Gene Symbol: Mir192
Description: microRNA 192
Alias: Mirn192, mmu-mir-192
Species: mouse

Top Publications

  1. Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi J, et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A. 2007;104:3432-7 pubmed
    ..These results uncover a role for miRs in the kidney and DN in controlling TGF-beta-induced Col1a2 expression by down-regulating E-box repressors. ..
  2. Wang B, Herman Edelstein M, Koh P, Burns W, Jandeleit Dahm K, Watson A, et al. E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta. Diabetes. 2010;59:1794-802 pubmed publisher
    ..These changes appear to occur independently of augmentation of matrix protein synthesis, suggesting that a multistep EMT program is not necessary for fibrogenesis to occur. ..
  3. Elvira Matelot E, Zhou X, Farman N, Beaurain G, Henrion Caude A, Hadchouel J, et al. Regulation of WNK1 expression by miR-192 and aldosterone. J Am Soc Nephrol. 2010;21:1724-31 pubmed publisher
    ..Taken together, these results suggest a miR-driven mechanism of gene regulation by aldosterone and a role for miR-192 in the regulation of sodium and potassium balance in the kidney. ..
  4. Kato M, ARCE L, Wang M, Putta S, Lanting L, Natarajan R. A microRNA circuit mediates transforming growth factor-?1 autoregulation in renal glomerular mesangial cells. Kidney Int. 2011;80:358-68 pubmed publisher
    ..Thus, miRNA-regulated circuits may amplify TGF-?1 signaling, accelerating chronic fibrotic diseases such as diabetic nephropathy. ..
  5. Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, et al. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A. 2009;106:4402-7 pubmed publisher
    ..These findings suggest the potential of using specific circulating microRNAs as sensitive and informative biomarkers for drug-induced liver injury. ..
  6. Hennessy E, Clynes M, Jeppesen P, O Driscoll L. Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells. Biochem Biophys Res Commun. 2010;396:457-62 pubmed publisher
    ..In this study, we have also identified 21 miRNAs not previously known to have a potential murine homologue. ..
  7. Feng S, Cong S, Zhang X, Bao X, Wang W, Li H, et al. MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Res. 2011;39:6669-78 pubmed publisher
    ..Furthermore, miR-192 was expressed at low levels in lung cancer samples, indicating that it might be a promising therapeutic target for lung cancer treatment. ..
  8. Archambaud C, Nahori M, Soubigou G, B├ęcavin C, Laval L, Lechat P, et al. Impact of lactobacilli on orally acquired listeriosis. Proc Natl Acad Sci U S A. 2012;109:16684-9 pubmed publisher
    ..monocytogenes infection by treatment with lactobacilli correlates with a decrease in host gene expression, in particular ISGs, miR regulation, and a dramatic reshaping of L. monocytogenes transcriptome. ..
  9. Mladinov D, Liu Y, Mattson D, Liang M. MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase ?1. Nucleic Acids Res. 2013;41:1273-83 pubmed publisher
    ..It supports an important role of miRNAs in determining cellular characteristics that may appear subtle yet are physiologically critical. ..

More Information


  1. Deshpande S, Putta S, Wang M, Lai J, Bitzer M, Nelson R, et al. Transforming growth factor-?-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy. Diabetes. 2013;62:3151-62 pubmed publisher
    ..Our results demonstrate for the first time a TGF-?-induced feedback amplification circuit between p53 and miR-192 related to the pathogenesis of DN, and that miR-192-knockout mice are protected from key features of DN. ..
  2. Roy S, Benz F, Alder J, Bantel H, Janssen J, Vucur M, et al. Down-regulation of miR-192-5p protects from oxidative stress-induced acute liver injury. Clin Sci (Lond). 2016;130:1197-207 pubmed publisher
  3. Morimoto A, Kannari M, Tsuchida Y, Sasaki S, Saito C, Matsuta T, et al. An HNF4?-microRNA-194/192 signaling axis maintains hepatic cell function. J Biol Chem. 2017;292:10574-10585 pubmed publisher
    ..These insights may contribute to the development of diagnostic markers for early HCC detection, and targeting of the miR-194/192 pathway could be useful for managing HCC. ..
  4. Yang R, Yang F, Huang Z, Jin Y, Sheng Y, Ji L. Serum microRNA-122-3p, microRNA-194-5p and microRNA-5099 are potential toxicological biomarkers for the hepatotoxicity induced by Airpotato yam. Toxicol Lett. 2017;280:125-132 pubmed publisher
    ..In conclusion, this study demonstrated that miR-122-3p and miRNA-194-5p were two sensitive biomarkers, and miR-5099 might be a specific biomarker for reflecting the liver injury induced by Airpotato yam. ..