Mnx1

Summary

Gene Symbol: Mnx1
Description: motor neuron and pancreas homeobox 1
Alias: HB9, Hlxb9, MNR2, homeobox gene HB9, homeobox protein HB9, motor neuron and pancreas homeobox protein 1
Species: mouse

Top Publications

  1. ncbi Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord
    Michiya Sugimori
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 134:1617-29. 2007
  2. pmc Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity
    Natalia V De Marco Garcia
    Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:217-31. 2008
  3. ncbi Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 412:194-8. 2001
  4. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
  5. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
  6. ncbi ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
    S Arber
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 101:485-98. 2000
  7. pmc Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program
    Floor J Stam
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 139:179-90. 2012
  8. pmc RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors
    Nancy Thompson
    Swiss Institute for Experimental Cancer Researcha and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
    Mol Cell Biol 32:1189-99. 2012
  9. ncbi Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells
    Noritaka Masahira
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8787, Japan
    Dev Biol 293:358-69. 2006
  10. pmc Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
    Salvatore Cortellino
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Biol 325:225-37. 2009

Scientific Experts

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  • Maike Sander
  • Kathryn V Anderson
  • Andrew P McMahon
  • Silvia Arber
  • Danwei Huangfu
  • Tamara Caspary
  • Lei Zhang
  • Weiguo Zhou
  • Dritan Agalliu
  • Natalie Kim
  • Yuanyuan Wu
  • Jonathan T Eggenschwiler
  • S Arber
  • Shelley B Nelson
  • Weichun Lin
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  • Ivo Lieberam
  • Juhee Jeong
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  • Q Richard Lu
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  • E Ivanova
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  • C Francius
  • Corinna Haupt
  • Lin Mei
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  • Yibo Qu
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  • Michiya Sugimori

Detail Information

Publications109 found, 100 shown here

  1. ncbi Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord
    Michiya Sugimori
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 134:1617-29. 2007
    ..We propose a molecular code model whereby the combinatorial actions of two classes of transcription factors coordinately regulate the domain-specific temporal sequence of neurogenesis and gliogenesis in the developing spinal cord...
  2. pmc Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity
    Natalia V De Marco Garcia
    Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:217-31. 2008
    ..Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity...
  3. ncbi Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 412:194-8. 2001
    ..The data indicate that dorsalizing signals activate transcription of Rab23 in order to silence the Shh pathway in dorsal neural cells...
  4. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  5. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
    ..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
  6. ncbi ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
    S Arber
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 101:485-98. 2000
    ..ER81 therefore controls a late step in the establishment of functional sensory-motor circuitry in the developing spinal cord...
  7. pmc Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program
    Floor J Stam
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 139:179-90. 2012
    ....
  8. pmc RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors
    Nancy Thompson
    Swiss Institute for Experimental Cancer Researcha and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
    Mol Cell Biol 32:1189-99. 2012
    ..We demonstrate that Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of PTF1a and is regulated by ..
  9. ncbi Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells
    Noritaka Masahira
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8787, Japan
    Dev Biol 293:358-69. 2006
    ..These findings demonstrate that motoneurons and oligodendrocytes are not the only cell types originating from this domain...
  10. pmc Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
    Salvatore Cortellino
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Biol 325:225-37. 2009
    ..We conclude that complex A and complex B factors play similar but distinct roles in ciliogenesis and Shh/Gli3 signaling...
  11. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    ..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
  12. pmc MuSK controls where motor axons grow and form synapses
    Natalie Kim
    Molecular Neurobiology Program, The Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, NY 10016, USA
    Nat Neurosci 11:19-27. 2008
    ....
  13. ncbi Loss of Mtmr2 phosphatase in Schwann cells but not in motor neurons causes Charcot-Marie-Tooth type 4B1 neuropathy with myelin outfoldings
    Annalisa Bolis
    Dulbecco Telethon Institute, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 25:8567-77. 2005
    ..Thus, therapeutical approaches might be designed in the future to specifically deliver the Mtmr2 phospholipid phosphatase to Schwann cells in affected nerves...
  14. pmc Cilia and Hedgehog responsiveness in the mouse
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:11325-30. 2005
    ....
  15. pmc Motor neurons with axial muscle projections specified by Wnt4/5 signaling
    Dritan Agalliu
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 61:708-20. 2009
    ..Thus, two dorsoventral signaling pathways, mediated by Shh and Wnt4/5, are required to establish an early binary divergence in motor neuron columnar identity...
  16. pmc Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation
    Haitao Wu
    Institute of Molecular Medicine and Genetics and Department of Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
    Neuron 75:94-107. 2012
    ..These observations uncovered distinct roles of LRP4 in motoneurons and muscles in NMJ development...
  17. doi Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development
    C Francius
    Universite Catholique de Louvain, Institute of Neuroscience, Brussels, Belgium
    Neuroscience 165:116-29. 2010
    ..Together, our data unveil a complex and dynamic expression profile of the OC proteins in spinal MN, which suggests that these factors may participate in regulatory networks that control different steps of motor neuron development...
  18. doi THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
    ..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event...
  19. doi Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb
    Victor Luria
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 60:1039-53. 2008
    ..The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program...
  20. ncbi Heterogeneous electrotonic coupling and synchronization of rhythmic bursting activity in mouse Hb9 interneurons
    J M Wilson
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada
    J Neurophysiol 98:2370-81. 2007
    ..b>Hb9 interneurons, a small population of discretely localized interneurons in the mouse spinal cord, are conditionally ..
  21. pmc HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction
    Feng Ye
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, USA
    Nat Neurosci 12:829-38. 2009
    ..Thus, crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation...
  22. ncbi V1 spinal neurons regulate the speed of vertebrate locomotor outputs
    Simon Gosgnach
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 440:215-9. 2006
    ....
  23. ncbi Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein
    Jennifer M Wilson
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    J Neurosci 25:5710-9. 2005
    ..in which expression of green fluorescent protein is driven by the promoter for the homeodomain transcription factor Hb9, as well as Hb9-lacZ knock-in mice, we describe a novel population of glutamatergic interneurons located adjacent ..
  24. ncbi Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation
    X Yang
    Molecular Neurobiology Program, Skirball Institute, New York University Medical School, New York, NY 10011, USA
    Neuron 30:399-410. 2001
    ..Our results demonstrate that AChR expression is patterned in the absence of innervation, raising the possibility that similarly prepatterned muscle-derived cues restrict axon growth and initiate synapse formation...
  25. ncbi Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9
    J Thaler
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Neuron 23:675-87. 1999
    ..This pattern resembles a composite of the avian homologs MNR2 and HB9...
  26. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    The homeobox gene Hb9, like its close relative MNR2, is expressed selectively by motor neurons (MNs) in the developing vertebrate CNS...
  27. pmc Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop
    Jun An Chen
    Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 69:721-35. 2011
    ....
  28. ncbi Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
    W Lin
    The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 410:1057-64. 2001
    ..In contrast, the subsequent stages of synaptic growth and maintenance require nerve-derived agrin, and a second nerve-derived signal that disperses ectopic postsynaptic apparatus...
  29. ncbi SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, D 91054 Erlangen, Germany
    Dev Cell 11:697-709. 2006
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development...
  30. pmc CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission
    Marko Jevsek
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:6374-9. 2006
    ..Because CD24 is also expressed in some neurons, additional experiments will be required to determine whether pre- or postsynaptic CD24 mediates these effects on presynaptic development and function...
  31. pmc ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons
    Aki Itoh
    Department of Neurology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
    J Neurosci 31:7223-8. 2011
    ..Nuclear HB9/MNX1-positive motoneuron pools were generated similarly in the spinal cord of both ZPK/DLK-deficient and wild-type ..
  32. pmc Lateral motor column axons execute a ternary trajectory choice between limb and body tissues
    Victor Luria
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Neural Dev 2:13. 2007
    ..The cellular logic that guides motor axon trajectory choices into non-limb tissues such as the ventral flank remains unclear...
  33. pmc HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside
    Basile Tarchini
    National Research Centre Frontiers in Genetics and Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Genes Dev 19:2862-76. 2005
    ..These results highlight the importance of a systematic approach when studying such clustered gene families, and give insights into the function and regulation of Hox and Evx2 genes during early spinal cord development...
  34. doi Retrograde regulation of motoneuron differentiation by muscle beta-catenin
    Xiao Ming Li
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    Nat Neurosci 11:262-8. 2008
    ..Taken together, these observations indicate a role for muscle beta-catenin in presynaptic differentiation and function, identifying a previously unknown retrograde signaling in the synapse formation and synaptic plasticity...
  35. pmc Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
    John Jacob
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 136:2477-85. 2009
    ..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
  36. doi Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns
    Corinna Haupt
    Institute of Developmental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Munich Neuherberg, Germany
    Eur J Neurosci 31:1164-72. 2010
    ..Thus, Sema3A-Npn-1 signaling plays an important role in the guidance and fasciculation of motor and sensory axons but does not contribute to the developmental elimination of these neurons...
  37. ncbi Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism
    Weichun Lin
    The Salk Institute, La Jolla, California 92037, USA
    Neuron 46:569-79. 2005
    ..Genetic elimination of Cdk5 or blocking ACh production prevents the dispersion of AChR clusters in agrin mutants. Therefore, we propose that ACh negatively regulates neuromuscular synapse formation through a Cdk5-dependent mechanism...
  38. ncbi Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain
    Anna Vallstedt
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Neuron 45:55-67. 2005
    ..Based on these findings, we propose that oligodendrocytes derive from several distinct positional origins and that the activation of Olig1/2 at different positions is controlled by distinct genetic programs...
  39. doi Neural cell adhesion molecule is required for stability of reinnervated neuromuscular junctions
    Peter H Chipman
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Eur J Neurosci 31:238-49. 2010
    ..Consideration is given to the role of NCAM in terminal Schwann cells for maintaining synaptic integrity and how NCAM dysfunction may contribute to motoneuron disorders...
  40. pmc A developmental switch in the response of DRG neurons to ETS transcription factor signaling
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Switzerland
    PLoS Biol 3:e159. 2005
    ..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation...
  41. pmc A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
    Mark Wijgerde
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 16:2849-64. 2002
    ..Thus, Hh signaling is essential for organizing ventral cell pattern, possibly through the control of differential cell affinities...
  42. ncbi T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration
    Mi Ryoung Song
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Development 133:4945-55. 2006
    ..Our study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway...
  43. pmc Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
    Madelen Persson
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S 171 77 Stockholm, Sweden
    Genes Dev 16:2865-78. 2002
    ..Together these data raise the possibility that Gli proteins act as common mediators integrating Shh signals, and other sources of positional information, to control patterning throughout the ventral neural tube...
  44. ncbi Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord
    R Scardigli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, B P 163, 67404 Illkirch Cedex, C U, de Strasbourg, France
    Neuron 31:203-17. 2001
    ..Thus, neuronal differentiation involves crossregulatory interactions between a bHLH-driven program of neurogenesis and genetic pathways specifying progenitor and neuronal identity in the spinal cord...
  45. ncbi The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Dev Biol 258:105-16. 2003
    ..Together with the known role of HNF-6 in pancreatic endocrine cell differentiation, our data point to HNF-6 as a key regulator of pancreas development...
  46. ncbi Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1
    Juhee Jeong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 132:143-54. 2005
    ..Furthermore, this feedback mechanism is crucial in generating a neural tube that contains appropriate numbers of all ventral and intermediate neuronal cell types...
  47. ncbi Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons
    Yuanyuan Wu
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 135:171-82. 2008
    ..Together, these results show that Hoxc10 and Hoxd10 play key roles in establishing lumbar motoneuron columnar, divisional and motor pool identity...
  48. ncbi Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Dev Biol 227:648-60. 2000
    ..The data indicate that opb(+) could act as either a novel component of a dorsalizing pathway or a novel intracellular negative regulator of the Shh signal transduction pathway...
  49. ncbi Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins
    Jonathan T Eggenschwiler
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Dev Biol 290:1-12. 2006
    ..Instead, Rab23 appears to regulate subcellular localization of essential components of the Hedgehog pathway that act downstream of Smoothened and upstream of Gli proteins...
  50. ncbi LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons
    K Sharma
    Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Cell 95:817-28. 1998
    ..Thus, Lhx3 and Lhx4 act in a binary fashion during a brief period in development to specify the trajectory of motor axons from the neural tube...
  51. pmc Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
    Soo Kyung Lee
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Genes Dev 19:282-94. 2005
    ....
  52. ncbi The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells
    Shelley B Nelson
    Department of Developmental and Cell Biology, University of California at Irvine, 4203 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 134:2491-500. 2007
    ..2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities and implies that both Nkx6.1 and Nkx6.2 possess alpha- and beta-cell-specifying activities...
  53. ncbi A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons
    Ivo Lieberam
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, New York, New York 10032, USA
    Neuron 47:667-79. 2005
    ..In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons...
  54. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
    ..Thus, normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals...
  55. ncbi Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents
    Tushar D Patel
    Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 38:403-16. 2003
    ..Finally, addition of NT3 to DRG explant cultures resulted in induction of ER81 protein. Our data indicate that NT3 mediates the formation of proprioceptive afferent-motor neuron connections via regulation of ER81...
  56. ncbi GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools
    Georg Haase
    INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, Marseille, France
    Neuron 35:893-905. 2002
    ..Thus, GDNF acts as a peripheral signal to induce PEA3 expression in specific motor neuron pools thereby regulating both cell body position and muscle innervation...
  57. ncbi Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points
    Matthieu Vermeren
    MRC Centre for Developmental Neurobiology, Guy s Campus, King s College London, SE1 1UL, London, United Kingdom
    Neuron 37:403-15. 2003
    ..Thus, before the formation of a mature transitional zone at the MEP, BC cells maintain a cell-tight boundary that allows motor axons to cross but blocks neuron migration...
  58. ncbi Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
    J Briscoe
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nature 398:622-7. 1999
    ..Thus, Nkx2.2 has an essential role in interpreting graded Shh signals and selecting neuronal identity...
  59. ncbi Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Neuron 50:35-47. 2006
    ..This phenotype is enhanced in mutant mice lacking Ret and EphA4. Thus, Ret and EphA4 signals cooperate to enforce the precision of the same binary choice in motor-axon guidance...
  60. ncbi Ftm is a novel basal body protein of cilia involved in Shh signalling
    Jeanette Vierkotten
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Development 134:2569-77. 2007
    ..Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways...
  61. doi The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
    Thomas W Gould
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 28:2131-46. 2008
    ..Therefore, although GDNF influences several aspects of MN development, the survival-promoting effects of GDNF during programmed cell death are mostly confined to spindle-innervating MNs...
  62. pmc Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice
    Yibo Qu
    Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, Brussels, Belgium
    J Neurosci 30:9392-401. 2010
    ..These data indicate that Celsr1-3 differentially regulate FBM neuron migration. Celsr1 helps to specify the direction of FBM neuron migration, whereas Celsr2 and 3 control its ability to migrate...
  63. ncbi ETS transcription factor Erm controls subsynaptic gene expression in skeletal muscles
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Neuron 55:726-40. 2007
    ..Together, our findings define Erm as an upstream regulator of a transcriptional program selective to subsynaptic nuclei at the NMJ and underscore the importance of transcriptional control of local synaptic protein accumulation...
  64. doi Tulp3 is a critical repressor of mouse hedgehog signaling
    Don A Cameron
    Department of Biochemistry, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Dev Dyn 238:1140-9. 2009
    ..This work uncovers a novel role for Tulp3 as a negative regulatory factor in the Hh pathway...
  65. pmc GluR1 controls dendrite growth through its binding partner, SAP97
    Weiguo Zhou
    Department of Pediatrics, Division of Neurology, Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:10220-33. 2008
    ..Our findings suggest that the C-terminal 7 aa of GluR1 are essential for bringing SAP97 to the plasma membrane, where it acts to translate the activity of AMPA receptors into dendrite growth...
  66. ncbi Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
    Qiubo Lei
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Development 131:3593-604. 2004
    ..Thus, multiple ventral neuronal types can develop in the absence of Gli function, but require balanced Gli protein activities for their correct patterning and differentiation...
  67. pmc Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling
    Vanessa L Horner
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Biol 355:43-54. 2011
    ..We demonstrate that Arl13b is required non-autonomously for BMP signaling and Wnt ligand expression, indicating that the abnormal Shh signaling environment in Arl13b(hnn) embryos indirectly causes dorsal defects...
  68. doi Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube
    Alisa S W Shum
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Dev Dyn 239:3192-203. 2010
    ..Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube...
  69. pmc Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures
    Megumi Hirose
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7332, USA
    J Neurosci Res 89:1363-74. 2011
    ..mice by immunofluorescence, on the other hand, revealed no obvious alterations in expressions of Islet1/2, MNR2, Lim1/2, Nkx2.2, or Shh, although the Pax6-positive area was slightly expanded in PACAP-deficient spinal cord...
  70. ncbi Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain
    Alexandre Pattyn
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Development 130:4149-59. 2003
    ..Thus, both visceral and somatic motoneuron differentiation appear to rely on the combined activity of cell intrinsic determinants, rather than on a single key determinant of neuronal cell fate...
  71. ncbi A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice
    R M Clark
    Department of Developmental Biology, Stanford University, California 94305 5327, USA
    Genomics 67:19-27. 2000
    ..The human ortholog of Lmbr1 maps within the recently described interval for human PPD, strengthening the possibility that both mouse and human limb abnormalities are due to defects in the same highly conserved gene...
  72. ncbi Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning
    Katrin Götz
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, Dusseldorf, Germany
    Dev Dyn 233:623-30. 2005
    ....
  73. pmc Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:10688-93. 2005
    ..However, coexpression of both Foxn4 and Mash1 promotes the V2b fate while inhibiting the V2a fate, indicating that Foxn4 cooperates with Mash1 to specify the identity of V2b neurons from bipotential p2 progenitors...
  74. pmc Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction
    Hyuk Wan Ko
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 18:237-47. 2010
    ..We propose that Bromi and CCRK control the structure of the primary cilium by coordinating assembly of the axoneme and ciliary membrane, allowing Gli proteins to be properly activated in response to Shh signaling...
  75. pmc TACE (ADAM17) inhibits Schwann cell myelination
    Rosa La Marca
    Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Nat Neurosci 14:857-65. 2011
    ..Thus, TACE is a modulator of NRG1 type III activity and is a negative regulator of myelination in the PNS...
  76. doi Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription
    Takanori Amano
    Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka, Japan
    Dev Cell 16:47-57. 2009
    ..These results suggest that chromosome conformation dynamics at the Shh locus allow transient pulses of Shh transcription...
  77. pmc Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP
    Seunghee Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 62:641-54. 2009
    ..Our study uncovers the mechanism by which extrinsic RA-signal and intrinsic transcription factor Ngn2 cooperate for cell fate specification through their synergistic activity to trigger transcriptionally active chromatin...
  78. pmc Characterization of transgenic mouse lines expressing Cre recombinase in the retina
    E Ivanova
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neuroscience 165:233-43. 2010
    ..In other lines, the Cre-induced recombination was found in several retinal cell types. These Cre lines provide a valuable resource for retinal research...
  79. pmc Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity
    Mi Ryoung Song
    Bioimaging Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    Development 136:2923-32. 2009
    ....
  80. doi TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons
    Koji Shibasaki
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurosci 30:4601-12. 2010
    ..Thus, for the first time we revealed that TRPV2 is an important regulator for axon outgrowth through its activation by membrane stretch during development...
  81. pmc The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2
    Ye Yan
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 138:1209-21. 2009
    ..These findings define Prdx1 as a pivotal regulator of GDE2 activity and suggest roles for coupled thiol-redox-dependent cascades in controlling neuronal differentiation in the spinal cord...
  82. doi Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis
    Yoshihiro Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
    Dev Neurosci 31:511-22. 2009
    ..These results suggest that Foxp1 may play some important roles in the determination of neuronal fates of the ventral spinal cord, possibly through the suppression of Lhx3 expression...
  83. ncbi Dorsal pancreas agenesis in N-cadherin- deficient mice
    F Esni
    Department of Medical Biochemistry, Box 440, Goteborg University, Goteborg, S 405 30, Sweden
    Dev Biol 238:202-12. 2001
    ..Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme...
  84. ncbi Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development
    H Li
    Umeå Center for Molecular Medicine, Umea University, Umea, SE 901 87, Sweden
    Dev Biol 240:247-53. 2001
    The homebox gene Hlxb9, encoding Hb9, exhibits a dual expression profile during pancreatic development...
  85. pmc Abnormal development of the neuromuscular junction in Nedd4-deficient mice
    Yun Liu
    Department of Neuroscience, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Dev Biol 330:153-66. 2009
    ..Together, these results demonstrate that Nedd4 is involved in regulating the formation and function of the NMJs through non-cell autonomous mechanisms...
  86. pmc Transcriptional dynamics of endodermal organ formation
    Richard I Sherwood
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Dev Dyn 238:29-42. 2009
    ..at the prospective stomach-intestine border, with the hepatic and pancreatic domains forming at this boundary, and Hlxb9 was revealed to have graded expression along the dorsal-ventral axis...
  87. ncbi An in vivo analysis of Schwann cell programmed cell death in embryonic mice: the role of axons, glial growth factor, and the pro-apoptotic gene Bax
    Adam K Winseck
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, One Medical Center Boulevard, Winston Salem, NC 27157, USA
    Eur J Neurosci 24:2105-17. 2006
    ....
  88. ncbi GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration
    Hideki Enomoto
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 44:623-36. 2004
    ..Thus RET-independent GFRalpha1 is dispensable for organogenesis and nerve regeneration in vivo, indicating that trans-signaling and GFRalpha-dependent NCAM signaling play a minor role physiologically...
  89. ncbi Selective expression of Bhlhb5 in subsets of early-born interneurons and late-born association neurons in the spinal cord
    Ben Liu
    The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Dev Dyn 236:829-35. 2007
    ..At late stages of development, Bhlhb5 expression is detected in a subset of late-born dorsal association interneurons that migrate into the uppermost layer of the dorsal horn...
  90. ncbi An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs
    Jonas Ahnfelt-Rønne
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Histochem Cytochem 55:925-30. 2007
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  91. ncbi Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo
    Sen Wu
    Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, Utah 84112, USA
    Development 133:581-90. 2006
    ..The data presented herein supports a sequential model in which motoneuron and oligodendrocyte precursors are sequentially generated in vivo from neuroepithelial stem cells, but do not share a common lineage-restricted progenitor...
  92. pmc Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems
    Merritt K Taylor
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Development 134:2435-47. 2007
    ..These results demonstrate that physiological Notch signaling is required for gliogenesis in vivo, independent of the role of Notch in the maintenance of undifferentiated neural progenitors...
  93. ncbi The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 266:178-89. 2004
    ..for appropriate initiation of beta-cell differentiation because loss of Pax4 prevents the expression of Pdx1, HB9 and insulin in beta-cell precursors...
  94. ncbi Generation of cerebellar neuron precursors from embryonic stem cells
    Hong Lin Su
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo, Kobe 650 0047, Japan
    Dev Biol 290:287-96. 2006
    ..This is the first report of in vitro recapitulation of early differentiation of cerebellar neurons by using the ES cell system...
  95. pmc Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation
    Ruth Simon
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 23:9046-60. 2003
    ..Intriguingly, our studies also demonstrated a striking autoregulation of the Sax2 gene in both positive- and negative-feedback mechanisms depending on the specific cell type expressing Sax2...
  96. ncbi Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons
    Gary O Gaufo
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 130:5191-201. 2003
    ....
  97. ncbi Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neurons
    Takahiro Nakano
    Department of Neurology and Neuroscience, Cornell University Medical Center, New York, NY 10021, USA
    Dev Biol 283:474-85. 2005
    The homeobox gene Hb9 is expressed selectively by motor neurons (MNs) in the developing CNS. Previous studies have identified a 9-kb 5' fragment of the mouse Hb9 gene that is sufficient to direct gene expression to spinal MNs in vivo...
  98. pmc VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5
    Dorota Szumska
    Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genes Dev 22:1465-77. 2008
    ..Pcsk5 mutation results in abnormal expression of several paralogous Hox genes (Hoxa, Hoxc, and Hoxd), and of Mnx1 (Hlxb9). These include known Gdf11 targets, and are necessary for caudal embryo development...
  99. pmc Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus
    Mark Merchant
    Department of Molecular Biology, South San Francisco, CA 94080, USA
    Mol Cell Biol 25:7054-68. 2005
    ..These results show that the mFu homologue is not required for Hh signaling during embryonic development but is required for proper postnatal development, possibly by regulating the CSF homeostasis or ciliary function...
  100. pmc A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 323:19-30. 2008
    ..Our findings therefore suggest that defective endocrine specification might underlie the pancreatic phenotype of individuals with CD...
  101. pmc Role of GluR1 in activity-dependent motor system development
    Lei Zhang
    Department of Pediatrics, Division of Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:9953-68. 2008
    ..GluR1 expression by neurons within the segmental spinal cord plays an essential role in formation of the neural network that underlies normal motor behavior...

Research Grants20

  1. Coordinating Center for Beta Cell Biology Consortium
    Mark Magnuson; Fiscal Year: 2007
    ..abstract_text> ..
  2. Coordinating Center for Beta Cell Biology Consortium
    Mark Magnuson; Fiscal Year: 2007
    ....
  3. GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELL
    Mark Magnuson; Fiscal Year: 2005
    ..In Aim 3 we will determine the role of alternate RNA processing the insulin receptor in modulating both GK gene transcription and subcellular localization in the pancreatic beta cell. ..
  4. GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELL
    Mark Magnuson; Fiscal Year: 2001
    ..Thus, these studies are also relevant to the pathogenesis and treatment of Type 2 diabetes mellitus. ..
  5. GLUCOKINASE GENE EXPRESSION IN THE PANCREATIC BETA CELL
    Mark Magnuson; Fiscal Year: 1993
    ..These factors will be studied further using mobility shift and methylation interference assays. Efforts to purify and clone one of these factors will be initiated...
  6. INVESTIGATING THE ROLE OF CDO IN BRAIN DEVELOPMENT
    Ami Okada; Fiscal Year: 2004
    ..These experiments should also contribute to the overall understanding of the signals that are important in the assembly of the nervous system. ..