Gene Symbol: Mirlet7e
Description: microRNA let7e
Alias: Mirnlet7e, mmu-let-7e
Species: mouse

Top Publications

  1. Mansfield J, Harfe B, Nissen R, Obenauer J, Srineel J, Chaudhuri A, et al. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004;36:1079-83 pubmed
    ..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex. ..
  2. Dai R, Phillips R, Zhang Y, Khan D, Crasta O, Ahmed S. Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood. 2008;112:4591-7 pubmed publisher
    ..Our data are the first to demonstrate the selective regulation of miRNA expression in immune cells by estrogen and are indicative of an important role of miRNAs in estrogen-mediated immune regulation. ..
  3. O Connell R, Chaudhuri A, Rao D, Gibson W, Balazs A, Baltimore D. MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A. 2010;107:14235-40 pubmed publisher
    ..Our study identifies an evolutionarily conserved subset of miRNAs that is expressed in HSCs and functions to modulate hematopoietic output. ..
  4. Tong M, Mitchell D, Evanoff R, Griswold M. Expression of Mirlet7 family microRNAs in response to retinoic acid-induced spermatogonial differentiation in mice. Biol Reprod. 2011;85:189-97 pubmed publisher
    ..These results suggest that Mirlet7 family miRNAs play a role in retinoic acid-induced spermatogonial differentiation. ..
  5. Golden E, Benito Gonzalez A, Doetzlhofer A. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015;112:E3864-73 pubmed publisher
    ..Together, these results implicate a key role for the LIN28B/let-7 axis in regulating postnatal SC plasticity. ..
  6. Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn F. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21:1469-77 pubmed
    ..miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development. ..
  7. Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn E, Michel G, et al. The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009;11:1411-20 pubmed publisher
    ..Furthermore, mLin41 cooperated with the pluripotency factor Lin-28 in suppressing let-7 activity, revealing a dual control mechanism regulating let-7 in stem cells. ..
  8. Dueck A, Meister G. TRIMming microRNA function in mouse stem cells. Nat Cell Biol. 2009;11:1392-3 pubmed publisher
  9. Guan H, Fan D, Mrelashvili D, Hao H, Singh N, Singh U, et al. MicroRNA let-7e is associated with the pathogenesis of experimental autoimmune encephalomyelitis. Eur J Immunol. 2013;43:104-14 pubmed publisher
    ..We also identified IL-10 as one of the functional targets of let-7e. Together, we propose that let-7e is a new miRNA involved in the regulation of encephalitogenic T-cell differentiation and the pathogenesis of EAE. ..

More Information


  1. Ota H, Sakurai M, Gupta R, Valente L, Wulff B, Ariyoshi K, et al. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013;153:575-89 pubmed publisher
    ..As expected, the expression of miRNAs is globally inhibited in ADAR1(-/-) mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype. ..
  2. Miyazawa H, Yamaguchi Y, Sugiura Y, Honda K, Kondo K, Matsuda F, et al. Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching. Development. 2017;144:63-73 pubmed publisher
    ..Perturbation of glucose metabolism rewiring by suppressing Lin28a downregulation resulted in perinatal lethality. Thus, our work demonstrates that developing embryos rewire glucose metabolism following CB for normal development. ..
  3. Shilo V, Mor Yosef Levi I, Abel R, Mihailovic A, Wasserman G, Naveh Many T, et al. Let-7 and MicroRNA-148 Regulate Parathyroid Hormone Levels in Secondary Hyperparathyroidism. J Am Soc Nephrol. 2017;28:2353-2363 pubmed publisher
    ..These findings may be utilized for therapeutic interventions aimed at altering PTH expression in diseases such as osteoporosis and secondary hyperparathyroidism. ..
  4. Wahi K, Friesen S, Coppola V, Cole S. Putative binding sites for mir-125 family miRNAs in the mouse Lfng 3'UTR affect transcript expression in the segmentation clock, but mir-125a-5p is dispensable for normal somitogenesis. Dev Dyn. 2017;246:740-748 pubmed publisher
    ..They further suggest the existence of compensatory mechanisms that can rescue the loss of mir-125a-5p in mice. Developmental Dynamics 246:740-748, 2017. © 2017 Wiley Periodicals, Inc. ..
  5. Viñas J, Ventayol M, Brüne B, Jung M, Sola A, Pi F, et al. miRNA let-7e modulates the Wnt pathway and early nephrogenic markers in mouse embryonic stem cell differentiation. PLoS ONE. 2013;8:e60937 pubmed publisher
  6. Ventayol M, Viñas J, Sola A, Jung M, Brune B, Pi F, et al. miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia. Cell Death Dis. 2014;5:e1048 pubmed publisher
    ..Using luciferase reporter assays, we also showed that MMP9 is a direct target of miRNA let-7e. Thus, our results suggest that miRNA let-7e acts as a matrix metalloproteinase-9 (MMP9) inhibitor and differentiation inducer in ASCs. ..