Gene Symbol: Mir26a-1
Description: microRNA 26a-1
Alias: Mirn26a, Mirn26a-1, miR-26a
Species: mouse

Top Publications

  1. Mohamed J, Hajira A, Li Z, Paulin D, Boriek A. Desmin regulates airway smooth muscle hypertrophy through early growth-responsive protein-1 and microRNA-26a. J Biol Chem. 2011;286:43394-404 pubmed publisher
    ..Overall, our data demonstrate a novel role for desmin as an anti-hypertrophic protein necessary for ASMC homeostasis and identifies desmin as a novel regulator of microRNA. ..
  2. Fu X, Jin L, Wang X, Luo A, Hu J, Zheng X, et al. MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A. 2013;110:17892-7 pubmed publisher
    ..These results establish a previously unknown link between miRNAs and TET expression levels, and suggest a potential role for miR-26a and TET family proteins in pancreatic cell differentiation. ..
  3. Dey B, Gagan J, Yan Z, Dutta A. miR-26a is required for skeletal muscle differentiation and regeneration in mice. Genes Dev. 2012;26:2180-91 pubmed publisher
    ..These findings provide evidence for the requirement of miR-26a for skeletal muscle differentiation and regeneration in vivo. ..
  4. Leeper N, Raiesdana A, Kojima Y, Chun H, Azuma J, Maegdefessel L, et al. MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. J Cell Physiol. 2011;226:1035-43 pubmed publisher
    ..MicroRNA-26a represents an important new regulator of SMC biology and a potential therapeutic target in AAA disease. ..
  5. Sander S, Bullinger L, Klapproth K, Fiedler K, Kestler H, Barth T, et al. MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood. 2008;112:4202-12 pubmed publisher
    ..Thus, in addition to directly targeting protein-coding genes, MYC modulates genes important to oncogenesis via deregulation of miRNAs, thereby vitally contributing to MYC-induced lymphomagenesis. ..
  6. Kota J, Chivukula R, O Donnell K, Wentzel E, Montgomery C, Hwang H, et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell. 2009;137:1005-17 pubmed publisher
    ..These findings suggest that delivery of miRNAs that are highly expressed and therefore tolerated in normal tissues but lost in disease cells may provide a general strategy for miRNA replacement therapies. ..
  7. Zhou J, Ju W, Wang D, Wu L, Zhu X, Guo Z, et al. Down-regulation of microRNA-26a promotes mouse hepatocyte proliferation during liver regeneration. PLoS ONE. 2012;7:e33577 pubmed publisher
    ..The current study reveals a novel miRNA-mediated regulation pattern during the proliferative phase of LR. ..
  8. Wei C, Kim I, Kumar S, Jayasinghe S, Hong N, Castoldi G, et al. NF-?B mediated miR-26a regulation in cardiac fibrosis. J Cell Physiol. 2013;228:1433-42 pubmed publisher
    ..The data indicate a potential role of miR-26a in cardiac fibrosis and, offer novel therapeutic intervention. ..
  9. Icli B, WARA A, Moslehi J, Sun X, Plovie E, Cahill M, et al. MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res. 2013;113:1231-41 pubmed publisher

More Information


  1. Wong C, Tellam R. MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis. J Biol Chem. 2008;283:9836-43 pubmed publisher
    ..These results reveal a model of regulation during myogenesis whereby the up-regulation of miR-26a acts to post-transcriptionally repress Ezh2, a known suppressor of skeletal muscle cell differentiation. ..
  2. Li S, Hu C, Li J, Liu L, Jing W, Tang W, et al. Effect of miR-26a-5p on the Wnt/Ca(2+) Pathway and Osteogenic Differentiation of Mouse Adipose-Derived Mesenchymal Stem Cells. Calcif Tissue Int. 2016;99:174-86 pubmed publisher
    ..Taken together, our results suggest that up-regulation of miR-26a-5p inhibits osteogenic differentiation of mADSCs by directly targeting the 3'UTR of Wnt5a, thereby down-regulating the Wnt/Ca(2+) signaling pathway. ..
  3. Yao L, Lv X, Wang X. MicroRNA 26a inhibits HMGB1 expression and attenuates cardiac ischemia-reperfusion injury. J Pharmacol Sci. 2016;131:6-12 pubmed publisher
    ..In conclusion, Mir-26a plays a protective role in cardiomyocyte IR injury and this is associated with inhibited HMGB1 expression. ..
  4. Xie F, Chai J, Zhang Z, Hu Q, Ma T. MicroRNA 26a prolongs skin allograft survival and promotes regulatory T cell expansion in mice. Transpl Int. 2015;28:1143-51 pubmed publisher
    ..In conclusion, Mir-26a prolongs skin allograft survival and promotes Tregs expansion in part through inhibition of IL-6 expression. ..
  5. He Q, Li F, Li J, Li R, Zhan G, Li G, et al. MicroRNA-26a-interleukin (IL)-6-IL-17 axis regulates the development of non-alcoholic fatty liver disease in a murine model. Clin Exp Immunol. 2017;187:174-184 pubmed publisher
    ..In conclusion, the Mir-26a-IL-6-IL-17 axis regulates the development of NAFLD in a murine model. ..
  6. Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn F. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21:1469-77 pubmed
    ..miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development. ..
  7. Kim K, Kim J, Kim I, Lee J, Seong S, Park Y, et al. MicroRNA-26a regulates RANKL-induced osteoclast formation. Mol Cells. 2015;38:75-80 pubmed publisher
    ..Collectively, our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF. ..
  8. Liang S, Wang W, Gou X. MicroRNA 26a modulates regulatory T cells expansion and attenuates renal ischemia-reperfusion injury. Mol Immunol. 2015;65:321-7 pubmed publisher
    ..Taken together, our data indicate an important role for Mir-26a in promoting tregs expansion in renal IRI that involving repression of IL-6 expression. ..
  9. Gu Q, Yu D, Hu Z, Liu X, Yang Y, Luo Y, et al. miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Nat Commun. 2015;6:6789 pubmed publisher
    ..This study reveals a novel miRNA-mediated mechanism for gene-specific regulation of translation in LTP, identifies two miRNAs required for long-lasting synaptic and spine plasticity and presents a catalogue of candidate 'LTP miRNAs'. ..
  10. Chen X, Xu H, Ding L, Lou G, Liu Y, Yao Y, et al. Identification of miR-26a as a target gene of bile acid receptor GPBAR-1/TGR5. PLoS ONE. 2015;10:e0131294 pubmed publisher
    ..These results unravel a new mechanism by which bile acid receptor TGR5 activates a miRNA gene expression. ..
  11. Liang H, Xu C, Pan Z, Zhang Y, Xu Z, Chen Y, et al. The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis. Mol Ther. 2014;22:1122-1133 pubmed publisher
    ..The current study also uncovered a novel positive feedback loop between miR-26a and p-Smad3, which is involved in pulmonary fibrosis. ..
  12. Hu S, Ren G, Liu J, Zhao Z, Yu Y, Su R, et al. MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem. 2008;283:23473-84 pubmed publisher
    ..Furthermore, we showed that Reck was the target gene of miR-21. Our data suggest that miR-21 may play a key role during embryo implantation. ..
  13. Chen X, Xiao W, Chen W, Liu X, Wu M, Bo Q, et al. MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway. Cell Death Differ. 2017;24:1431-1442 pubmed publisher
    ..Given the general involvement of EMT in most fibrotic diseases, cancer metastasis and recurrence, miR-26 family and Notch pathway may have therapeutic uses in treating fibrotic diseases and cancers. ..
  14. Sahu S, Kumar M, Chakraborty S, Banerjee S, Kumar R, Gupta P, et al. MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBP? regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection. PLoS Pathog. 2017;13:e1006410 pubmed publisher
    ..These studies expand our understanding of how Mtb hijacks host signaling pathways to survive in macrophages, and open up new exploratory avenues for host-targeted interventions. ..
  15. Zhang Y, Qin W, Zhang L, Wu X, Du N, Hu Y, et al. MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis. Sci Rep. 2015;5:9401 pubmed publisher
    ..Taken together, our study reveals a novel role of miR-26a in endothelial apoptosis and indicates a therapeutic potential of miR-26a for atherosclerosis associated with apoptotic cell death. ..
  16. Jones M, Quinton L, Blahna M, Neilson J, Fu S, Ivanov A, et al. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol. 2009;11:1157-63 pubmed publisher
    ..Thus, Zcchc11 fine tunes IL-6 production by uridylating miR-26a, which we propose is an enzymatic modification of the terminal nucleotide sequence of mature miRNA as a means to regulate gene expression. ..
  17. Luo X, Pan Z, Shan H, Xiao J, Sun X, Wang N, et al. MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. J Clin Invest. 2013;123:1939-51 pubmed publisher
    ..Our results demonstrate that miR-26 controls the expression of KCNJ2 and suggest that this downregulation may promote AF...
  18. Sun D, Zhang J, Xie J, Wei W, Chen M, Zhao X. MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7. FEBS Lett. 2012;586:1472-9 pubmed publisher
    ..These findings have not only figured out an alternative mechanism for LXR regulation, but also provided a potential therapeutic target for cholesterol metabolic disorders...
  19. Kumar A, Bhatia H, de Oliveira A, Fiebich B. microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia. J Neurochem. 2015;135:1189-202 pubmed publisher
    ..On the other hand, miR-26a also increases the production of tumor necrosis factor α (TNFα) by a mechanism independent of ATF2. ..
  20. Su X, Liao L, Shuai Y, Jing H, Liu S, Zhou H, et al. MiR-26a functions oppositely in osteogenic differentiation of BMSCs and ADSCs depending on distinct activation and roles of Wnt and BMP signaling pathway. Cell Death Dis. 2015;6:e1851 pubmed publisher
    ..The distinct transcriptional regulation and post-transcriptional regulation network suggested the intrinsic molecular differences between tissue-specific MSCs and the complexity in MSC research and MSC-based cell therapy. ..
  21. Zhu Y, Lu Y, Zhang Q, Liu J, Li T, Yang J, et al. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res. 2012;40:4615-25 pubmed publisher
    ..Our findings highlight the functional association of miR-26a/b and their host genes and provide new insight into the regulatory network of the G1/S-phase transition. ..
  22. Song Y, Jin D, Jiang X, Lv C, Zhu H. Overexpression of microRNA-26a protects against deficient ?-cell function via targeting phosphatase with tensin homology in mouse models of type 2 diabetes. Biochem Biophys Res Commun. 2018;495:1312-1316 pubmed publisher
    ..In conclusion, our data indicated that miR-26a potentially contributes to the ?-cell dysfunction in T2DM, and miR-26a may be a new therapeutic strategy against T2DM. ..
  23. Zhou J, Ju W, Yuan X, Zhu X, Wang D, He X. miR-26a regulates mouse hepatocyte proliferation via directly targeting the 3' untranslated region of CCND2 and CCNE2. Hepatobiliary Pancreat Dis Int. 2016;15:65-72 pubmed
    ..Our data suggested that miR-26a may be a promising regulator in liver regeneration. ..
  24. Hede K. MicroRNAs as Onco-miRs, drivers of cancer. J Natl Cancer Inst. 2010;102:1306-8 pubmed publisher
  25. Li Y, Fan L, Hu J, Zhang L, Liao L, Liu S, et al. MiR-26a Rescues Bone Regeneration Deficiency of Mesenchymal Stem Cells Derived From Osteoporotic Mice. Mol Ther. 2015;23:1349-1357 pubmed publisher
    ..Our findings indicate that miR-26a may be a promising therapeutic candidate to enhance bone formation in treatment of osteoporosis and to promote bone regeneration in osteoporotic fracture healing. ..
  26. Schlosser K, White R, Stewart D. miR-26a linked to pulmonary hypertension by global assessment of circulating extracellular microRNAs. Am J Respir Crit Care Med. 2013;188:1472-5 pubmed publisher
  27. Zhang R, Tian A, Wang J, Shen X, Qi G, Tang Y. miR26a modulates Th17/T reg balance in the EAE model of multiple sclerosis by targeting IL6. Neuromolecular Med. 2015;17:24-34 pubmed publisher
    ..Taken together, our data indicate an important role for miR26a in maintaining the Th17 and Treg cell balance in MS that involves repression of IL6 expression. ..
  28. Jiang J, Liu C, Zhang B, Wang X, Zhang M, Saijilafu -, et al. MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression. Cell Death Dis. 2015;6:e1865 pubmed publisher
    ..Moreover, we provide the first evidence that, in addition to inhibition of GSK3β kinase activity, maintaining a lower protein level of GSK3β in neurons by the microRNA is necessary for efficient axon regeneration. ..
  29. Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, et al. MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. J Clin Invest. 2015;125:2497-509 pubmed publisher
    ..These findings reveal miR-26a as a regulator of liver metabolism and suggest miR-26a should be further explored as a potential target for the treatment of T2D. ..
  30. Icli B, Nabzdyk C, Lujan Hernandez J, Cahill M, Auster M, WARA A, et al. Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a. J Mol Cell Cardiol. 2016;91:151-9 pubmed publisher
  31. Cui C, Xu G, Qiu J, Fan X. Up-regulation of miR-26a promotes neurite outgrowth and ameliorates apoptosis by inhibiting PTEN in bupivacaine injured mouse dorsal root ganglia. Cell Biol Int. 2015;39:933-42 pubmed publisher
    ..Up-regulating miR-26a to suppress PTEN signaling pathway may be an effective method to protect local anesthetic-induced nerve injury in spinal cord. ..
  32. Etich J, Holzer T, Pitzler L, Bluhm B, Brachvogel B. MiR-26a modulates extracellular matrix homeostasis in cartilage. Matrix Biol. 2015;43:27-34 pubmed publisher
    ..In conclusion, miR-26a suppresses hypertrophic and ECM adaptor protein production. Dysregulation of miR-26a expression could contribute to ECM changes in cartilage diseases and this miRNA may therefore act as a therapeutic target. ..
  33. Yang C, Zheng S, Liu T, Liu Q, Dai F, Zhou J, et al. Down-regulated miR-26a promotes proliferation, migration, and invasion via negative regulation of MTDH in esophageal squamous cell carcinoma. FASEB J. 2017;31:2114-2122 pubmed publisher
    ..Zheng, S., Liu, T., Liu, Q., Dai, F., Zhou, J., Chen, Y., Sheyhidin, I., Lu, X. Down-regulated miR-26a promotes proliferation, migration, and invasion via negative regulation of MTDH in esophageal squamous cell carcinoma. ..
  34. Zeitels L, Acharya A, Shi G, Chivukula D, Chivukula R, Anandam J, et al. Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis. Genes Dev. 2014;28:2585-90 pubmed publisher
    ..These studies reveal a tumor suppressor role for miR-26 in intestinal cancer that overrides putative oncogenic activity, highlighting the therapeutic potential of miR-26 delivery to this tumor type. ..
  35. Ichii O, Otsuka Kanazawa S, Horino T, Kimura J, Nakamura T, Matsumoto M, et al. Decreased miR-26a expression correlates with the progression of podocyte injury in autoimmune glomerulonephritis. PLoS ONE. 2014;9:e110383 pubmed publisher
    ..These data indicate that miR-26a regulates podocyte differentiation and cytoskeletal integrity, and its altered levels in glomerulus and urine may serve as a marker of injured podocytes in autoimmune glomerulonephritis. ..
  36. Koga K, Yokoi H, Mori K, Kasahara M, Kuwabara T, Imamaki H, et al. MicroRNA-26a inhibits TGF-β-induced extracellular matrix protein expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy. Diabetologia. 2015;58:2169-80 pubmed publisher
    ..The downregulation of miR-26a is involved in the progression of diabetic nephropathy both in humans and in mice through enhanced TGF-β/CTGF signalling. ..
  37. Liang H, Liu S, Chen Y, Bai X, Liu L, Dong Y, et al. miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF. J Mol Med (Berl). 2016;94:655-65 pubmed publisher
    ..Lin28B is one of the targets of microRNA-26a. miR-26a enhances the expression of let-7d via targeting regulation of Lin28B. A regulatory network among miRNAs involved in the progression of IPF. ..
  38. Kwon Y, Kim Y, Eom S, Kim M, Park D, Kim H, et al. MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells. J Biol Chem. 2015;290:14245-66 pubmed publisher
    ..Taken together, our results indicate that the miR26a/-26b-COX-2-MIP-2 loop regulates allergic inflammation and the feedback relationship between allergic inflammation and the enhanced tumorigenic and metastatic potential. ..