Gene Symbol: Mir23b
Description: microRNA 23b
Alias: Mirn23b, mmu-mir-23b
Species: mouse

Top Publications

  1. Chen Q, Xu J, Li L, Li H, Mao S, Zhang F, et al. MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death Dis. 2014;5:e1132 pubmed publisher
    ..Our findings may also have implications for the potential target role of microRNAs in the treatment of neuronal apoptosis-related diseases. ..
  2. Jevnaker A, Osmundsen H. MicroRNA expression profiling of the developing murine molar tooth germ and the developing murine submandibular salivary gland. Arch Oral Biol. 2008;53:629-45 pubmed publisher
    ..g., epithelical cell proliferation, mesodermal cell fate determination and salivary gland morphogenesis...
  3. Zhao B, Li H, Liu J, Han P, Zhang C, Bai H, et al. MicroRNA-23b Targets Ras GTPase-Activating Protein SH3 Domain-Binding Protein 2 to Alleviate Fibrosis and Albuminuria in Diabetic Nephropathy. J Am Soc Nephrol. 2016;27:2597-608 pubmed publisher
    ..In conclusion, these results reveal a role for miR-23b in DN and indicate a novel potential therapeutic target. ..
  4. Rogler C, Levoci L, Ader T, Massimi A, Tchaikovskaya T, Norel R, et al. MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads. Hepatology. 2009;50:575-84 pubmed publisher
    ..Concomitantly, low levels of the miR-23b miRNAs are needed in cholangiocytes to allow TGFbeta signaling and bile duct formation. ..
  5. Chinchilla A, Lozano E, Daimi H, Esteban F, Crist C, Aranega A, et al. MicroRNA profiling during mouse ventricular maturation: a role for miR-27 modulating Mef2c expression. Cardiovasc Res. 2011;89:98-108 pubmed publisher
  6. Zhou Q, Gallagher R, Ufret Vincenty R, Li X, Olson E, Wang S. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci U S A. 2011;108:8287-92 pubmed publisher
    ..Manipulating miR-23/27 levels may have important therapeutic implications in neovascular age-related macular degeneration and other vascular disorders. ..
  7. Oommen S, Otsuka Tanaka Y, Imam N, Kawasaki M, Kawasaki K, Jalani Ghazani F, et al. Distinct roles of microRNAs in epithelium and mesenchyme during tooth development. Dev Dyn. 2012;241:1465-72 pubmed publisher
    ..To investigate the role of miRNAs in tooth development, we examined mice with either mesenchymal (Wnt1Cre/Dicer(fl/fl)) or epithelial (ShhCre/Dicer(fl/fl)) conditional deletion of Dicer, which is essential for miRNA processing...
  8. Thomson J, Newman M, Parker J, Morin Kensicki E, Wright T, Hammond S. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006;20:2202-7 pubmed
    ..These data uncover a novel regulatory step in miRNA function and provide a mechanism for miRNA down-regulation in cancer. ..
  9. Liu X, Edinger R, Klemens C, Phua Y, Bodnar A, LaFramboise W, et al. A MicroRNA Cluster miR-23-24-27 Is Upregulated by Aldosterone in the Distal Kidney Nephron Where it Alters Sodium Transport. J Cell Physiol. 2017;232:1306-1317 pubmed publisher
    ..These findings reinforce a role for miRs in aldosterone regulation of Na+ transport, and implicate miR-27 in aldosterone's action via a novel target. J. Cell. Physiol. 232: 1306-1317, 2017. © 2016 Wiley Periodicals, Inc. ..

More Information


  1. Chen C, Tang Z, Song Q, Yang M, Shi Q, Weng Y. Downregulated microRNA-23b promotes BMP9-mediated osteogenesis in C2C12 myoblast cells by targeting Runx2. Mol Med Rep. 2016;13:2492-8 pubmed publisher
    ..The current study contributes to the understanding of the functions of BMP9 in ossification. ..
  2. Chen Q, Zhang F, Wang Y, Liu Z, Sun A, Zen K, et al. The transcription factor c-Myc suppresses MiR-23b and MiR-27b transcription during fetal distress and increases the sensitivity of neurons to hypoxia-induced apoptosis. PLoS ONE. 2015;10:e0120217 pubmed publisher
    ..In summary, our study demonstrates that c-Myc may suppress the expression of the miR-23b-27b cluster, resulting in additional neuronal apoptosis during hypoxia. ..
  3. Karachi A, Fazeli M, Karimi M, Geramizadeh B, Moravej A, Ebrahimnezhad S, et al. Evaluation of Immunomodulatory Effects of Mesenchymal Stem Cells Soluble Factors on miR-155 and miR-23b Expression in Mice Dendritic Cells. Immunol Invest. 2015;44:427-37 pubmed publisher
    ..Production of TGF-β and IL-23 were not influenced by C.S. In conclusion, miR-23b is considered to be one of the mechanisms involved in tolerogenic DCs induction by C.S. in a time-dependent manner. ..
  4. Liu H, Wang X, Liu S, Li H, Yuan X, Feng B, et al. Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy. Int J Biochem Cell Biol. 2016;70:149-60 pubmed publisher
  5. Chen M, Huang L, Shi J, Lin X, Lv Z, Zhang W, et al. MiR-23b controls TGF-β1 induced airway smooth muscle cell proliferation via TGFβR2/p-Smad3 signals. Mol Immunol. 2016;70:84-93 pubmed publisher
    ..MiR-23b may function as an inhibitor of airway smooth muscle cells proliferation through inactivation of TGFβR2/p-Smad3 pathway. ..
  6. Cho S, Wu C, Yasuda T, Cruz L, Khan A, Lin L, et al. miR-23∼27∼24 clusters control effector T cell differentiation and function. J Exp Med. 2016;213:235-49 pubmed publisher
  7. Wu Q, Law P, Wei L, Loh H. Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b. FASEB J. 2008;22:4085-95 pubmed publisher
    ..We propose a mechanism in which miRNA23b blocks the association of MOR1 mRNA with polysomes, thereby arresting its translation and suppressing the production of MOR1 protein. ..
  8. Zhan L, Yao Y, Fu H, Li Z, Wang F, Zhang X, et al. Protective role of miR-23b-3p in kainic acid-induced seizure. Neuroreport. 2016;27:764-8 pubmed publisher
    ..Together, these results indicate that miR-23b-3p plays a crucial role in suppressing seizure formation in experimental models of epilepsy and that miR-23b-3p supplement may be a potential anabolic strategy for ameliorating seizure. ..
  9. Chen M, Shi J, Huang L, Lin X, Lv Z, Zhang W, et al. MiR-23b controls TGF-?1 induced airway smooth muscle cell proliferation via direct targeting of Smad3. Pulm Pharmacol Ther. 2017;42:33-42 pubmed publisher
    ..Dual-Luciferase Reporter Assay System demonstrated that Smad3 was a direct target of miR-23b. MiR-23b may function as an inhibitor of asthma airway remodeling by suppressing ASMCs proliferation via direct targeting of Smad3. ..
  10. Ayyadurai S, Charania M, Xiao B, Viennois E, Zhang Y, Merlin D. Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, plays an important role in cell-to-cell communication during colitis. PLoS ONE. 2014;9:e87614 pubmed publisher
    ..Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, could play a crucial role in cell-to-cell communication during colitis. ..
  11. Li B, Sun M, Gao F, Liu W, Yang Y, Liu H, et al. Up-regulated expression of miR-23a/b targeted the pro-apoptotic Fas in radiation-induced thymic lymphoma. Cell Physiol Biochem. 2013;32:1729-40 pubmed publisher
    ..In this study, using a radiation induced thymic lymphoma model in BALB/c mice, We conclude that the expression of miR-23a/b is up-regulated in radiation-induced thymic lymphoma and it maybe a novel therapeutic target of that cancer. ..
  12. Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, et al. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-?. Nat Med. 2012;18:1077-86 pubmed publisher
    ..Thus, IL-17 contributes to autoimmune pathogenesis by suppressing miR-23b expression in radio-resident cells and promoting proinflammatory cytokine expression. ..
  13. Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn F. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21:1469-77 pubmed
    ..miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development. ..
  14. Wu J, Ji C, Cao F, Lui H, Xia B, Wang L. Bone marrow mesenchymal stem cells inhibit dendritic cells differentiation and maturation by microRNA-23b. Biosci Rep. 2017;37: pubmed publisher
    ..In conclusion, BMSCs affected the activation of NF-κB pathway through miR-23b overexpression resulting in inhibition of the maturation and differentiation of DCs. ..