Gene Symbol: Mov10l1
Description: Moloney leukemia virus 10-like 1
Alias: CHAMP, Csm, RNA helicase Mov10l1, MOV10-like protein 1 homolog, Moloney leukemia virus 10-like 1 protein, cardiac helicase activated by MEF2 protein, cardiac-specific RNA helicase, moloney leukemia virus 10-like protein 1 homolog
Species: mouse
Products:     Mov10l1

Top Publications

  1. Liu Z, Nakagawa O, Nakagawa M, Yanagisawa H, Passier R, Richardson J, et al. CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev Biol. 2001;234:497-509 pubmed
    ..describe a novel MEF2C-dependent gene that encodes a cardiac-restricted protein, called CHAMP (cardiac helicase activated by MEF2 protein), that contains seven conserved motifs characteristic of helicases involved in RNA processing, ..
  2. Zheng K, Xiol J, Reuter M, Eckardt S, Leu N, McLaughlin K, et al. Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A. 2010;107:11841-6 pubmed publisher
    ..Here we demonstrate that MOV10L1, a germ cell-specific putative RNA helicase, is associated with Piwi proteins...
  3. Frost R, Hamra F, Richardson J, Qi X, Bassel Duby R, Olson E. MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A. 2010;107:11847-52 pubmed publisher
    ..Here we show that the putative DExD-box helicase MOV10-like-1 (MOV10L1) is essential for silencing retrotransposons in the mouse male germline...
  4. De Fazio S, Bartonicek N, Di Giacomo M, Abreu Goodger C, Sankar A, Funaya C, et al. The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature. 2011;480:259-63 pubmed publisher
    ..In addition, the hallmarks of piRNA amplification are observed in Miwi2-deficient gonadocytes. We conclude that cycles of intra-Mili secondary piRNA biogenesis fuel piRNA amplification that is absolutely required for LINE1 silencing. ..
  5. Bao J, Zhang Y, Schuster A, Ortogero N, Nilsson E, Skinner M, et al. Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice. Cell Death Differ. 2014;21:783-96 pubmed publisher
    ..Our data not only validate those from global Miwi2 KO studies, but also suggest that MIWI2 and MIWI2-associated piRNAs have functions beyond TE suppression. ..
  6. Reichmann J, Reddington J, Best D, Read D, Ollinger R, Meehan R, et al. The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice. Hum Mol Genet. 2013;22:1791-806 pubmed publisher
  7. Newkirk S, Lee S, Grandi F, Gaysinskaya V, Rosser J, Vanden Berg N, et al. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017;114:E5635-E5644 pubmed publisher
    ..Analysis of Mov10l1-/- testes established that de novo methylation of the L1 transgene required the intact piRNA ..
  8. Ueyama T, Kasahara H, Ishiwata T, Yamasaki N, Izumo S. Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart. J Biol Chem. 2003;278:28750-7 pubmed
    ..5 null embryos is an isoform of Mov10 like-1 (Mov10l1), a putative RNA helicase expressed in testis...
  9. Wang X, Merritt A, Seyfried J, Guo C, Papadakis E, Finegan K, et al. Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol. 2005;25:336-45 pubmed
    ..Overall, this is the first study to rigorously establish the role of MEK5 in vivo as an activator of ERK5 and as an essential regulator of cell survival that is required for normal embryonic development. ..

More Information


  1. Bao J, Ma H, Schuster A, Lin Y, Yan W. Incomplete cre-mediated excision leads to phenotypic differences between Stra8-iCre; Mov10l1(lox/lox) and Stra8-iCre; Mov10l1(lox/?) mice. Genesis. 2013;51:481-90 pubmed publisher
    ..expressing iCre under the control of the male germ cell-specific Stra8 promoter, could efficiently delete one Mov10l1 flox allele in spermatogenic cells, whereas the excision was incomplete when two Mov10l1 flox alleles were ..
  2. Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, et al. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol Cell. 2012;47:970-9 pubmed publisher
    ..We propose that the chaperone machinery normally ejects these inhibitory RNAs, allowing turnover of Piwi complexes for their continued participation in piRNA amplification...
  3. Ding D, Liu J, Midic U, Wu Y, Dong K, Melnick A, et al. TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice. Nat Commun. 2018;9:127 pubmed publisher
    ..These observations establish TDRD5 as a piRNA biogenesis factor and reveal two genetically separable steps at the start of pachytene piRNA processing. ..
  4. Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, et al. The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015;29:617-29 pubmed publisher
    ..Here we show that MOV10L1 exhibits 5'-to-3' directional RNA-unwinding activity in vitro and that a point mutation that abolishes this ..
  5. Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H. HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Genes Cells. 2012;17:439-54 pubmed publisher
    ..Our present results provide clues to HORMAD1-dependent checkpoint in response to asynapsis in mammalian meiosis...
  6. Shin Y, Choi Y, Erdin S, Yatsenko S, Kloc M, Yang F, et al. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet. 2010;6:e1001190 pubmed publisher
    ..HORMAD1 is therefore a critical component of the synaptonemal complex that affects synapsis, recombination, and meiotic sex chromosome inactivation and transcriptional silencing...
  7. Lovasco L, Seymour K, Zafra K, O Brien C, Schorl C, Freiman R. Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice. Biol Reprod. 2010;82:23-34 pubmed publisher
    ..One significantly reduced transcript in the young TAF4B-null ovary codes for MOV10L1, a putative germline-specific RNA helicase that is related to the Drosophila RNA interference protein, armitage...
  8. Zheng K, Wang P. Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity. PLoS Genet. 2012;8:e1003038 pubmed publisher
    ..Here, we report that conditional inactivation of the putative RNA helicase MOV10L1 in mouse spermatocytes produces a specific loss of pachytene piRNAs, significant accumulation of pachytene ..
  9. Goodier J, Cheung L, Kazazian H. MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells. PLoS Genet. 2012;8:e1002941 pubmed publisher
    ..With homologs in other vertebrates, insects, and plants, MOV10 may represent an ancient and innate form of immunity against both infective viruses and endogenous retroelements...
  10. Yu Q, Carbone C, Katlinskaya Y, Zheng H, Zheng K, Luo M, et al. Type I interferon controls propagation of long interspersed element-1. J Biol Chem. 2015;290:10191-9 pubmed publisher
    ..Here we report that increased levels of IFNβ were found in testes from mice deficient in MOV10L1, a germ cell-specific RNA helicase that plays a key role in limiting the propagation of retrotransposons ..
  11. Fu Q, Pandey R, Leu N, Pillai R, Wang P. Mutations in the MOV10L1 ATP Hydrolysis Motif Cause piRNA Biogenesis Failure and Male Sterility in Mice. Biol Reprod. 2016;95:103 pubmed
    ..Most piRNA pathway proteins are evolutionarily conserved. MOV10L1, a testis-specific RNA helicase, binds to piRNA precursors and is a master regulator of piRNA biogenesis in mouse...
  12. Regan C, Li W, Boucher D, Spatz S, Su M, Kuida K. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A. 2002;99:9248-53 pubmed
    ..Moreover, the inability of Erk5-deficient mice to form a complex vasculature suggests that Erk5 may play an important role in controlling angiogenesis. ..
  13. Liu Z, Olson E. Suppression of proliferation and cardiomyocyte hypertrophy by CHAMP, a cardiac-specific RNA helicase. Proc Natl Acad Sci U S A. 2002;99:2043-8 pubmed
    ..Recently, we described a novel cardiac helicase activated by MEF2 protein (CHAMP), which is expressed specifically in the heart throughout prenatal and postnatal ..