Gene Symbol: Mir214
Description: microRNA 214
Alias: Mirn214, mmu-mir-214
Species: mouse

Top Publications

  1. Irie K, Tsujimura K, Nakashima H, Nakashima K. MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki). J Biol Chem. 2016;291:13891-904 pubmed publisher
    ..Moreover, overexpression of Qki abolished the dendritic growth induced by miR-214 overexpression. Taken together, our findings reveal a crucial role for the miR-214-Qki pathway in the regulation of neuronal dendritic development. ..
  2. Wang X, Guo B, Li Q, Peng J, Yang Z, Wang A, et al. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2013;19:93-100 pubmed publisher
    ..These data suggest that miR-214 has a crucial role in suppressing bone formation and that miR-214 inhibition in osteoblasts may be a potential anabolic strategy for ameliorating osteoporosis...
  3. Aurora A, Mahmoud A, Luo X, Johnson B, van Rooij E, Matsuzaki S, et al. MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²? overload and cell death. J Clin Invest. 2012;122:1222-32 pubmed publisher
    ..These findings reveal a pivotal role for miR-214 as a regulator of cardiomyocyte Ca²? homeostasis and survival during cardiac injury. ..
  4. Jevnaker A, Osmundsen H. MicroRNA expression profiling of the developing murine molar tooth germ and the developing murine submandibular salivary gland. Arch Oral Biol. 2008;53:629-45 pubmed publisher
    ..g., epithelical cell proliferation, mesodermal cell fate determination and salivary gland morphogenesis...
  5. Zhu W, Tang C, Xiao Z, Zhu J, Lin Q, Fu Y, et al. Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts. Oncotarget. 2016;7:78331-78342 pubmed publisher
    ..Taken together, our results revealed that EZH1 and -2 were novel targets of miR-214-3p, and miR-214-3p might be one potential miRNA for the prevention of cardiac fibrosis. ..
  6. Ramazzotti G, Bavelloni A, Blalock W, Piazzi M, Cocco L, Faenza I. BMP-2 Induced Expression of PLCβ1 That is a Positive Regulator of Osteoblast Differentiation. J Cell Physiol. 2016;231:623-9 pubmed publisher
    ..The results indicated that inhibition of miR-214 in C2C12 cells significantly enhances the protein level of PLCβ1 and promotes C2C12 BMP-2-induced osteogenesis by targeting PLCβ1. ..
  7. Arkatkar T, Gupta R, Li W, Yu J, Wali S, Neal Guentzel M, et al. Murine MicroRNA-214 regulates intracellular adhesion molecule (ICAM1) gene expression in genital Chlamydia muridarum infection. Immunology. 2015;145:534-42 pubmed publisher
    ..This report provides evidence for early-stage regulation of ICAM1 by microRNAs, resulting in reduction of genital pathology associated with chlamydial infection. ..
  8. Ahmed M, Alam M, Emelianov V, Poterlowicz K, Patel A, Sharov A, et al. MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. J Cell Biol. 2014;207:549-67 pubmed publisher
    ..These data provide an important foundation for further analyses of miR-214 as a key regulator of Wnt pathway activity and stem cell functions during normal tissue homeostasis, regeneration, and aging. ..
  9. van Mil A, Grundmann S, Goumans M, Lei Z, Oerlemans M, Jaksani S, et al. MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release. Cardiovasc Res. 2012;93:655-65 pubmed publisher
    ..The anti-angiogenic effect of miR-214 is mediated through the down-regulation of Quaking and pro-angiogenic growth factor expression. This study presents miR-214 as a potential important target for pro- or anti-angiogenic therapies. ..

More Information


  1. Keck Wherley J, Grover D, Bhattacharyya S, Xu X, Holman D, Lombardini E, et al. Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes. Dev Neurosci. 2011;33:451-67 pubmed publisher
    ..Our findings provide insights into miRNA-mediated gene regulation in Ts65Dn mice and their potential contribution to impaired hippocampal synaptic plasticity and neurogenesis, as well as hemopoietic abnormalities observed in DS. ..
  2. Liao Y, Du X, Lonnerdal B. miR-214 regulates lactoferrin expression and pro-apoptotic function in mammary epithelial cells. J Nutr. 2010;140:1552-6 pubmed publisher
    ..05). In summary, our data showed that miR-214 is directly involved in lactoferrin expression and lactoferrin mediated cancer susceptibility (proapoptotic activities) in mammary epithelial cells...
  3. Liu M, Liu L, Bai M, Zhang L, Ma F, Yang X, et al. Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis. Biochem Biophys Res Commun. 2018;495:2324-2330 pubmed publisher
    ..Overall, hypoxia-induced activation of Twist/miR-214/E-cadherin axis is involved in the EMT of TECs, and anti-miR-214 may be an attractive strategy to ameliorate the progression of renal fibrosis. ..
  4. Wu Y, Li Z, Yang M, Dai B, Hu F, Yang F, et al. MicroRNA-214 regulates smooth muscle cell differentiation from stem cells by targeting RNA-binding protein QKI. Oncotarget. 2017;8:19866-19878 pubmed publisher
    ..Taken together, we have uncovered a central role of miR-214 in ESC-VSMC differentiation, and successfully identified QKI as a functional modulating target in miR-214 mediated VSMCs differentiation. ..
  5. Afzal T, Luong L, Chen D, Zhang C, Yang F, Chen Q, et al. NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia. J Am Heart Assoc. 2016;5: pubmed
    ..We uncovered an important role of miR-214 and its target gene NCKAP1 in modulating VSMC functions and neointima hyperplasia. Our findings suggest that miR-214 represents a potential therapeutic target for vascular diseases. ..
  6. Alimirah F, Peng X, Gupta A, Yuan L, Welsh J, Cleary M, et al. Crosstalk between the vitamin D receptor (VDR) and miR-214 in regulating SuFu, a hedgehog pathway inhibitor in breast cancer cells. Exp Cell Res. 2016;349:15-22 pubmed publisher
    ..miR-214 on the other hand suppressed SuFu protein expression. These findings suggest a crosstalk between VDR and miR-214 in regulating hedgehog signaling in breast cancer cells, providing new therapies for breast cancer. ..
  7. Zhao E, Keller M, Rabaglia M, Oler A, Stapleton D, Schueler K, et al. Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome. 2009;20:476-85 pubmed publisher
    ..Understanding the influence that obesity and genetics exert on the regulation of miRNA expression will reveal the role miRNAs play in the context of obesity-induced type 2 diabetes. ..
  8. Li K, Zhang J, Yu J, Liu B, Guo Y, Deng J, et al. MicroRNA-214 suppresses gluconeogenesis by targeting activating transcriptional factor 4. J Biol Chem. 2015;290:8185-95 pubmed publisher
    ..Taken together, our results suggest that the miR-214-ATF4 axis is a novel pathway for the regulation of hepatic gluconeogenesis. ..
  9. Penna E, Orso F, Cimino D, Tenaglia E, Lembo A, Quaglino E, et al. microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J. 2011;30:1990-2007 pubmed publisher
    ..Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases. ..
  10. Chen L, Chen R, Kemper S, Charrier A, Brigstock D. Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1. Am J Physiol Gastrointest Liver Physiol. 2015;309:G491-9 pubmed publisher
    ..These findings reveal a unique function for cellular or exosomal Twist1 in CCN2-dependent fibrogenesis. ..
  11. Denby L, Ramdas V, Lu R, Conway B, Grant J, Dickinson B, et al. MicroRNA-214 antagonism protects against renal fibrosis. J Am Soc Nephrol. 2014;25:65-80 pubmed publisher
    ..These studies demonstrate that miR-214 functions to promote fibrosis in renal injury independent of TGF-? signaling in vivo and that antagonism of miR-214 may represent a novel antifibrotic treatment in the kidney. ..
  12. Salomonis N, Schlieve C, Pereira L, Wahlquist C, Colas A, Zambon A, et al. Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Proc Natl Acad Sci U S A. 2010;107:10514-9 pubmed publisher
    ..The findings herein illustrate a critical role for AS in the specification of ES cells with differentiation, and highlight the utility of global functional analyses of AS. ..
  13. Sehic A, Risnes S, Khuu C, Khan Q, Osmundsen H. Effects of in vivo transfection with anti-miR-214 on gene expression in murine molar tooth germ. Physiol Genomics. 2011;43:488-98 pubmed publisher
    ..It is therefore suggested that effects of miR-214 on amelogenesis are indirect, perhaps mediated by the observed miR-214-dependent changes in levels of expression of numerous transcription factors...
  14. Gu C, Zhou X, Yuan Y, Miao X, Liu Y, Ru Y, et al. MicroRNA-214 induces dendritic cell switching from tolerance to immunity by targeting β-Catenin signaling. Int J Clin Exp Pathol. 2015;8:10050-60 pubmed
    ..The results suggest that β-catenin is a critical regulator of tolerance in DCs via miR-214. The expression of miR-214 could be a potential therapeutic strategy in organ transplantation or autoimmunity patients. ..
  15. el Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, et al. The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation. Cell Metab. 2013;18:341-54 pubmed publisher
  16. Liu J, Luo X, Xiong A, Zhang Z, Yue S, Zhu M, et al. MicroRNA-214 promotes myogenic differentiation by facilitating exit from mitosis via down-regulation of proto-oncogene N-ras. J Biol Chem. 2010;285:26599-607 pubmed publisher
    ..Thus, our data uncovered a novel microRNA-mediated mechanism that controls myogenic differentiation. ..
  17. Wang X, Ha T, Hu Y, Lu C, Liu L, Zhang X, et al. MicroRNA-214 protects against hypoxia/reoxygenation induced cell damage and myocardial ischemia/reperfusion injury via suppression of PTEN and Bim1 expression. Oncotarget. 2016;7:86926-86936 pubmed publisher
    ..The mechanisms involve activation of PI3K/Akt signaling by targeting PTEN expression, induction of Bad phosphorylation, and suppression of Bim1 expression, resulting in decreases in I/R-induced myocardial apoptosis. ..
  18. Watanabe T, Sato T, Amano T, Kawamura Y, Kawamura N, Kawaguchi H, et al. Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dyn. 2008;237:3738-48 pubmed publisher
    ..Thus, Dnm3os has emerged as an miRNA-encoding gene that is indispensable for normal skeletal development and body growth in mammals. ..
  19. Juan A, Kumar R, Marx J, Young R, Sartorelli V. Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol Cell. 2009;36:61-74 pubmed publisher
    ..Thus, miR-214 and Ezh2 establish a regulatory loop controlling PcG-dependent gene expression during differentiation. ..
  20. Chen H, Shalom Feuerstein R, Riley J, Zhang S, Tucci P, Agostini M, et al. miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro. Biochem Biophys Res Commun. 2010;394:921-7 pubmed publisher
    ..These findings provide an important step toward further elucidation of miR function and miR-related gene regulatory networks in the mammalian central nervous system. ..
  21. Zhao C, Sun W, Zhang P, Ling S, Li Y, Zhao D, et al. miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway. RNA Biol. 2015;12:343-53 pubmed publisher
    ..These results reveal a crucial role of miR-214 in the differentiation of osteoclasts, which will provide a potential therapeutic target for osteoporosis. ..
  22. Li D, Liu J, Guo B, Liang C, Dang L, Lu C, et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun. 2016;7:10872 pubmed publisher
    ..Inhibition of miR-214-3p in osteoclasts may be a strategy for treating skeletal disorders involving a reduction in bone formation. ..
  23. Duan Q, Yang L, Gong W, Chaugai S, Wang F, Chen C, et al. MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis. J Cell Physiol. 2015;230:1964-73 pubmed publisher
  24. Lynn F, Skewes Cox P, Kosaka Y, McManus M, Harfe B, German M. MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes. 2007;56:2938-45 pubmed
    ..The expression of a unique profile of miRNAs is required during pancreas development and is necessary for beta-cell formation. ..
  25. Williams K, Renthal N, Gerard R, Mendelson C. The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor. Mol Endocrinol. 2012;26:1857-67 pubmed publisher
    ..Together, these findings identify miR-199a-3p/miR-214 as important regulators of myometrial contractility and provide new insight into strategies to prevent preterm birth. ..
  26. Wang X, Shen E, Wang Y, Li J, Cheng D, Chen Y, et al. Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions. Sci Rep. 2016;6:31506 pubmed publisher
    ..In conclusion, cross talk between miR-214 and PTEN attenuated glomerular hypertrophy under diabetic conditions in vivo and in vitro. Therefore, miR-214 may represent a novel therapeutic target for DN. ..
  27. Ghatak S, Raha S. Micro RNA-214 contributes to proteasome independent downregulation of beta catenin in Huntington's disease knock-in striatal cell model STHdhQ111/Q111. Biochem Biophys Res Commun. 2015;459:509-14 pubmed publisher
  28. Zhao L, Liu Y, Yang T, Gan L, Yang N, Dai S, et al. The mutual regulation between miR-214 and A2AR signaling plays an important role in inflammatory response. Cell Signal. 2015;27:2026-34 pubmed publisher
  29. Yang L, Ge D, Cao X, Ge Y, Chen H, Wang W, et al. MiR-214 Attenuates Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1. Cell Physiol Biochem. 2016;38:809-20 pubmed publisher
    ..MiR-214 attenuates osteogenesis by inhibiting the FGFR1/FGF signaling pathway. Our findings suggest that targeting miR-214 promises to be a potential therapy in treatment of postmenopausal osteoporosis. ..
  30. Das S, Bhattacharyya N. Heat Shock Factor 1-Regulated miRNAs Can Target Huntingtin and Suppress Aggregates of Mutant Huntingtin. Microrna. 2015;4:185-93 pubmed
    ..Moreover, the suppressive effect of HSF1-regulated miRNAs on mutant huntingtin aggregates indicates their potential as therapeutic agents for the treatment of HD. ..
  31. Yang T, Gu H, Chen X, Fu S, Wang C, Xu H, et al. Cardiac hypertrophy and dysfunction induced by overexpression of miR-214 in vivo. J Surg Res. 2014;192:317-25 pubmed publisher
    ..MiR-214 may therefore be a potential therapeutic target for treating certain cardiac disease states. ..
  32. Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, et al. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology. 2014;59:1118-29 pubmed publisher
    ..Exosomal transfer of miR-214 is a paradigm for the regulation of CCN2-dependent fibrogenesis and identifies fibrotic pathways as targets of intercellular regulation by exosomal miRs. ..
  33. van Balkom B, de Jong O, Smits M, Brummelman J, Den Ouden K, de Bree P, et al. Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells. Blood. 2013;121:3997-4006, S1-15 pubmed publisher
    ..Collectively, our data indicate that endothelial cells release miR-214-containing exosomes to stimulate angiogenesis through the silencing of ataxia telangiectasia mutated in neighboring target cells. ..
  34. Polytarchou C, Hommes D, Palumbo T, Hatziapostolou M, Koutsioumpa M, Koukos G, et al. MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice. Gastroenterology. 2015;149:981-92.e11 pubmed publisher
    ..and carcinogenesis was induced by addition of azoxymethane; some mice also were given an inhibitor of microRNA214 (miR214)...
  35. Chen Z, Liu H, Zhang J, Zhang S, Zhao L, Liang W. Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection. Mol Med Rep. 2015;12:1258-64 pubmed publisher
  36. Shi K, Lu J, Zhao Y, Wang L, Li J, Qi B, et al. MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix. Bone. 2013;55:487-94 pubmed publisher
    ..Taken together, these results indicate that miR-214 is a novel regulator of Osx, and that it plays an important role in the osteogenic differentiation of C2C12 cells as a suppressor. ..
  37. Jindra P, Bagley J, Godwin J, Iacomini J. Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten. J Immunol. 2010;185:990-7 pubmed publisher
    ..Thus, the requirement for T cell costimulation is, in part, related to its ability to regulate expression of miRNAs that control T cell activation...
  38. Bera A, Das F, Ghosh Choudhury N, Mariappan M, Kasinath B, Ghosh Choudhury G. Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. Am J Physiol Cell Physiol. 2017;313:C430-C447 pubmed publisher
    ..These results uncover a significant role of miR-214 in the activation of mTORC1 that contributes to high-glucose-induced mesangial and proximal tubular cell hypertrophy and fibronectin expression. ..