Gene Symbol: Mir302d
Description: microRNA 302d
Schneider M, Andersen D, Silahtaroglu A, Lyngbæk S, Kauppinen S, Hansen J, et al
. Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry. J Mol Histol. 2011;42:289-99 pubmed publisher
..This approach will hopefully aid in identifying relevant miRNA targets of both the heart and other organs. ..
Chang H, Martinez N, Thornton J, Hagan J, Nguyen K, Gregory R. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012;3:923 pubmed publisher
..Thus, we demonstrate that Trim71 is a factor that facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal. ..
Faherty N, Curran S, O Donovan H, Martin F, Godson C, Brazil D, et al
. CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGF? type II receptor with implications for nephropathic cell phenotypes. J Cell Sci. 2012;125:5621-9 pubmed publisher
..In summary, we demonstrate a new mode of regulation of TGF? by CCN2, and conclude that the miR-302 family has a role in regulating growth factor signalling pathways, with implications for nephropathic cell fate transitions. ..
Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, et al
. A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med. 2015;7:279ra38 pubmed publisher
..Our data demonstrate the ability of microRNA-based therapeutic approaches to promote mammalian cardiac repair and regeneration through the transient activation of cardiomyocyte proliferation. ..
Card D, Hebbar P, Li L, Trotter K, Komatsu Y, Mishina Y, et al
. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol. 2008;28:6426-38 pubmed publisher
..The transcriptional activation of miR-302 and the translational repression of its targets, such as cyclin D1, may provide a link between Oct4/Sox2 and cell cycle regulation in pluripotent cells. ..
Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu M, et al
. Regulation of lung endoderm progenitor cell behavior by miR302/367. Development. 2011;138:1235-45 pubmed publisher
..Thus, miR302/367 directs lung endoderm development by coordinating multiple aspects of progenitor cell behavior, including proliferation, differentiation and apical-basal polarity. ..