Gene Symbol: Mir320
Description: microRNA 320
Alias: Mirn320, mmu-mir-320
Species: mouse

Top Publications

  1. Yin Z, Zhao Y, Li H, Yan M, Zhou L, Chen C, et al. miR-320a mediates doxorubicin-induced cardiotoxicity by targeting VEGF signal pathway. Aging (Albany NY). 2016;8:192-207 pubmed
  2. Meng F, Chen W, Huang G, He A, Hou C, Long Y, et al. MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses. Osteoarthritis Cartilage. 2016;24:932-41 pubmed publisher
    ..Cartilage development and homeostasis are influenced by miR-320, which directly targets MMP-13 and regulates chondrogenesis and the IL-1β-stimulated catabolic effect in mouse chondrocytes. ..
  3. Zhang T, Zou P, Wang T, Xiang J, Cheng J, Chen D, et al. Down-regulation of miR-320 associated with cancer progression and cell apoptosis via targeting Mcl-1 in cervical cancer. Tumour Biol. 2016;37:8931-40 pubmed publisher
    ..In addition, miR-320 inhibits cervical cancer progression by down-regulation of Mcl-1. These results indicate that miR-320 may be an important biomarker and target for diagnosis and treatment of cervical cancer patient. ..
  4. Yin M, Wang X, Yao G, Lü M, Liang M, Sun Y, et al. Transactivation of micrornA-320 by microRNA-383 regulates granulosa cell functions by targeting E2F1 and SF-1 proteins. J Biol Chem. 2014;289:18239-57 pubmed publisher
    ..Understanding the regulation of miRNA biogenesis and function in the follicular development will potentiate the usefulness of miRNA in the treatment of reproduction and some steroid-related disorders. ..
  5. Hojjati M, Azarkeivan A, Pourfathollah A, Amirizadeh N. Comparison of MicroRNAs Mediated in Reactivation of the ?-Globin in ?-Thalassemia Patients, Responders and Non-Responders to Hydroxyurea. Hemoglobin. 2017;41:110-115 pubmed publisher
    ..However, further investigations need to be performed to verify this hypothesis. ..
  6. Kim B, Choi M. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells. Biochem Biophys Res Commun. 2012;426:183-9 pubmed publisher
    ..This is accomplished by targeting the 3'-untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs. ..
  7. Garner A, Rowland D, Hwang S, Baumgaertel K, Roth B, Kentros C, et al. Generation of a synthetic memory trace. Science. 2012;335:1513-6 pubmed publisher
    ..Similar stimulation impaired recall when not part of the initial conditioning. ..
  8. White R, Giffard R. MicroRNA-320 induces neurite outgrowth by targeting ARPP-19. Neuroreport. 2012;23:590-5 pubmed publisher
    ..These data suggest that miR-320 could play a role in neuronal development and might be a target to enhance neuronal regeneration following injury. ..
  9. Bronisz A, Godlewski J, Wallace J, Merchant A, Nowicki M, Mathsyaraja H, et al. Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol. 2011;14:159-67 pubmed publisher
    ..This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. ..

More Information


  1. Wu H, Li W, Zhang M, Zhu S, Zhang D, Wang X. Inhibitory roles of miR-320 in osteosarcoma via regulating E2F1. J Cancer Res Ther. 2016;12:68-71 pubmed publisher
    ..Besides, we proved that miR-320 could directly regulate the expression of E2F1 in U2OS cells. These data suggested that miR-320 regulates the proliferation and cell cycle by targeting E2F1 in human OsC progression. ..
  2. Guclu A, Koçak C, Koçak F, Akcılar R, Dodurga Y, Akcılar A, et al. Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion. Ren Fail. 2016;38:1468-1475 pubmed
    ..miR-320 might be a novel diagnosis and treatment target in renal ischemic reperfusion injury. Also, for the first time, we showed that CAP and TEL cause functional and histopathological recovery and lower miR-146a and miR-320. ..
  3. Wang W, Yang J, Xiang Y, Pi J, Bian J. Overexpression of Hsa-miR-320 Is Associated With Invasion and Metastasis of Ovarian Cancer. J Cell Biochem. 2017;118:3654-3661 pubmed publisher
    ..These findings reveal that hsa-miR-320 may serve as an important therapeutic target in ovarian cancer therapy. J. Cell. Biochem. 118: 3654-3661, 2017. © 2017 Wiley Periodicals, Inc. ..
  4. Ren X, Wu J, Wang X, Sartor M, Jones K, Qian J, et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation. 2009;119:2357-2366 pubmed publisher
    ..Our data demonstrate that miR-320 is involved in the regulation of I/R-induced cardiac injury and dysfunction via antithetical regulation of Hsp20. Thus, miR-320 may constitute a new therapeutic target for ischemic heart diseases. ..
  5. Tang H, Lee M, Sharpe O, Salamone L, Noonan E, Hoang C, et al. Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems. FASEB J. 2012;26:4710-21 pubmed publisher
    ..These findings suggest that oxidative stress-responsive microRNA-320a may regulate glycolysis broadly within nature. ..
  6. Chen C, Wang Y, Yang S, Li H, Zhao G, Wang F, et al. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. J Cell Mol Med. 2015;19:970-85 pubmed publisher
    ..We also found that SP1 transcriptionally up-regulates hsa-miR-320a expression. Our observations indicate that miR-320a is a key regulator contributing to multiple aspects of atherogenesis. ..
  7. Feng R, Sang Q, Zhu Y, Fu W, Liu M, Xu Y, et al. MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro. Sci Rep. 2015;5:8689 pubmed publisher
    ..Wnt signaling pathway components had abnormal expression level in miR-320 inhibitor-injected oocytes. This study provides the first evidence that miRNAs in human follicular fluid are indicative of and can influence embryo quality. ..
  8. Hennessy E, Clynes M, Jeppesen P, O Driscoll L. Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells. Biochem Biophys Res Commun. 2010;396:457-62 pubmed publisher
    ..In this study, we have also identified 21 miRNAs not previously known to have a potential murine homologue. ..
  9. Ling H, Ou H, Feng S, Zhang X, Tuo Q, Chen L, et al. CHANGES IN microRNA (miR) profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes. Clin Exp Pharmacol Physiol. 2009;36:e32-9 pubmed publisher
    ..Anti-miR-320 oligo was found to regulate insulin resistance in adipocytes by improving insulin–PI3-K signalling pathways. The findings provide information regarding a potentially new therapeutic strategy to control insulin resistance. ..
  10. Babiarz J, Ruby J, Wang Y, Bartel D, Blelloch R. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev. 2008;22:2773-85 pubmed publisher
    ..Our results extend the known diversity of mammalian small RNA-generating pathways and show that mammalian siRNAs exist in cell types other than oocytes. ..