Gene Symbol: Mog
Description: myelin oligodendrocyte glycoprotein
Alias: B230317G11Rik, myelin-oligodendrocyte glycoprotein
Species: mouse
Products:     Mog

Top Publications

  1. Bettelli E, Baeten D, Jäger A, Sobel R, Kuchroo V. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest. 2006;116:2393-402 pubmed
    ..The immunological bases of the different forms of MS are unknown. We previously generated myelin oligodendrocyte glycoprotein-specific (MOG-specific) TCR transgenic mice (TCRMOG mice; also referred to as 2D2 mice) and ..
  2. Johns T, Bernard C. The structure and function of myelin oligodendrocyte glycoprotein. J Neurochem. 1999;72:1-9 pubmed
    b>Myelin oligodendrocyte glycoprotein (MOG) is a quantitatively minor component of CNS myelin whose function remains relatively unknown...
  3. Frühbeis C, Fröhlich D, Kuo W, Amphornrat J, Thilemann S, Saab A, et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013;11:e1001604 pubmed publisher
    ..These findings indicate that oligodendroglial exosomes participate in a novel mode of bidirectional neuron-glia communication contributing to neuronal integrity. ..
  4. Buch T, Heppner F, Tertilt C, Heinen T, Kremer M, Wunderlich F, et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods. 2005;2:419-26 pubmed
    ..Notably, we show that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT. Our results validate the use of iDTR mice as a tool for cell ablation in vivo. ..
  5. Hövelmeyer N, Hao Z, Kranidioti K, Kassiotis G, Buch T, Frommer F, et al. Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol. 2005;175:5875-84 pubmed
    ..Although only moderate reduction of lymphocyte infiltration into CNS tissue was observed, the absence of these receptors appears to confer protection from demyelination and development of clinical disease. ..
  6. Krishnamoorthy G, Lassmann H, Wekerle H, Holz A. Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest. 2006;116:2385-92 pubmed
    ..OSE mice have recombination-competent immune cells expressing a TCR-alphabeta specific for myelin oligodendrocyte glycoprotein (MOG) aa 35-55 peptide in the context of I-Ab along with an Ig J region replaced by the recombined ..
  7. Ghosh A, Manrique Hoyos N, Voigt A, Schulz J, Kreutzfeldt M, Merkler D, et al. Targeted ablation of oligodendrocytes triggers axonal damage. PLoS ONE. 2011;6:e22735 pubmed publisher
    ..The models used in this study provide valuable systems for the investigation of therapeutic strategies to prevent axonal or neuronal damage. ..
  8. Delarasse C, Daubas P, Mars L, Vizler C, Litzenburger T, Iglesias A, et al. Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J Clin Invest. 2003;112:544-53 pubmed
    We studied the immunological basis for the very potent encephalitogenicity of myelin/oligodendrocyte glycoprotein (MOG), a minor component of myelin in the CNS that is widely used to induce experimental autoimmune encephalomyelitis (EAE)...
  9. Pham Dinh D, Mattei M, Nussbaum J, Roussel G, Pontarotti P, Roeckel N, et al. Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Proc Natl Acad Sci U S A. 1993;90:7990-4 pubmed
    Myelin/oligodendrocyte glycoprotein (MOG) is found on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system, and it is a target antigen in experimental autoimmune ..

More Information


  1. Salehi Z, Hadiyan S, Navidi R. Ciliary neurotrophic factor role in myelin oligodendrocyte glycoprotein expression in Cuprizone-induced multiple sclerosis mice. Cell Mol Neurobiol. 2013;33:531-5 pubmed publisher
    ..b>Myelin oligodendrocyte glycoprotein (MOG) is a minor component of the myelin sheath, but is an important autoantigen linked to the ..
  2. Probst H, Lagnel J, Kollias G, Van Den Broek M. Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity. 2003;18:713-20 pubmed
    ..On the other hand, antigen presentation by activated DC primed endogenous CTL to expand and to develop protective effector function. ..
  3. Jung J, Dudek E, Michalak M. The role of N-glycan in folding, trafficking and pathogenicity of myelin oligodendrocyte glycoprotein (MOG). Biochim Biophys Acta. 2015;1853:2115-21 pubmed publisher
    b>Myelin oligodendrocyte glycoprotein (MOG) is a type I integral membrane protein that is expressed in the central nervous system. MOG has a single N-glycosylation site within its extracellular domain...
  4. Klingler E, Martin P, Garcia M, Moreau Fauvarque C, Falk J, Chareyre F, et al. The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development. Development. 2015;142:2026-36 pubmed publisher
    ..Thus, our results reveal new evidence for the involvement of cortical cytoskeleton-associated proteins in the regulation of axon development and their importance for the formation of neuronal circuits. ..
  5. Daubas P, Pham Dinh D, Dautigny A. Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene. Genomics. 1994;23:36-41 pubmed
    We have isolated and characterized genomic clones containing the mouse myelin/oligodendrocyte glycoprotein (MOG) gene. It spans a region of 12.5 kb and consists of eight exons...
  6. Fujita M, Otsuka T, Mizuno M, Tomi C, Yamamura T, Miyake S. Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via an iNKT cell-dependent mechanism. Am J Pathol. 2009;175:1116-23 pubmed publisher
    ..fusion protein, a homophilic ligand of CEACAM1, inhibited the severity of EAE and reduced myelin oligodendrocyte glycoprotein-derived peptide (MOG(35-55))-reactive interferon-gamma and interleukin-17 production...
  7. Saxena A, Bauer J, Scheikl T, Zappulla J, Audebert M, Desbois S, et al. Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J Immunol. 2008;181:1617-21 pubmed
    ..These results provide new insights with regard to CNS tissue damage mediated by CD8 T cells and for understanding the role of CD8 T cells in MS. ..
  8. Moreau Fauvarque C, Kumanogoh A, Camand E, Jaillard C, Barbin G, Boquet I, et al. The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. J Neurosci. 2003;23:9229-39 pubmed
    ..This upregulation was transient because from 1 month after the lesion, Sema4D expression was back to its normal level. These results indicate that Sema4D is a novel inhibitory factor for axonal regeneration expressed in myelin. ..
  9. Mc Guire C, Volckaert T, Wolke U, Sze M, De Rycke R, Waisman A, et al. Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination. J Immunol. 2010;185:7646-53 pubmed publisher
    ..Collectively, our data show that FADD is critical for ODC apoptosis and the development of autoimmune demyelinating disease. ..
  10. Linares D, Maña P, Goodyear M, Chow A, Clavarino C, Huntington N, et al. The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice. J Autoimmun. 2003;21:339-51 pubmed
    b>Myelin oligodendrocyte glycoprotein (MOG) is a minor component of central nervous system myelin presumably implicated in the pathogenesis of Multiple Sclerosis (MS)...
  11. Pham Dinh D, Jones E, Pitiot G, Della Gaspera B, Daubas P, Mallet J, et al. Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region. Immunogenetics. 1995;42:386-91 pubmed
    Myelin/oligodendrocyte glycoprotein (MOG) is expressed specifically in the central nervous system (CNS) by myelinating glial cells, the oligodendrocytes...
  12. Berer K, Mues M, Koutrolos M, Rasbi Z, Boziki M, Johner C, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011;479:538-41 pubmed publisher
    ..B cells from the endogenous immune repertoire depends on availability of the target autoantigen, myelin oligodendrocyte glycoprotein (MOG), and commensal microbiota...
  13. Aloulou M, Carr E, Gador M, Bignon A, Liblau R, Fazilleau N, et al. Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells. Nat Commun. 2016;7:10579 pubmed publisher
    ..These findings have important implications for Tfr cell biology and for improving vaccine efficacy by formulating vaccines that modify the Tfr:Tfh cell ratio. ..
  14. Spörkel O, Uschkureit T, Bussow H, Stoffel W. Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development. Glia. 2002;37:19-30 pubmed
  15. Chitnis T, Najafian N, Benou C, Salama A, Grusby M, Sayegh M, et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;108:739-47 pubmed
    ..In addition, adoptive transfer studies confirm the regulatory functions of a Th2 environment in vivo. These novel data indicate that STAT4 and STAT6 genes play a critical role in regulating the autoimmune response in EAE. ..
  16. Akirav E, Xu Y, Ruddle N. Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein. J Neuroimmunol. 2011;235:33-9 pubmed publisher
    ..B cell-deficient ?MT mice exhibited reduced medullary thymic epithelial cell (mTEC) numbers and reduced MOG and insulin mRNA expression...
  17. Turnescu T, Arter J, Reiprich S, Tamm E, Waisman A, Wegner M. Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes. Glia. 2018;66:279-294 pubmed publisher
    ..One direct target gene of both Sox proteins is the late myelin gene Mog. Our results point to at least partial functional redundancy between both related Sox proteins in mature ..
  18. Amadou C, Ribouchon M, Mattei M, Jenkins N, Gilbert D, Copeland N, et al. Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes. Genomics. 1995;26:9-20 pubmed
    ..Finally, we show that the region found around the breakpoint was involved several times in chromosome recombinations in the mouse lineage, as it seems to correspond also to the t-complex distal inversion point. ..
  19. Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, et al. Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice. Nat Commun. 2014;5:5472 pubmed publisher
    ..These data reveal a role for oligodendrocytes in modulating pain and suggest that perturbation of oligodendrocyte functions that maintain axonal integrity can lead to central neuropathic pain independent of immune contributions. ..
  20. Chung J, Figgett W, Fairfax K, Bernard C, Chan J, Toh B, et al. Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion. J Immunol. 2014;192:2593-601 pubmed publisher
    ..autoimmune encephalomyelitis that transfer of bone marrow (BM) transduced with retrovirus encoding myelin oligodendrocyte glycoprotein (MOG) promotes disease resistance and CD4(+) T cell deletion within the thymus...
  21. Uozumi N, Kume K, Nagase T, Nakatani N, Ishii S, Tashiro F, et al. Role of cytosolic phospholipase A2 in allergic response and parturition. Nature. 1997;390:618-22 pubmed
    ..Considered together with previous findings, our results indicate that cytosolic PLA2 plays a non-redundant role in allergic responses and reproductive physiology. ..
  22. O Connor R, Li X, Blumerman S, Anderton S, Noelle R, Dalton D. Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system. J Immunol. 2012;188:2093-101 pubmed publisher
    ..Subsequently, CD4(+) T cells coexpressing the cognate chemokine receptors CXCR3 and CXCR6 and myelin oligodendrocyte glycoprotein (MOG)-specific CD4(+) T cells accumulated within the chemokine-expressing dLNs, rather than within ..
  23. Menge T, Lalive P, von Büdingen H, Genain C. Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. J Neuroinflammation. 2011;8:161 pubmed publisher
    Myelin/oligodendrocyte glycoprotein (MOG) is a putative autoantigen in multiple sclerosis (MS)...
  24. Bettelli E, Pagany M, Weiner H, Linington C, Sobel R, Kuchroo V. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003;197:1073-81 pubmed
    ..We have generated novel T cell receptor (TCR) transgenic mice specific for myelin oligodendrocyte glycoprotein (MOG). MOG-specific transgenic T cells are not deleted nor tolerized and are functionally competent...
  25. Stecca B, Southwood C, Gragerov A, Kelley K, Friedrich V, Gow A. The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. J Neurosci. 2000;20:4002-10 pubmed
  26. Coulpier F, Decker L, Funalot B, Vallat J, Garcia Bragado F, Charnay P, et al. CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function. J Neurosci. 2010;30:5958-67 pubmed publisher
    ..This indicates that transgression of the CNS/PNS boundary by central glia can occur in pathological situations in humans and suggests that the underlying mechanisms are common with the mouse. ..
  27. Pöllinger B, Krishnamoorthy G, Berer K, Lassmann H, Bösl M, Dunn R, et al. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med. 2009;206:1303-16 pubmed publisher
    ..T cell receptor (TCR) transgenic mice (relapsing-remitting [RR] mice) carrying a TCR specific for myelin oligodendrocyte glycoprotein (MOG) peptide 92-106 in the context of I-A(s)...
  28. Marta C, Montano M, Taylor C, Taylor A, Bansal R, Pfeiffer S. Signaling cascades activated upon antibody cross-linking of myelin oligodendrocyte glycoprotein: potential implications for multiple sclerosis. J Biol Chem. 2005;280:8985-93 pubmed
    ..In particular, antibodies to myelin oligodendrocyte glycoprotein (MOG) are elevated in multiple sclerosis patients, and they have been implicated as mediators of ..
  29. Mesleh M, Belmar N, Lu C, Krishnan V, Maxwell R, Genain C, et al. Marmoset fine B cell and T cell epitope specificities mapped onto a homology model of the extracellular domain of human myelin oligodendrocyte glycoprotein. Neurobiol Dis. 2002;9:160-72 pubmed
    Aberrant association of autoantibodies with myelin oligodendrocyte glycoprotein (MOG), an integral membrane protein of the central nervous system (CNS) myelin, has been implicated in the pathogenesis of multiple sclerosis (MS)...
  30. Delarasse C, Smith P, Baker D, Amor S. Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice. Immunology. 2013;140:456-64 pubmed publisher
    b>Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica...
  31. Badawi A, Siahaan T. Suppression of MOG- and PLP-induced experimental autoimmune encephalomyelitis using a novel multivalent bifunctional peptide inhibitor. J Neuroimmunol. 2013;263:20-7 pubmed publisher
    ..In this study, a multivalent BPI (MVBMOG/PLP) with two antigenic peptides derived from myelin oligodendrocyte glycoprotein (MOG38-50) and myelin proteolipid protein (PLP139-151) was evaluated in suppressing MOG38-50- and ..
  32. Hirata S, Matsuyoshi H, Fukuma D, Kurisaki A, Uemura Y, Nishimura Y, et al. Involvement of regulatory T cells in the experimental autoimmune encephalomyelitis-preventive effect of dendritic cells expressing myelin oligodendrocyte glycoprotein plus TRAIL. J Immunol. 2007;178:918-25 pubmed
    We previously reported the protection from myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) by the adoptive transfer of genetically modified embryonic stem cell-derived dendritic cells (ES-..
  33. Zhang X, Liu J, Shi Y, Reid H, Boyd R, Khattabi M, et al. CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes. Eur J Immunol. 2012;42:924-35 pubmed publisher
    ..The CD24-deficient 2D2 TCR transgenic mice (2D2(+) CD24(-/-) ), whose TCR recognizes myelin oligodendrocyte glycoprotein (MOG), fail to generate functional 2D2 T cells...
  34. Winterstein C, Trotter J, Krämer Albers E. Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling. J Cell Sci. 2008;121:834-42 pubmed publisher
    ..Interestingly, we found that PLP, myelin-associated glycoprotein (MAG) and myelin-oligodendrocyte glycoprotein (MOG), which localize to compact myelin, periaxonal loops and abaxonal loops, respectively, exhibit distinct endocytic ..
  35. Tompkins S, Padilla J, Dal Canto M, Ting J, Van Kaer L, Miller S. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J Immunol. 2002;168:4173-83 pubmed
    ..II, invariant chain (Ii), and H-2M (DM) expression, are resistant to initiation of myelin oligodendrocyte protein (MOG) peptide, MOG(35-55)-specific EAE by both priming and adoptive transfer of encephalitogenic T cells...
  36. Smith P, Heijmans N, Ouwerling B, Breij E, Evans N, van Noort J, et al. Native myelin oligodendrocyte glycoprotein promotes severe chronic neurological disease and demyelination in Biozzi ABH mice. Eur J Immunol. 2005;35:1311-9 pubmed
    b>Myelin oligodendrocyte glycoprotein (MOG) is a powerful encephalitogen for experimental autoimmune demyelination...
  37. Braun S, Pilz G, Machado R, Moss J, Becher B, Toni N, et al. Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury. Cell Rep. 2015;11:1679-85 pubmed publisher
    ..These findings highlight the potential of targeting hippocampal NSPCs for the treatment of demyelinated lesions in the adult brain. ..
  38. von Büdingen H, Mei F, Greenfield A, Jahn S, Shen Y, Reid H, et al. The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry. J Cell Biol. 2015;210:891-8 pubmed
    b>Myelin oligodendrocyte glycoprotein (MOG) is a central nervous system myelin-specific molecule expressed on the outer lamellae of myelin...
  39. Moyon S, Huynh J, Dutta D, Zhang F, Ma D, Yoo S, et al. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Rep. 2016;15:748-760 pubmed publisher
    ..Therefore, loss of Dnmt1 in OPCs is not sufficient to induce a lineage switch but acts as an important determinant of the coordination between RNA splicing and protein synthesis necessary for myelin formation. ..
  40. Schreiner B, Ingold Heppner B, Pehl D, Locatelli G, Berrit Schönthaler H, Becher B. Deletion of Jun proteins in adult oligodendrocytes does not perturb cell survival, or myelin maintenance in vivo. PLoS ONE. 2015;10:e0120454 pubmed publisher
    ..We conclude that JunB and c-Jun expression in post-mitotic oligodendrocytes is mostly dispensable for the maintainance of white matter tracts throughout adult life, even under demyelinating conditions. ..
  41. Jones E, Xiao H, Schultz R, Flaherty L, Trachtulec Z, Vincek V, et al. MHC class I gene organization in > 1.5-Mb YAC contigs from the H2-M region. Genomics. 1995;27:40-51 pubmed
    ..markers was determined in the cloned DNA from the centromere as T1, Tu32A, (M1-M7-M8), Tu32B, B30, M6, M4, M5, Mog, Tu42A parallel M2, Leh525, M3, Tu42B, where the orientation with respect to the centromere is unknown for M1-M7-M8. ..
  42. Amiguet P, Gardinier M, Zanetta J, Matthieu J. Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J Neurochem. 1992;58:1676-82 pubmed
    The myelin/oligodendrocyte glycoprotein (MOG) is found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. The monoclonal antibody 8-18C5 identifies MOG...
  43. Blanchfield L, Sabatino J, Lawrence L, Evavold B. NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease. J Immunol. 2017;199:2680-2691 pubmed publisher
    ..T cells due to cross-recognition of multiple self-epitopes such as has been suggested for myelin oligodendrocyte glycoprotein epitope 35-55 (MOG35-55) and neurofilament medium protein epitope 15-35 (NFM15-35
  44. Bettini M, Rosenthal K, Evavold B. Pathogenic MOG-reactive CD8+ T cells require MOG-reactive CD4+ T cells for sustained CNS inflammation during chronic EAE. J Neuroimmunol. 2009;213:60-8 pubmed publisher
    ..CD8+ T cells reactive to MOG37-46 are pro-inflammatory and traffic to the CNS; however, the presence of CD4+ T cells elicits more severe disease and sustained inflammation of the CNS. ..
  45. Ballenthin P, Gardinier M. Myelin/oligodendrocyte glycoprotein is alternatively spliced in humans but not mice. J Neurosci Res. 1996;46:271-81 pubmed
    Myelin/oligodendrocyte glycoprotein (MOG) is an integral membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths...
  46. Lalive P, Molnarfi N, Benkhoucha M, Weber M, Santiago Raber M. Antibody response in MOG(35-55) induced EAE. J Neuroimmunol. 2011;240-241:28-33 pubmed publisher
    ..We show that mice immunized with encephalitogenic myelin oligodendrocyte glycoprotein (MOG(35-55)) peptide develop significant serum levels of anti-MOG antibodies in parallel with ..
  47. Jones E, Kumanovics A, Yoshino M, Fischer Lindahl K. Mhc class I and non-class I gene organization in the proximal H2-M region of the mouse. Immunogenetics. 1999;49:183-95 pubmed
    ..The contig is composed of 28 clones that span approximately 1 megabasepair (Mb), from H2-T1 to Mog, and contains three H2-T genes and 18 H2-M genes...
  48. Jung J, Michalak M. Cell surface targeting of myelin oligodendrocyte glycoprotein (MOG) in the absence of endoplasmic reticulum molecular chaperones. Biochim Biophys Acta. 2011;1813:1105-10 pubmed publisher
    b>Myelin oligodendrocyte glycoprotein (MOG) is a type I integral membrane glycoprotein that localizes to myelin sheaths in the central nervous system...
  49. Ransohoff R. A mighty mouse: building a better model of multiple sclerosis. J Clin Invest. 2006;116:2313-6 pubmed
    ..The studies describe an important new model for MS research. ..
  50. Soares R, Dias A, de Castro S, Alves C, Evangelista M, Da Silva L, et al. Optical neuritis induced by different concentrations of myelin oligodendrocyte glycoprotein presents different profiles of the inflammatory process. Autoimmunity. 2013;46:480-5 pubmed publisher
    ..The results suggest that two different concentrations of MOG35-55 lead to different forms of evolution of optic neuritis. ..
  51. Arepalli S, Jones E, Howcroft T, Carlo I, Wang C, Lindahl K, et al. Characterization of two class I genes from the H2-M region: evidence for a new subfamily. Immunogenetics. 1998;47:264-71 pubmed
    ..M9 is only 64% similar to M10 and 60% to H2-K k. Probes from M10 define a new subfamily of eight class I genes in C3H mice; five cluster directly distal to H2-T1, and three are located between M9-1-7-8 and M6-4-5 in the H2-M region. ..
  52. Yoshikawa F, Sato Y, Tohyama K, Akagi T, Hashikawa T, Nagakura Takagi Y, et al. Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. J Biol Chem. 2008;283:20830-40 pubmed publisher
    ..These results suggest a role for highly sialylglycosylated Opalin in an intermembranous function of the myelin paranodal loops in the central nervous system. ..
  53. Bhowmick S, Clark R, Brocke S, Cone R. Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase. Int Immunol. 2011;23:119-28 pubmed publisher
    ..Here we show that an injection of encephalitogenic myelin oligodendrocyte glycoprotein (MOG(35-55)) peptide into the anterior chamber of the eye (AC-MOG), before the induction of or ..
  54. Calida D, Constantinescu C, Purev E, Zhang G, Ventura E, Lavi E, et al. Cutting edge: C3, a key component of complement activation, is not required for the development of myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in mice. J Immunol. 2001;166:723-6 pubmed
    ..EAE, we immunized mice deficient in C3 (C3(-/-)) and their wild-type (C3(+/+)) littermates with myelin oligodendrocyte glycoprotein peptide 35-55. C3(-/-) mice were susceptible to EAE as much as the C3(+/+) mice were...
  55. Terényi N, Nagy N, Papp K, Prechl J, Oláh I, Erdei A. Transient decomplementation of mice delays onset of experimental autoimmune encephalomyelitis and impairs MOG-specific T cell response and autoantibody production. Mol Immunol. 2009;47:57-63 pubmed publisher
    ..Our results show that in decomplemented C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide 35-55, the onset of the disease is significantly delayed...
  56. Carrillo Vico A, Leech M, Anderton S. Contribution of myelin autoantigen citrullination to T cell autoaggression in the central nervous system. J Immunol. 2010;184:2839-46 pubmed publisher
    ..experimental autoimmune encephalomyelitis (EAE) induced with the immunodominant 35-55 peptide of myelin oligodendrocyte glycoprotein (pMOG) in C57BL/6 mice to test whether citrullination of a T cell epitope can contribute to disease ..
  57. Litzenburger T, Blüthmann H, Morales P, Pham Dinh D, Dautigny A, Wekerle H, et al. Development of myelin oligodendrocyte glycoprotein autoreactive transgenic B lymphocytes: receptor editing in vivo after encounter of a self-antigen distinct from myelin oligodendrocyte glycoprotein. J Immunol. 2000;165:5360-6 pubmed
    ..18C5, specific for the myelin oligodendrocyte glycoprotein (MOG)...
  58. Krishnamoorthy G, Saxena A, Mars L, Domingues H, Mentele R, Ben Nun A, et al. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med. 2009;15:626-32 pubmed publisher
    ..of spontaneous experimental autoimmune encephalomyelitis (EAE) in transgenic mice expressing a myelin oligodendrocyte glycoprotein (MOG)-specific T cell antigen receptor (TCR) in the absence of MOG...