Gene Symbol: Mir24-2
Description: microRNA 24-2
Alias: Mirn24-2
Species: mouse

Top Publications

  1. Yi R, Poy M, Stoffel M, Fuchs E. A skin microRNA promotes differentiation by repressing 'stemness'. Nature. 2008;452:225-9 pubmed publisher
    ..Our findings suggest that miR-203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers. ..
  2. Andl T, Murchison E, Liu F, Zhang Y, Yunta Gonzalez M, Tobias J, et al. The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol. 2006;16:1041-9 pubmed
    ..These results reveal critical roles for Dicer in the skin and implicate miRNAs in key aspects of epidermal and hair-follicle development and function. ..
  3. Hassan M, Gordon J, Beloti M, Croce C, Van Wijnen A, Stein J, et al. A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program. Proc Natl Acad Sci U S A. 2010;107:19879-84 pubmed publisher
    ..Taken together, we have established a regulatory network with a central role for the miR cluster 23a?27a?24-2 in both progression and maintenance of the osteocyte phenotype. ..
  4. Ahn E, Higashi T, Yan M, Matsuura S, Hickey C, Lo M, et al. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster. J Biol Chem. 2013;288:5381-8 pubmed publisher
    ..Our data revealed a previously unidentified role of SON in microRNA production via regulating the transcription process, thereby modulating GATA-2 at the protein level during hematopoietic differentiation...
  5. Wei W, Hou J, Alder O, Ye X, Lee S, Cullum R, et al. Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling. Hepatology. 2013;57:2491-501 pubmed publisher
    ..Collectively, we uncovered dynamic patterns of individual miRNAs during liver development, as well as miRNA networks that could be essential for the specification and differentiation of liver progenitors. (HEPATOLOGY 2013). ..
  6. Wang B, Zhang C, Zhang A, Cai H, Price S, WANG X. MicroRNA-23a and MicroRNA-27a Mimic Exercise by Ameliorating CKD-Induced Muscle Atrophy. J Am Soc Nephrol. 2017;28:2631-2640 pubmed publisher
    ..These findings provide new insights about the roles of the miR-23a/27a-24-2 cluster in CKD-induced muscle atrophy in mice and suggest a mechanism by which exercise helps to maintain muscle mass. ..
  7. Lee S, Chen T, Dhar S, Gu B, Chen K, Kim Y, et al. A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness. Nucleic Acids Res. 2016;44:10603-10618 pubmed
  8. Wang F, Zhu Y, Guo L, Dong L, Liu H, Yin H, et al. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Res. 2014;42:442-57 pubmed publisher
    ..Taken together, these data integrated micro RNA expression and function into GATA factor coordinated networks and provided mechanistic insight into a regulatory circuit that comprised GATA1/2 switch and miR-27a/24 in erythropoiesis...
  9. Vijayaraghavan J, Maggi E, Crabtree J. miR-24 regulates menin in the endocrine pancreas. Am J Physiol Endocrinol Metab. 2014;307:E84-92 pubmed publisher
    ..Furthermore, our data show a feedback regulation between miR-24 and menin that is present in the pancreas, suggesting that miR-24 regulates menin levels in the pancreatic islet. ..

More Information


  1. Li R, Tao J, Guo Y, Wu H, Liu R, Bai Y, et al. In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice. Circ Res. 2013;112:601-5 pubmed publisher
    ..MiR-24 suppression prevented the transition from compensated hypertrophy to decompensated hypertrophy, providing a potential strategy for early treatment against heart failure. ..
  2. Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, et al. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 2007;27:123-34 pubmed
    ..Our data suggest that host miRNA can play a role in host interactions with viruses. ..
  3. Amelio I, Lena A, Viticchiè G, Shalom Feuerstein R, Terrinoni A, Dinsdale D, et al. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J Cell Biol. 2012;199:347-63 pubmed publisher
    ..Our results uncover a new regulatory pathway involving a differentiation-promoting microribonucleic acid that regulates actin adhesion dynamics in human and mouse epidermis...
  4. Cho S, Wu C, Nguyen D, Lin L, Chen M, Khan A, et al. A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses. J Immunol. 2017;198:3919-3926 pubmed publisher
    ..Together, our data demonstrate a novel miR-24-TCF1 pathway in controlling effector cytokine production by T cells and further suggest miR-24 could function as a key upstream molecule regulating TCF1-mediated immune responses. ..
  5. Chan M, Hilyard A, Wu C, Davis B, Hill N, Lal A, et al. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010;29:559-73 pubmed publisher
    ..Thus, this study provides a molecular basis for the antagonism between the PDGF and TGFbeta pathways, and its effect on the control of the vSMC phenotype. ..
  6. Zhu Y, You W, Wang H, Li Y, Qiao N, Shi Y, et al. MicroRNA-24/MODY gene regulatory pathway mediates pancreatic ?-cell dysfunction. Diabetes. 2013;62:3194-206 pubmed publisher
    ..Our findings functionally link the miR-24/MODY gene regulatory pathway to the onset of type 2 diabetes and create a novel network between nutrient overload and genetic diabetes via miR-24. ..
  7. Zhang Z, Florez S, Gutierrez Hartmann A, Martin J, Amendt B. MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. J Biol Chem. 2010;285:34718-28 pubmed publisher
  8. Jevnaker A, Osmundsen H. MicroRNA expression profiling of the developing murine molar tooth germ and the developing murine submandibular salivary gland. Arch Oral Biol. 2008;53:629-45 pubmed publisher
    ..g., epithelical cell proliferation, mesodermal cell fate determination and salivary gland morphogenesis...
  9. Du W, Fang L, Li M, Yang X, Liang Y, Peng C, et al. MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling. J Cell Sci. 2013;126:1440-53 pubmed publisher
    ..Our results suggest that miR-24 plays a key role in breast cancer invasion and metastasis. miR-24 could potentially be a target for cancer intervention. ..
  10. Talasila A, Yu H, Ackers Johnson M, Bot M, Van Berkel T, Bennett M, et al. Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-?. Arterioscler Thromb Vasc Biol. 2013;33:2355-65 pubmed publisher
  11. Chen Q, Xu J, Li L, Li H, Mao S, Zhang F, et al. MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death Dis. 2014;5:e1132 pubmed publisher
    ..Our findings may also have implications for the potential target role of microRNAs in the treatment of neuronal apoptosis-related diseases. ..
  12. Ma Y, Yao N, Liu G, Dong L, Liu Y, Zhang M, et al. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells. EMBO J. 2015;34:361-78 pubmed publisher
    ..Altogether, our findings uncover the essential role of miR-27 and miR-24 in ESC differentiation and also demonstrate novel microRNAs responsible for ESC differentiation. ..
  13. Thomson J, Newman M, Parker J, Morin Kensicki E, Wright T, Hammond S. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006;20:2202-7 pubmed
    ..These data uncover a novel regulatory step in miRNA function and provide a mechanism for miRNA down-regulation in cancer. ..
  14. Kang M, Yan L, Li Y, Zhang W, Wang H, Tang A, et al. Inhibitory effect of microRNA-24 on fatty acid-binding protein expression on 3T3-L1 adipocyte differentiation. Genet Mol Res. 2013;12:5267-77 pubmed publisher
    ..The mechanism involved may be the upregulation of AP-1. ..
  15. Ro S, Park C, Young D, Sanders K, Yan W. Tissue-dependent paired expression of miRNAs. Nucleic Acids Res. 2007;35:5944-53 pubmed
  16. Repetto E, Briata P, Kuziner N, Harfe B, McManus M, Gherzi R, et al. Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012;8:e1002823 pubmed publisher
    ..Our study unveils a functional crosstalk between miRNA- and AMD-dependent gene regulation during mammalian organogenesis events. ..
  17. Zhou Q, Gallagher R, Ufret Vincenty R, Li X, Olson E, Wang S. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci U S A. 2011;108:8287-92 pubmed publisher
    ..Manipulating miR-23/27 levels may have important therapeutic implications in neovascular age-related macular degeneration and other vascular disorders. ..
  18. Frezzetti D, Reale C, Cali G, Nitsch L, Fagman H, Nilsson O, et al. The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS ONE. 2011;6:e27648 pubmed publisher
  19. Ma S, Liu M, Xu Z, Li Y, Guo H, Ge Y, et al. A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression. Oncotarget. 2016;7:13502-19 pubmed publisher
    ..Moreover, miR-23a/27a/24-2 regulates the polarization of tumor-associated macrophages and thus promotes cancer progression. ..
  20. Cho S, Wu C, Yasuda T, Cruz L, Khan A, Lin L, et al. miR-23∼27∼24 clusters control effector T cell differentiation and function. J Exp Med. 2016;213:235-49 pubmed publisher