Gene Symbol: Mir29b-2
Description: microRNA 29b-2
Alias: Mirn29b-2
Species: mouse

Top Publications

  1. Zhang Y, Wu L, Wang Y, Zhang M, Li L, Zhu D, et al. Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury. J Biol Chem. 2012;287:14851-62 pubmed publisher
    ..In conclusion, our results collectively demonstrate that estrogen can inhibit CCl(4)-induced hepatic injury through the induction of hepatic miR-29. ..
  2. van Rooij E, Sutherland L, Thatcher J, Dimaio J, Naseem R, Marshall W, et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A. 2008;105:13027-32 pubmed publisher
    ..We conclude that miR-29 acts as a regulator of cardiac fibrosis and represents a potential therapeutic target for tissue fibrosis in general. ..
  3. Pullen T, Da Silva Xavier G, Kelsey G, Rutter G. miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1). Mol Cell Biol. 2011;31:3182-94 pubmed publisher
    ..We show that inhibition of miR-29a in primary mouse islets increases Mct1 mRNA levels, demonstrating that miR-29 isoforms contribute to the ?-cell-specific silencing of the MCT1 transporter and may thus affect insulin release. ..
  4. Salama A, Fichou N, Allard M, Dubreil L, De Beaurepaire L, Viel A, et al. MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity. PLoS ONE. 2014;9:e106153 pubmed publisher
    ..Hence, microRNA sequences modulate innate and ongoing adaptive immune responses raising the question of their potential role in the breakdown of tolerance and opening up new applications for microRNA-based immune therapy. ..
  5. Wang Y, Zhou T, Wan J, Yang Y, Chen X, Wang J, et al. Comparative transcriptome analysis reveals a regulatory network of microRNA-29b during mouse early embryonic development. Oncotarget. 2016;7:53772-53782 pubmed publisher
    ..In conclusion, miR-29b controls an extensive regulatory network in early mouse embryos, which comprises reprogramming factors and molecular regulators of post-transcriptional modification processes. ..
  6. Lochhead R, Ma Y, Zachary J, Baltimore D, Zhao J, Weis J, et al. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. PLoS Pathog. 2014;10:e1004212 pubmed publisher
    ..Together, these data show that miR-146a-mediated regulation of TRAF6 and NF-?B, and downstream targets such as IL-1?, IL-6 and CXCL1, are critical for modulation of Lyme arthritis during chronic infection with B. burgdorferi. ..
  7. Liu C, Li J, Su J, Jiao T, Gou L, He X, et al. Expression of microRNA-29b2-c cluster is positively regulated by MyoD in L6 cells. Chin Med Sci J. 2013;28:140-6 pubmed
    ..Enforced expression of myoD led to a marked increase of miR-29b and miR-29c levels in L6 cells. MyoD might act as a crucial regulator of myogenesis and glucose metabolism in muscle through regulating the expression of miR-29b2-c. ..
  8. Andl T, Murchison E, Liu F, Zhang Y, Yunta Gonzalez M, Tobias J, et al. The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol. 2006;16:1041-9 pubmed
    ..These results reveal critical roles for Dicer in the skin and implicate miRNAs in key aspects of epidermal and hair-follicle development and function. ..
  9. Frezzetti D, Reale C, Cali G, Nitsch L, Fagman H, Nilsson O, et al. The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS ONE. 2011;6:e27648 pubmed publisher

More Information


  1. Li Z, Hassan M, Jafferji M, Aqeilan R, Garzon R, Croce C, et al. Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem. 2009;284:15676-84 pubmed publisher
    ..Thus, miR-29b is a key regulator of development of the osteoblast phenotype by targeting anti-osteogenic factors and modulating bone extracellular matrix proteins. ..
  2. Castoldi M, Vujic Spasic M, Altamura S, Elmen J, Lindow M, Kiss J, et al. The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest. 2011;121:1386-96 pubmed publisher
    ..These data help to explain the increased Hamp mRNA levels and subsequent iron deficiency in mice with reduced miR-122 levels and establish a direct mechanistic link between miR-122 and the regulation of systemic iron metabolism. ..
  3. Yamada Y, Takanashi M, Sudo K, Ueda S, Ohno S, Kuroda M. Novel form of miR-29b suppresses bleomycin-induced pulmonary fibrosis. PLoS ONE. 2017;12:e0171957 pubmed publisher
    ..This novel form of miR-29b may become the foundation for developing an effective therapeutic drug for pulmonary fibrosis. ..
  4. Lee H, Palkovits M, Young W. miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation. Proc Natl Acad Sci U S A. 2006;103:15669-74 pubmed
    ..Various pathways have been identified through which Fos family proteins are degraded; our results indicate a significant additional mechanism by which Fos protein and activity may be regulated. ..
  5. Maegdefessel L, Azuma J, Toh R, Merk D, Deng A, Chin J, et al. Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development. J Clin Invest. 2012;122:497-506 pubmed publisher
    ..These data suggest that therapeutic manipulation of miR-29b and its target genes holds promise for limiting AAA disease progression and protecting from rupture. ..
  6. Cicchini C, de Nonno V, Battistelli C, Cozzolino A, De Santis Puzzonia M, Ciafrè S, et al. Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. Biochim Biophys Acta. 2015;1849:919-29 pubmed publisher
    ..HNF4α maintains hepatocyte identity by regulating miR-29a and -29b expression, which in turn control epigenetic modifications by limiting DNMT3A and DNMT3B levels. ..
  7. Wang J, Chu E, Chen H, Man K, Go M, Huang X, et al. microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway. Oncotarget. 2015;6:7325-38 pubmed
    ..In conclusion, miR-29b prevents liver fibrogenesis by inhibiting HSC activation and inducing HSC apoptosis through inhibiting PI3K/AKT pathway. These results provide novel mechanistic insights for the anti-fibrotic effect of miR-29b. ..
  8. Zhang K, Cai H, Gao S, Yang G, Deng H, Xu G, et al. TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals. Oncotarget. 2016;7:69436-69449 pubmed publisher
    ..These findings suggest that VEGF gene expression can be suppressed by TNFSF15-stimulated activation of the JNK-GATA3 signaling pathway which gives rise to up-regulation of miR-29b. ..
  9. Zhou Q, Costinean S, Croce C, Brasier A, Merwat S, Larson S, et al. MicroRNA 29 targets nuclear factor-κB-repressing factor and Claudin 1 to increase intestinal permeability. Gastroenterology. 2015;148:158-169.e8 pubmed publisher
    ..Strategies to block MIR29 might be developed to restore intestinal permeability in patients with IBS-D. ..
  10. Bhandari A, Gordon W, Dizon D, Hopkin A, Gordon E, Yu Z, et al. The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1. Oncogene. 2013;32:1497-507 pubmed publisher
    ..These findings indicate that decreased Grhl3 expression contributes to tumor progression and upregulation of the oncomir miR-21 in squamous cell carcinoma of the skin. ..
  11. Ye Y, Hu Z, Lin Y, Zhang C, Perez Polo J. Downregulation of microRNA-29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2010;87:535-44 pubmed publisher
    ..The modulation of miRNAs can be achieved by pharmacological intervention. These findings provide a rationale for the development of miRNA-based strategies for the attenuation of IR injury. ..
  12. Ugalde A, Ramsay A, de la Rosa J, Varela I, Mariño G, Cadinanos J, et al. Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO J. 2011;30:2219-32 pubmed publisher
    ..Based on these results, we propose the existence of a novel regulatory circuitry involving miR-29, Ppm1d and p53, which is activated in aging and in response to DNA damage. ..
  13. Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, et al. Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature. PLoS Genet. 2015;11:e1005238 pubmed publisher
    ..Together, our findings suggested a vessel specific role of miR-29 in vSMC differentiation and function by targeting several key negative regulators. ..
  14. Tu J, Ng S, Luk A, Liao J, Jiang X, Feng B, et al. MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res. 2015;43:7805-22 pubmed publisher
    ..MiR-29b could potentially be applied to enrich production of mesoderm and endoderm derivatives and be further differentiated into desired organ-specific cells. ..
  15. Vanden Oever M, Muldoon D, Mathews W, McElmurry R, Tolar J. miR-29 Regulates Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa. J Invest Dermatol. 2016;136:2013-2021 pubmed publisher
    ..Collectively, we identify miR-29 as an important factor in both regulating COL7A1 and inhibiting transforming growth factor-?-mediated fibrosis. ..
  16. Smith K, Guerau de Arellano M, Costinean S, Williams J, Bottoni A, Mavrikis Cox G, et al. miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis. J Immunol. 2012;189:1567-76 pubmed publisher
    ..miR-29 thus serves as a novel regulator of Th1 differentiation, adding to the understanding of T cell-intrinsic regulatory mechanisms that maintain a balance between protective immunity and autoimmunity. ..
  17. Montgomery R, Yu G, Latimer P, Stack C, Robinson K, Dalby C, et al. MicroRNA mimicry blocks pulmonary fibrosis. EMBO Mol Med. 2014;6:1347-56 pubmed publisher
    ..Our data support the feasibility of using miRNA mimics to therapeutically increase miRNAs and indicate miR-29 to be a potent therapeutic miRNA for treating pulmonary fibrosis. ..
  18. Polajeva J, Swartling F, Jiang Y, Singh U, Pietras K, Uhrbom L, et al. miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma. BMC Cancer. 2012;12:378 pubmed publisher
    ..Furthermore, we believe that miR-21 is a mediator of PDGF-driven brain tumors, which suggests miR-21 as a promising target for treatment of glioma. ..
  19. Lippi G, Steinert J, Marczylo E, D Oro S, Fiore R, Forsythe I, et al. Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology. J Cell Biol. 2011;194:889-904 pubmed publisher
    ..This work provides evidence that targeting of Arpc3 by miR-29a/b fine tunes structural plasticity by regulating actin network branching in mature and developing spines. ..
  20. Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn F. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21:1469-77 pubmed
    ..miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development. ..