Gene Symbol: Mirlet7a-2
Description: microRNA let7a-2
Alias: Mirnlet7a-2
Species: mouse

Top Publications

  1. Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn F. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21:1469-77 pubmed
    ..miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development. ..
  2. Holm M, Nieto Gonzalez J, Vardya I, Vaegter C, Nykjaer A, Jensen K. Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus. J Neurosci. 2009;29:12412-8 pubmed publisher
    ..Thus, by affecting the firing of GABAergic interneurons, mature BDNF may play an important role in regulating network oscillations in the hippocampus. ..
  3. Li Q, Bian S, Hong J, Kawase Koga Y, Zhu E, Zheng Y, et al. Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development. PLoS ONE. 2011;6:e26000 pubmed publisher
    ..Collectively, our studies indicate the importance of the Dicer-mediated miRNA pathway in hippocampal development and functions. ..
  4. Mansfield J, Harfe B, Nissen R, Obenauer J, Srineel J, Chaudhuri A, et al. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004;36:1079-83 pubmed
    ..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex. ..
  5. Dueck A, Meister G. TRIMming microRNA function in mouse stem cells. Nat Cell Biol. 2009;11:1392-3 pubmed publisher
  6. Golden E, Benito Gonzalez A, Doetzlhofer A. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015;112:E3864-73 pubmed publisher
    ..Together, these results implicate a key role for the LIN28B/let-7 axis in regulating postnatal SC plasticity. ..
  7. Sun T, Fu M, Bookout A, Kliewer S, Mangelsdorf D. MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol. 2009;23:925-31 pubmed publisher
    ..These results suggest that let-7 plays an important role in adipocyte differentiation and that it does so in part by targeting HMGA2, thereby regulating the transition from clonal expansion to terminal differentiation. ..
  8. Yi R, O Carroll D, Pasolli H, Zhang Z, Dietrich F, Tarakhovsky A, et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006;38:356-62 pubmed
    ..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ. ..
  9. Sasaguri H, Mitani T, Anzai M, Kubodera T, Saito Y, Yamada H, et al. Silencing efficiency differs among tissues and endogenous microRNA pathway is preserved in short hairpin RNA transgenic mice. FEBS Lett. 2009;583:213-8 pubmed publisher
    ..Neither endogenous miRNAs nor their target gene levels were altered, indicating the preservation of endogenous miRNA pathways. We think that the shRNA transgenic mice can be utilized for gene analysis. ..

More Information


  1. Hu S, Ren G, Liu J, Zhao Z, Yu Y, Su R, et al. MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem. 2008;283:23473-84 pubmed publisher
    ..Furthermore, we showed that Reck was the target gene of miR-21. Our data suggest that miR-21 may play a key role during embryo implantation. ..
  2. Tong M, Mitchell D, Evanoff R, Griswold M. Expression of Mirlet7 family microRNAs in response to retinoic acid-induced spermatogonial differentiation in mice. Biol Reprod. 2011;85:189-97 pubmed publisher
    ..These results suggest that Mirlet7 family miRNAs play a role in retinoic acid-induced spermatogonial differentiation. ..
  3. Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn E, Michel G, et al. The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009;11:1411-20 pubmed publisher
    ..Furthermore, mLin41 cooperated with the pluripotency factor Lin-28 in suppressing let-7 activity, revealing a dual control mechanism regulating let-7 in stem cells. ..
  4. Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl E, Nitsch R, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008;10:987-93 pubmed publisher
  5. Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, et al. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 2007;27:123-34 pubmed
    ..Our data suggest that host miRNA can play a role in host interactions with viruses. ..
  6. Inyawilert W, Fu T, Lin C, Tang P. Let-7-mediated suppression of mucin 1 expression in the mouse uterus during embryo implantation. J Reprod Dev. 2015;61:138-44 pubmed publisher
    ..Additionally, the current study suggests that miRNAs are novel targets which can be used to facilitate a successful pregnancy and repair implantation failure. ..
  7. Ota H, Sakurai M, Gupta R, Valente L, Wulff B, Ariyoshi K, et al. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013;153:575-89 pubmed publisher
    ..As expected, the expression of miRNAs is globally inhibited in ADAR1(-/-) mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype. ..
  8. Yu H, Sun H, Wang Z, Liu Y. MicroRNA let-7a up-regulates OPN expression in a mouse model of allergic rhinitis. J Laryngol Otol. 2017;131:955-960 pubmed publisher
    ..05). In addition, microRNA let-7a treated mice had significantly enhanced OPN expression in nasal mucosa (p < 0.05). MicroRNA let-7a can promote allergic rhinitis development partly by regulating OPN expression. ..
  9. Liu P, Baumgart M, Groth M, Wittmann J, Jack H, Platzer M, et al. Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation. Sci Rep. 2016;6:32112 pubmed publisher
    ..Therefore, Dicer-dependent small RNA biogenesis in osteoblasts plays only a minor role in the pathogenesis of GC-induced inhibition of bone formation. ..
  10. Nicklas S, Okawa S, Hillje A, González Cano L, del Sol A, Schwamborn J. The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs. Nucleic Acids Res. 2015;43:2638-54 pubmed publisher
    ..Furthermore, we provide evidence that DDX6 is necessary and sufficient for neuronal differentiation and that it functions in cooperation with TRIM32. ..
  11. Arora A, Guduric Fuchs J, Harwood L, Dellett M, Cogliati T, Simpson D. Prediction of microRNAs affecting mRNA expression during retinal development. BMC Dev Biol. 2010;10:1 pubmed publisher
    ..Misregulation of these miRNAs might contribute to retinal degeneration and disease. Conversely, manipulation of their expression could potentially be used as a therapeutic tool in the future. ..
  12. Beaudoin S, Vanderperre B, Grenier C, Tremblay I, Leduc F, Roucou X. A large ribonucleoprotein particle induced by cytoplasmic PrP shares striking similarities with the chromatoid body, an RNA granule predicted to function in posttranscriptional gene regulation. Biochim Biophys Acta. 2009;1793:335-45 pubmed publisher
  13. Frost R, Hamra F, Richardson J, Qi X, Bassel Duby R, Olson E. MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A. 2010;107:11847-52 pubmed publisher
  14. Cao L, Kong L, Yu Z, Han S, Bai Y, Zhu J, et al. microRNA expression profiling of the developing mouse heart. Int J Mol Med. 2012;30:1095-104 pubmed publisher
    ..Findings of this analysis may thus clarify the mechanisms of normal heart development and provide a physiological basis for future studies on congenital heart disease. ..
  15. Chen P, Su J, Cha S, Tarn W, Wang M, Hsu H, et al. miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans. J Clin Invest. 2011;121:3442-55 pubmed publisher
    ..Altogether, we have identified an oncogenic role for miR-107 and provide evidence of a transregulational interaction among miRNAs in human cancer development. ..
  16. Miyazawa H, Yamaguchi Y, Sugiura Y, Honda K, Kondo K, Matsuda F, et al. Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching. Development. 2017;144:63-73 pubmed publisher
    ..Perturbation of glucose metabolism rewiring by suppressing Lin28a downregulation resulted in perinatal lethality. Thus, our work demonstrates that developing embryos rewire glucose metabolism following CB for normal development. ..
  17. Colas A, McKeithan W, Cunningham T, Bushway P, Garmire L, Duester G, et al. Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev. 2012;26:2567-79 pubmed publisher
    ..These findings suggest a crucial role for the let-7 and miR-18 families in germ layer specification and reveal a remarkable conservation of function from amphibians to mammals. ..