Mir302a

Summary

Gene Symbol: Mir302a
Description: microRNA 302a
Alias: Mirn302, Mirn302a, mmu-mir-302
Species: mouse

Top Publications

  1. Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, et al. MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem. 2011;286:17359-64 pubmed publisher
    ..Our work thus provides an interesting alternative for improving reprogramming using miRNAs and adds new evidence for the emerging relationship between pluripotency and the epithelial phenotype. ..
  2. Subramanyam D, Lamouille S, Judson R, Liu J, Bucay N, Derynck R, et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011;29:443-8 pubmed publisher
    ..We propose that individual miRNAs generally act through numerous pathways that synergize to regulate and enforce cell fate decisions. ..
  3. Card D, Hebbar P, Li L, Trotter K, Komatsu Y, Mishina Y, et al. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol. 2008;28:6426-38 pubmed publisher
    ..The transcriptional activation of miR-302 and the translational repression of its targets, such as cyclin D1, may provide a link between Oct4/Sox2 and cell cycle regulation in pluripotent cells. ..
  4. Judson R, Babiarz J, Venere M, Blelloch R. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol. 2009;27:459-61 pubmed publisher
    ..cMyc binds the promoter of the miRNAs, suggesting that they are downstream effectors of cMyc during reprogramming. However, unlike cMyc, the miRNAs induce a homogeneous population of iPS cell colonies. ..
  5. Wang H, Wang X, Archer T, Zwaka T, Cooney A. GCNF-dependent activation of cyclin D1 expression via repression of Mir302a during ESC differentiation. Stem Cells. 2014;32:1527-37 pubmed publisher
    ..This was determined to be an indirect effect of deregulation Mir302a, which is a cyclin D1 suppressor via binding to the 3'UTR of cyclin D1 mRNA...
  6. Jeong B, Kang I, Koh J. MicroRNA-302a inhibits adipogenesis by suppressing peroxisome proliferator-activated receptor γ expression. FEBS Lett. 2014;588:3427-34 pubmed publisher
    ..These findings suggest that miR-302a might be a negative regulator of adipocyte differentiation and that the dysregulation of miR-302a should lead to metabolic disorders. ..
  7. Bräutigam C, Raggioli A, Winter J. The Wnt/?-catenin pathway regulates the expression of the miR-302 cluster in mouse ESCs and P19 cells. PLoS ONE. 2013;8:e75315 pubmed publisher
    ..Interestingly, mutations in the two Tcf/Lef binding sites and the Oct4/Nanog binding sites abolished miR-302 promoter responsiveness to Wnt signaling, suggesting that the Tcf/Lef and the Oct4/Nanog sites interact genetically. ..
  8. Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu M, et al. Regulation of lung endoderm progenitor cell behavior by miR302/367. Development. 2011;138:1235-45 pubmed publisher
    ..Thus, miR302/367 directs lung endoderm development by coordinating multiple aspects of progenitor cell behavior, including proliferation, differentiation and apical-basal polarity. ..
  9. Pernaute B, Spruce T, Smith K, Sánchez Nieto J, Manzanares M, Cobb B, et al. MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM. Genes Dev. 2014;28:1873-8 pubmed publisher
    ..These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death. ..

More Information

Publications22

  1. Guo W, Wang X, Yan Y, Li Y, Yin X, Zhang Q, et al. Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells. Cell Death Differ. 2015;22:1158-69 pubmed publisher
  2. Zhu R, Yang Y, Tian Y, Bai J, Zhang X, Li X, et al. Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells. PLoS ONE. 2012;7:e32170 pubmed publisher
    ..Ascl2 may be a potential target for the inhibition of colon cancer progenitor cells, and functions through a miR-302b-related mechanism. ..
  3. Parchem R, Moore N, Fish J, Parchem J, Braga T, Shenoy A, et al. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep. 2015;12:760-73 pubmed publisher
    ..Our results show that mir-302 helps regulate neurulation by suppressing neural progenitor expansion and precocious differentiation. Furthermore, these results uncover redundant roles for mir-290 and mir-302 early in development. ..
  4. Mukhopadhyay P, Brock G, Appana S, Webb C, Greene R, Pisano M. MicroRNA gene expression signatures in the developing neural tube. Birth Defects Res A Clin Mol Teratol. 2011;91:744-62 pubmed publisher
    ..This study is the first to identify miRNA expression profiles and their potential regulatory networks in the developing mammalian NT. ..
  5. Chang H, Martinez N, Thornton J, Hagan J, Nguyen K, Gregory R. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012;3:923 pubmed publisher
    ..Thus, we demonstrate that Trim71 is a factor that facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal. ..
  6. Zhang G, Bao C, Wan F, Cao D, Qin X, Zhang H, et al. MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer. PLoS ONE. 2015;10:e0124410 pubmed publisher
    ..These results reveal miRNA-302a as a tumor suppressor in PCa, suggesting that miRNA-302a may be used as a potential target for therapeutic intervention in PCa. ..
  7. Taha M, Javeri A, Rohban S, Mowla S. Upregulation of pluripotency markers in adipose tissue-derived stem cells by miR-302 and leukemia inhibitory factor. Biomed Res Int. 2014;2014:941486 pubmed publisher
    ..These findings showed that mouse adipose tissue contains a population of cells with molecular resemblance to embryonic stem cells, and LIF and miR-302 family positively affect the expression of pluripotency markers. ..
  8. Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, et al. A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med. 2015;7:279ra38 pubmed publisher
    ..Our data demonstrate the ability of microRNA-based therapeutic approaches to promote mammalian cardiac repair and regeneration through the transient activation of cardiomyocyte proliferation. ..
  9. Kang I, Jeong B, Hur S, Choi H, Choi S, Ryu J, et al. MicroRNA-302a stimulates osteoblastic differentiation by repressing COUP-TFII expression. J Cell Physiol. 2015;230:911-21 pubmed publisher
    ..These results indicate that miR-302a is induced by osteogenic stimuli and promotes osteoblast differentiation by targeting COUP-TFII. MiR-302a could be a positive regulator for osteoblast differentiation. ..
  10. Meiler S, Baumer Y, Toulmin E, Seng K, Boisvert W. MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35:323-31 pubmed publisher
    ..These studies identify miR-302a as a novel modulator of cholesterol efflux and a potential therapeutic target for suppressing atherosclerosis. ..
  11. Liang Y, Li Y, Li Z, Liu Z, Zhang Z, Chang S, et al. Mechanism of folate deficiency-induced apoptosis in mouse embryonic stem cells: Cell cycle arrest/apoptosis in G1/G0 mediated by microRNA-302a and tumor suppressor gene Lats2. Int J Biochem Cell Biol. 2012;44:1750-60 pubmed publisher
    ..Together, these results suggest that the effects of folate deficiency on mammalian development may be mediated by miRNAs that regulate proliferation and/or cell cycle progression in ESCs. ..
  12. Hu W, Zhao J, Pei G. Activation of aryl hydrocarbon receptor (ahr) by tranilast, an anti-allergy drug, promotes miR-302 expression and cell reprogramming. J Biol Chem. 2013;288:22972-84 pubmed publisher
    ..These results elucidate that miR-302 expression can be regulated by AhR and thus provide a strategy for promoting somatic cell reprogramming by AhR ligands. ..
  13. Parchem R, Ye J, Judson R, Larussa M, Krishnakumar R, Blelloch A, et al. Two miRNA clusters reveal alternative paths in late-stage reprogramming. Cell Stem Cell. 2014;14:617-31 pubmed publisher
    ..These results demonstrate that cells can follow multiple paths during the late stages of reprogramming, and that the trajectory of any individual cell is strongly influenced by the combination of factors introduced. ..