Gene Symbol: Mob1b
Description: MOB kinase activator 1B
Alias: 1110003E08Rik, AU015450, B230364F10, Mobkl1a, MOB kinase activator 1B, MOB1, Mps One Binder kinase activator-like 1A, mob1 homolog 1A, mps one binder kinase activator-like 1A
Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, et al
. Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest. 2012;122:4505-18 pubmed publisher
Mps one binder 1a (MOB1A) and MOB1B are key components of the Hippo signaling pathway and are mutated or inactivated in many human cancers...
Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, et al
. Dysregulated YAP1/TAZ and TGF-Î² signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 2016;113:E71-80 pubmed publisher
..Targeting YAP1/TAZ with these drugs in combination with inhibition of the TGF-Î² pathway may be effective treatment for cHC-CCs and ICCs. ..
Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, et al
. MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017;36:4201-4211 pubmed publisher
..epithelium-specific, null mutations of MOB1A/B in mice (SPC-rtTA/(tetO)7-Cre/Mob1aflox/flox/Mob1b-/-; termed luMob1DKO mice). Most mutants (70%) receiving Dox in utero (luMob1DKO (E6.5-18...
Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol. 2008;18:311-21 pubmed publisher
..MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MOBKL1A and MOBKL1B polypeptides, homologs of the Drosophila MATS polypeptide, are identified as preferred MST1/MST2 ..
Zhou D, Medoff B, Chen L, Li L, Zhang X, Praskova M, et al
. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008;105:20321-6 pubmed publisher
..Among known Mst1 substrates, only the phosphorylation of the cell cycle inhibitory proteins MOBKL1A/B is lost entirely in TCR-stimulated, Mst1-deficient T cells...
Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, et al
. A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med. 2015;7:279ra38 pubmed publisher
..Our data demonstrate the ability of microRNA-based therapeutic approaches to promote mammalian cardiac repair and regeneration through the transient activation of cardiomyocyte proliferation. ..