Gene Symbol: Mir199a-1
Description: microRNA 199a-1
Alias: Mirn199, Mirn199a-1
Species: mouse

Top Publications

  1. Chakrabarty A, Tranguch S, Daikoku T, Jensen K, Furneaux H, Dey S. MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proc Natl Acad Sci U S A. 2007;104:15144-9 pubmed
    ..Thus, elucidating the physiological roles of uterine miRNAs will help us better understand the genetic control of implantation, the gateway to a successful pregnancy. ..
  2. Watanabe T, Sato T, Amano T, Kawamura Y, Kawamura N, Kawaguchi H, et al. Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dyn. 2008;237:3738-48 pubmed publisher
    ..Thus, Dnm3os has emerged as an miRNA-encoding gene that is indispensable for normal skeletal development and body growth in mammals. ..
  3. Friedman L, Dror A, Mor E, Tenne T, Toren G, Satoh T, et al. MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A. 2009;106:7915-20 pubmed publisher
    ..Our data support the hypothesis that inner ear tissue differentiation and maintenance are regulated and controlled by conserved sets of cell-specific miRNAs in both mouse and zebrafish. ..
  4. Zhang Y, Fan K, Sun Q, Chen A, Shen W, Zhao Z, et al. Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-? signalling pathway. Nucleic Acids Res. 2012;40:9286-97 pubmed publisher
    ..In conclusion, our functional screening uncovers multiple miRNAs that regulate the cellular responsiveness to TGF-? signalling and reveals important roles of miR-199a in gastric cancer by directly targeting Smad4. ..
  5. Lin E, Kong L, Bai X, Luan Y, Liu C. miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1. J Biol Chem. 2009;284:11326-35 pubmed publisher
    ..Taken together, miR-199a(*) is the first BMP2 responsive microRNA found to adversely regulate early chondrocyte differentiation via direct targeting of the Smad1 transcription factor. ..
  6. Ota H, Sakurai M, Gupta R, Valente L, Wulff B, Ariyoshi K, et al. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013;153:575-89 pubmed publisher
    ..As expected, the expression of miRNAs is globally inhibited in ADAR1(-/-) mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype. ..
  7. Qi R, Long D, Wang J, Wang Q, Huang X, Cao C, et al. MicroRNA-199a Targets the Fatty Acid Transport Protein 1 Gene and Inhibits the Adipogenic Trans-Differentiation of C2C12 Myoblasts. Cell Physiol Biochem. 2016;39:1087-97 pubmed publisher
    ..Our study reveals an important role for miR-199a in the regulation of adipogenic trans-differentiation in muscle cells via suppression of Fatp1 gene. ..
  8. Li Z, Margariti A, Wu Y, Yang F, Hu J, Zhang L, et al. MicroRNA-199a induces differentiation of induced pluripotent stem cells into endothelial cells by targeting sirtuin 1. Mol Med Rep. 2015;12:3711-3717 pubmed publisher
  9. Shi C, Huang P, Kang H, Hu B, Qi J, Jiang M, et al. Glucocorticoid inhibits cell proliferation in differentiating osteoblasts by microRNA-199a targeting of WNT signaling. J Mol Endocrinol. 2015;54:325-37 pubmed publisher
    ..These results indicated that microRNA-199a-5p may play a significant role in GC-inhibited osteoblast proliferation by regulating the WNT signaling pathway. ..

More Information


  1. Jia L, Li Y, Wu G, Song Z, Lu H, Song C, et al. MiRNA-199a-3p regulates C2C12 myoblast differentiation through IGF-1/AKT/mTOR signal pathway. Int J Mol Sci. 2013;15:296-308 pubmed publisher
    ..Thus, our studies have established miR-199a-3p as a potential regulator of myogenesis through the suppression of IGF-1/AKT/mTOR signal pathway. ..
  2. Inyawilert W, Fu T, Lin C, Tang P. MicroRNA-199a mediates mucin 1 expression in mouse uterus during implantation. Reprod Fertil Dev. 2014;26:653-64 pubmed publisher
    ..Therefore, the present study provides evidence that MUC1 is a direct target of miRNA-199a and suggests that development of novel strategies to facilitate a successful pregnancy and repair implantation failure humans may include miRNA. ..
  3. Lino Cardenas C, Henaoui I, Courcot E, Roderburg C, Cauffiez C, Aubert S, et al. miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1. PLoS Genet. 2013;9:e1003291 pubmed publisher
    ..MiR-199a-5p thus behaves as a major regulator of tissue fibrosis with therapeutic potency to treat fibroproliferative diseases. ..
  4. Chan Y, Roy S, Huang Y, Khanna S, Sen C. The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway. J Biol Chem. 2012;287:41032-43 pubmed publisher
    ..Thus, down-regulation of miR-199a-5p is involved in the induction of wound angiogenesis through derepressing of the Ets-1-MMP1 pathway. ..
  5. Schneider M, Andersen D, Silahtaroglu A, Lyngbæk S, Kauppinen S, Hansen J, et al. Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry. J Mol Histol. 2011;42:289-99 pubmed publisher
    ..This approach will hopefully aid in identifying relevant miRNA targets of both the heart and other organs. ..
  6. Hassan Z, Al Olayan E. Curcumin reorganizes miRNA expression in a mouse model of liver fibrosis. Asian Pac J Cancer Prev. 2012;13:5405-8 pubmed
    ..This is the first study that highlighted the effect of curcumin on liver fibrosis through regulation of miRNAs. ..
  7. Joshi H, Subramanian I, Schnettler E, Ghosh G, Rupaimoole R, Evans C, et al. Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. Proc Natl Acad Sci U S A. 2014;111:5331-6 pubmed publisher
    ..LOX levels negatively correlated with progression-free survival in ovarian cancer patients. These results demonstrate a regulatory relationship between DNM2, miR-199a, and HIF, with implications in cancer metastasis. ..
  8. Möbus S, Yang D, Yuan Q, Lüdtke T, Balakrishnan A, Sgodda M, et al. MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells. J Hepatol. 2015;62:101-10 pubmed publisher
    ..Thus, our findings suggest that miRNA modulation may serve as a promising approach to generate more mature HLCs from stem cell sources for the treatment of liver diseases. ..
  9. Li Z, Song Y, Liu L, Hou N, An X, Zhan D, et al. miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. Cell Death Differ. 2017;24:1205-1213 pubmed publisher
    ..These results reveal a novel role of miR-199a as a key regulator of cardiac autophagy, suggesting that targeting miRNAs controlling autophagy as a potential therapeutic strategy for cardiac disease. ..
  10. Conde Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, et al. A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nat Commun. 2015;6:8093 pubmed publisher
    ..These data reveal a mechanism by which loss of PTEN increases CAV1-mediated dissociation of β-catenin from membranous E-cadherin, which may promote senescence bypass and metastasis. ..
  11. Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, et al. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009;104:879-86 pubmed publisher
    ..In addition, the data demonstrate a functional link between 2 key molecules that regulate hypoxia preconditioning and longevity. ..
  12. Huang G, Shan H, Li D, Zhou B, Pang P. MiR-199a-5p suppresses tumorigenesis by targeting clathrin heavy chain in hepatocellular carcinoma. Cell Biochem Funct. 2017;35:98-104 pubmed publisher
    ..We conclude that the frequently down-regulated miR-199a-5p can regulate CLTC and might function as a tumor suppressor in HCC. Therefore, miR-199a-5p may serve as a useful therapeutic agent for miRNA-based HCC therapy. ..
  13. Fu J, Hao L, Tian Y, Liu Y, Gu Y, Wu J. miR-199a-3p is involved in estrogen-mediated autophagy through the IGF-1/mTOR pathway in osteocyte-like MLO-Y4 cells. J Cell Physiol. 2017;: pubmed publisher
    ..Thus, miR-199a-3p appears to be involved in the estrogen regulatory networks that mediate bone cell autophagy, potentially by targeting IGF-1 and mTOR. ..
  14. Yi R, O Carroll D, Pasolli H, Zhang Z, Dietrich F, Tarakhovsky A, et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006;38:356-62 pubmed
    ..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ. ..
  15. Liu T, Chen Q, Huang Y, Huang Q, Jiang L, Guo L. Low microRNA-199a expression in human amniotic epithelial cell feeder layers maintains human-induced pluripotent stem cell pluripotency via increased leukemia inhibitory factor expression. Acta Biochim Biophys Sin (Shanghai). 2012;44:197-206 pubmed publisher
  16. Mukhopadhyay P, Brock G, Appana S, Webb C, Greene R, Pisano M. MicroRNA gene expression signatures in the developing neural tube. Birth Defects Res A Clin Mol Teratol. 2011;91:744-62 pubmed publisher
    ..This study is the first to identify miRNA expression profiles and their potential regulatory networks in the developing mammalian NT. ..
  17. Celià Terrassa T, Liu D, Choudhury A, Hang X, Wei Y, Zamalloa J, et al. Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol. 2017;19:711-723 pubmed publisher
    ..Our study therefore reveals a common mechanism shared by normal and malignant stem cells to protect them from suppressive immune cytokine signalling. ..