Gene Symbol: Mpdz
Description: multiple PDZ domain protein
Alias: AI225843, B930003D11Rik, MUPP1, multiple PDZ domain protein, multi-PDZ domain protein 1
Species: mouse
Products:     Mpdz

Top Publications

  1. Karpyak V, Kim J, Biernacka J, Wieben E, Mrazek D, Black J, et al. Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry. Alcohol Clin Exp Res. 2009;33:712-21 pubmed publisher
    b>Mpdz gene variations are known contributors of acute alcohol withdrawal severity and seizures in mice...
  2. van de Pavert S, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, et al. Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci. 2004;117:4169-77 pubmed
    ..We show that it is associated here with multiple PDZ protein 1 (Mupp1), protein associated with Lin-7 (Pals1 or Mpp5) and Mpp4...
  3. Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S. Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem. 2002;277:455-61 pubmed
    ..Using the yeast two-hybrid system, we identified ZO-1 and MUPP1 (multi-PDZ domain protein 1) as binding partners for the COOH terminus of claudin-1...
  4. Fujita E, Tanabe Y, Imhof B, Momoi M, Momoi T. A complex of synaptic adhesion molecule CADM1, a molecule related to autism spectrum disorder, with MUPP1 in the cerebellum. J Neurochem. 2012;123:886-94 pubmed publisher
    ..The C-terminal peptide of Cadm1 associated with Mupp1 at PSD-95/Dlg/ZO-1 (PDZ)(1-5), a scaffold protein containing 13 PDZ domains, which interacted with gamma-..
  5. Li X, Lynn B, Nagy J. The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain. Eur J Neurosci. 2012;35:166-81 pubmed publisher
    ..Here, we demonstrate that two proteins known to be associated with tight and adherens junctions, namely AF6 and MUPP1, are components of neuronal gap junctions in rodent brain...
  6. Shirley R, Walter N, Reilly M, Fehr C, Buck K. Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat Neurosci. 2004;7:699-700 pubmed
    ..Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
  7. Ackermann F, Zitranski N, Borth H, Buech T, Gudermann T, Boekhoff I. CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis. J Cell Sci. 2009;122:4547-57 pubmed publisher
    ..exocytosis in neurons, we investigated whether cognate neuronal binding partners of the multi-PDZ domain protein MUPP1, which recruits molecules that control the initial tethering and/or docking between the acrosomal vesicle and the ..
  8. Sugihara Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y, Nishimura M, Imai T, et al. Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes Cells. 2007;12:473-86 pubmed
    We have previously shown that MUPP1, which has an MRE domain and 13 PDZ domains, is expressed in epithelial cells and localize at tight junctions (TJs) and apical membranes...
  9. Barritt D, Pearn M, Zisch A, Lee S, Javier R, Pasquale E, et al. The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. J Cell Biochem. 2000;79:213-24 pubmed
    ..sequence to a DNA segment coding for the most amino-terminal of the 13 PDZ domains found in the multi-PDZ-protein MUPP1. Antibodies made against recombinant polypeptides representing these two clones (NIP-2 and NIP-7) are reactive ..

More Information


  1. Fehr C, Shirley R, Metten P, Kosobud A, Belknap J, Crabbe J, et al. Potential pleiotropic effects of Mpdz on vulnerability to seizures. Genes Brain Behav. 2004;3:8-19 pubmed
    ..e., pentobarbital) withdrawal convulsion liability to a < 1 cM (1.8 Mb) interval of mouse chromosome 4. To date, Mpdz, which encodes the multiple PSD95/DLG/ZO-1 (PDZ) domain protein (MPDZ), is the only gene within the interval shown ..
  2. Lee S, Weiss R, Javier R. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A. 1997;94:6670-5 pubmed
  3. Heydecke D, Meyer D, Ackermann F, Wilhelm B, Gudermann T, Boekhoff I. The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa. J Androl. 2006;27:390-404 pubmed
    ..of the RT-PCR approaches were performed with specific primer pairs for the vertebrate INAD-like PDZ domain protein MUPP1. The results revealed that this scaffolding protein, which comprises 13 different PDZ domains, is expressed in ..
  4. Ishiuchi T, Misaki K, Yonemura S, Takeichi M, Tanoue T. Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex. J Cell Biol. 2009;185:959-67 pubmed publisher
    ..Depletion of Fat4 or Pals1 abolished this membrane apposition. These results highlight the importance of the Fat4-Dachsous1-Pals1 complex in organizing the apical membrane architecture of neural progenitor cells. ..
  5. Parker L, Backstrom J, Sanders Bush E, Shieh B. Agonist-induced phosphorylation of the serotonin 5-HT2C receptor regulates its interaction with multiple PDZ protein 1. J Biol Chem. 2003;278:21576-83 pubmed
    b>Multiple PDZ domain protein 1 (MUPP1), a putative scaffolding protein containing 13 PSD-95, Dlg, ZO-1 (PDZ) domains, was identified by a yeast two-hybrid screen as a serotonin2C receptor (5-HT2C R)-interacting protein (Ullmer, C...
  6. Poliak S, Matlis S, Ullmer C, Scherer S, Peles E. Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. J Cell Biol. 2002;159:361-72 pubmed
    ..PATJ is mainly found at the paranodal loops, where it colocalized with claudin-1. MUPP1 and claudin-5 colocalized in the incisures, and the COOH-terminal region of claudin-5 interacts with MUPP1 in a ..
  7. Donaldson R, Sun Y, Liang D, Zheng M, Sahbaie P, Dill D, et al. The multiple PDZ domain protein Mpdz/MUPP1 regulates opioid tolerance and opioid-induced hyperalgesia. BMC Genomics. 2016;17:313 pubmed publisher
    ..The strongest of these was the highly polymorphic Mpdz gene coding for the post-synaptic scaffolding protein Mpdz/MUPP1. Heterozygous Mpdz +/- mice displayed reduced opioid tolerance and OIH...
  8. Adam M, Berger C, Feldner A, Yang W, W├╝stehube Lausch J, Herberich S, et al. Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res. 2013;113:1206-18 pubmed publisher
    ..These data identify SYNJ2BP as a novel inhibitor of tip cell formation, executing its functions predominately by promoting Delta-Notch signaling. ..
  9. Jang W, Choi S, Jeong J, Park J, Kim S, Seog D. Neuronal cell-surface protein neurexin 1 interaction with multi-PDZ domain protein MUPP1. Biosci Biotechnol Biochem. 2014;78:644-6 pubmed publisher
    ..Using the yeast two-hybrid screening, we found that neurexin 1 interacted with multi-PDZ domain protein 1 (MUPP1) through PDZ domain. Neurexin 2 and 3 also interacted with MUPP1...
  10. Badouel C, Zander M, Liscio N, Bagherie Lachidan M, Sopko R, Coyaud E, et al. Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development. Development. 2015;142:2781-91 pubmed publisher
    ..We propose a model in which Fat1 and Fat4 binding coordinates distinct pathways at apical junctions to regulate neural progenitor proliferation, neural tube closure and apical constriction. ..
  11. Feldner A, Adam M, Tetzlaff F, Moll I, Komljenovic D, Sahm F, et al. Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med. 2017;9:890-905 pubmed publisher
    Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ (MUPP1) are the only known human gene loci associated with non-syndromic hydrocephalus...
  12. Li X, Penes M, Odermatt B, Willecke K, Nagy J. Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions. Eur J Neurosci. 2008;28:1503-17 pubmed publisher
    ..Here, we investigated the localization of multi-PDZ domain protein 1 (MUPP1) at these gap junctions and examined accessory proteins and connexins associated with oligodendrocytes in Cx47-..
  13. Lanaspa M, Andres Hernando A, Rivard C, Dai Y, Berl T. Hypertonic stress increases claudin-4 expression and tight junction integrity in association with MUPP1 in IMCD3 cells. Proc Natl Acad Sci U S A. 2008;105:15797-802 pubmed publisher
    We reported that the multiple PDZ protein 1 (MUPP1) is an osmotic response protein in kidney cells. This up-regulation was found to be necessary for the maintenance of tight epithelial properties in these cells...
  14. Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, et al. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood. 2009;113:244-53 pubmed publisher
    ..We show that Amot forms a ternary complex together with Patj (or its paralogue Mupp1) and Syx...
  15. Sharma S, Rupasinghe C, Parisien R, Spaller M. Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1. Biochemistry. 2007;46:12709-20 pubmed
    PDZ10 is the 10th of 13 PDZ domains found within MUPP1, a cytoplasmic scaffolding protein first identified as an endogenous binding partner of serotonin receptor type 2c (5HT2c)...
  16. Lad H, Liu L, Paya Cano J, Fernandes C, Schalkwyk L. Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping. Mamm Genome. 2007;18:482-91 pubmed
    ..A second trial of the test has greater duration of immobility and a completely different genetic profile. Frequency of mobility is also an independent phenotype, with a distal chromosome 1 locus. ..
  17. Coyne C, Voelker T, Pichla S, Bergelson J. The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction. J Biol Chem. 2004;279:48079-84 pubmed
    ..In a yeast two-hybrid screen we identified the multi-PDZ domain protein MUPP1 as an interaction partner for the CAR cytoplasmic domain...
  18. Simpson E, Suffolk R, Bell J, Jordan S, Johnson D, Hunsicker P, et al. A comparative transcript map and candidates for mutant phenotypes in the Tyrp1 (brown) deletion complex homologous to human 9p21-23. Mamm Genome. 2000;11:58-63 pubmed
    ..On the basis of location and/or expression, we exclude genes as candidates for several known phenotypes in the region and identify a candidate transcript for the neonatal lethal phenotype l(4)Rn2. ..
  19. Sitek B, Poschmann G, Schmidtke K, Ullmer C, Maskri L, Andriske M, et al. Expression of MUPP1 protein in mouse brain. Brain Res. 2003;970:178-87 pubmed
    ..5-HT(2C) receptors have previously been shown to interact with MUPP1, a multi PDZ domain protein, in heterologous systems and in rat choroid plexus...
  20. Wright G, Leslie J, Ariza McNaughton L, Lewis J. Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. Development. 2004;131:5659-69 pubmed
    ..They do, however, show an anomalous distribution of Rohon-Beard neurons in the dorsal neural tube, suggesting that the Delta-MAGI interaction may play some part in the control of neuron migration. ..
  21. Ozcelik M, Cotter L, Jacob C, Pereira J, Relvas J, Suter U, et al. Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J Neurosci. 2010;30:4120-31 pubmed publisher
    ..We conclude that regulation of epithelial-like polarization is a critical determinant of myelin sheath structure and function. ..
  22. Fehr C, Shirley R, Belknap J, Crabbe J, Buck K. Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J Neurosci. 2002;22:3730-8 pubmed
    ..To date, Mpdz, which encodes the multiple PSD95/DLG/ZO-1 (PDZ) domain protein (MPDZ), is the only gene within the interval shown ..
  23. Lee S, Glaunsinger B, Mantovani F, Banks L, Javier R. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J Virol. 2000;74:9680-93 pubmed
    ..motifs of Ad9 E4-ORF1 and high-risk HPV-18 E6 also mediate binding to the widely expressed cellular factor MUPP1, a large multi-PDZ domain protein predicted to function as an adapter in signal transduction...
  24. Kruse L, Walter N, Buck K. Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal. Genes Brain Behav. 2014;13:769-76 pubmed publisher
    Association studies implicate the multiple PDZ domain protein (MUPP1/MPDZ) gene in risk for alcoholism in humans and alcohol withdrawal in mice...
  25. Reilly M, MILNER L, Shirley R, Crabbe J, Buck K. 5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice. Brain Res. 2008;1198:124-31 pubmed publisher
    ..We recently identified Mpdz within this chromosomal region as a gene that influences alcohol and barbiturate withdrawal convulsions...
  26. Simpson E, Suffolk R, Jackson I. Identification, sequence, and mapping of the mouse multiple PDZ domain protein gene, Mpdz. Genomics. 1999;59:102-4 pubmed
    ..We have identified and completely sequenced a gene, Mpdz, that encodes a mouse protein containing 13 such domains...
  27. Hevner R, Miyashita Lin E, Rubenstein J. Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J Comp Neurol. 2002;447:8-17 pubmed
    ..This type of mechanism ensures that thalamocortical and corticothalamic axons project reciprocally. However, the exact nature of the interaction between cortical and thalamic pioneer axons remains to be elucidated. ..
  28. Baliova M, Juhasova A, Jursky F. Using a collection of MUPP1 domains to investigate the similarities of neurotransmitter transporters C-terminal PDZ motifs. Biochem Biophys Res Commun. 2014;454:25-9 pubmed publisher
    ..compared their interactions with the natural collection of all 13 PDZ domains of the largest PDZ binding protein MUPP1. The GABA, glycine and serotonin transporters showed unique binding preferences scattered over one or several ..
  29. Mancini A, Koch A, Stefan M, Niemann H, Tamura T. The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. FEBS Lett. 2000;482:54-8 pubmed
    We have identified the multiple PDZ domain containing protein (MUPP-1 or MPDZ) as a novel binding partner of the human c-Kit. c-Kit binds specifically to the 10th PDZ domain of MUPP-1 via its C-terminal sequence...
  30. Ackermann F, Zitranski N, Heydecke D, Wilhelm B, Gudermann T, Boekhoff I. The Multi-PDZ domain protein MUPP1 as a lipid raft-associated scaffolding protein controlling the acrosome reaction in mammalian spermatozoa. J Cell Physiol. 2008;214:757-68 pubmed
    ..are known to spatially organize sequential signaling pathways, we examined whether the Multi-PDZ domain protein MUPP1, recently identified in mammalian spermatozoa, is functionally active in controlling acrosomal secretion in ..
  31. MILNER L, Shirley R, Kozell L, Walter N, Kruse L, Komiyama N, et al. Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption. Addict Biol. 2015;20:143-7 pubmed publisher
    Association studies implicate multiple PDZ domain protein (MPDZ/MUPP1) sequence and/or expression in risk for alcoholism in humans and ethanol withdrawal (EW) in mice, but confirmation has been hindered by the dearth of targeted genetic ..
  32. Dudok J, Sanz A, Lundvig D, Wijnholds J. MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex. J Neurosci. 2013;33:8518-27 pubmed publisher
    ..These data show that MPP3 is required for maintenance of the apical protein complex and adherens junctions and for stratification and proper migration of neurons during the development of the cortex. ..
  33. Dooley R, Baumgart S, Rasche S, Hatt H, Neuhaus E. Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1. FEBS J. 2009;276:7279-90 pubmed publisher
    ..In the present study, we show that multi-PDZ domain protein 1 (MUPP1) is expressed in the apical compartment of olfactory sensory neurons...
  34. Lanaspa M, Almeida N, Andres Hernando A, Rivard C, Capasso J, Berl T. The tight junction protein, MUPP1, is up-regulated by hypertonicity and is important in the osmotic stress response in kidney cells. Proc Natl Acad Sci U S A. 2007;104:13672-7 pubmed
    ..Noteworthy was the up-regulation of several tight junction-related proteins, including MUPP1 (multi-PDZ protein-1), ZO1 (zonula occludens 1), and Af6...
  35. Baumgart S, Jansen F, Bintig W, Kalbe B, Herrmann C, Klumpers F, et al. The scaffold protein MUPP1 regulates odorant-mediated signaling in olfactory sensory neurons. J Cell Sci. 2014;127:2518-27 pubmed publisher
    ..a macromolecular assembly of signal transduction components in mouse olfactory neurons, organized through MUPP1. Disruption of the PDZ signaling complex, through use of an inhibitory peptide, strongly impaired odor responses ..
  36. Vassilev A, Kaneko K, Shu H, Zhao Y, DePamphilis M. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 2001;15:1229-41 pubmed
    ..Because TEAD-dependent transcription was limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine kinases, we propose that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals. ..
  37. Zhu H, Liu Z, Huang Y, Zhang C, Li G, Liu W. Biochemical and structural characterization of MUPP1-PDZ4 domain from Mus musculus. Acta Biochim Biophys Sin (Shanghai). 2015;47:199-206 pubmed publisher
    ..Multi-PDZ-domain protein 1 (MUPP1), as a scaffold protein, contains 13 PDZ domains and plays an important role in cytoskeletal organization, cell ..
  38. Alves C, Sanz A, Park B, Pellissier L, Tanimoto N, Beck S, et al. Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013;22:35-50 pubmed publisher
    ..The data suggest an essential role for CRB2 in proper lamination of the photoreceptor layer and suppression of proliferation of late-born retinal progenitor cells...