oxidative stress during inflammation. This abundant enzyme of neutrophils uses hydrogen peroxide to oxidize chloride to highly reactive and toxic chlorine bleach...
  5. Sugamata R, Dobashi H, Nagao T, Yamamoto K, Nakajima N, Sato Y, et al. Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection. Microbiol Immunol. 2012;56:171-82 pubmed publisher
    ..We focused on neutrophil myeloperoxidase (MPO) as a potent tissue damage factor and examined its contribution in influenza pneumonia by using mice ..
  6. Chang C, Song M, Jeon S, Yoon H, Lee D, Kim I, et al. Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells. Am J Pathol. 2011;179:964-79 pubmed publisher
    ..Herein, we report that myeloperoxidase (MPO) may have a potential regulatory role in rotenone-exposed brain-resident immune cells...
  7. Matthijsen R, Huugen D, Hoebers N, de Vries B, Peutz Kootstra C, Aratani Y, et al. Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion. Am J Pathol. 2007;171:1743-52 pubmed
    In this study the role of myeloperoxidase (MPO) in a murine (C57BL/6) model of ischemia and reperfusion (I/R)-induced renal failure was investigated...
  8. Aratani Y, Koyama H, Nyui S, Suzuki K, Kura F, Maeda N. Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun. 1999;67:1828-36 pubmed
    b>Myeloperoxidase (MPO) catalyzes the reaction of hydrogen peroxide with chloride ion to produce hypochlorous acid (HOCl), which is used for microbial killing by phagocytic cells...
  9. Klinke A, Nussbaum C, Kubala L, Friedrichs K, Rudolph T, Rudolph V, et al. Myeloperoxidase attracts neutrophils by physical forces. Blood. 2011;117:1350-8 pubmed publisher
    ..We provide evidence for myeloperoxidase (MPO), an abundant PMN-derived heme protein, facilitating PMN recruitment by its positive surface charge...

More Information

Publications94

  1. Haegens A, Heeringa P, van Suylen R, Steele C, Aratani Y, O Donoghue R, et al. Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production. J Immunol. 2009;182:7990-6 pubmed publisher
    ..b>Myeloperoxidase (MPO) is an enzyme stored in the azurophilic granula of neutrophils...
  2. McMillen T, Heinecke J, LeBoeuf R. Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice. Circulation. 2005;111:2798-804 pubmed
    b>Myeloperoxidase (MPO) colocalizes with macrophages in the human artery wall, and its characteristic oxidation products have been detected in atherosclerotic lesions. Thus, oxidants produced by the enzyme might promote atherosclerosis...
  3. Milla C, Yang S, Cornfield D, Brennan M, Hazen S, Panoskaltsis Mortari A, et al. Myeloperoxidase deficiency enhances inflammation after allogeneic marrow transplantation. Am J Physiol Lung Cell Mol Physiol. 2004;287:L706-14 pubmed
    b>Myeloperoxidase (MPO)-derived oxidants participate in the respiratory antimicrobial defense system but are also implicated in oxidant-mediated acute lung injury...
  4. Eiserich J, Baldus S, Brennan M, Ma W, Zhang C, Tousson A, et al. Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science. 2002;296:2391-4 pubmed
    b>Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions...
  5. Brennan M, Anderson M, Shih D, Qu X, Wang X, Mehta A, et al. Increased atherosclerosis in myeloperoxidase-deficient mice. J Clin Invest. 2001;107:419-30 pubmed
    b>Myeloperoxidase (MPO), a heme enzyme secreted by activated phagocytes, generates an array of oxidants proposed to play critical roles in host defense and local tissue damage...
  6. Schreiber A, Xiao H, Falk R, Jennette J. Bone marrow-derived cells are sufficient and necessary targets to mediate glomerulonephritis and vasculitis induced by anti-myeloperoxidase antibodies. J Am Soc Nephrol. 2006;17:3355-64 pubmed
    ..One of the major target antigens for ANCA is myeloperoxidase (MPO)...
  7. Chang C, Choi D, Lee D, Hong Y, Park E. Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells. PLoS ONE. 2013;8:e60654 pubmed publisher
    b>Myeloperoxidase (MPO) functions as a key molecular component of the host defense system against diverse pathogens...
  8. Brovkovych V, Gao X, Ong E, Brovkovych S, Brennan M, Su X, et al. Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. Am J Physiol Lung Cell Mol Physiol. 2008;295:L96-103 pubmed publisher
    The myeloperoxidase (MPO)-hydrogen peroxide-halide system is an efficient oxygen-dependent antimicrobial component of polymorphonuclear leukocyte (PMN)-mediated host defense...
  9. Nguyen H, Lusis A, Tidball J. Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo. J Physiol. 2005;565:403-13 pubmed
    ..application of mechanical loads to co-cultures of muscle cells and neutrophils that are null mutants for myeloperoxidase (MPO) showed no mechanical activation of neutrophil cytotoxicity...
  10. Chen X, Kurre U, Jenkins N, Copeland N, Funk C. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994;269:13979-87 pubmed
    ..Antibodies prepared against the two forms of 12-lipoxygenase revealed the differential distribution of the two enzymes throughout the mouse. ..
  11. Morris Rosendahl D, Schriever Schwemmer G, Robinson T. Derivation and characterization of a somatic cell hybrid containing the portion of mouse chromosome 11 (MMU11) homologous to human chromosome 17q. J Hered. 1996;87:252-8 pubmed
    ..T16Ad translocation breakpoint between the proximal markers Atplb2 and Acrb and the more distal markers Scya2 and Mpo. Loci for D11Mit5, Rpo2-1, Trp53, Glut4, Acrb, and Atplb2 could all be localized proximal to the T16Ad breakpoint ..
  12. El Kebir D, Jozsef L, Pan W, Filep J. Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation. Circ Res. 2008;103:352-9 pubmed publisher
    ..b>Myeloperoxidase (MPO), a heme protein abundantly expressed in neutrophils, is generally associated with killing of bacteria ..
  13. Brennan M, Gaur A, Pahuja A, Lusis A, Reynolds W. Mice lacking myeloperoxidase are more susceptible to experimental autoimmune encephalomyelitis. J Neuroimmunol. 2001;112:97-105 pubmed
    EAE is a demyelinating disease which serves as an animal model for multiple sclerosis (MS). Myeloperoxidase (MPO) has been implicated in MS through its presence in invading macrophages, and by association of a -463G/A promoter ..
  14. Demir M, Sert S, Kaleli I, Demir S, Cevahir N, Yildirim U, et al. Liver lipid peroxidation in experimental Escherichia coli peritonitis: the role of myeloperoxidase and nitric oxide inhibition. Med Sci Monit. 2007;13:BR225-9 pubmed
    The pathogenic mechanism of peritonitis is complex. The role of nitric oxide (NO) and myeloperoxidase (MPO) in liver lipid peroxidation accompanying bacterial peritonitis was evaluated. Peritonitis was induced by 0...
  15. Bayer S, Maghzal G, Stocker R, Hampton M, Winterbourn C. Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. FASEB J. 2013;27:3315-22 pubmed publisher
    ..Studies with inhibitors and myeloperoxidase-deficient neutrophils showed that H2O2 generated by the neutrophil NADPH oxidase was responsible...
  16. Levine A, Duchen M, de Villiers S, Rich P, Segal A. Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity. PLoS ONE. 2015;10:e0125906 pubmed publisher
    ..Conditions in the vacuole are optimal for bacterial killing by the neutral proteases, cathepsin G and elastase, and not by myeloperoxidase, activity of which was unphysiologically low at alkaline pH.
  17. Schreiber A, Rolle S, Peripelittchenko L, Rademann J, Schneider W, Luft F, et al. Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis. Kidney Int. 2010;77:118-28 pubmed publisher
    ..We transplanted bone marrow from wild-type mice or PI3Kgamma-deficient mice into myeloperoxidase-deficient mice immunized with myeloperoxidase...
  18. Yu Y, Morishima M, Pao A, Wang D, Wen X, Baldini A, et al. A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Genetics. 2006;173:297-307 pubmed
    ..Within the deletion interval, there is a genomic segment that is bounded by the myeloperoxidase and homeobox B1 genes...
  19. Katakami N, Kume S, Kaneto H, Uzu T, Kashiwagi A, Yamasaki Y, et al. Association of myeloperoxidase G-463A gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic subjects. Endocr J. 2013;60:457-71 pubmed
    It is possible that myeloperoxidase (MPO) contributes to the pathogenesis of diabetic nephropathy through the production of reactive oxygen species and HOCl/OCl?...
  20. Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher M, Wiltshire T, et al. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet. 2005;37:225-32 pubmed
    ..Our data are accessible through WebQTL, a web-based interface that allows custom genetic linkage analysis and identification of coregulated transcripts. ..
  21. Jerke U, Rolle S, Purfürst B, Luft F, Nauseef W, Kettritz R. ?2 integrin-mediated cell-cell contact transfers active myeloperoxidase from neutrophils to endothelial cells. J Biol Chem. 2013;288:12910-9 pubmed publisher
    ..Neutrophil myeloperoxidase (MPO) can disrupt normal EC function, although the mechanism(s) by which MPO is transferred to ECs are ..
  22. Askari A, Brennan M, Zhou X, Drinko J, Morehead A, Thomas J, et al. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med. 2003;197:615-24 pubmed
    ..b>Myeloperoxidase (MPO), which accumulates in the infarct zone, is released from neutrophils and monocytes leading to the ..
  23. Maghzal G, Cergol K, Shengule S, Suarna C, Newington D, Kettle A, et al. Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium. J Biol Chem. 2014;289:5580-95 pubmed publisher
    Oxidants derived from myeloperoxidase (MPO) contribute to inflammatory diseases...
  24. Xiao H, Ciavatta D, Aylor D, Hu P, de Villena F, Falk R, et al. Genetically determined severity of anti-myeloperoxidase glomerulonephritis. Am J Pathol. 2013;182:1219-26 pubmed publisher
    b>Myeloperoxidase (MPO) is a target antigen for antineutrophil cytoplasmic autoantibodies (ANCA). There is evidence that MPO-ANCA cause necrotizing and crescentic glomerulonephritis (NCGN) and vasculitis...
  25. Lehners A, Lange S, Niemann G, Rosendahl A, Meyer Schwesinger C, Oh J, et al. Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice. Am J Physiol Renal Physiol. 2014;307:F407-17 pubmed publisher
    b>Myeloperoxidase (MPO) is an enzyme expressed in neutrophils and monocytes/macrophages. Beside its well-defined role in innate immune defence, it may also be responsible for tissue damage...
  26. Birkner K, Steiner B, Rinkler C, Kern Y, Aichele P, Bogdan C, et al. The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol. 2008;38:3395-410 pubmed publisher
    ..phagocytophilum infection, because mice deficient for antimicrobial effectors of neutrophils such as myeloperoxidase, granulocyte elastase, and cathepsin G were fully competent in pathogen elimination...
  27. Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C, et al. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 1997;11:774-85 pubmed
    ..Using single cell RT-PCR we show that erythroid (beta-globin) and myeloid (myeloperoxidase) gene expression programs can be initiated by the same cell prior to exclusive commitment to the erythroid or ..
  28. Buchberg A, Brownell E, Nagata S, Jenkins N, Copeland N. A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics. 1989;122:153-61 pubmed
    ..human chromosomes and the known linkage homologies that exist between murine chromosome 11 and human chromosomes (Mpo, Ngfr, Pdgfr and Fms). Two of the latter genes, Mpo and Ngfr, mapped to mouse chromosome 11...
  29. Baldacci P, Cohen Tannoudji M, Kress C, Pournin S, Babinet C. A high-resolution map around the locus Om on mouse Chromosome 11. Mamm Genome. 1996;7:114-6 pubmed
    ..The distance between these two markers is about 2 cM. These data should facilitate the positional cloning and molecular characterization of Om. ..
  30. Wang Z, Nicholls S, Rodriguez E, Kummu O, Horkko S, Barnard J, et al. Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med. 2007;13:1176-84 pubmed
    ..for cyanate formation and protein carbamylation at sites of inflammation and atherosclerotic plaque: myeloperoxidase-catalyzed oxidation of thiocyanate, an anion abundant in blood whose levels are elevated in smokers...
  31. Ostanin D, Barlow S, Shukla D, Grisham M. NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections. Biochem Biophys Res Commun. 2007;355:801-6 pubmed
    ..The objective of this study was to ascertain what role phagocyte-associated NADPH oxidase or myeloperoxidase (MPO) plays in host defense in mice lacking both T- and B-cells...
  32. Al Salihi M, Reichert E, Fitzpatrick F. Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice. Redox Biol. 2015;6:218-25 pubmed publisher
    ..We report that myeloperoxidase (MPO), an ancestor of the COX isoenzymes, is a determinant of colitis-associated colon tumors in Apc(Min/+) ..
  33. Suzow J, Friedman A. The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1). Mol Cell Biol. 1993;13:2141-51 pubmed
    The myeloperoxidase (MPO) gene is expressed specifically in myeloid cells. There is significant homology between the murine and human MPO genes in the 1.6-kb region located upstream of the murine MPO transcription initiation sites...
  34. Cruz Baquero A, Cárdenas Jaramillo L, Gutiérrez Meza M, Jarillo Luna R, Campos Rodríguez R, Rivera Aguilar V, et al. Different behavior of myeloperoxidase in two rodent amoebic liver abscess models. PLoS ONE. 2017;12:e0182480 pubmed publisher
    ..b>Myeloperoxidase is the most abundant enzyme secreted by neutrophils...
  35. Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, et al. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood. 2012;120:3793-802 pubmed publisher
    ..We propose that selective targeting of IL-17A signaling might provide a new therapeutic option for the treatment of stroke. ..
  36. Endo D, Saito T, Umeki Y, Suzuki K, Aratani Y. Myeloperoxidase negatively regulates the expression of proinflammatory cytokines and chemokines by zymosan-induced mouse neutrophils. Inflamm Res. 2016;65:151-9 pubmed publisher
    We have previously reported that myeloperoxidase-deficient (MPO(-/-)) neutrophils produce greater amounts of macrophage inflammatory protein-2 (MIP-2) upon in vitro stimulation with zymosan than wild-type neutrophils...
  37. Zhang H, Ray A, Miller N, Hartwig D, Pritchard K, Dittel B. Inhibition of myeloperoxidase at the peak of experimental autoimmune encephalomyelitis restores blood-brain barrier integrity and ameliorates disease severity. J Neurochem. 2016;136:826-836 pubmed publisher
    ..b>Myeloperoxidase (MPO), a potent peroxidase that generates toxic radicals and oxidants, is increased in the CNS during MS...
  38. Galijasevic S, Saed G, Diamond M, Abu Soud H. Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition. Proc Natl Acad Sci U S A. 2003;100:14766-71 pubmed
    ..b>Myeloperoxidase (MPO), a major NO scavenger, is a pivotal enzyme involved in leukocyte-mediated host defenses...
  39. Kubala L, Schmelzer K, Klinke A, Kolarova H, Baldus S, Hammock B, et al. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. Free Radic Biol Med. 2010;48:1311-20 pubmed publisher
    ..b>Myeloperoxidase (MPO) is an abundant phagocyte-derived hemoprotein released during phagocyte activation...
  40. Sancho Shimizu V, Khan R, Mostowy S, Larivière L, Wilkinson R, Riendeau N, et al. Molecular genetic analysis of two loci (Ity2 and Ity3) involved in the host response to infection with Salmonella typhimurium using congenic mice and expression profiling. Genetics. 2007;177:1125-39 pubmed
    ..The combination of the use of congenics in QTL confirmation and fine mapping and in the identification of candidate genes by expression profiling has been successful and represents a step toward quantitative gene(s) identification. ..
  41. Todd J, Aitman T, Cornall R, Ghosh S, Hall J, Hearne C, et al. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature. 1991;351:542-7 pubmed
    ..On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17. ..
  42. llen A, Singewald E, Konya V, Fauler G, Reicher H, Nusshold C, et al. Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo. PLoS ONE. 2013;8:e64034 pubmed publisher
    ..One of the oxidants released by activated leukocytes is hypochlorous acid (HOCl) formed via the myeloperoxidase (MPO)-H2O2-Cl(-) system...
  43. Byrd L. Regional localization of the nu mutation on mouse chromosome 11. Immunogenetics. 1993;37:157-9 pubmed
  44. Sakamaki K, Ueda T, Nagata S. The evolutionary conservation of the mammalian peroxidase genes. Cytogenet Genome Res. 2002;98:93-5 pubmed
    b>Myeloperoxidase (MPO), eosinophil peroxidase (EPX) and lactoperoxidase (LPO) are mammalian peroxidase enzymes possessing similar structures and functions...
  45. Olson M, Scott E, Hack A, Su G, Tenen D, Singh H, et al. PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity. 1995;3:703-14 pubmed
    ..Early genes such as GM-CSFR, G-CSFR, and myeloperoxidase are expressed in PU.1-/- embryos and differentiated PU.1-/- ES cells...
  46. Feil R, Baldacci P, Tarttelin E, Rhodes M, Singh P, Reik W. Cbx-rs2 (M31), a mouse homolog of the Drosophila Heterochromatin protein 1 gene, maps to distal chromosome 11 and is nonallelic to Om. Mamm Genome. 1995;6:469-71 pubmed
  47. Long E, Klimowicz A, Paula Neto H, Millen B, McCafferty D, Kubes P, et al. A subclass of acylated anti-inflammatory mediators usurp Toll-like receptor 2 to inhibit neutrophil recruitment through peroxisome proliferator-activated receptor gamma. Proc Natl Acad Sci U S A. 2011;108:16357-62 pubmed publisher
    ..These inhibitory TLR2 ligands also have broader implications with respect to their potential use in various inflammatory disease settings. ..
  48. Warnatsch A, Tsourouktsoglou T, Branzk N, Wang Q, Reincke S, Herbst S, et al. Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size. Immunity. 2017;46:421-432 pubmed publisher
    ..These findings highlight the impact of ROS localization on signal transduction. ..
  49. Rensen S, Bieghs V, Xanthoulea S, Arfianti E, Bakker J, Shiri Sverdlov R, et al. Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice. PLoS ONE. 2012;7:e52411 pubmed publisher
    ..Previously, we reported that myeloperoxidase (MPO), an aggressive oxidant-generating neutrophil enzyme, is associated with NASH severity in man...
  50. Annema W, Nijstad N, Tölle M, de Boer J, Buijs R, Heeringa P, et al. Myeloperoxidase and serum amyloid A contribute to impaired in vivo reverse cholesterol transport during the acute phase response but not group IIA secretory phospholipase A(2). J Lipid Res. 2010;51:743-54 pubmed publisher
    ..05), whereas secretory phospholipase A(2) (sPLA(2), transgenic mice) had no effect. Myeloperoxidase injection reduced tracer appearance in plasma (P < 0.05) as well as RCT (-36%, P < 0.05)...
  51. Nagamachi A, Htun P, Ma F, Miyazaki K, Yamasaki N, Kanno M, et al. A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. Dev Biol. 2010;345:226-36 pubmed publisher
    ..The findings reported here demonstrate the essential roles of the IRES element in Runx1 function under physiological and pathological conditions. ..
  52. Morishita K, Kubota N, Asano S, Kaziro Y, Nagata S. Molecular cloning and characterization of cDNA for human myeloperoxidase. J Biol Chem. 1987;262:3844-51 pubmed
    Partial amino acid sequence of human myeloperoxidase was determined, and a 41-base oligonucleotide containing deoxyinosines at four positions was chemically synthesized...
  53. LeCouter J, Kablar B, Hardy W, Ying C, Megeney L, May L, et al. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol Cell Biol. 1998;18:7455-65 pubmed
    ..Therefore, we conclude that p107 is an important player in negatively regulating the rate of progression of the cell cycle, but in a strain-dependent manner. ..
  54. Hart M, Henn M, Kohler D, Kloor D, Mittelbronn M, Gorzolla I, et al. Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury. FASEB J. 2008;22:2784-97 pubmed publisher
    ..local intestinal injury, but also secondary organ injury, following IR as measured by intestinal and lung myeloperoxidase, aspartate and alanine aminotransferase, interleukin (IL) -1, IL-6, and histological injury...
  55. Gusdon A, Votyakova T, Mathews C. mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III. J Biol Chem. 2008;283:10690-7 pubmed publisher
    ..In all assays mitochondria from mt-Nd2(a)-encoding strains exhibited low ROS production. Our data suggest that lowering overall mitochondrial ROS production is a key mechanism of disease protection provided by mt-Nd2(a). ..
  56. Reber L, Gillis C, Starkl P, Jönsson F, Sibilano R, Marichal T, et al. Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide. J Exp Med. 2017;214:1249-1258 pubmed publisher
    ..Blockade or genetic deletion of myeloperoxidase (MPO), a key neutrophil enzyme, significantly increased mortality after LPS challenge, and adoptive transfer ..
  57. Borrego A, Peters L, Jensen J, Ribeiro O, Koury Cabrera W, Starobinas N, et al. Genetic determinants of acute inflammation regulate Salmonella infection and modulate Slc11a1 gene (formerly Nramp1) effects in selected mouse lines. Microbes Infect. 2006;8:2766-71 pubmed
    ..Typhimurium susceptibility QTL described in other mouse lines showed specific allele fixation in AIRmax or AIRmin mice, suggesting that these chromosomal regions also segregate with inflammatory phenotypes. ..
  58. Sampaio T, Marcondes Sari M, Pesarico A, Nogueira C. δ-Aminolevulinate Dehydratase Activity is Stimulated in a MPTP Mouse Model of Parkinson's Disease: Correlation with Myeloperoxidase Activity. Cell Mol Neurobiol. 2017;37:911-917 pubmed publisher
    b>Myeloperoxidase (MPO) is an inducible heme peroxidase responsive to some stress situations...
  59. Ishida Okawara A, Oharaseki T, Takahashi K, Hashimoto Y, Aratani Y, Koyama H, et al. Contribution of myeloperoxidase to coronary artery vasculitis associated with MPO-ANCA production. Inflammation. 2001;25:381-7 pubmed
    The role of myeloperoxidase (MPO) in the pathogenesis of vasculitis associated with MPO-specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) was examined in a murine animal model...
  60. Fujii T, Cvecklova K, Gilbert D, Copeland N, Jenkins N, Westphal H. Genomic structure and chromosomal localization of the murine LIM class homeobox gene Lhx1. Mamm Genome. 1998;9:81-3 pubmed
  61. Latchoumycandane C, Nagy L, McIntyre T. Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption. Free Radic Biol Med. 2015;86:179-90 pubmed publisher
    ..PAF receptor (PTAFR) abundantly expressed by neutrophils and kidney tubules, and inflammatory cells and myeloperoxidase-containing neutrophils accumulated in the kidneys of ethanol-fed mice after significant hysteresis...
  62. Sager H, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, et al. Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015;132:1880-90 pubmed publisher
    ..The presented insight into post-MI bone marrow activation identifies a mechanistic target for muting inflammation in the ischemically damaged heart. ..
  63. Steinbach K, Piedavent M, Bauer S, Neumann J, Friese M. Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs. J Immunol. 2013;191:4531-9 pubmed publisher
    ..Neutrophil-related enzymes such as myeloperoxidase and neutrophil elastase did not contribute in mounting CNS inflammation, as analyzed by using respective ..
  64. Badiei A, Chambers S, Gaddam R, Bhatia M. Cystathionine-γ-lyase gene silencing with siRNA in monocytes/ macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse. J Biosci. 2016;41:87-95 pubmed
    ..Cecal ligation puncture (CLP)-induced sepsis is characterized by increased levels of myeloperoxidase (MPO) activity, morphological changes in liver and pro-inflammatory cytokines and chemokines in the liver and ..
  65. Lin H, Levison B, Buffa J, Huang Y, Fu X, Wang Z, et al. Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo. Free Radic Biol Med. 2017;104:20-31 pubmed publisher
    ..While in vitro studies suggest redox active transition metals or myeloperoxidase (MPO) generated hypochlorous acid (HOCl) may produce protein-bound 2-AAA, the mechanism(s) responsible for ..
  66. Venturelli D, Bittenbender S, Rovera G. Sequence of the murine myeloperoxidase (MPO) gene. Nucleic Acids Res. 1989;17:7987-8 pubmed
  67. Yeung R, Hino O, Vilensky M, Buetow K, Szpirer C, Szpirer J, et al. Assignment of 22 loci in the rat by somatic hybrid and linkage analysis. Mamm Genome. 1993;4:585-8 pubmed
    ..Results of this study further support the extensive conservation of synteny between the rat and mouse and, to a lesser degree, between rat and human. ..
  68. Yan Z, Liang F, Guo L, Wang J, Wang X, Cheng X, et al. Myeloperoxidase increased cardiomyocyte protein nitration in mice subjected to nonlethal mechanical trauma. Biochem Biophys Res Commun. 2010;393:531-5 pubmed publisher
    ..The present study was designed to identify whether myeloperoxidase may contribute to protein nitration in nonlethal mechanical trauma and subsequent cardiomyocyte apoptosis, ..
  69. Matsuda M, Hoshino T, Yamashita Y, Tanaka K, Maji D, Sato K, et al. Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70. J Biol Chem. 2010;285:5848-58 pubmed publisher
    ..The findings here also suggest that the protective action of HSP70 is mediated by anti-apoptotic, anti-inflammatory, and anti-DNA damage effects. ..
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    ..This finding raises the possibility that a beta-chemokine(s) may regulate T-cell unresponsiveness as well as diabetes susceptibility in NOD mice. ..
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    ..on angiotensin II (Ang II)-induced mRNA and protein expressions of toll-like receptor 4 (TLR4) and myeloperoxidase (MPO) activity in RAW264.7 cells to explore its anti- inflammatory and anti-atherosclerotic mechanisms...
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    ..Although ANCAs, particularly antimyeloperoxidase (anti-MPO), have been shown to promote leukocyte adhesion in postcapillary venules, their ability to promote adhesion in the ..
  76. Mazzon E, Esposito E, Di Paola R, Muià C, Crisafulli C, Genovese T, et al. Effect of tumour necrosis factor-alpha receptor 1 genetic deletion on carrageenan-induced acute inflammation: a comparison with etanercept. Clin Exp Immunol. 2008;153:136-49 pubmed publisher
    ..Our results showed that administration of etanercept resulted in the same outcome as that of deletion of the TNF-alphaR1 receptor, adding a new insight to TNF-alpha as an excellent target by therapeutic applications. ..
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    ..monophosphate shunt, and the amplitude is coupled to the peroxidase cycle, we tested the hypothesis that myeloperoxidase (MPO) participates in IFN-gamma priming for oxidant production...
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    ..Here, we show that inhaled chrysotile asbestos fibers cause increased myeloperoxidase activity in bronchoalveolar lavage fluids (BALF) and myeloperoxidase immunoreactivity in epithelial cells ..
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    b>Myeloperoxidase (MPO) is located within neutrophils capable of producing HOCl. To define the in vivo role of MPO, we have generated MPO-knockout (MPO-KO) mice. The mice without MPO developed normally...
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    An animal study using myeloperoxidase-knockout (MPO-KO) mice to examine the in vivo role of myeloperoxidase (MPO) in spinal cord injury (SCI)...
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    ..complex synergies among the phagosomal contents, and optimal action relies on oxidants generated in the presence of MPO. The absence of life-threatening infectious complications in individuals with MPO deficiency is frequently offered ..
  85. Gan P, Holdsworth S, Kitching A, Ooi J. Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis. Cell Immunol. 2013;282:21-7 pubmed publisher
    Autoimmunity to the neutrophil enzyme myeloperoxidase (MPO) is an important cause of rapidly progressive glomerulonephritis, but the relative roles of MPO-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA) and autoreactive ..