Mnt

Summary

Gene Symbol: Mnt
Description: max binding protein
Alias: Rox, bHLHd3, max-binding protein MNT, myc antagonist MNT
Species: mouse

Top Publications

  1. ncbi Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, La Jolla 92093 0627, USA
    Hum Mol Genet 13:1057-67. 2004
  2. ncbi Mnt transcriptional repressor is functionally regulated during cell cycle progression
    Nikita Popov
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Oncogene 24:8326-37. 2005
  3. ncbi Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites
    P J Hurlin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Genes Dev 11:44-58. 1997
  4. pmc Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor
    G Meroni
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    EMBO J 16:2892-906. 1997
  5. pmc Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis
    Peter J Hurlin
    Shriners Hospitals for Children, Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, OR, USA
    EMBO J 22:4584-96. 2003
  6. pmc Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation
    Jonas A Nilsson
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 24:1560-9. 2004
  7. pmc A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis
    Jason M Link
    Shriners Hospitals for Children Portland, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 109:19685-90. 2012
  8. pmc Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region
    S Hirotsune
    Genome Res 7:625-34. 1997
  9. pmc Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse
    Jessica Yingling
    Departments of Pediatrics and Medicine, University of California at San Diego School of Medicine, La Jolla, CA, 92093, USA
    Am J Hum Genet 73:475-88. 2003
  10. ncbi Evidence of mnt-myc antagonism revealed by mnt gene deletion
    Peter J Hurlin
    Shriners Hospital for Children, Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon USA
    Cell Cycle 3:97-9. 2004

Research Grants

Scientific Experts

  • Peter Hurlin
  • Anthony Wynshaw-Boris
  • Kazuhito Toyo-oka
  • Sara Ota
  • Zi Qiang Zhou
  • Jason M Link
  • Nicole A Vasilevsky
  • Heping Yang
  • Shala Dezfouli
  • Michael G Rosenfeld
  • William Walker
  • Robert Eisenman
  • Shinji Hirotsune
  • Nikita Popov
  • Jonas A Nilsson
  • Jessica Yingling
  • Colin J Daniel
  • Rosalie C Sears
  • Andrew D Weinberg
  • Carl E Ruby
  • Meng Xia
  • Kwang Suk Ko
  • Tony W H Li
  • Shelly C Lu
  • Bing Ren
  • Sonia Jain
  • Laure Escoubet Lozach
  • Timothy J Bowen
  • Jean Lozach
  • Christopher K Glass
  • Laure Escoubet-Lozach
  • Antony Bakke
  • Zirong Li
  • Ivan Garcia Bassett
  • Ivan Garcia-Bassets
  • Jie Huang
  • Therese Wahlström
  • Marie Henriksson
  • Helene Pendeville
  • D H Ledbetter
  • Michael J Gambello
  • G Meroni
  • Kirsteen H Maclean
  • John L Cleveland
  • S Hirotsune
  • Ulrich B Keller
  • Troy A Baudino
  • Lorin Olson
  • S S Chong
  • A Wynshaw-Boris
  • G Borsani
  • S D Pack
  • C Lo Nigro
  • S Messali
  • A Ballabio
  • R Tonlorenzi
  • M Alcalay
  • W J Pavan
  • A Reymond
  • C M Robbins
  • M Zollo
  • A Tanigami
  • R Carrozzo
  • R Brent

Detail Information

Publications15

  1. ncbi Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, La Jolla 92093 0627, USA
    Hum Mol Genet 13:1057-67. 2004
    The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3...
  2. ncbi Mnt transcriptional repressor is functionally regulated during cell cycle progression
    Nikita Popov
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Oncogene 24:8326-37. 2005
    ..Similar to other proteins of the network, Mnt forms heterodimers with Max and binds CACGTG E-Box elements...
  3. ncbi Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites
    P J Hurlin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Genes Dev 11:44-58. 1997
    ..We have identified a novel bHLHZip Max-binding protein, Mnt, which belongs to neither the Myc nor the Mad families and which is coexpressed with Myc in a number of ..
  4. pmc Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor
    G Meroni
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    EMBO J 16:2892-906. 1997
    ..and mapping of a human gene and its mouse homolog encoding a new member of this family of proteins, named Rox. Through interaction mating and immunoprecipitation techniques, we demonstrate that Rox heterodimerizes with Max ..
  5. pmc Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis
    Peter J Hurlin
    Shriners Hospitals for Children, Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, OR, USA
    EMBO J 22:4584-96. 2003
    b>Mnt is a Max-interacting transcriptional repressor that has been hypothesized to function as a Myc antagonist. To investigate Mnt function we deleted the Mnt gene in mice...
  6. pmc Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation
    Jonas A Nilsson
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 24:1560-9. 2004
    ..Here we report that in quiescent cells the Odc E-boxes are occupied by Max and Mnt, a putative Myc antagonist, and that this complex is displaced by Myc-Max complexes in proliferating cells...
  7. pmc A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis
    Jason M Link
    Shriners Hospitals for Children Portland, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 109:19685-90. 2012
    b>Mnt (Max's next tango) is a Max-interacting transcriptional repressor that can antagonize both the proproliferative and proapoptotic functions of Myc in vitro...
  8. pmc Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region
    S Hirotsune
    Genome Res 7:625-34. 1997
    ..We have isolated the murine homologs of three genes located inside and outside the MDS region: Lis1, Mnt/Rox, and 14-3-3 epsilon...
  9. pmc Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse
    Jessica Yingling
    Departments of Pediatrics and Medicine, University of California at San Diego School of Medicine, La Jolla, CA, 92093, USA
    Am J Hum Genet 73:475-88. 2003
  10. ncbi Evidence of mnt-myc antagonism revealed by mnt gene deletion
    Peter J Hurlin
    Shriners Hospital for Children, Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon USA
    Cell Cycle 3:97-9. 2004
    ..The repressor with similar DNA binding specificity raised the possibility that Mnt may serve a general role as a Myc antagonist.
  11. pmc Mnt-Max to Myc-Max complex switching regulates cell cycle entry
    William Walker
    Shriners Hospitals for Children, Portland, OR 97201, USA
    J Cell Biol 169:405-13. 2005
    ..In contrast to c-Myc, the putative Myc antagonist Mnt is maintained at a constant level during cell cycle entry...
  12. pmc Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells
    Shala Dezfouli
    Shriners Hospital for Children, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Mol Cell Biol 26:2080-92. 2006
    b>Mnt is a Max-interacting protein that can antagonize the activities of Myc oncoproteins in cultured cells. Mnt null mice die soon after birth, but conditional deletion of Mnt in breast epithelium leads to tumor formation...
  13. ncbi Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression
    Kazuhito Toyo-oka
    Department of Pediatrics, University of California, San Diego Comprehensive Cancer Center, La Jolla, California, USA
    Cancer Res 66:5565-73. 2006
    ..Max also interacts with Mnt but Mnt-Max complexes repress transcription when bound to these sequences. MNT maps to human chromosome 17p13...
  14. pmc Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 49:860-70. 2009
    ..Both p53 and cyclin D1 are targets of c-Myc, which is also up-regulated in cholestasis. Myc and Mnt use Max as a cofactor for DNA binding. Myc-Max typically activates transcription via E-box binding...
  15. pmc OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival
    Nicole A Vasilevsky
    Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213 2933, USA
    Eur J Immunol 41:1024-34. 2011
    ..Direct ex vivo examination of Ag-stimulated murine T cells show that the Myc antagonists, Mxd4 and Mnt, are transiently upregulated and translocated to the nucleus following OX40 engagement and may be involved in ..

Research Grants2

  1. FUNCTION OF A DUAL SPECIFICITY TRANSCRIPTION FACTOR
    Peter Hurlin; Fiscal Year: 2003
    ..a similar role in mediating the transcriptional and biological activities of the Myc-related proteins Mad 1-4, Mnt, and Mga...
  2. Myc Antagonism and Tumor Suppression by Mnt
    Peter Hurlin; Fiscal Year: 2008
    ..One of these proteins, Mnt, is unique among this group of repressors in that it is coexpressed with Myc proteins in most, if not all ..