Gene Symbol: Mir363
Description: microRNA 363
Alias: Mirn363, mmu-mir-363
Ventura A, Young A, Winslow M, Lintault L, Meissner A, Erkeland S, et al
. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008;132:875-86 pubmed publisher
..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development. ..
Kuppers D, Hwang H, Jackson A, Linsley P, Clurman B, Fero M. Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma. PLoS ONE. 2011;6:e14758 pubmed publisher
..Confirmation of miR-106a~363 gene targeting relevant to the tumor phenotype requires in vivo validation, because only a subset of predicted targets are consistently reduced in tumors that overexpress miR-106a~363. ..
Kästle M, Bartel S, Geillinger Kästle K, Irmler M, Beckers J, Ryffel B, et al
. microRNA cluster 106a~363 is involved in T helper 17 cell differentiation. Immunology. 2017;152:402-413 pubmed publisher
..Here, we provide evidence that miRNAs are involved in controlling the differentiation and function of T helper cells, offering useful tools to study and modify Th17-mediated inflammation. ..
Lu Y, Thomson J, Wong H, Hammond S, Hogan B. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol. 2007;310:442-53 pubmed
..Together, these studies suggest that mir-17-92 normally promotes the high proliferation and undifferentiated phenotype of lung epithelial progenitor cells. ..
Hoesel B, Bhujabal Z, Przemeck G, Kurz Drexler A, Weisenhorn D, Angelis M, et al
. Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis. Gene Expr Patterns. 2010;10:265-73 pubmed publisher
..5 dpc. This suggests that these miRNAs could possibly target the Dll1 3'UTR in these regions. The other miRNAs are not expressed or below the detection limit and thus are unlikely to regulate Dll1 at the analyzed embryonic stages. ..
Oommen S, Otsuka Tanaka Y, Imam N, Kawasaki M, Kawasaki K, Jalani Ghazani F, et al
. Distinct roles of microRNAs in epithelium and mesenchyme during tooth development. Dev Dyn. 2012;241:1465-72 pubmed publisher
..To investigate the role of miRNAs in tooth development, we examined mice with either mesenchymal (Wnt1Cre/Dicer(fl/fl)) or epithelial (ShhCre/Dicer(fl/fl)) conditional deletion of Dicer, which is essential for miRNA processing...
Costa A, Afonso J, Osório C, Gomes A, Caiado F, Valente J, et al
. miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells. J Hematol Oncol. 2013;6:87 pubmed publisher
..Further studies on the importance of miR-363-5p on normal BM function and in disease are warranted. ..
Hu F, Min J, Cao X, Liu L, Ge Z, Hu J, et al
. MiR-363-3p inhibits the epithelial-to-mesenchymal transition and suppresses metastasis in colorectal cancer by targeting Sox4. Biochem Biophys Res Commun. 2016;474:35-42 pubmed publisher
..Therefore, the up-regulation of miR-363-3p in human CRC may have therapeutic benefits. ..