Gene Symbol: Mmel1
Description: membrane metallo-endopeptidase-like 1
Alias: Mell1, NEP2, NEPII, Nl1, SEP, membrane metallo-endopeptidase-like 1, NEP2(m), NEPLP alpha, NEPLP beta, NEPLP gamma, NL-1, NL2, mel transforming oncogene-like 1, neprilysin 2, neprilysin II, neprilysin-like 1, neprilysin-like peptidase, soluble secreted endopeptidase
Species: mouse
Products:     Mmel1

Top Publications

  1. Ghaddar G, Ruchon A, Carpentier M, Marcinkiewicz M, Seidah N, Crine P, et al. Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family. Biochem J. 2000;347:419-29 pubmed
    ..We now report the cloning from mouse testis of a novel neprilysin-like peptidase that we called NL1. NL1 is a glycoprotein that, among the members of the family, shows the strongest sequence identity with neprilysin...
  2. Whyteside A, Turner A. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008;582:2382-6 pubmed publisher
    Neprilysin-2 (NEP2) is a novel metallopeptidase homologous to neprilysin (NEP), an enzyme involved in regulation of neuropeptide signalling. NEP2 exists as two alternatively spliced isoforms, NEP2 and NEP2(Delta)...
  3. Hanson L, Hafez D, Svitak A, Burns R, Li X, Frey W, et al. Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice. J Mol Neurosci. 2011;43:424-7 pubmed publisher
    ..infusion of thiorphan or phosphoramidon to block the activity of key A? degrading enzymes (NEP, NEP2) resulting in accumulation of A?...
  4. Wick M, Loomis Z, Harral J, Le M, Wehling C, Miller Y, et al. Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern. Transgenic Res. 2016;25:773-784 pubmed
    ..These studies help to characterize our complex transgenic model of NEP overexpression and further demonstrate NEP's protective effects against plasma extravasation. ..
  5. Ikeda K, Emoto N, Raharjo S, Nurhantari Y, Saiki K, Yokoyama M, et al. Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides. J Biol Chem. 1999;274:32469-77 pubmed
    ..and characterization of a novel member of this type II membrane-bound metalloprotease family, termed soluble secreted endopeptidase (SEP)...
  6. Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, et al. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem. 2001;276:21895-901 pubmed
    ..we searched for neprilysin (NEP) homologues and cloned neprilysin-like peptidase (NEPLP) alpha, NEPLP beta, and NEPLP gamma cDNAs...
  7. Carpentier M, Guillemette C, Bailey J, Boileau G, Jeannotte L, DesGroseillers L, et al. Reduced fertility in male mice deficient in the zinc metallopeptidase NL1. Mol Cell Biol. 2004;24:4428-37 pubmed
    ..Recently, a mouse NL1 protein, a novel member of the family, was identified and shown to be expressed mainly in the testis as a secreted ..
  8. Voisin S, Ouimet T. The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity. Biochem Biophys Res Commun. 2005;335:356-60 pubmed
    Modeling the three-dimensional structure of neprilysin 2 (NEP2) using the crystal structure of neprilysin as template revealed that their active sites share many common features, though slight differences therein cannot completely account ..
  9. Oh hashi K, Ohkubo K, Shizu K, Fukuda H, Hirata Y, Kiuchi K. Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2. Mol Cell Biochem. 2008;313:103-11 pubmed publisher
    b>Neprilysin 2 (NEP2) has been recently identified as a new member of the M13 subfamily of zinc-dependent metalloproteases and shares a highly homologous amino acid sequence with neprilysin (EC, NEP)...

More Information


  1. Hafez D, Huang J, Huynh A, Valtierra S, Rockenstein E, Bruno A, et al. Neprilysin-2 is an important ?-amyloid degrading enzyme. Am J Pathol. 2011;178:306-12 pubmed publisher
    ..Of particular interest is the NEP homolog neprilysin 2 (NEP2), which is thiorphan/phosphoramidon-sensitive and degrades A?...
  2. Rossier J, Bernard A, Cabungcal J, Perrenoud Q, Savoye A, Gallopin T, et al. Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. Mol Psychiatry. 2015;20:154-61 pubmed publisher
    ..By using Wisteria floribunda agglutinin, a specific marker for PNN, PV-MP interneurons were found surrounded by PNN, whereas the ones expressing Sst, PV-Sst, were not. ..
  3. Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, et al. Accumulation of murine amyloid-β mimics early Alzheimer's disease. Brain. 2015;138:2370-82 pubmed publisher