Mir92-2

Summary

Gene Symbol: Mir92-2
Description: microRNA 92-2
Alias: Mirn92-2
Species: mouse

Top Publications

  1. Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, et al. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science. 2009;324:1710-3 pubmed publisher
    ..MiR-92a appears to target mRNAs corresponding to several proangiogenic proteins, including the integrin subunit alpha5. Thus, miR-92a may serve as a valuable therapeutic target in the setting of ischemic disease. ..
  2. Ventura A, Young A, Winslow M, Lintault L, Meissner A, Erkeland S, et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008;132:875-86 pubmed publisher
    ..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development. ..
  3. Pan Y, Balazs L, Tigyi G, Yue J. Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality. Biochem Biophys Res Commun. 2011;408:369-74 pubmed publisher
    ..5. Expression of most miRNAs examined was compromised in VSMCs of Dicer KO. Our results indicate that Dicer is required for vascular development and regulates vascular remodeling by modulating VSMC proliferation and differentiation. ..
  4. Deo M, Yu J, Chung K, Tippens M, Turner D. Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides. Dev Dyn. 2006;235:2538-48 pubmed
    ..The ability to visualize expression of specific miRNAs in embryos and tissues should aid studies on miRNA function. ..
  5. Kuppers D, Hwang H, Jackson A, Linsley P, Clurman B, Fero M. Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma. PLoS ONE. 2011;6:e14758 pubmed publisher
    ..Confirmation of miR-106a~363 gene targeting relevant to the tumor phenotype requires in vivo validation, because only a subset of predicted targets are consistently reduced in tumors that overexpress miR-106a~363. ..
  6. Chen Z, Wu J, Yang C, Fan P, Balazs L, Jiao Y, et al. DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice. J Biol Chem. 2012;287:19018-28 pubmed publisher
    ..Our results indicate that the DGCR8 gene is required for vascular development through the regulation of VSMC proliferation, apoptosis, and differentiation...
  7. Dirkx E, Gladka M, Philippen L, Armand A, Kinet V, Leptidis S, et al. Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol. 2013;15:1282-93 pubmed publisher
    ..Our results reveal that signalling cascades integrate with microRNAs to induce the expression of the bHLH transcription factor Hand2 in the postnatal mammalian myocardium with impact on embryonic gene programs in heart failure. ..
  8. Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, et al. MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Cell Death Differ. 2016;23:1658-69 pubmed publisher
    ..In addition, the downregulation of miR-17-92 during myogenesis is transcriptionally regulated by E2F1. Overall, our results reveal a E2F1/miR-17-92/ENH1/Id1 regulatory axis during myogenesis. ..
  9. Yi R, Poy M, Stoffel M, Fuchs E. A skin microRNA promotes differentiation by repressing 'stemness'. Nature. 2008;452:225-9 pubmed publisher
    ..Our findings suggest that miR-203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers. ..

More Information

Publications16

  1. Chen J, Huang Z, Seok H, Ding J, Kataoka M, Zhang Z, et al. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013;112:1557-66 pubmed publisher
    ..Our studies therefore identify miR-17-92 as a critical regulator of cardiomyocyte proliferation, and suggest this cluster of microRNAs could become therapeutic targets for cardiac repair and heart regeneration. ..
  2. Jevnaker A, Khuu C, Kjøle E, Bryne M, Osmundsen H. Expression of members of the miRNA17-92 cluster during development and in carcinogenesis. J Cell Physiol. 2011;226:2257-66 pubmed publisher
    ..Additionally, the six microRNAs exhibit variable tissue expression, suggesting selective processing of these microRNAs. ..
  3. Jin J, Kim S, Liu X, Zhang H, Zhang C, Seo J, et al. miR-17-92 Cluster Regulates Adult Hippocampal Neurogenesis, Anxiety, and Depression. Cell Rep. 2016;16:1653-1663 pubmed publisher
    ..Our study uncovers a crucial role for miR-17-92 in adult neural progenitors through regulation of neurogenesis and anxiety- and depression-like behaviors. ..
  4. Li L, Shi J, Zhu G, Shi B. MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFB pathway in mouse palatal mesenchymal cells. J Cell Biochem. 2012;113:1235-44 pubmed publisher
    ..We thus conclude that miR-17-92 cluster could inhibit TGFB pathway induced proliferation inhibition and collagen synthesis in PMCs by directly targeting TGFBR2, SMAD2, and SMAD4. ..
  5. Pernaute B, Spruce T, Smith K, Sánchez Nieto J, Manzanares M, Cobb B, et al. MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM. Genes Dev. 2014;28:1873-8 pubmed publisher
    ..These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death. ..
  6. de Pontual L, Yao E, Callier P, Faivre L, Drouin V, Cariou S, et al. Germline deletion of the miR-17?92 cluster causes skeletal and growth defects in humans. Nat Genet. 2011;43:1026-30 pubmed publisher
    ..These findings identify a regulatory function for miR-17?92 in growth and skeletal development and represent the first example of an miRNA gene responsible for a syndromic developmental defect in humans. ..
  7. Jiang C, Ji N, Luo G, Ni S, Zong J, Chen Z, et al. The effects and mechanism of miR-92a and miR-126 on myocardial apoptosis in mouse ischemia-reperfusion model. Cell Biochem Biophys. 2014;70:1901-6 pubmed publisher
    ..The change of miR-92a was in accordance with AI of myocardial cells. However, the change of miR-126 is in contrary with AI of myocardial cells, which may be related to the HSP70 expression in myocardial cells. ..