Mnt

Summary

Gene Symbol: Mnt
Description: max binding protein
Alias: Rox, bHLHd3, max-binding protein MNT, myc antagonist MNT
Species: mouse
Products:     Mnt

Top Publications

  1. Toyo oka K, Hirotsune S, Gambello M, Zhou Z, Olson L, Rosenfeld M, et al. Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet. 2004;13:1057-67 pubmed
    The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3...
  2. Popov N, Wahlström T, Hurlin P, Henriksson M. Mnt transcriptional repressor is functionally regulated during cell cycle progression. Oncogene. 2005;24:8326-37 pubmed
    ..Similar to other proteins of the network, Mnt forms heterodimers with Max and binds CACGTG E-Box elements...
  3. Hurlin P, Queva C, Eisenman R. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev. 1997;11:44-58 pubmed
    ..We have identified a novel bHLHZip Max-binding protein, Mnt, which belongs to neither the Myc nor the Mad families and which is coexpressed with Myc in a number of ..
  4. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, et al. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. EMBO J. 1997;16:2892-906 pubmed
    ..and mapping of a human gene and its mouse homolog encoding a new member of this family of proteins, named Rox. Through interaction mating and immunoprecipitation techniques, we demonstrate that Rox heterodimerizes with Max ..
  5. Hurlin P, Zhou Z, Toyo oka K, Ota S, Walker W, Hirotsune S, et al. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 2003;22:4584-96 pubmed
    b>Mnt is a Max-interacting transcriptional repressor that has been hypothesized to function as a Myc antagonist. To investigate Mnt function we deleted the Mnt gene in mice...
  6. Nilsson J, Maclean K, Keller U, Pendeville H, Baudino T, Cleveland J. Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Mol Cell Biol. 2004;24:1560-9 pubmed
    ..Here we report that in quiescent cells the Odc E-boxes are occupied by Max and Mnt, a putative Myc antagonist, and that this complex is displaced by Myc-Max complexes in proliferating cells...
  7. Toyo oka K, Bowen T, Hirotsune S, Li Z, Jain S, Ota S, et al. Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res. 2006;66:5565-73 pubmed
    ..Max also interacts with Mnt but Mnt-Max complexes repress transcription when bound to these sequences. MNT maps to human chromosome 17p13...
  8. Walker W, Zhou Z, Ota S, Wynshaw Boris A, Hurlin P. Mnt-Max to Myc-Max complex switching regulates cell cycle entry. J Cell Biol. 2005;169:405-13 pubmed
    ..In contrast to c-Myc, the putative Myc antagonist Mnt is maintained at a constant level during cell cycle entry...
  9. Dezfouli S, Bakke A, Huang J, Wynshaw Boris A, Hurlin P. Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells. Mol Cell Biol. 2006;26:2080-92 pubmed
    b>Mnt is a Max-interacting protein that can antagonize the activities of Myc oncoproteins in cultured cells. Mnt null mice die soon after birth, but conditional deletion of Mnt in breast epithelium leads to tumor formation...
  10. Yang H, Li T, Ko K, Xia M, Lu S. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. Hepatology. 2009;49:860-70 pubmed publisher
    ..Both p53 and cyclin D1 are targets of c-Myc, which is also up-regulated in cholestasis. Myc and Mnt use Max as a cofactor for DNA binding. Myc-Max typically activates transcription via E-box binding...

Detail Information

Publications15

  1. Toyo oka K, Hirotsune S, Gambello M, Zhou Z, Olson L, Rosenfeld M, et al. Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet. 2004;13:1057-67 pubmed
    The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3...
  2. Popov N, Wahlström T, Hurlin P, Henriksson M. Mnt transcriptional repressor is functionally regulated during cell cycle progression. Oncogene. 2005;24:8326-37 pubmed
    ..Similar to other proteins of the network, Mnt forms heterodimers with Max and binds CACGTG E-Box elements...
  3. Hurlin P, Queva C, Eisenman R. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev. 1997;11:44-58 pubmed
    ..We have identified a novel bHLHZip Max-binding protein, Mnt, which belongs to neither the Myc nor the Mad families and which is coexpressed with Myc in a number of ..
  4. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, et al. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. EMBO J. 1997;16:2892-906 pubmed
    ..and mapping of a human gene and its mouse homolog encoding a new member of this family of proteins, named Rox. Through interaction mating and immunoprecipitation techniques, we demonstrate that Rox heterodimerizes with Max ..
  5. Hurlin P, Zhou Z, Toyo oka K, Ota S, Walker W, Hirotsune S, et al. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 2003;22:4584-96 pubmed
    b>Mnt is a Max-interacting transcriptional repressor that has been hypothesized to function as a Myc antagonist. To investigate Mnt function we deleted the Mnt gene in mice...
  6. Nilsson J, Maclean K, Keller U, Pendeville H, Baudino T, Cleveland J. Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Mol Cell Biol. 2004;24:1560-9 pubmed
    ..Here we report that in quiescent cells the Odc E-boxes are occupied by Max and Mnt, a putative Myc antagonist, and that this complex is displaced by Myc-Max complexes in proliferating cells...
  7. Toyo oka K, Bowen T, Hirotsune S, Li Z, Jain S, Ota S, et al. Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res. 2006;66:5565-73 pubmed
    ..Max also interacts with Mnt but Mnt-Max complexes repress transcription when bound to these sequences. MNT maps to human chromosome 17p13...
  8. Walker W, Zhou Z, Ota S, Wynshaw Boris A, Hurlin P. Mnt-Max to Myc-Max complex switching regulates cell cycle entry. J Cell Biol. 2005;169:405-13 pubmed
    ..In contrast to c-Myc, the putative Myc antagonist Mnt is maintained at a constant level during cell cycle entry...
  9. Dezfouli S, Bakke A, Huang J, Wynshaw Boris A, Hurlin P. Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells. Mol Cell Biol. 2006;26:2080-92 pubmed
    b>Mnt is a Max-interacting protein that can antagonize the activities of Myc oncoproteins in cultured cells. Mnt null mice die soon after birth, but conditional deletion of Mnt in breast epithelium leads to tumor formation...
  10. Yang H, Li T, Ko K, Xia M, Lu S. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. Hepatology. 2009;49:860-70 pubmed publisher
    ..Both p53 and cyclin D1 are targets of c-Myc, which is also up-regulated in cholestasis. Myc and Mnt use Max as a cofactor for DNA binding. Myc-Max typically activates transcription via E-box binding...
  11. Vasilevsky N, Ruby C, Hurlin P, Weinberg A. OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival. Eur J Immunol. 2011;41:1024-34 pubmed publisher
    ..Direct ex vivo examination of Ag-stimulated murine T cells show that the Myc antagonists, Mxd4 and Mnt, are transiently upregulated and translocated to the nucleus following OX40 engagement and may be involved in ..
  12. Link J, Ota S, Zhou Z, Daniel C, Sears R, Hurlin P. A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis. Proc Natl Acad Sci U S A. 2012;109:19685-90 pubmed publisher
    b>Mnt (Max's next tango) is a Max-interacting transcriptional repressor that can antagonize both the proproliferative and proapoptotic functions of Myc in vitro...
  13. Hirotsune S, Pack S, Chong S, Robbins C, Pavan W, Ledbetter D, et al. Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region. Genome Res. 1997;7:625-34 pubmed
    ..We have isolated the murine homologs of three genes located inside and outside the MDS region: Lis1, Mnt/Rox, and 14-3-3 epsilon...
  14. Yingling J, Toyo oka K, Wynshaw Boris A. Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse. Am J Hum Genet. 2003;73:475-88 pubmed
  15. Hurlin P, Zhou Z, Toyo oka K, Ota S, Walker W, Hirotsune S, et al. Evidence of mnt-myc antagonism revealed by mnt gene deletion. Cell Cycle. 2004;3:97-9 pubmed
    ..The repressor with similar DNA binding specificity raised the possibility that Mnt may serve a general role as a Myc antagonist.