Gene Symbol: Mir19b-1
Description: microRNA 19b-1
Alias: Mirn19b-1
Species: mouse

Top Publications

  1. de Pontual L, Yao E, Callier P, Faivre L, Drouin V, Cariou S, et al. Germline deletion of the miR-17?92 cluster causes skeletal and growth defects in humans. Nat Genet. 2011;43:1026-30 pubmed publisher
    ..These findings identify a regulatory function for miR-17?92 in growth and skeletal development and represent the first example of an miRNA gene responsible for a syndromic developmental defect in humans. ..
  2. Ventura A, Young A, Winslow M, Lintault L, Meissner A, Erkeland S, et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008;132:875-86 pubmed publisher
    ..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development. ..
  3. Li L, Shi J, Zhu G, Shi B. MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFB pathway in mouse palatal mesenchymal cells. J Cell Biochem. 2012;113:1235-44 pubmed publisher
    ..We thus conclude that miR-17-92 cluster could inhibit TGFB pathway induced proliferation inhibition and collagen synthesis in PMCs by directly targeting TGFBR2, SMAD2, and SMAD4. ..
  4. Lu Y, Thomson J, Wong H, Hammond S, Hogan B. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol. 2007;310:442-53 pubmed
    ..Together, these studies suggest that mir-17-92 normally promotes the high proliferation and undifferentiated phenotype of lung epithelial progenitor cells. ..
  5. Rolls A, Pang W, Ibarra I, Colas D, Bonnavion P, Korin B, et al. Sleep disruption impairs haematopoietic stem cell transplantation in mice. Nat Commun. 2015;6:8516 pubmed publisher
  6. Chen Z, Wu J, Yang C, Fan P, Balazs L, Jiao Y, et al. DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice. J Biol Chem. 2012;287:19018-28 pubmed publisher
    ..Our results indicate that the DGCR8 gene is required for vascular development through the regulation of VSMC proliferation, apoptosis, and differentiation...
  7. Zindy F, Kawauchi D, Lee Y, Ayrault O, Ben Merzoug L, McKinnon P, et al. Role of the miR-17?92 cluster family in cerebellar and medulloblastoma development. Biol Open. 2014;3:597-605 pubmed publisher
    ..Taken together, our findings demonstrate that the miR-17?92 cluster is dispensable for cerebellar development, but required for SHH-MB development. ..
  8. Song D, Ryu J, Kim J, Kwon E, Kim D. The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1. Biochem J. 2014;457:151-62 pubmed publisher
    ..Taken together, the results of the present study demonstrate that the miR-19a/b family regulates phenotypes of cardiomyocytes via suppression of multiple direct target genes. ..
  9. Li C, Li S, Zhang F, Wu M, Liang H, Song J, et al. Endothelial microparticles-mediated transfer of microRNA-19b promotes atherosclerosis via activating perivascular adipose tissue inflammation in apoE-/- mice. Biochem Biophys Res Commun. 2018;495:1922-1929 pubmed publisher
    ..Our findings demonstrate that miR-19b in EMPs exaggerates atherosclerosis progression by augmenting PVAT-specific inflammation proceeded by downregulating SOCS3 expression. ..

More Information


  1. Ricoy U, Mao P, Manczak M, Reddy P, FRERKING M. A transgenic mouse model for Alzheimer's disease has impaired synaptic gain but normal synaptic dynamics. Neurosci Lett. 2011;500:212-5 pubmed publisher
    ..We conclude that the chronic accumulation of A? impairs synaptic transmission through a reduction in the synaptic gain, while preserving the synaptic dynamics. ..
  2. Ries R, Yu W, Holton N, Cao H, Amendt B. Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis. J Dent Res. 2017;96:1257-1264 pubmed publisher
    ..The differential regulation of palatogenesis by members of the miR-17-92 cluster indicates that several gene combinations regulate palate elevation and extension during development. ..
  3. Volk N, Paul E, Haramati S, Eitan C, Fields B, Zwang R, et al. MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1. J Neurosci. 2014;34:15070-82 pubmed publisher
    ..These findings suggest a key role for miR-19b in modulating behavioral responses to chronic stress and Adrb1 as an important target of miR-19b in stress-linked brain regions. ..
  4. Lv Y, Tang Y, Peng J, Zhao G, Yang J, Yao F, et al. MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. Atherosclerosis. 2014;236:215-26 pubmed publisher
    ..MiR-19b promotes macrophage cholesterol accumulation, foam cell formation and aortic atherosclerotic development by targeting ABCA1. ..
  5. Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, et al. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012;287:5979-87 pubmed publisher
  6. Clovis Y, Enard W, Marinaro F, Huttner W, De Pietri Tonelli D. Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons. Development. 2012;139:3332-42 pubmed publisher
    ..Our results uncover a new layer of control of Foxp2 expression that may be required for proper neuronal maturation. ..
  7. Pan Y, Balazs L, Tigyi G, Yue J. Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality. Biochem Biophys Res Commun. 2011;408:369-74 pubmed publisher
    ..5. Expression of most miRNAs examined was compromised in VSMCs of Dicer KO. Our results indicate that Dicer is required for vascular development and regulates vascular remodeling by modulating VSMC proliferation and differentiation. ..
  8. Pernaute B, Spruce T, Smith K, Sánchez Nieto J, Manzanares M, Cobb B, et al. MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM. Genes Dev. 2014;28:1873-8 pubmed publisher
    ..These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death. ..
  9. Kuppers D, Hwang H, Jackson A, Linsley P, Clurman B, Fero M. Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma. PLoS ONE. 2011;6:e14758 pubmed publisher
    ..Confirmation of miR-106a~363 gene targeting relevant to the tumor phenotype requires in vivo validation, because only a subset of predicted targets are consistently reduced in tumors that overexpress miR-106a~363. ..
  10. Kobayashi S, Totoki Y, Soma M, Matsumoto K, Fujihara Y, Toyoda A, et al. Identification of an imprinted gene cluster in the X-inactivation center. PLoS ONE. 2013;8:e71222 pubmed publisher
    ..This finding may help in understanding the molecular mechanisms regulating imprinted X-chromosome inactivation during early mammalian development. ..
  11. Jevnaker A, Khuu C, Kjøle E, Bryne M, Osmundsen H. Expression of members of the miRNA17-92 cluster during development and in carcinogenesis. J Cell Physiol. 2011;226:2257-66 pubmed publisher
    ..Additionally, the six microRNAs exhibit variable tissue expression, suggesting selective processing of these microRNAs. ..
  12. Lv Y, Yang J, Yao F, Xie W, Tang Y, Ouyang X, et al. Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1. Atherosclerosis. 2015;240:80-9 pubmed publisher
    ..The present study demonstrates that Dgn enhances ABCA1-dependent cholesterol efflux and inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression. ..
  13. Deo M, Yu J, Chung K, Tippens M, Turner D. Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides. Dev Dyn. 2006;235:2538-48 pubmed
    ..The ability to visualize expression of specific miRNAs in embryos and tissues should aid studies on miRNA function. ..
  14. ZHANG Z, Zhang L, Ding L, Wang F, Sun Y, An Y, et al. MicroRNA-19b downregulates insulin 1 through targeting transcription factor NeuroD1. FEBS Lett. 2011;585:2592-8 pubmed publisher
    ..These results suggest that miR-19b can downregulate insulin 1 expression through targeting transcription factor NeuroD1, and thus regulate the differentiation and function of ?-cells. ..