Mir18

Summary

Gene Symbol: Mir18
Description: microRNA 18
Alias: Mirn18, mmu-mir-18, mmu-mir-18a
Species: mouse

Top Publications

  1. Ventura A, Young A, Winslow M, Lintault L, Meissner A, Erkeland S, et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008;132:875-86 pubmed publisher
    ..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development. ..
  2. Colas A, McKeithan W, Cunningham T, Bushway P, Garmire L, Duester G, et al. Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev. 2012;26:2567-79 pubmed publisher
    ..These findings suggest a crucial role for the let-7 and miR-18 families in germ layer specification and reveal a remarkable conservation of function from amphibians to mammals. ..
  3. Liu C, Wang M, Chen M, Zhang K, Gu L, Li Q, et al. miR-18a induces myotubes atrophy by down-regulating IgfI. Int J Biochem Cell Biol. 2017;90:145-154 pubmed publisher
    ..These findings strongly support the idea that miR-18a has a functional role in muscle physiology and suggest that miR-18a is a potential novel therapeutic target for skeletal muscle atrophy. ..
  4. Yi R, Poy M, Stoffel M, Fuchs E. A skin microRNA promotes differentiation by repressing 'stemness'. Nature. 2008;452:225-9 pubmed publisher
    ..Our findings suggest that miR-203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers. ..
  5. Geng H, Guan J. MiR-18a-5p inhibits endothelial-mesenchymal transition and cardiac fibrosis through the Notch2 pathway. Biochem Biophys Res Commun. 2017;491:329-336 pubmed publisher
    ..In conclusion, our findings demonstrated that miR-18a-5p/Notch2 signaling pathway participates in the regulation of high glucose-induced EndMT, and may act as a novel promising target for myocardial fibrosis in diabetic cardiomyopathy. ..
  6. Montoya M, Maul J, Singh P, Pua H, Dahlström F, Wu N, et al. A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation. J Immunol. 2017;199:559-569 pubmed publisher
    ..These findings indicate that activating signals influence the outcome of Th cell differentiation via differential regulation of mature microRNAs within a common cluster. ..
  7. Björk J, Sandqvist A, Elsing A, Kotaja N, Sistonen L. miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis. Development. 2010;137:3177-84 pubmed publisher
    ..Our results reveal that miR-18 regulates HSF2 activity in spermatogenesis and link miR-18 to HSF2-mediated physiological processes such as male germ cell maturation. ..
  8. Jevnaker A, Khuu C, Kjøle E, Bryne M, Osmundsen H. Expression of members of the miRNA17-92 cluster during development and in carcinogenesis. J Cell Physiol. 2011;226:2257-66 pubmed publisher
    ..Additionally, the six microRNAs exhibit variable tissue expression, suggesting selective processing of these microRNAs. ..
  9. de Pontual L, Yao E, Callier P, Faivre L, Drouin V, Cariou S, et al. Germline deletion of the miR-17?92 cluster causes skeletal and growth defects in humans. Nat Genet. 2011;43:1026-30 pubmed publisher
    ..These findings identify a regulatory function for miR-17?92 in growth and skeletal development and represent the first example of an miRNA gene responsible for a syndromic developmental defect in humans. ..

More Information

Publications24

  1. Yang Y, Ding L, An Y, ZHANG Z, Lang Y, Tai S, et al. MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells. FEBS Lett. 2012;586:422-7 pubmed publisher
    ..These results indicate that miR-18a plays a fine-tuning role in regulating pancreatic progenitors and exocrine cells through the repression of Ptf1a expression. ..
  2. Shimizu S, Tanaka T, Takeda T, Tohyama M, Miyata S. The Kampo Medicine Yokukansan Decreases MicroRNA-18 Expression and Recovers Glucocorticoid Receptors Protein Expression in the Hypothalamus of Stressed Mice. Biomed Res Int. 2015;2015:797280 pubmed publisher
    ..Collectively, these data suggest that YKS normalizes GR protein levels by regulating miR-18 expression in the hypothalamus, thus normalizing HPA axis activity following stress exposure. ..
  3. Han Y, Vidigal J, Mu P, Yao E, Singh I, González A, et al. An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015;47:766-75 pubmed publisher
    ..The reagents and data sets reported here will accelerate exploration of the complex biological functions of this important miRNA cluster. ..
  4. Chen J, Huang Z, Seok H, Ding J, Kataoka M, Zhang Z, et al. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013;112:1557-66 pubmed publisher
    ..Our studies therefore identify miR-17-92 as a critical regulator of cardiomyocyte proliferation, and suggest this cluster of microRNAs could become therapeutic targets for cardiac repair and heart regeneration. ..
  5. Masuya H, Nishida K, Furuichi T, Toki H, Nishimura G, Kawabata H, et al. A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice. Hum Mol Genet. 2007;16:2366-75 pubmed
    ..This study further highlights a critical role of GDF5 in joint formation and the development of OA, and this mouse should serve as a good model for OA. ..
  6. Li L, Shi J, Zhu G, Shi B. MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFB pathway in mouse palatal mesenchymal cells. J Cell Biochem. 2012;113:1235-44 pubmed publisher
    ..We thus conclude that miR-17-92 cluster could inhibit TGFB pathway induced proliferation inhibition and collagen synthesis in PMCs by directly targeting TGFBR2, SMAD2, and SMAD4. ..
  7. Chen J, Huang Y, Mazzoni E, Tan G, Zavadil J, Wichterle H. Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron. 2011;69:721-35 pubmed publisher
  8. Friedman L, Dror A, Mor E, Tenne T, Toren G, Satoh T, et al. MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A. 2009;106:7915-20 pubmed publisher
    ..Our data support the hypothesis that inner ear tissue differentiation and maintenance are regulated and controlled by conserved sets of cell-specific miRNAs in both mouse and zebrafish. ..
  9. Dai R, Phillips R, Zhang Y, Khan D, Crasta O, Ahmed S. Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood. 2008;112:4591-7 pubmed publisher
    ..Our data are the first to demonstrate the selective regulation of miRNA expression in immune cells by estrogen and are indicative of an important role of miRNAs in estrogen-mediated immune regulation. ..
  10. Mouw J, Yui Y, Damiano L, Bainer R, Lakins J, Acerbi I, et al. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med. 2014;20:360-7 pubmed publisher
    ..Our findings identify a mechanically regulated microRNA circuit that can promote malignancy and suggest potential prognostic roles for HOXA9 and miR-18a levels in stratifying patients with luminal breast cancers. ..
  11. Lochhead R, Ma Y, Zachary J, Baltimore D, Zhao J, Weis J, et al. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. PLoS Pathog. 2014;10:e1004212 pubmed publisher
    ..Together, these data show that miR-146a-mediated regulation of TRAF6 and NF-?B, and downstream targets such as IL-1?, IL-6 and CXCL1, are critical for modulation of Lyme arthritis during chronic infection with B. burgdorferi. ..
  12. Pan Y, Balazs L, Tigyi G, Yue J. Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality. Biochem Biophys Res Commun. 2011;408:369-74 pubmed publisher
    ..5. Expression of most miRNAs examined was compromised in VSMCs of Dicer KO. Our results indicate that Dicer is required for vascular development and regulates vascular remodeling by modulating VSMC proliferation and differentiation. ..
  13. Lu Y, Thomson J, Wong H, Hammond S, Hogan B. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol. 2007;310:442-53 pubmed
    ..Together, these studies suggest that mir-17-92 normally promotes the high proliferation and undifferentiated phenotype of lung epithelial progenitor cells. ..
  14. Chen Z, Wu J, Yang C, Fan P, Balazs L, Jiao Y, et al. DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice. J Biol Chem. 2012;287:19018-28 pubmed publisher
    ..Our results indicate that the DGCR8 gene is required for vascular development through the regulation of VSMC proliferation, apoptosis, and differentiation...
  15. Ries R, Yu W, Holton N, Cao H, Amendt B. Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis. J Dent Res. 2017;96:1257-1264 pubmed publisher
    ..The differential regulation of palatogenesis by members of the miR-17-92 cluster indicates that several gene combinations regulate palate elevation and extension during development. ..