Gene Symbol: Mir192
Description: microRNA 192
Alias: Mirn192, mmu-mir-192
Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi J, et al
. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A. 2007;104:3432-7 pubmed
..These results uncover a role for miRs in the kidney and DN in controlling TGF-beta-induced Col1a2 expression by down-regulating E-box repressors. ..
Wang B, Herman Edelstein M, Koh P, Burns W, Jandeleit Dahm K, Watson A, et al
. E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta. Diabetes. 2010;59:1794-802 pubmed publisher
..These changes appear to occur independently of augmentation of matrix protein synthesis, suggesting that a multistep EMT program is not necessary for fibrogenesis to occur. ..
Elvira Matelot E, Zhou X, Farman N, Beaurain G, Henrion Caude A, Hadchouel J, et al
. Regulation of WNK1 expression by miR-192 and aldosterone. J Am Soc Nephrol. 2010;21:1724-31 pubmed publisher
..Taken together, these results suggest a miR-driven mechanism of gene regulation by aldosterone and a role for miR-192 in the regulation of sodium and potassium balance in the kidney. ..
Kato M, ARCE L, Wang M, Putta S, Lanting L, Natarajan R. A microRNA circuit mediates transforming growth factor-?1 autoregulation in renal glomerular mesangial cells. Kidney Int. 2011;80:358-68 pubmed publisher
..Thus, miRNA-regulated circuits may amplify TGF-?1 signaling, accelerating chronic fibrotic diseases such as diabetic nephropathy. ..
Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, et al
. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A. 2009;106:4402-7 pubmed publisher
..These findings suggest the potential of using specific circulating microRNAs as sensitive and informative biomarkers for drug-induced liver injury. ..
Hennessy E, Clynes M, Jeppesen P, O Driscoll L. Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells. Biochem Biophys Res Commun. 2010;396:457-62 pubmed publisher
..In this study, we have also identified 21 miRNAs not previously known to have a potential murine homologue. ..
Feng S, Cong S, Zhang X, Bao X, Wang W, Li H, et al
. MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Res. 2011;39:6669-78 pubmed publisher
..Furthermore, miR-192 was expressed at low levels in lung cancer samples, indicating that it might be a promising therapeutic target for lung cancer treatment. ..
Archambaud C, Nahori M, Soubigou G, Bécavin C, Laval L, Lechat P, et al
. Impact of lactobacilli on orally acquired listeriosis. Proc Natl Acad Sci U S A. 2012;109:16684-9 pubmed publisher
..monocytogenes infection by treatment with lactobacilli correlates with a decrease in host gene expression, in particular ISGs, miR regulation, and a dramatic reshaping of L. monocytogenes transcriptome. ..
Mladinov D, Liu Y, Mattson D, Liang M. MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase ?1. Nucleic Acids Res. 2013;41:1273-83 pubmed publisher
..It supports an important role of miRNAs in determining cellular characteristics that may appear subtle yet are physiologically critical. ..