Gene Symbol: Mkrn1
Description: makorin, ring finger protein, 1
Alias: RFP, E3 ubiquitin-protein ligase makorin-1, RING-type E3 ubiquitin transferase makorin-1
Species: mouse
Products:     Mkrn1

Top Publications

  1. Hirotsune S, Yoshida N, Chen A, Garrett L, Sugiyama F, Takahashi S, et al. An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature. 2003;423:91-6 pubmed
    ..Either Makorin1 or Makorin1-p1 transgenes could rescue these phenotypes. Our findings demonstrate a specific regulatory role of an expressed pseudogene, and point to the functional significance of non-coding RNAs. ..
  2. Lee E, Lee M, Camus S, Ghim J, Yang M, Oh W, et al. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. EMBO J. 2009;28:2100-13 pubmed publisher
    Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co-regulator and an E3 ligase. Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of p53 and p21...
  3. Gray T, Wilson A, Fortin P, Nicholls R. The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans. Proc Natl Acad Sci U S A. 2006;103:12039-44 pubmed
    ..The authors concluded that the transgene reduced the expression of a nearby transcribed and imprinted pseudogene, Mkrn1-p1...
  4. Gray T, Hernandez L, Carey A, Schaldach M, Smithwick M, Rus K, et al. The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Genomics. 2000;66:76-86 pubmed
    ..We report here the identification and characterization of the Makorin ring finger protein 1 gene (MKRN1), a highly transcribed, intron-containing source for this family of genes...
  5. Shimada H, Shiratori T, Yasuraoka M, Kagaya A, Kuboshima M, Nomura F, et al. Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma. BMC Cancer. 2009;9:232 pubmed publisher
    ..The presence of serum anti-makorin 1 (MKRN1) antibodies (s-MKRN1-Abs) was examined by Western blotting using bacterially expressed MKRN1 protein...
  6. Lee J, Ward W, Knapp G, Ren H, Vallanat B, Abbott B, et al. Transcriptional ontogeny of the developing liver. BMC Genomics. 2012;13:33 pubmed publisher
    ..Overall, these findings reveal the complexity of gene expression changes during liver development and maturation, and provide a foundation to predict responses to chemical and drug exposure as a function of early life-stages. ..
  7. Ko A, Shin J, Seo J, Lee K, Lee E, Lee M, et al. Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF. J Natl Cancer Inst. 2012;104:1660-72 pubmed publisher
    We investigated whether Makorin ring finger protein 1 (MKRN1), an E3 ligase, affects p14ARF-associated cellular senescence and tumorigenesis by posttranslational modification in gastric tumorigenesis...
  8. Gray T, Azama K, Whitmore K, Min A, Abe S, Nicholls R. Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene. Genomics. 2001;77:119-26 pubmed
    ..This places the gene duplication event that created this locus from an ancestral MKRN1 gene early in vertebrate evolution, over 450 million years ago...
  9. Wang L, Zheng A, Yi L, Xu C, Ding M, Deng H. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Biochem Biophys Res Commun. 2004;325:302-7 pubmed
    ..The method can be used to study epigenetic modification of chromatin during nuclear reprogramming, cell differentiation, and transdifferentiation. ..

More Information


  1. Kim J, Park K, Lee E, Jang W, Seo J, Shin S, et al. Suppression of PPAR? through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation. Cell Death Differ. 2014;21:594-603 pubmed publisher
    ..Here we report that MKRN1 is an E3 ligase of PPAR? that induces its ubiquitination, followed by proteasome-dependent degradation...
  2. Kaneko S, Aki I, Tsuda K, Mekada K, Moriwaki K, Takahata N, et al. Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals. Genetics. 2006;172:2421-9 pubmed publisher
    ..The evolutionary rate and pattern of Makorin1-derived processed pseudogenes depend heavily on how frequently they are disseminated in the genome...